{"id":"https://openalex.org/W2995348795","doi":"https://doi.org/10.14412/2074-2711-2019-4-68-76","title":"Genetic risk factors for behavioral adverse reactions in epileptic patients taking levetiracetam","display_name":"Genetic risk factors for behavioral adverse reactions in epileptic patients taking levetiracetam","publication_year":2019,"publication_date":"2019-12-08","ids":{"openalex":"https://openalex.org/W2995348795","doi":"https://doi.org/10.14412/2074-2711-2019-4-68-76","mag":"2995348795"},"language":"en","primary_location":{"id":"doi:10.14412/2074-2711-2019-4-68-76","doi":"https://doi.org/10.14412/2074-2711-2019-4-68-76","is_oa":true,"landing_page_url":"https://doi.org/10.14412/2074-2711-2019-4-68-76","pdf_url":"https://nnp.ima-press.net/nnp/article/download/1212/966","source":{"id":"https://openalex.org/S4210231845","display_name":"Neurology neuropsychiatry Psychosomatics","issn_l":"2074-2711","issn":["2074-2711","2310-1342"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312717","host_organization_name":"IMA-PRESS LLC","host_organization_lineage":["https://openalex.org/P4310312717"],"host_organization_lineage_names":["IMA-PRESS LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology, Neuropsychiatry, Psychosomatics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://nnp.ima-press.net/nnp/article/download/1212/966","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065610255","display_name":"\u0423\u0441\u043e\u043b\u044c\u0446\u0435\u0432\u0430 \u0410\u043d\u043d\u0430 \u0410\u043b\u0435\u043a\u0441\u0430\u043d\u0434\u0440\u043e\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0002-9678-6719","observed_orcids":["https://orcid.org/0000-0002-9678-6719"]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. A. Usoltseva","raw_affiliation_strings":["Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia","institution_ids":["https://openalex.org/I4210090231","https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037778467","display_name":"\u0414. \u0412. \u0414\u043c\u0438\u0442\u0440\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0003-4639-6365","observed_orcids":["https://orcid.org/0000-0003-4639-6365"]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D. V. Dmitrenko","raw_affiliation_strings":["Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia","institution_ids":["https://openalex.org/I4210090231","https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044795716","display_name":"\u0417\u043e\u0431\u043e\u0432\u0430 \u0421\u0432\u0435\u0442\u043b\u0430\u043d\u0430 \u041d\u0438\u043a\u043e\u043b\u0430\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0003-2748-3164","observed_orcids":["https://orcid.org/0000-0003-2748-3164"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210088310","display_name":"Krasnoyarsk Scientific Center","ror":"https://ror.org/007ebp326","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210088310","https://openalex.org/I4210127387"]},{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]},{"id":"https://openalex.org/I4210099851","display_name":"Research Institute of Medical Problems of the North","ror":"https://ror.org/01vjps349","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210099851"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S. N. Zobova","raw_affiliation_strings":["Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia;\r\nResearch Institute of Medical Problems of the North (Separate Subdivision), Federal Research Center \u00abKrasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences\u00bb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia;\r\nResearch Institute of Medical Problems of the North (Separate Subdivision), Federal Research Center \u00abKrasnoyarsk Research Center, Siberian Branch, Russian Academy of Sciences\u00bb","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210088310","https://openalex.org/I4210090231","https://openalex.org/I4210099851","https://openalex.org/I4210117042","https://openalex.org/I4210127387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086480376","display_name":"\u0411\u043e\u0447\u0430\u043d\u043e\u0432\u0430 \u0415\u043b\u0435\u043d\u0430 \u041d\u0438\u043a\u043e\u043b\u0430\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0003-4371-2342","observed_orcids":["https://orcid.org/0000-0003-4371-2342"]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. N. Bochanova","raw_affiliation_strings":["Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia","institution_ids":["https://openalex.org/I4210090231","https://openalex.org/I4210117042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033552717","display_name":"Natalia Alekseevna Shnayder","orcid":"https://orcid.org/0000-0002-2840-837X","observed_orcids":["https://orcid.org/0000-0002-2840-837X"]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. A. Shnayder","raw_affiliation_strings":["Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia;\r\nV.M. Bekhterev National Medical Research Center of Psychiatry and Neurology, Ministry of Health of Russia","V.M. Bekhterev National Medical Research Center of Psychiatry and Neurology, Ministry of Health of Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia;\r\nV.M. Bekhterev National Medical Research Center of Psychiatry and Neurology, Ministry of Health of Russia","institution_ids":["https://openalex.org/I4210090231","https://openalex.org/I4210117042"]},{"raw_affiliation_string":"V.M. Bekhterev National Medical Research Center of Psychiatry and Neurology, Ministry of Health of Russia","institution_ids":["https://openalex.org/I4210117042"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"11","issue":"4","first_page":"68","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.7333999872207642,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.7333999872207642,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.22390000522136688,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levetiracetam","display_name":"levetiracetam","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.8650000095367432},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.6740000247955322},{"id":"https://openalex.org/keywords/impulsivity","display_name":"impulsivity","score":0.8629999756813049},{"id":"https://openalex.org/keywords/aggression","display_name":"aggression","score":0.7360000014305115},{"id":"https://openalex.org/keywords/irritability","display_name":"irritability","score":0.7020000219345093},{"id":"https://openalex.org/keywords/hyperexcitability","display_name":"hyperexcitability","score":0.7879999876022339},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.7929999828338623},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.7540000081062317},{"id":"https://openalex.org/keywords/comt-val158met-polymorphism","display_name":"COMT Val158Met polymorphism","score":0.9639999866485596},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.44699999690055847},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2778524067","wikidata":"https://www.wikidata.org/wiki/Q17142059","display_name":"rs4680","level":5,"score":0.9351547956466675},{"id":"https://openalex.org/C2777332695","wikidata":"https://www.wikidata.org/wiki/Q417227","display_name":"Levetiracetam","level":3,"score":0.8374346494674683},{"id":"https://openalex.org/C2780820931","wikidata":"https://www.wikidata.org/wiki/Q29299","display_name":"Irritability","level":3,"score":0.6969103217124939},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6911717057228088},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5276466608047485},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.5274287462234497},{"id":"https://openalex.org/C2780319597","wikidata":"https://www.wikidata.org/wiki/Q1549918","display_name":"Impulsivity","level":2,"score":0.527381420135498},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.44105178117752075},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.37121811509132385},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.32192596793174744},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2765806317329407},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.1841479241847992},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09166696667671204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0883556604385376},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.14412/2074-2711-2019-4-68-76","doi":"https://doi.org/10.14412/2074-2711-2019-4-68-76","is_oa":true,"landing_page_url":"https://doi.org/10.14412/2074-2711-2019-4-68-76","pdf_url":"https://nnp.ima-press.net/nnp/article/download/1212/966","source":{"id":"https://openalex.org/S4210231845","display_name":"Neurology neuropsychiatry Psychosomatics","issn_l":"2074-2711","issn":["2074-2711","2310-1342"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312717","host_organization_name":"IMA-PRESS LLC","host_organization_lineage":["https://openalex.org/P4310312717"],"host_organization_lineage_names":["IMA-PRESS LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology, Neuropsychiatry, Psychosomatics","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:35ffd1976a7347b2922d85e1ea18a535","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/35ffd1976a7347b2922d85e1ea18a535","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u041d\u0435\u0432\u0440\u043e\u043b\u043e\u0433\u0438\u044f, \u043d\u0435\u0439\u0440\u043e\u043f\u0441\u0438\u0445\u0438\u0430\u0442\u0440\u0438\u044f, \u043f\u0441\u0438\u0445\u043e\u0441\u043e\u043c\u0430\u0442\u0438\u043a\u0430, Vol 11, Iss 4, Pp 68-76 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.14412/2074-2711-2019-4-68-76","doi":"https://doi.org/10.14412/2074-2711-2019-4-68-76","is_oa":true,"landing_page_url":"https://doi.org/10.14412/2074-2711-2019-4-68-76","pdf_url":"https://nnp.ima-press.net/nnp/article/download/1212/966","source":{"id":"https://openalex.org/S4210231845","display_name":"Neurology neuropsychiatry Psychosomatics","issn_l":"2074-2711","issn":["2074-2711","2310-1342"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312717","host_organization_name":"IMA-PRESS LLC","host_organization_lineage":["https://openalex.org/P4310312717"],"host_organization_lineage_names":["IMA-PRESS LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology, Neuropsychiatry, Psychosomatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2995348795.pdf","grobid_xml":"https://content.openalex.org/works/W2995348795.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1969052084","https://openalex.org/W1970586330","https://openalex.org/W1989054396","https://openalex.org/W2053813408","https://openalex.org/W2055866540","https://openalex.org/W2056039600","https://openalex.org/W2101442317","https://openalex.org/W2118869247","https://openalex.org/W2136062733","https://openalex.org/W2146454742","https://openalex.org/W2367812079","https://openalex.org/W2898309205","https://openalex.org/W2913870447"],"related_works":["https://openalex.org/W3111993843","https://openalex.org/W2101442317","https://openalex.org/W3088176442","https://openalex.org/W1979519368","https://openalex.org/W1995446121","https://openalex.org/W2131109274","https://openalex.org/W2110264327","https://openalex.org/W4416265045","https://openalex.org/W4221080261","https://openalex.org/W4389464670"],"abstract_inverted_index":{"Levetiracetam":[0],"(LEV)":[1],"is":[2,11,280,297],"an":[3],"effective":[4],"antiepileptic":[5],"drug.":[6],"Nevertheless,":[7],"when":[8],"the":[9,71,80,110,147,201,204,212,240,243,259,300,324],"drug":[10,16],"used,":[12],"its":[13],"behavioral":[14,50,89,216,278,309,329],"adverse":[15],"reactions":[17],"(ADRs),":[18],"such":[19],"as":[20,321],"aggressivity,":[21],"irritability,":[22],"hyperexcitability,":[23],"and":[24,58,75,109,125,134,138,156,161,164,181,185,189,211,223,252,285,305,331],"anxiety,":[25],"occur":[26],"in":[27,52,93,146,152,178,186,226,239,282,292],"almost":[28],"30%":[29],"of":[30,73,83,112,117,150,203,208,214,242,248,258,277,302,323],"cases.":[31],"Recent":[32],"studies":[33],"show":[34],"that":[35,317],"personality":[36],"traits":[37],"can":[38,318],"predispose":[39],"to":[40,44,67,107,313],"LEV-induced":[41,308],"ARs.":[42],"Objective:":[43],"establish":[45],"genetic":[46,115,326],"risk":[47],"factors":[48],"for":[49,70,88,174,269,328],"ADRs":[51,225,279,310,330],"epileptic":[53,95,293],"patients":[54,96,287,294],"taking":[55,97,288,295],"LEV.":[56,289],"Patients":[57],"methods.":[59],"Single":[60],"nucleotide":[61],"variants":[62],"(SNVs)":[63],"were":[64,101,172,237,267],"chosen":[65],"according":[66,106],"their":[68],"importance":[69],"development":[72],"impulsivity":[74,235],"aggressivity.":[76],"At":[77],"Stage":[78,131],"1,":[79],"dose-dependent":[81,275],"effect":[82,276],"LEV,":[84],"which":[85],"was":[86,91,128,195],"responsible":[87],"ADRs,":[90],"studied":[92],"179":[94],"this":[98],"drug,":[99],"who":[100],"divided":[102],"into":[103],"four":[104],"groups":[105,140],"age":[108],"presence":[111],"ADRs.":[113],"Molecular":[114],"testing":[116],"SNVs":[118],"DRD2":[119],"rs1800497":[120,250,304],"(DRD2/ANKK1":[121],"Taq1A),":[122],"COMT":[123],"rs4680,":[124],"DBH":[126,315],"rs1611115":[127,210,253,316],"done":[129],"at":[130],"2.":[132],"Results":[133],"discussion.":[135],"The":[136,169,274,307],"ADR":[137],"non-ADR":[139],"showed":[141],"no":[142],"statistically":[143,197,263],"significant":[144,198,264],"differences":[145,266],"daily":[148],"dose":[149],"LEV":[151,176,296],"both":[153,215,283],"children":[154,179],"(696.1":[155],"500.0":[157],"mg/day,":[158,166],"respectively;":[159,167,192],"p=0.087)":[160],"adults":[162,187],"(750.9":[163],"750.9":[165],"p=0.13).":[168],"similar":[170],"data":[171],"obtained":[173,268],"blood":[175],"concentrations":[177],"(31.6":[180],"27.3":[182],"\u03bcg/ml,":[183,191],"p=0.12)":[184],"(23.1":[188],"17.6":[190],"p=0.12).":[193],"There":[194],"a":[196],"association":[199],"between":[200],"carriage":[202,301],"heterozygous":[205],"CT":[206,244],"genotype":[207],"SNV":[209,249,270,303,314],"rate":[213],"(OR,":[217,228],"3.38;":[218],"95%":[219,230],"CI,":[220,231],"1.25\u20139.14;":[221],"p=0.042)":[222],"CNS":[224],"general":[227],"3.29;":[229],"1.29\u20138.44;":[232],"p=0.036).":[233],"Higher":[234],"values":[236],"recorded":[238],"carriers":[241],"+":[245],"TT":[246],"genotypes":[247],"(p<0.05)":[251],"(p<0.01)":[254],"compared":[255],"with":[256,299],"those":[257],"CC":[260],"genotype.":[261],"No":[262],"intergroup":[265],"COMP":[271],"rs4680.":[272],"Conclusion.":[273],"absent":[281],"pediatric":[284],"adult":[286],"Increased":[290],"impulsiveness":[291],"associated":[298],"rs1611115.":[306],"are":[311],"related":[312],"be":[319],"considered":[320],"one":[322],"potential":[325],"predictors":[327],"impulsivity.":[332]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}