{"id":"https://openalex.org/W2995254155","doi":"https://doi.org/10.17650/1818-8346-2019-14-4-73-83","title":"Results of a phase I open randomized comparative crossover clinical trial to assess the safety and pharmacokinetics of Glurazyme\u00ae (imiglucerase) in comparison with the reference product in healthy volunteers","display_name":"Results of a phase I open randomized comparative crossover clinical trial to assess the safety and pharmacokinetics of Glurazyme\u00ae (imiglucerase) in comparison with the reference product in healthy volunteers","publication_year":2019,"publication_date":"2019-12-22","ids":{"openalex":"https://openalex.org/W2995254155","doi":"https://doi.org/10.17650/1818-8346-2019-14-4-73-83","mag":"2995254155"},"language":"en","primary_location":{"id":"doi:10.17650/1818-8346-2019-14-4-73-83","doi":"https://doi.org/10.17650/1818-8346-2019-14-4-73-83","is_oa":true,"landing_page_url":"https://doi.org/10.17650/1818-8346-2019-14-4-73-83","pdf_url":null,"source":{"id":"https://openalex.org/S4210226809","display_name":"Oncohematology","issn_l":"1818-8346","issn":["1818-8346","2413-4023"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312679","host_organization_name":"ABV-press","host_organization_lineage":["https://openalex.org/P4310312679"],"host_organization_lineage_names":["ABV-press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncohematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.17650/1818-8346-2019-14-4-73-83","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053430131","display_name":"Sergey B. Fitilev","orcid":"https://orcid.org/0000-0001-8395-419X","observed_orcids":["https://orcid.org/0000-0001-8395-419X"]},"institutions":[{"id":"https://openalex.org/I126527374","display_name":"Peoples' Friendship University of Russia","ror":"https://ror.org/02dn9h927","country_code":"RU","type":"education","lineage":["https://openalex.org/I126527374"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S. B. Fitilev","raw_affiliation_strings":["City Polyclinic No. 2 of the Moscow Department of Health","Peoples\u2019 Friendship University of Russia","Peoples\u2019 Friendship University of Russia; City Polyclinic No. 2 of the Moscow Department of Health"],"raw_orcid":"https://orcid.org/0000-0001-8395-419X","affiliations":[{"raw_affiliation_string":"City Polyclinic No. 2 of the Moscow Department of Health","institution_ids":[]},{"raw_affiliation_string":"Peoples\u2019 Friendship University of Russia","institution_ids":["https://openalex.org/I126527374"]},{"raw_affiliation_string":"Peoples\u2019 Friendship University of Russia; City Polyclinic No. 2 of the Moscow Department of Health","institution_ids":["https://openalex.org/I126527374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037099386","display_name":"Alexander V. Vozzhaev","orcid":"https://orcid.org/0000-0002-2687-5986","observed_orcids":["https://orcid.org/0000-0002-2687-5986"]},"institutions":[{"id":"https://openalex.org/I126527374","display_name":"Peoples' Friendship University of Russia","ror":"https://ror.org/02dn9h927","country_code":"RU","type":"education","lineage":["https://openalex.org/I126527374"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. V. Vozzhaev","raw_affiliation_strings":["Peoples\u2019 Friendship University of Russia"],"raw_orcid":"https://orcid.org/0000-0002-2687-5986","affiliations":[{"raw_affiliation_string":"Peoples\u2019 Friendship University of Russia","institution_ids":["https://openalex.org/I126527374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029520268","display_name":"\u0428\u043a\u0440\u0435\u0431\u043d\u0451\u0432\u0430 \u0418\u0440\u0438\u043d\u0430 \u0418\u0432\u0430\u043d\u043e\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0002-0070-3115","observed_orcids":["https://orcid.org/0000-0002-0070-3115"]},"institutions":[{"id":"https://openalex.org/I126527374","display_name":"Peoples' Friendship University of Russia","ror":"https://ror.org/02dn9h927","country_code":"RU","type":"education","lineage":["https://openalex.org/I126527374"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I. I. Shkrebneva","raw_affiliation_strings":["City Polyclinic No. 2 of the Moscow Department of Health","Peoples\u2019 Friendship University of Russia","Peoples\u2019 Friendship University of Russia; City Polyclinic No. 2 of the Moscow Department of Health"],"raw_orcid":"https://orcid.org/0000-0002-0070-3115","affiliations":[{"raw_affiliation_string":"City Polyclinic No. 2 of the Moscow Department of Health","institution_ids":[]},{"raw_affiliation_string":"Peoples\u2019 Friendship University of Russia","institution_ids":["https://openalex.org/I126527374"]},{"raw_affiliation_string":"Peoples\u2019 Friendship University of Russia; City Polyclinic No. 2 of the Moscow Department of Health","institution_ids":["https://openalex.org/I126527374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001572944","display_name":"Dmitry Anatolievich Kudlay","orcid":"https://orcid.org/0000-0003-1878-4467","observed_orcids":["https://orcid.org/0000-0003-1878-4467"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D. A. Kudlay","raw_affiliation_strings":["JSC GENERIUM"],"raw_orcid":"https://orcid.org/0000-0003-1878-4467","affiliations":[{"raw_affiliation_string":"JSC GENERIUM","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036222383","display_name":"Elena V. Gapchenko","orcid":"https://orcid.org/0000-0002-6817-5531","observed_orcids":["https://orcid.org/0000-0002-6817-5531"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. V. Gapchenko","raw_affiliation_strings":["JSC GENERIUM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JSC GENERIUM","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035417997","display_name":"\u041e. \u0410. Markova","orcid":"https://orcid.org/0000-0002-1179-3881","observed_orcids":["https://orcid.org/0000-0002-1179-3881"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"O. A. Markova","raw_affiliation_strings":["JSC GENERIUM"],"raw_orcid":"https://orcid.org/0000-0002-1179-3881","affiliations":[{"raw_affiliation_string":"JSC GENERIUM","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069705379","display_name":"A.Yu. Borozinets","orcid":"https://orcid.org/0000-0002-4863-8471","observed_orcids":["https://orcid.org/0000-0002-4863-8471"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. Yu. Bor\u043ezinets","raw_affiliation_strings":["JSC GENERIUM"],"raw_orcid":"https://orcid.org/0000-0002-4863-8471","affiliations":[{"raw_affiliation_string":"JSC GENERIUM","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037234015","display_name":"A. A. Kazarov","orcid":"https://orcid.org/0000-0003-0682-6113","observed_orcids":["https://orcid.org/0000-0003-0682-6113"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. A. Kazarov","raw_affiliation_strings":["International Biotechnological Center \u201cGenerium\u201d"],"raw_orcid":"https://orcid.org/0000-0003-0682-6113","affiliations":[{"raw_affiliation_string":"International Biotechnological Center \u201cGenerium\u201d","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057838409","display_name":"\u041c. S. Pantyushenko","orcid":"https://orcid.org/0000-0002-2766-2560","observed_orcids":["https://orcid.org/0000-0002-2766-2560"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u041c. S. Pantyushenko","raw_affiliation_strings":["International Biotechnological Center \u201cGenerium\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Biotechnological Center \u201cGenerium\u201d","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4603,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.6135434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"14","issue":"4","first_page":"73","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosimilars","display_name":"biosimilars","score":0.7409999966621399},{"id":"https://openalex.org/keywords/gaucher-disease","display_name":"Gaucher disease","score":0.8399999737739563},{"id":"https://openalex.org/keywords/enzyme-replacement-therapy","display_name":"enzyme replacement therapy","score":0.878000020980835},{"id":"https://openalex.org/keywords/glucocerebrosidase","display_name":"glucocerebrosidase","score":0.9269999861717224},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9520000219345093},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.8149999976158142},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.6359999775886536},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.7400000095367432},{"id":"https://openalex.org/keywords/biosimilar-equivalence","display_name":"biosimilar equivalence","score":0.5299999713897705},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7620000243186951},{"id":"https://openalex.org/keywords/crossover-trial","display_name":"crossover trial","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8443444967269897},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6804047226905823},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.6673729419708252},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6452975869178772},{"id":"https://openalex.org/C59491497","wikidata":"https://www.wikidata.org/wiki/Q864715","display_name":"Biosimilar","level":2,"score":0.6277114152908325},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5306545495986938},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.46104687452316284},{"id":"https://openalex.org/C2779969927","wikidata":"https://www.wikidata.org/wiki/Q916766","display_name":"Enzyme replacement therapy","level":3,"score":0.4144701659679413},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37818410992622375},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.25838667154312134},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06414687633514404},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.17650/1818-8346-2019-14-4-73-83","doi":"https://doi.org/10.17650/1818-8346-2019-14-4-73-83","is_oa":true,"landing_page_url":"https://doi.org/10.17650/1818-8346-2019-14-4-73-83","pdf_url":null,"source":{"id":"https://openalex.org/S4210226809","display_name":"Oncohematology","issn_l":"1818-8346","issn":["1818-8346","2413-4023"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312679","host_organization_name":"ABV-press","host_organization_lineage":["https://openalex.org/P4310312679"],"host_organization_lineage_names":["ABV-press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncohematology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:3727d50786d248acb2c75158dae94797","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3727d50786d248acb2c75158dae94797","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u041e\u043d\u043a\u043e\u0433\u0435\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f, Vol 14, Iss 4, Pp 73-83 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.17650/1818-8346-2019-14-4-73-83","doi":"https://doi.org/10.17650/1818-8346-2019-14-4-73-83","is_oa":true,"landing_page_url":"https://doi.org/10.17650/1818-8346-2019-14-4-73-83","pdf_url":null,"source":{"id":"https://openalex.org/S4210226809","display_name":"Oncohematology","issn_l":"1818-8346","issn":["1818-8346","2413-4023"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312679","host_organization_name":"ABV-press","host_organization_lineage":["https://openalex.org/P4310312679"],"host_organization_lineage_names":["ABV-press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncohematology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1968659034","https://openalex.org/W2075627172","https://openalex.org/W2078624247","https://openalex.org/W2531281122","https://openalex.org/W2533008867","https://openalex.org/W4241764465","https://openalex.org/W4392145873"],"related_works":["https://openalex.org/W3011859925","https://openalex.org/W4411298250","https://openalex.org/W4408838760","https://openalex.org/W7215046087","https://openalex.org/W4389611858","https://openalex.org/W2127072507","https://openalex.org/W1987406270","https://openalex.org/W2035280943","https://openalex.org/W2144615875","https://openalex.org/W2340326356"],"abstract_inverted_index":{"Background.":[0],"Currently,":[1],"the":[2,16,31,55,58,65,70,82,95,100,111,139,150,155,159,162,166,175,182,188,198,201,206,213,220,223,241,257,266,294,343,346,362,375,385],"main":[3,363],"treatment":[4,32],"for":[5,20,30,84,212],"Gaucher":[6,39],"disease":[7,40],"is":[8,15],"enzyme":[9,21],"replacement":[10,22],"therapy.":[11],"Recombinant":[12],"glucocerebrosidase":[13],"(imiglu-cerase)":[14],"first":[17,66],"biotechnological":[18],"drug":[19,71,225,296,348,368,387],"therapy":[23],"with":[24,38,110,219,301,325],"proven":[25],"clinical":[26,48,91,134],"efficacy":[27],"and":[28,43,103,121,141,203,243,279,297,315,345,374],"safety":[29,102,308],"of":[33,35,57,68,78,94,106,171,194,200,222,230,240,248,273,277,293,307,317,322,328,342,352,361,377,384],"patients":[34],"different":[36],"ages":[37],"type":[41,44],"1":[42],"3,":[45],"used":[46],"in":[47,108,131,169,246,256,311,349],"practice":[49],"since":[50],"1994.":[51],"In":[52],"Russia,":[53],"within":[54],"framework":[56],"\u201cPharma":[59],"2020\u201d":[60],"pharmaceutical":[61],"industry":[62],"development":[63],"strategy,":[64],"biosimilar":[67],"imiglucerase,":[69],"Glurazyme\u00ae,":[72,160],"was":[73,97,144,179,209,255,371],"developed.":[74],"The":[75,136,339],"obtained":[76],"results":[77],"preclinical":[79],"studies":[80],"became":[81],"basis":[83],"a":[85,114,132,228,350,381],"phase":[86],"I":[87],"randomized":[88],"comparative":[89,305],"crossover":[90],"trial.The":[92],"objective":[93],"study":[96,137,295,313,386],"to":[98,118,181,187,261],"assess":[99],"short-term":[101],"pharmacokinetic":[104,236,267,340,364],"parameters":[105,310,365],"Glurazyme\u00ae":[107,185,344],"comparison":[109],"Cerezyme\u00ae":[112,167,178],"after":[113,238,291,380],"single":[115,382],"intravenous":[116],"administration":[117,221,239,292],"healthy":[119,124,323],"volunteers.Materials":[120],"methods.":[122],"23":[123],"volunteers":[125,153,324],"aged":[126],"18\u201445":[127],"years":[128],"were":[129,282,289,298],"included":[130],"3-stage":[133],"trial.":[135],"during":[138],"1st":[140,151,156,183,202],"2nd":[142,163,176,189,204],"stages":[143],"open,":[145],"randomized,":[146],"comparative,":[147],"crossover.":[148],"At":[149,174],"stage,":[152,177],"from":[154,161,259],"group":[157,164,190,215],"received":[158],"\u2014":[165],"once":[168,191,226],"doses":[170,193,247],"30":[172,195,249,353],"U/kg.":[173,196],"administered":[180,369],"group,":[184],"-":[186],"at":[192,227],"After":[197],"end":[199],"stages,":[205],"3rd":[207,214],"stage":[208],"carried":[210],"out":[211],"(n":[216],"=":[217],"5)":[218],"test":[224,242],"dose":[229,351,370],"60":[231],"U/kg.Results.":[232],"For":[233],"all":[234],"studied":[235,367],"parameters,":[237],"reference":[244,347],"drugs":[245,269],"U/kg,":[250],"90":[251],"%":[252],"confidence":[253],"interval":[254],"range":[258],"80":[260],"125":[262],"%,":[263],"which":[264],"indicates":[265],"compared":[268],"equivalence.":[270],"A":[271,304,358],"total":[272],"6":[274],"adverse":[275,287,318,378],"events":[276,288],"mild":[278],"moderate":[280],"severity":[281,316],"recorded.":[283],"Of":[284],"these,":[285],"4":[286],"noted":[290],"not":[299,335],"associated":[300],"its":[302],"administration.":[303],"analysis":[306],"assessment":[309,327],"this":[312],"(frequency":[314],"events,":[319],"physical":[320],"examination":[321],"an":[326],"vital":[329],"signs,":[330],"laboratory":[331],"tests,":[332],"electrocardiography)":[333],"did":[334],"reveal":[336],"intergroup":[337],"differences.Conclusion.":[338],"equivalence":[341],"U/kg":[354],"has":[355],"been":[356],"established.":[357],"nonlinear":[359],"dependence":[360],"on":[366],"revealed.":[372],"Safety":[373],"absence":[376],"reactions":[379],"injection":[383],"are":[388],"shown.":[389]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}
