{"id":"https://openalex.org/W2995351456","doi":null,"title":"Plasma Endothelin in Patients With End-Stage Renal Disease on Hemodialysis","display_name":"Plasma Endothelin in Patients With End-Stage Renal Disease on Hemodialysis","publication_year":2019,"publication_date":"2019-05-30","ids":{"openalex":"https://openalex.org/W2995351456","mag":"2995351456"},"language":"en","primary_location":{"id":"pmh:oai:dash.harvard.edu:1/42061458","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:42061458","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:42061458","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:42061458","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100435448","display_name":"Ping Li","orcid":"https://orcid.org/0000-0001-5330-1040","observed_orcids":["https://orcid.org/0000-0001-5330-1040"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ping Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5330-1040","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100435448"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.7720000147819519,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.7720000147819519,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.21690000593662262,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.6489999890327454},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.9929999709129333},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.6000000238418579},{"id":"https://openalex.org/keywords/endothelin-receptor-antagonists","display_name":"endothelin receptor antagonists","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6790000200271606},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.30300000309944153},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C3019040382","wikidata":"https://www.wikidata.org/wiki/Q476921","display_name":"End stage renal disease","level":3,"score":0.8364391326904297},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.8267578482627869},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.6227396130561829},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.580564558506012},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.48220813274383545},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4587429463863373},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.38640838861465454},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.33287838101387024},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dash.harvard.edu:1/42061458","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:42061458","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:42061458","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},{"id":"mag:2995351456","doi":null,"is_oa":false,"landing_page_url":"https://dash.harvard.edu/handle/1/42061458","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dash.harvard.edu:1/42061458","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:42061458","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:42061458","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2995351456.pdf","grobid_xml":"https://content.openalex.org/works/W2995351456.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1813207029","https://openalex.org/W1975370982","https://openalex.org/W1990460736","https://openalex.org/W1991210746","https://openalex.org/W1998943227","https://openalex.org/W2009282512","https://openalex.org/W2011837005","https://openalex.org/W2016736330","https://openalex.org/W2020359290","https://openalex.org/W2025252445","https://openalex.org/W2037083937","https://openalex.org/W2040029744","https://openalex.org/W2044604651","https://openalex.org/W2049663603","https://openalex.org/W2049862929","https://openalex.org/W2060059231","https://openalex.org/W2073077423","https://openalex.org/W2074470038","https://openalex.org/W2083980460","https://openalex.org/W2091625713","https://openalex.org/W2096179755","https://openalex.org/W2096537254","https://openalex.org/W2102108097","https://openalex.org/W2103295047","https://openalex.org/W2123664981","https://openalex.org/W2127195061","https://openalex.org/W2132872400","https://openalex.org/W2133952618","https://openalex.org/W2134487085","https://openalex.org/W2137247821","https://openalex.org/W2145632027","https://openalex.org/W2150277101","https://openalex.org/W2150976198","https://openalex.org/W2156481396","https://openalex.org/W2159819952","https://openalex.org/W2162804111","https://openalex.org/W2163370089","https://openalex.org/W2164569629","https://openalex.org/W2293720744","https://openalex.org/W2297865244","https://openalex.org/W2321166940","https://openalex.org/W2322234452","https://openalex.org/W2331665138","https://openalex.org/W2341398312","https://openalex.org/W2406351639","https://openalex.org/W2413889436","https://openalex.org/W2467621924","https://openalex.org/W2498485491","https://openalex.org/W2736116220","https://openalex.org/W2772105842","https://openalex.org/W2793672077"],"related_works":["https://openalex.org/W3023199095","https://openalex.org/W2127195061","https://openalex.org/W2073077423","https://openalex.org/W2019226659","https://openalex.org/W7213247817","https://openalex.org/W2414798675","https://openalex.org/W2069749152","https://openalex.org/W2332757123","https://openalex.org/W2977246941","https://openalex.org/W1929551814"],"abstract_inverted_index":{"End-stage":[0],"renal":[1,62,84],"disease":[2,63,85],"(ESRD)":[3],"is":[4,15,36,88],"a":[5,37,113,163,177,231],"worldwide":[6],"public":[7],"health":[8],"problem.":[9],"The":[10,125,134],"main":[11],"treatment":[12],"for":[13,194,227],"ESRD":[14,120],"still":[16],"hemodialysis":[17,66,87,105,210],"(HD).":[18],"Despite":[19],"the":[20,44,72,92,151,159,224],"substantial":[21],"improvements":[22],"in":[23,43,79,104,112,150,158,190,209,234],"dialysis":[24],"therapy,":[25],"HD":[26],"patients":[27,211],"continue":[28],"to":[29,130,148,203,222],"experience":[30],"significant":[31],"mortality":[32],"and":[33,51,132,176,197],"morbidity.Endothelin-1":[34],"(ET-1)":[35],"potent":[38],"endothelium-derived":[39],"vasoconstrictor":[40],"peptide":[41],"implicated":[42],"pathogenesis":[45],"of":[46,54,60,74,115,154,167,181,213],"hypertension,":[47],"congestive":[48],"heart":[49],"failure,":[50],"inflammation,":[52],"all":[53],"which":[55],"are":[56,98,220],"key":[57],"pathophysiologic":[58],"features":[59],"end-stage":[61],"(ESRD).":[64],"In":[65],"patients,":[67,106],"ET-1":[68,75,96,110,137,201,228],"increases":[69],"strikingly":[70],"but":[71],"association":[73],"with":[76,81,100,118,122,206],"adverse":[77,102,207],"outcomes":[78,127],"individuals":[80,117,149],"end":[82],"stage":[83],"on":[86],"unclear.":[89],"To":[90],"test":[91,223],"hypothesis":[93],"that":[94],"increased":[95,101,179],"levels":[97,111],"associated":[99,205],"events":[103,208],"we":[107],"measured":[108],"plasma":[109,136,155,200],"cohort":[114],"794":[116],"prevalent":[119],"treated":[121],"maintenance":[123],"hemodialysis.":[124],"primary":[126],"were":[128],"time":[129],"death":[131,168],"hospitalization.":[133],"median":[135],"level":[138],"was":[139],"2.02":[140],"(interquartile":[141],"range,":[142],"1.57":[143],"\u2013":[144,174,188],"2.71)":[145],"pg/mL.":[146],"Compared":[147],"lowest":[152],"quartile":[153,161],"ET-1,":[156],"those":[157],"highest":[160],"had":[162],"2.52-fold":[164],"higher":[165],"risk":[166,180,216],"(HR":[169,183],"2.52,":[170],"95%":[171,185],"CI":[172,186],"1.68":[173],"3.79)":[175],"1.13-fold":[178],"hospitalization":[182],"1.16,":[184],"1.04":[187],"1.23)":[189],"multivariable":[191],"models":[192],"adjusting":[193],"demographic,":[195],"clinical,":[196],"laboratory":[198],"variables.Higher":[199],"appears":[202],"be":[204],"independent":[212],"previously":[214],"described":[215],"factors.":[217],"Future":[218],"trials":[219],"expected":[221],"potential":[225],"role":[226],"antagonists":[229],"as":[230],"pharmacological":[232],"intervention":[233],"ESRD.":[235]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}