{"id":"https://openalex.org/W2995337046","doi":"https://doi.org/10.1080/21541264.2019.1698934","title":"The role of enhancer RNAs in epigenetic regulation of gene expression","display_name":"The role of enhancer RNAs in epigenetic regulation of gene expression","publication_year":2019,"publication_date":"2019-12-11","ids":{"openalex":"https://openalex.org/W2995337046","doi":"https://doi.org/10.1080/21541264.2019.1698934","mag":"2995337046","pmid":"https://pubmed.ncbi.nlm.nih.gov/31823686","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7053929"},"language":"en","primary_location":{"id":"doi:10.1080/21541264.2019.1698934","doi":"https://doi.org/10.1080/21541264.2019.1698934","is_oa":false,"landing_page_url":"https://doi.org/10.1080/21541264.2019.1698934","pdf_url":null,"source":{"id":"https://openalex.org/S4210168212","display_name":"Transcription","issn_l":"2154-1264","issn":["2154-1264","2154-1272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transcription","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7053929","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077673258","display_name":"Homa Rahnamoun","orcid":"https://orcid.org/0000-0002-0555-2328","observed_orcids":["https://orcid.org/0000-0002-0555-2328"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Homa Rahnamoun","raw_affiliation_strings":["Section of Molecular Biology, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-0555-2328","affiliations":[{"raw_affiliation_string":"Section of Molecular Biology, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053590590","display_name":"Paola Orozco","orcid":"https://orcid.org/0000-0001-6616-6749","observed_orcids":["https://orcid.org/0000-0001-6616-6749"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paola Orozco","raw_affiliation_strings":["Section of Molecular Biology, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Molecular Biology, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008867130","display_name":"Shannon\u00a0M. Lauberth","orcid":"https://orcid.org/0000-0003-4131-8536","observed_orcids":["https://orcid.org/0000-0003-4131-8536"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shannon M. Lauberth","raw_affiliation_strings":["Section of Molecular Biology, University of California, San Diego, La Jolla, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-4131-8536","affiliations":[{"raw_affiliation_string":"Section of Molecular Biology, University of California, San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008867130"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":0.1927,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.17545928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"19","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8682000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8682000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.08089999854564667,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enhancer-rna","display_name":"enhancer RNA","score":0.9890000224113464},{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.6930000185966492},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/bromodomain-proteins","display_name":"bromodomain proteins","score":0.925000011920929},{"id":"https://openalex.org/keywords/chromatin-acetylation","display_name":"chromatin acetylation","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.9160336256027222},{"id":"https://openalex.org/C74401373","wikidata":"https://www.wikidata.org/wiki/Q1829843","display_name":"Bromodomain","level":4,"score":0.7717531323432922},{"id":"https://openalex.org/C21784809","wikidata":"https://www.wikidata.org/wiki/Q17119097","display_name":"Enhancer RNAs","level":5,"score":0.7433596253395081},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7007182240486145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6356947422027588},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6189578771591187},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5324783325195312},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.48573070764541626},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.475816547870636},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.46967893838882446},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4509626030921936},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44682377576828003},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.41318878531455994},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3910343647003174},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3392835557460785},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1080/21541264.2019.1698934","doi":"https://doi.org/10.1080/21541264.2019.1698934","is_oa":false,"landing_page_url":"https://doi.org/10.1080/21541264.2019.1698934","pdf_url":null,"source":{"id":"https://openalex.org/S4210168212","display_name":"Transcription","issn_l":"2154-1264","issn":["2154-1264","2154-1272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transcription","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7053929","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7053929","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transcription","raw_type":"Text"},{"id":"pmid:31823686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31823686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transcription","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7053929","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7053929","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transcription","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G123118827","display_name":"The Roles of Enhancer RNAs in the Regulation of Gene Expression","funder_award_id":"R35GM128900","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2086217188","display_name":"Cell and Molecular Genetics Training Program","funder_award_id":"T32GM007240","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W1500148822","https://openalex.org/W1523117612","https://openalex.org/W1595665778","https://openalex.org/W1625510017","https://openalex.org/W1854281301","https://openalex.org/W1863874155","https://openalex.org/W1964963969","https://openalex.org/W1976033223","https://openalex.org/W1978901723","https://openalex.org/W1979187818","https://openalex.org/W1981030303","https://openalex.org/W1985105928","https://openalex.org/W1986586739","https://openalex.org/W1992127633","https://openalex.org/W1992918548","https://openalex.org/W1995226230","https://openalex.org/W1996060670","https://openalex.org/W1998871958","https://openalex.org/W2004966039","https://openalex.org/W2005986419","https://openalex.org/W2014677321","https://openalex.org/W2014787267","https://openalex.org/W2015845481","https://openalex.org/W2016326408","https://openalex.org/W2017297735","https://openalex.org/W2017789254","https://openalex.org/W2041535798","https://openalex.org/W2045362835","https://openalex.org/W2051959262","https://openalex.org/W2052741109","https://openalex.org/W2064897513","https://openalex.org/W2069695937","https://openalex.org/W2078059415","https://openalex.org/W2078081719","https://openalex.org/W2082161548","https://openalex.org/W2094468530","https://openalex.org/W2094654932","https://openalex.org/W2096010243","https://openalex.org/W2099828463","https://openalex.org/W2110485236","https://openalex.org/W2111099379","https://openalex.org/W2113945915","https://openalex.org/W2114763268","https://openalex.org/W2115628336","https://openalex.org/W2118532317","https://openalex.org/W2120572492","https://openalex.org/W2123564569","https://openalex.org/W2123647733","https://openalex.org/W2127996002","https://openalex.org/W2129129812","https://openalex.org/W2129265683","https://openalex.org/W2131820599","https://openalex.org/W2134397552","https://openalex.org/W2144578935","https://openalex.org/W2154077612","https://openalex.org/W2154746182","https://openalex.org/W2161671616","https://openalex.org/W2166810745","https://openalex.org/W2167421769","https://openalex.org/W2261819980","https://openalex.org/W2295037017","https://openalex.org/W2320459985","https://openalex.org/W2518319998","https://openalex.org/W2536839675","https://openalex.org/W2568322231","https://openalex.org/W2578822114","https://openalex.org/W2733066269","https://openalex.org/W2734641630","https://openalex.org/W2763907932","https://openalex.org/W2786141666","https://openalex.org/W2794654572","https://openalex.org/W2809057270","https://openalex.org/W2863481345","https://openalex.org/W2883217678","https://openalex.org/W2895877323","https://openalex.org/W2920174847","https://openalex.org/W2943855616","https://openalex.org/W2951348608"],"related_works":["https://openalex.org/W2883217678","https://openalex.org/W3033842668","https://openalex.org/W2944661061","https://openalex.org/W3092177456","https://openalex.org/W2027347575","https://openalex.org/W2171096629","https://openalex.org/W4377042743","https://openalex.org/W2907456810","https://openalex.org/W2992086063","https://openalex.org/W2148485748"],"abstract_inverted_index":{"Since":[0],"the":[1,8,38,42],"discovery":[2],"that":[3,19],"enhancers":[4],"can":[5],"support":[6],"transcription,":[7],"roles":[9],"of":[10,46],"enhancer":[11,20,47],"RNAs":[12,21],"have":[13],"remained":[14],"largely":[15],"elusive.":[16],"We":[17],"identified":[18],"interact":[22],"with":[23,28],"and":[24,37,44],"augment":[25],"bromodomain":[26],"engagement":[27],"acetylated":[29],"chromatin.":[30],"Here,":[31],"we":[32],"discuss":[33],"our":[34],"recent":[35],"findings":[36],"potential":[39],"mechanisms":[40],"underlying":[41],"regulation":[43],"functions":[45],"RNA-bromodomain":[48],"associations.":[49]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-26T00:00:00"}