{"id":"https://openalex.org/W2995304516","doi":"https://doi.org/10.17116/hirurgia201912174","title":"New possibilities in antibacterial treatment of intra-abdominal infections caused by multiresistant microflora","display_name":"New possibilities in antibacterial treatment of intra-abdominal infections caused by multiresistant microflora","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2995304516","doi":"https://doi.org/10.17116/hirurgia201912174","mag":"2995304516","pmid":"https://pubmed.ncbi.nlm.nih.gov/31825346"},"language":"ru","primary_location":{"id":"doi:10.17116/hirurgia201912174","doi":"https://doi.org/10.17116/hirurgia201912174","is_oa":false,"landing_page_url":"https://doi.org/10.17116/hirurgia201912174","pdf_url":null,"source":{"id":"https://openalex.org/S4210185770","display_name":"Pirogov Russian Journal of Surgery","issn_l":"0023-1207","issn":["0023-1207","2309-5628"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310321066","host_organization_name":"Meditsina","host_organization_lineage":["https://openalex.org/P4310321066"],"host_organization_lineage_names":["Meditsina"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Khirurgiya. Zhurnal im. N.I. Pirogova","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081114003","display_name":"\u041c. \u0414. \u0414\u0438\u0431\u0438\u0440\u043e\u0432","orcid":"https://orcid.org/0000-0002-2079-0957","observed_orcids":["https://orcid.org/0000-0002-2079-0957"]},"institutions":[{"id":"https://openalex.org/I136268261","display_name":"Russian University of Medicine","ror":"https://ror.org/04bgrkn57","country_code":"RU","type":"education","lineage":["https://openalex.org/I136268261"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M. D. Dibirov","raw_affiliation_strings":["Department of Surgery and Clinical Angiology at Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Clinical Angiology at Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia","institution_ids":["https://openalex.org/I136268261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061526066","display_name":"Nana N. Khachatryan","orcid":"https://orcid.org/0000-0003-1109-6864","observed_orcids":["https://orcid.org/0000-0003-1109-6864"]},"institutions":[{"id":"https://openalex.org/I136268261","display_name":"Russian University of Medicine","ror":"https://ror.org/04bgrkn57","country_code":"RU","type":"education","lineage":["https://openalex.org/I136268261"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. N. Khachatryan","raw_affiliation_strings":["Department of Surgery and Clinical Angiology at Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Clinical Angiology at Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia","institution_ids":["https://openalex.org/I136268261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019066635","display_name":"\u0410. \u0418. \u0418\u0441\u0430\u0435\u0432","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136268261","display_name":"Russian University of Medicine","ror":"https://ror.org/04bgrkn57","country_code":"RU","type":"education","lineage":["https://openalex.org/I136268261"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. I. Isaev","raw_affiliation_strings":["Department of Surgery and Clinical Angiology at Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Clinical Angiology at Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia","institution_ids":["https://openalex.org/I136268261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014191744","display_name":"Karsot'ian Gs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136268261","display_name":"Russian University of Medicine","ror":"https://ror.org/04bgrkn57","country_code":"RU","type":"education","lineage":["https://openalex.org/I136268261"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"G. S. Karsotyan","raw_affiliation_strings":["Department of Surgery and Clinical Angiology at Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Clinical Angiology at Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, Russia","institution_ids":["https://openalex.org/I136268261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089483334","display_name":"E E Alimova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. E. Alimova","raw_affiliation_strings":["Moscow city hospital named after S.I. Spasokukotskiy, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moscow city hospital named after S.I. Spasokukotskiy, Moscow, Russia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019936783","display_name":"E.A. Kostyuk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. A. Kostyuk","raw_affiliation_strings":["Moscow city hospital named after S.I. Spasokukotskiy, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moscow city hospital named after S.I. Spasokukotskiy, Moscow, Russia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":null,"issue":"12","first_page":"74","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intra-abdominal-infection","display_name":"intra-abdominal infection","score":0.9100000262260437},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9070000052452087},{"id":"https://openalex.org/keywords/antibiotic-therapy","display_name":"antibiotic therapy","score":0.6460000276565552},{"id":"https://openalex.org/keywords/ceftolozane-tazobactam","display_name":"ceftolozane/tazobactam","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ceftazidime-avibactam","display_name":"ceftazidime-avibactam","score":0.9520000219345093},{"id":"https://openalex.org/keywords/metronidazole","display_name":"metronidazole","score":0.9919999837875366},{"id":"https://openalex.org/keywords/carbapenem-resistant-klebsiella-pneumoniae","display_name":"carbapenem-resistant Klebsiella pneumoniae","score":0.8560000061988831},{"id":"https://openalex.org/keywords/empirical-antibiotic-therapy","display_name":"empirical antibiotic therapy","score":0.765999972820282},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6840000152587891},{"id":"https://openalex.org/keywords/antimicrobial-resistance-surveillance","display_name":"antimicrobial resistance surveillance","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C2777396551","wikidata":"https://www.wikidata.org/wiki/Q169569","display_name":"Metronidazole","level":3,"score":0.7361152172088623},{"id":"https://openalex.org/C2776933286","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumonia","level":4,"score":0.6171464920043945},{"id":"https://openalex.org/C2778266534","wikidata":"https://www.wikidata.org/wiki/Q423376","display_name":"Tazobactam","level":5,"score":0.6048129200935364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5781970024108887},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.5205615162849426},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4289170205593109},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4235111176967621},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.39636361598968506},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.376179039478302},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2803307771682739},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.2205851972103119},{"id":"https://openalex.org/C2779631663","wikidata":"https://www.wikidata.org/wiki/Q425152","display_name":"Imipenem","level":4,"score":0.15807035565376282},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.15761780738830566},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.14970210194587708},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002442","descriptor_name":"Ceftazidime","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002511","descriptor_name":"Cephalosporins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010397","descriptor_name":"Penicillanic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D053961","descriptor_name":"Azabicyclo Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D059413","descriptor_name":"Intraabdominal Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D059413","descriptor_name":"Intraabdominal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.17116/hirurgia201912174","doi":"https://doi.org/10.17116/hirurgia201912174","is_oa":false,"landing_page_url":"https://doi.org/10.17116/hirurgia201912174","pdf_url":null,"source":{"id":"https://openalex.org/S4210185770","display_name":"Pirogov Russian Journal of Surgery","issn_l":"0023-1207","issn":["0023-1207","2309-5628"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310321066","host_organization_name":"Meditsina","host_organization_lineage":["https://openalex.org/P4310321066"],"host_organization_lineage_names":["Meditsina"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Khirurgiya. Zhurnal im. N.I. Pirogova","raw_type":"journal-article"},{"id":"pmid:31825346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31825346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Khirurgiia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W76317723","https://openalex.org/W1658434241","https://openalex.org/W1959513603","https://openalex.org/W1969370213","https://openalex.org/W1969500929","https://openalex.org/W1989214550","https://openalex.org/W1989886020","https://openalex.org/W1996464076","https://openalex.org/W2010231427","https://openalex.org/W2056317617","https://openalex.org/W2092279762","https://openalex.org/W2103111051","https://openalex.org/W2108615287","https://openalex.org/W2117154145","https://openalex.org/W2163025725","https://openalex.org/W2294833633","https://openalex.org/W2339819000","https://openalex.org/W2342079999","https://openalex.org/W2345934860","https://openalex.org/W2347027545","https://openalex.org/W2404119229","https://openalex.org/W2561036368","https://openalex.org/W2591044857","https://openalex.org/W2618911885","https://openalex.org/W2729161724","https://openalex.org/W2791015146","https://openalex.org/W2802730328","https://openalex.org/W2924739878","https://openalex.org/W2981806901"],"related_works":["https://openalex.org/W4301026462","https://openalex.org/W7097463761","https://openalex.org/W2979414763","https://openalex.org/W2953601600","https://openalex.org/W2274092967","https://openalex.org/W2983753834","https://openalex.org/W2155453170","https://openalex.org/W2226350358","https://openalex.org/W3089188288","https://openalex.org/W2538071431"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"determine":[2],"the":[3,17,48,64,123,134,145],"place":[4],"of":[5,14,19,30,50,66,88,104,119,130,136],"new":[6],"drugs":[7,62],"with":[8,38,111],"activity":[9,125],"against":[10],"multidrug":[11,67],"resistant":[12,51,68,106,128],"strains":[13,52,107,129],"microorganisms":[15],"in":[16,36,82,109,116],"treatment":[18,65,87],"complicated":[20,89],"intraabdominal":[21,90],"infections.":[22],"MATERIAL":[23],"AND":[24],"METHODS:":[25],"The":[26,44],"incidence":[27],"and":[28,72,84,101,133],"distribution":[29],"pathogens":[31,54],"isolated":[32],"from":[33],"intra-abdominal":[34,39,56],"specimens":[35],"patients":[37],"infections":[40,57,69,91],"are":[41],"analyzed.":[42],"RESULTS:":[43],"current":[45],"situation":[46],"on":[47,126],"growth":[49],"among":[53],"causing":[55],"is":[58,92,139],"rewied.":[59],"New":[60],"combined":[61],"for":[63,144],"-":[70],"ceftolozane/tazobactam":[71],"ceftazidim/avibactam":[73],"plus":[74],"metronidazole,":[75],"has":[76],"been":[77],"suggested.":[78],"Their":[79],"potential":[80],"role":[81],"empiric":[83,117],"targeted":[85,146],"antibacterial":[86],"defined.":[93],"CONCLUSION:":[94],"Taking":[95],"into":[96],"consideration":[97],"local":[98],"monitoring":[99],"data":[100],"risk":[102],"factors":[103],"multi":[105],"Ceftolozane/tazobactam":[108],"combination":[110],"metronidazole":[112],"can":[113],"be":[114],"used":[115],"regime":[118],"treatment.":[120],"Due":[121],"to":[122,141],"high":[124],"carbapenem":[127],"Klebsiella":[131],"pneumonia":[132],"lack":[135],"alternatives,":[137],"it":[138],"advisable":[140],"use":[142],"Ceftazidim/avibactam":[143],"therapy.":[147]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}
