{"id":"https://openalex.org/W2995207676","doi":"https://doi.org/10.1182/blood.2019002320","title":"Lack of the multidrug transporter MRP4/ABCC4 defines the PEL-negative blood group and impairs platelet aggregation","display_name":"Lack of the multidrug transporter MRP4/ABCC4 defines the PEL-negative blood group and impairs platelet aggregation","publication_year":2019,"publication_date":"2019-12-11","ids":{"openalex":"https://openalex.org/W2995207676","doi":"https://doi.org/10.1182/blood.2019002320","mag":"2995207676","pmid":"https://pubmed.ncbi.nlm.nih.gov/31826245","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7005362"},"language":"en","primary_location":{"id":"doi:10.1182/blood.2019002320","doi":"https://doi.org/10.1182/blood.2019002320","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2019002320","pdf_url":"https://ashpublications.org/blood/article-pdf/135/6/441/1633303/bloodbld2019002320.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/135/6/441/1633303/bloodbld2019002320.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031563065","display_name":"Slim Azouzi","orcid":"https://orcid.org/0000-0001-5519-4031","observed_orcids":["https://orcid.org/0000-0001-5519-4031"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091780","display_name":"Institut National de la Transfusion Sanguine","ror":"https://ror.org/00fh58138","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210091780"]},{"id":"https://openalex.org/I4210092978","display_name":"Laboratory of Excellence GR-Ex","ror":"https://ror.org/00ezvft90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210092978"]},{"id":"https://openalex.org/I4210152746","display_name":"Biologie int\u00e9gr\u00e9e du globule rouge et de l'Erythropo\u00ef\u00e8se","ror":"https://ror.org/048cbmc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I24715933","https://openalex.org/I4210091780","https://openalex.org/I4210092978","https://openalex.org/I4210152746","https://openalex.org/I52585520"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Slim Azouzi","raw_affiliation_strings":["D\u00e9partement Centre National de R\u00e9f\u00e9rence pour les Groupes Sanguins, Paris, France;","Institut National de Transfusion Sanguine, Paris, France;","Laboratoire d\u2019Excellence GR-Ex, Paris, France;","Universit\u00e9 de Paris, Unit\u00e9 Mixte de Recherche (UMR)_S1134, Biologie Int\u00e9gr\u00e9e du Globule Rouge, INSERM, Paris, France;"],"raw_orcid":"https://orcid.org/0000-0001-5519-4031","affiliations":[{"raw_affiliation_string":"D\u00e9partement Centre National de R\u00e9f\u00e9rence pour les Groupes Sanguins, Paris, France;","institution_ids":[]},{"raw_affiliation_string":"Institut National de Transfusion Sanguine, Paris, France;","institution_ids":["https://openalex.org/I4210091780"]},{"raw_affiliation_string":"Laboratoire d\u2019Excellence GR-Ex, Paris, France;","institution_ids":["https://openalex.org/I4210092978"]},{"raw_affiliation_string":"Universit\u00e9 de Paris, Unit\u00e9 Mixte de Recherche (UMR)_S1134, Biologie Int\u00e9gr\u00e9e du Globule Rouge, INSERM, Paris, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210152746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029741890","display_name":"Mahmoud Mikdar","orcid":"https://orcid.org/0000-0003-3449-2851","observed_orcids":["https://orcid.org/0000-0003-3449-2851"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091780","display_name":"Institut National de la Transfusion Sanguine","ror":"https://ror.org/00fh58138","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210091780"]},{"id":"https://openalex.org/I4210092978","display_name":"Laboratory of Excellence GR-Ex","ror":"https://ror.org/00ezvft90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210092978"]},{"id":"https://openalex.org/I4210152746","display_name":"Biologie int\u00e9gr\u00e9e du globule rouge et de l'Erythropo\u00ef\u00e8se","ror":"https://ror.org/048cbmc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I24715933","https://openalex.org/I4210091780","https://openalex.org/I4210092978","https://openalex.org/I4210152746","https://openalex.org/I52585520"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Mahmoud Mikdar","raw_affiliation_strings":["D\u00e9partement Centre National de R\u00e9f\u00e9rence pour les Groupes Sanguins, Paris, France;","Institut National de Transfusion Sanguine, Paris, France;","Laboratoire d\u2019Excellence GR-Ex, Paris, France;","Universit\u00e9 de Paris, Unit\u00e9 Mixte de Recherche (UMR)_S1134, Biologie Int\u00e9gr\u00e9e du Globule Rouge, INSERM, Paris, France;"],"raw_orcid":"https://orcid.org/0000-0003-3449-2851","affiliations":[{"raw_affiliation_string":"D\u00e9partement Centre National de R\u00e9f\u00e9rence pour les Groupes Sanguins, Paris, France;","institution_ids":[]},{"raw_affiliation_string":"Institut National de Transfusion Sanguine, Paris, France;","institution_ids":["https://openalex.org/I4210091780"]},{"raw_affiliation_string":"Laboratoire d\u2019Excellence GR-Ex, Paris, France;","institution_ids":["https://openalex.org/I4210092978"]},{"raw_affiliation_string":"Universit\u00e9 de Paris, Unit\u00e9 Mixte de Recherche (UMR)_S1134, Biologie Int\u00e9gr\u00e9e du Globule Rouge, INSERM, Paris, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210152746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080368669","display_name":"Patricia Hermand","orcid":"https://orcid.org/0000-0003-0628-9733","observed_orcids":["https://orcid.org/0000-0003-0628-9733"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091780","display_name":"Institut National de la Transfusion Sanguine","ror":"https://ror.org/00fh58138","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210091780"]},{"id":"https://openalex.org/I4210092978","display_name":"Laboratory of Excellence GR-Ex","ror":"https://ror.org/00ezvft90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210092978"]},{"id":"https://openalex.org/I4210152746","display_name":"Biologie int\u00e9gr\u00e9e du globule rouge et de l'Erythropo\u00ef\u00e8se","ror":"https://ror.org/048cbmc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I24715933","https://openalex.org/I4210091780","https://openalex.org/I4210092978","https://openalex.org/I4210152746","https://openalex.org/I52585520"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patricia Hermand","raw_affiliation_strings":["Institut National de Transfusion Sanguine, Paris, France;","Laboratoire d\u2019Excellence GR-Ex, Paris, France;","Universit\u00e9 de Paris, Unit\u00e9 Mixte de Recherche (UMR)_S1134, Biologie Int\u00e9gr\u00e9e du Globule Rouge, INSERM, Paris, France;"],"raw_orcid":"https://orcid.org/0000-0003-0628-9733","affiliations":[{"raw_affiliation_string":"Institut National de Transfusion Sanguine, Paris, France;","institution_ids":["https://openalex.org/I4210091780"]},{"raw_affiliation_string":"Laboratoire d\u2019Excellence GR-Ex, Paris, France;","institution_ids":["https://openalex.org/I4210092978"]},{"raw_affiliation_string":"Universit\u00e9 de Paris, Unit\u00e9 Mixte de Recherche (UMR)_S1134, Biologie Int\u00e9gr\u00e9e du Globule Rouge, INSERM, Paris, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210152746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003260433","display_name":"Emilie\u2010Fleur Gautier","orcid":"https://orcid.org/0000-0002-0394-6606","observed_orcids":["https://orcid.org/0000-0002-0394-6606"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210092978","display_name":"Laboratory of Excellence GR-Ex","ror":"https://ror.org/00ezvft90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210092978"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emilie-Fleur Gautier","raw_affiliation_strings":["Laboratoire d\u2019Excellence GR-Ex, Paris, France;","Universit\u00e9 de Paris, UMR_S1016, UMR 8104, Plateforme de Prot\u00e9omique, Institut Cochin, INSERM, Centre National de la Recherche Scientifique (CNRS), Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Excellence GR-Ex, Paris, France;","institution_ids":["https://openalex.org/I4210092978"]},{"raw_affiliation_string":"Universit\u00e9 de Paris, UMR_S1016, UMR 8104, Plateforme de Prot\u00e9omique, Institut Cochin, INSERM, Centre National de la Recherche Scientifique (CNRS), Paris, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210141964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086778812","display_name":"Virginie Salnot","orcid":"https://orcid.org/0000-0002-7530-4493","observed_orcids":["https://orcid.org/0000-0002-7530-4493"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210092978","display_name":"Laboratory of Excellence GR-Ex","ror":"https://ror.org/00ezvft90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210092978"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Virginie Salnot","raw_affiliation_strings":["Laboratoire d\u2019Excellence GR-Ex, Paris, France;","Universit\u00e9 de Paris, UMR_S1016, UMR 8104, Plateforme de Prot\u00e9omique, Institut Cochin, INSERM, Centre National de la Recherche Scientifique (CNRS), Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Excellence GR-Ex, Paris, France;","institution_ids":["https://openalex.org/I4210092978"]},{"raw_affiliation_string":"Universit\u00e9 de Paris, UMR_S1016, UMR 8104, Plateforme de Prot\u00e9omique, Institut Cochin, INSERM, Centre National de la Recherche Scientifique (CNRS), Paris, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210141964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037719295","display_name":"Alexandra Willemetz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091780","display_name":"Institut National de la Transfusion Sanguine","ror":"https://ror.org/00fh58138","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210091780"]},{"id":"https://openalex.org/I4210092978","display_name":"Laboratory of Excellence GR-Ex","ror":"https://ror.org/00ezvft90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210092978"]},{"id":"https://openalex.org/I4210152746","display_name":"Biologie int\u00e9gr\u00e9e du globule rouge et de l'Erythropo\u00ef\u00e8se","ror":"https://ror.org/048cbmc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I24715933","https://openalex.org/I4210091780","https://openalex.org/I4210092978","https://openalex.org/I4210152746","https://openalex.org/I52585520"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexandra Willemetz","raw_affiliation_strings":["D\u00e9partement Centre National de R\u00e9f\u00e9rence pour les Groupes Sanguins, Paris, France;","Institut National de Transfusion Sanguine, Paris, France;","Laboratoire d\u2019Excellence GR-Ex, Paris, France;","Universit\u00e9 de Paris, Unit\u00e9 Mixte de Recherche (UMR)_S1134, Biologie Int\u00e9gr\u00e9e du Globule Rouge, INSERM, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement Centre National de R\u00e9f\u00e9rence pour les Groupes Sanguins, Paris, France;","institution_ids":[]},{"raw_affiliation_string":"Institut National de Transfusion Sanguine, Paris, France;","institution_ids":["https://openalex.org/I4210091780"]},{"raw_affiliation_string":"Laboratoire d\u2019Excellence GR-Ex, Paris, France;","institution_ids":["https://openalex.org/I4210092978"]},{"raw_affiliation_string":"Universit\u00e9 de Paris, Unit\u00e9 Mixte de Recherche (UMR)_S1134, Biologie Int\u00e9gr\u00e9e du Globule Rouge, INSERM, Paris, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210152746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080318207","display_name":"Ga\u00ebl Nicolas","orcid":"https://orcid.org/0000-0002-1671-8274","observed_orcids":["https://orcid.org/0000-0002-1671-8274"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210092978","display_name":"Laboratory of Excellence GR-Ex","ror":"https://ror.org/00ezvft90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210092978"]},{"id":"https://openalex.org/I4210130096","display_name":"Centre de Recherche sur l'Inflammation","ror":"https://ror.org/02gn50d10","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210130096"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ga\u00ebl Nicolas","raw_affiliation_strings":["Laboratoire d\u2019Excellence GR-Ex, Paris, France;","Universit\u00e9 de Paris, UMR_S1149, Equipe Recherche Labellis\u00e9e 8252, Centre de Recherche sur l\u2019Inflammation, INSERM, CNRS, Paris, France;"],"raw_orcid":"https://orcid.org/0000-0002-1671-8274","affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Excellence GR-Ex, Paris, France;","institution_ids":["https://openalex.org/I4210092978"]},{"raw_affiliation_string":"Universit\u00e9 de Paris, UMR_S1149, Equipe Recherche Labellis\u00e9e 8252, Centre de Recherche sur l\u2019Inflammation, INSERM, CNRS, Paris, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210130096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055750095","display_name":"C\u00e9dric Vrignaud","orcid":"https://orcid.org/0000-0001-5317-1549","observed_orcids":["https://orcid.org/0000-0001-5317-1549"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091780","display_name":"Institut National de la Transfusion Sanguine","ror":"https://ror.org/00fh58138","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210091780"]},{"id":"https://openalex.org/I4210092978","display_name":"Laboratory of Excellence GR-Ex","ror":"https://ror.org/00ezvft90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210092978"]},{"id":"https://openalex.org/I4210152746","display_name":"Biologie int\u00e9gr\u00e9e du globule rouge et de l'Erythropo\u00ef\u00e8se","ror":"https://ror.org/048cbmc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I24715933","https://openalex.org/I4210091780","https://openalex.org/I4210092978","https://openalex.org/I4210152746","https://openalex.org/I52585520"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9dric Vrignaud","raw_affiliation_strings":["D\u00e9partement Centre National de R\u00e9f\u00e9rence pour les Groupes Sanguins, Paris, France;","Institut National de Transfusion Sanguine, Paris, France;","Laboratoire d\u2019Excellence GR-Ex, Paris, France;","Universit\u00e9 de Paris, Unit\u00e9 Mixte de Recherche (UMR)_S1134, Biologie Int\u00e9gr\u00e9e du Globule Rouge, INSERM, Paris, France;"],"raw_orcid":"https://orcid.org/0000-0001-5317-1549","affiliations":[{"raw_affiliation_string":"D\u00e9partement Centre National de R\u00e9f\u00e9rence pour les Groupes Sanguins, Paris, France;","institution_ids":[]},{"raw_affiliation_string":"Institut National de Transfusion Sanguine, Paris, France;","institution_ids":["https://openalex.org/I4210091780"]},{"raw_affiliation_string":"Laboratoire d\u2019Excellence GR-Ex, Paris, France;","institution_ids":["https://openalex.org/I4210092978"]},{"raw_affiliation_string":"Universit\u00e9 de Paris, Unit\u00e9 Mixte de Recherche (UMR)_S1134, Biologie Int\u00e9gr\u00e9e du Globule Rouge, INSERM, Paris, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210152746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003953859","display_name":"Alexandre Raneri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091780","display_name":"Institut National de la Transfusion Sanguine","ror":"https://ror.org/00fh58138","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210091780"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexandre Raneri","raw_affiliation_strings":["D\u00e9partement Centre National de R\u00e9f\u00e9rence pour les Groupes Sanguins, Paris, France;","Institut National de Transfusion Sanguine, Paris, France;","INTS - Institut National de la Transfusion Sanguine [Paris] (6 rue Alexandre Cabanel, 75739 Paris cedex 15 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement Centre National de R\u00e9f\u00e9rence pour les Groupes Sanguins, Paris, France;","institution_ids":[]},{"raw_affiliation_string":"Institut National de Transfusion Sanguine, Paris, France;","institution_ids":["https://openalex.org/I4210091780"]},{"raw_affiliation_string":"INTS - Institut National de la Transfusion Sanguine [Paris] (6 rue Alexandre Cabanel, 75739 Paris cedex 15 - France)","institution_ids":["https://openalex.org/I4210091780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026525163","display_name":"Patrick Mayeux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210092978","display_name":"Laboratory of Excellence GR-Ex","ror":"https://ror.org/00ezvft90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210092978"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrick Mayeux","raw_affiliation_strings":["Laboratoire d\u2019Excellence GR-Ex, Paris, France;","Universit\u00e9 de Paris, UMR_S1016, UMR 8104, Plateforme de Prot\u00e9omique, Institut Cochin, INSERM, Centre National de la Recherche Scientifique (CNRS), Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Excellence GR-Ex, Paris, France;","institution_ids":["https://openalex.org/I4210092978"]},{"raw_affiliation_string":"Universit\u00e9 de Paris, UMR_S1016, UMR 8104, Plateforme de Prot\u00e9omique, Institut Cochin, INSERM, Centre National de la Recherche Scientifique (CNRS), Paris, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210141964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034526107","display_name":"Christine B\u00f4le\u2010Feysot","orcid":"https://orcid.org/0000-0002-1935-3063","observed_orcids":["https://orcid.org/0000-0002-1935-3063","https://orcid.org/0000-0002-5932-3061"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210165077","display_name":"Institut des Maladies G\u00e9n\u00e9tiques Imagine","ror":"https://ror.org/05rq3rb55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210100892","https://openalex.org/I4210165077"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christine Bole-Feysot","raw_affiliation_strings":["Universit\u00e9 de Paris, UMR 1163, Genomic Platform, INSERM, Institut des Maladies G\u00e9n\u00e9tiques (IMAGINE), Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, UMR 1163, Genomic Platform, INSERM, Institut des Maladies G\u00e9n\u00e9tiques (IMAGINE), Paris, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210165077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028326580","display_name":"Patrick Nitschk\u00e9","orcid":"https://orcid.org/0000-0002-2094-3298","observed_orcids":["https://orcid.org/0000-0002-2094-3298"]},"institutions":[{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrick Nitschk\u00e9","raw_affiliation_strings":["Universit\u00e9 de Paris, Bioinformatics Platform, IMAGINE, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, Bioinformatics Platform, IMAGINE, Paris, France;","institution_ids":["https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078440038","display_name":"Jean\u2010Pierre Cartron","orcid":"https://orcid.org/0000-0003-2929-3065","observed_orcids":["https://orcid.org/0000-0003-2929-3065"]},"institutions":[{"id":"https://openalex.org/I4210091780","display_name":"Institut National de la Transfusion Sanguine","ror":"https://ror.org/00fh58138","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210091780"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Pierre Cartron","raw_affiliation_strings":["Institut National de Transfusion Sanguine, Paris, France;","INTS - Institut National de la Transfusion Sanguine [Paris] (6 rue Alexandre Cabanel, 75739 Paris cedex 15 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de Transfusion Sanguine, Paris, France;","institution_ids":["https://openalex.org/I4210091780"]},{"raw_affiliation_string":"INTS - Institut National de la Transfusion Sanguine [Paris] (6 rue Alexandre Cabanel, 75739 Paris cedex 15 - France)","institution_ids":["https://openalex.org/I4210091780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029545816","display_name":"Yves Colin","orcid":"https://orcid.org/0000-0001-5196-4254","observed_orcids":["https://orcid.org/0000-0001-5196-4254"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091780","display_name":"Institut National de la Transfusion Sanguine","ror":"https://ror.org/00fh58138","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210091780"]},{"id":"https://openalex.org/I4210092978","display_name":"Laboratory of Excellence GR-Ex","ror":"https://ror.org/00ezvft90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210092978"]},{"id":"https://openalex.org/I4210152746","display_name":"Biologie int\u00e9gr\u00e9e du globule rouge et de l'Erythropo\u00ef\u00e8se","ror":"https://ror.org/048cbmc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I24715933","https://openalex.org/I4210091780","https://openalex.org/I4210092978","https://openalex.org/I4210152746","https://openalex.org/I52585520"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yves Colin","raw_affiliation_strings":["Institut National de Transfusion Sanguine, Paris, France;","Laboratoire d\u2019Excellence GR-Ex, Paris, France;","Universit\u00e9 de Paris, Unit\u00e9 Mixte de Recherche (UMR)_S1134, Biologie Int\u00e9gr\u00e9e du Globule Rouge, INSERM, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de Transfusion Sanguine, Paris, France;","institution_ids":["https://openalex.org/I4210091780"]},{"raw_affiliation_string":"Laboratoire d\u2019Excellence GR-Ex, Paris, France;","institution_ids":["https://openalex.org/I4210092978"]},{"raw_affiliation_string":"Universit\u00e9 de Paris, Unit\u00e9 Mixte de Recherche (UMR)_S1134, Biologie Int\u00e9gr\u00e9e du Globule Rouge, INSERM, Paris, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210152746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064856085","display_name":"Olivier Hermine","orcid":"https://orcid.org/0000-0003-2574-3874","observed_orcids":["https://orcid.org/0000-0003-2574-3874"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Hermine","raw_affiliation_strings":["Universit\u00e9 de Paris, UMR 8147, CNRS, Paris, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Paris, UMR 8147, CNRS, Paris, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032519603","display_name":"Gabriele Jedlitschky","orcid":"https://orcid.org/0009-0007-3045-4301","observed_orcids":["https://orcid.org/0009-0007-3045-4301"]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]},{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gabriele Jedlitschky","raw_affiliation_strings":["Department of Pharmacology, Center of Drug Absorption and Transport, University of Medicine Greifswald, Greifswald, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Center of Drug Absorption and Transport, University of Medicine Greifswald, Greifswald, Germany;","institution_ids":["https://openalex.org/I2799318839","https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028915593","display_name":"Marc Cloutier","orcid":"https://orcid.org/0000-0002-0598-8754","observed_orcids":["https://orcid.org/0000-0002-0598-8754"]},"institutions":[{"id":"https://openalex.org/I1328242539","display_name":"H\u00e9ma-Qu\u00e9bec","ror":"https://ror.org/008jvv944","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I1328242539","https://openalex.org/I2801902503","https://openalex.org/I4210139015"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marc Cloutier","raw_affiliation_strings":["H\u00e9ma-Qu\u00e9bec, Qu\u00e9bec, QC, Canada; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00e9ma-Qu\u00e9bec, Qu\u00e9bec, QC, Canada; and","institution_ids":["https://openalex.org/I1328242539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013589318","display_name":"Jessica Constanzo\u2010Yanez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1328242539","display_name":"H\u00e9ma-Qu\u00e9bec","ror":"https://ror.org/008jvv944","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I1328242539","https://openalex.org/I2801902503","https://openalex.org/I4210139015"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jessica Constanzo-Yanez","raw_affiliation_strings":["H\u00e9ma-Qu\u00e9bec, Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00e9ma-Qu\u00e9bec, Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I1328242539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090432285","display_name":"Carole \u00c9thier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1328242539","display_name":"H\u00e9ma-Qu\u00e9bec","ror":"https://ror.org/008jvv944","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I1328242539","https://openalex.org/I2801902503","https://openalex.org/I4210139015"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Carole Ethier","raw_affiliation_strings":["H\u00e9ma-Qu\u00e9bec, Qu\u00e9bec, QC, Canada; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00e9ma-Qu\u00e9bec, Qu\u00e9bec, QC, Canada; and","institution_ids":["https://openalex.org/I1328242539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052047853","display_name":"Nancy Robitaille","orcid":"https://orcid.org/0009-0009-0450-1818","observed_orcids":["https://orcid.org/0009-0009-0450-1818"]},"institutions":[{"id":"https://openalex.org/I1328242539","display_name":"H\u00e9ma-Qu\u00e9bec","ror":"https://ror.org/008jvv944","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I1328242539","https://openalex.org/I2801902503","https://openalex.org/I4210139015"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nancy Robitaille","raw_affiliation_strings":["H\u00e9ma-Qu\u00e9bec, Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00e9ma-Qu\u00e9bec, Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I1328242539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113887088","display_name":"Maryse St\u2010Louis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1328242539","display_name":"H\u00e9ma-Qu\u00e9bec","ror":"https://ror.org/008jvv944","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I1328242539","https://openalex.org/I2801902503","https://openalex.org/I4210139015"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Maryse St-Louis","raw_affiliation_strings":["H\u00e9ma-Qu\u00e9bec, Qu\u00e9bec, QC, Canada; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00e9ma-Qu\u00e9bec, Qu\u00e9bec, QC, Canada; and","institution_ids":["https://openalex.org/I1328242539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076084805","display_name":"Caroline Le Van Kim","orcid":"https://orcid.org/0000-0002-3251-1310","observed_orcids":["https://orcid.org/0000-0002-3251-1310"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091780","display_name":"Institut National de la Transfusion Sanguine","ror":"https://ror.org/00fh58138","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210091780"]},{"id":"https://openalex.org/I4210092978","display_name":"Laboratory of Excellence GR-Ex","ror":"https://ror.org/00ezvft90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210092978"]},{"id":"https://openalex.org/I4210152746","display_name":"Biologie int\u00e9gr\u00e9e du globule rouge et de l'Erythropo\u00ef\u00e8se","ror":"https://ror.org/048cbmc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I24715933","https://openalex.org/I4210091780","https://openalex.org/I4210092978","https://openalex.org/I4210152746","https://openalex.org/I52585520"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Caroline Le Van Kim","raw_affiliation_strings":["Institut National de Transfusion Sanguine, Paris, France;","Laboratoire d\u2019Excellence GR-Ex, Paris, France;","Universit\u00e9 de Paris, Unit\u00e9 Mixte de Recherche (UMR)_S1134, Biologie Int\u00e9gr\u00e9e du Globule Rouge, INSERM, Paris, France;"],"raw_orcid":"https://orcid.org/0000-0002-3251-1310","affiliations":[{"raw_affiliation_string":"Institut National de Transfusion Sanguine, Paris, France;","institution_ids":["https://openalex.org/I4210091780"]},{"raw_affiliation_string":"Laboratoire d\u2019Excellence GR-Ex, Paris, France;","institution_ids":["https://openalex.org/I4210092978"]},{"raw_affiliation_string":"Universit\u00e9 de Paris, Unit\u00e9 Mixte de Recherche (UMR)_S1134, Biologie Int\u00e9gr\u00e9e du Globule Rouge, INSERM, Paris, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210152746"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052450042","display_name":"Thierry Peyrard","orcid":"https://orcid.org/0000-0002-7715-568X","observed_orcids":["https://orcid.org/0000-0002-7715-568X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091780","display_name":"Institut National de la Transfusion Sanguine","ror":"https://ror.org/00fh58138","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210091780"]},{"id":"https://openalex.org/I4210092978","display_name":"Laboratory of Excellence GR-Ex","ror":"https://ror.org/00ezvft90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210092978"]},{"id":"https://openalex.org/I4210152746","display_name":"Biologie int\u00e9gr\u00e9e du globule rouge et de l'Erythropo\u00ef\u00e8se","ror":"https://ror.org/048cbmc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I24715933","https://openalex.org/I4210091780","https://openalex.org/I4210092978","https://openalex.org/I4210152746","https://openalex.org/I52585520"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Thierry Peyrard","raw_affiliation_strings":["D\u00e9partement Centre National de R\u00e9f\u00e9rence pour les Groupes Sanguins, Paris, France;","Institut National de Transfusion Sanguine, Paris, France;","Laboratoire d\u2019Excellence GR-Ex, Paris, France;","Universit\u00e9 de Paris, Unit\u00e9 Mixte de Recherche (UMR)_S1134, Biologie Int\u00e9gr\u00e9e du Globule Rouge, INSERM, Paris, France;"],"raw_orcid":"https://orcid.org/0000-0002-7715-568X","affiliations":[{"raw_affiliation_string":"D\u00e9partement Centre National de R\u00e9f\u00e9rence pour les Groupes Sanguins, Paris, France;","institution_ids":[]},{"raw_affiliation_string":"Institut National de Transfusion Sanguine, Paris, France;","institution_ids":["https://openalex.org/I4210091780"]},{"raw_affiliation_string":"Laboratoire d\u2019Excellence GR-Ex, Paris, France;","institution_ids":["https://openalex.org/I4210092978"]},{"raw_affiliation_string":"Universit\u00e9 de Paris, Unit\u00e9 Mixte de Recherche (UMR)_S1134, Biologie Int\u00e9gr\u00e9e du Globule Rouge, INSERM, Paris, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210152746"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5029741890","https://openalex.org/A5031563065","https://openalex.org/A5052450042","https://openalex.org/A5076084805"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210091780","https://openalex.org/I4210092978","https://openalex.org/I4210152746"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.3739,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.8965039,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"135","issue":"6","first_page":"441","last_page":"448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.8241999745368958,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.8241999745368958,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.06400000303983688,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.04230000078678131,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abcc4","display_name":"ABCC4","score":0.8199999928474426},{"id":"https://openalex.org/keywords/mrp4","display_name":"MRP4","score":0.9829999804496765},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.6700000166893005},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/loss-of-function-variants","display_name":"loss-of-function mutations","score":0.6729999780654907},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.6850000023841858},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5711962580680847},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.5161031484603882},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5148926973342896},{"id":"https://openalex.org/C2993802102","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet aggregation","level":3,"score":0.5080161094665527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46509161591529846},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4193479120731354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3680857717990875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.249047189950943},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1411186158657074},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0998731255531311}],"mesh":[{"descriptor_ui":"D001789","descriptor_name":"Blood Group Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027425","descriptor_name":"ATP-Binding Cassette, Sub-Family C Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D041905","descriptor_name":"Erythroid Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D041905","descriptor_name":"Erythroid Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1182/blood.2019002320","doi":"https://doi.org/10.1182/blood.2019002320","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2019002320","pdf_url":"https://ashpublications.org/blood/article-pdf/135/6/441/1633303/bloodbld2019002320.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7005362","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7005362","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"},{"id":"pmid:31826245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31826245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02416860v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-02416860v1/document","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood, 2019, 135 (6), pp.441-448. &#x27E8;10.1182/blood.2019002320&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1182/blood.2019002320","doi":"https://doi.org/10.1182/blood.2019002320","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2019002320","pdf_url":"https://ashpublications.org/blood/article-pdf/135/6/441/1633303/bloodbld2019002320.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G304773848","display_name":null,"funder_award_id":"ANR 11 IDEX 0005-02","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4507058828","display_name":"Biogen\u00e8se et pathologies du globule rouge","funder_award_id":"ANR-11-LABX-0051","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4774453313","display_name":null,"funder_award_id":"IDEX-0005","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4866930200","display_name":null,"funder_award_id":"ANR-11-IDEX","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8336719376","display_name":"Universit\u00e9 Sorbonne Paris Cit\u00e9","funder_award_id":"ANR-11-IDEX-0005","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320323765","display_name":"Institut National de la Transfusion Sanguine","ror":"https://ror.org/00fh58138"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2995207676.pdf","grobid_xml":"https://content.openalex.org/works/W2995207676.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1578997579","https://openalex.org/W1765174061","https://openalex.org/W1931530489","https://openalex.org/W1974176052","https://openalex.org/W1977709885","https://openalex.org/W1986246195","https://openalex.org/W1992332701","https://openalex.org/W1995777114","https://openalex.org/W1996309730","https://openalex.org/W1997246656","https://openalex.org/W1999664492","https://openalex.org/W2021955451","https://openalex.org/W2022611134","https://openalex.org/W2023024840","https://openalex.org/W2025822298","https://openalex.org/W2027903299","https://openalex.org/W2040950751","https://openalex.org/W2065965392","https://openalex.org/W2068825356","https://openalex.org/W2085653932","https://openalex.org/W2102991688","https://openalex.org/W2107967405","https://openalex.org/W2120082193","https://openalex.org/W2124458675","https://openalex.org/W2145782793","https://openalex.org/W2152404944","https://openalex.org/W2157194582","https://openalex.org/W2174049160","https://openalex.org/W2333783097","https://openalex.org/W2402447196","https://openalex.org/W2416476767","https://openalex.org/W2504220050","https://openalex.org/W2521133475","https://openalex.org/W2581492008","https://openalex.org/W2605560890","https://openalex.org/W2617496089","https://openalex.org/W2735134220","https://openalex.org/W2753442568","https://openalex.org/W2767607992","https://openalex.org/W2794088760","https://openalex.org/W2795119407","https://openalex.org/W2889307419","https://openalex.org/W2901124171","https://openalex.org/W3004942713","https://openalex.org/W6634632233","https://openalex.org/W6683265739"],"related_works":["https://openalex.org/W2990534398","https://openalex.org/W4377029629","https://openalex.org/W4388491013","https://openalex.org/W2416476767","https://openalex.org/W2003313355","https://openalex.org/W2979363978","https://openalex.org/W159660096","https://openalex.org/W1765174061","https://openalex.org/W4381190317","https://openalex.org/W2065965392"],"abstract_inverted_index":{"The":[0,43],"rare":[1],"PEL-negative":[2,41,102],"phenotype":[3],"is":[4,62,73],"one":[5],"of":[6,45,134],"the":[7,31,63,66,124,132,135],"last":[8],"blood":[9,68,80],"groups":[10],"with":[11,128],"an":[12,35,74,105],"unknown":[13],"genetic":[14],"basis.":[15],"By":[16],"combining":[17],"whole-exome":[18],"sequencing":[19],"and":[20,52],"comparative":[21],"global":[22],"proteomic":[23],"investigations,":[24],"we":[25,118],"found":[26],"a":[27,86,93,110,147],"large":[28],"deletion":[29],"in":[30,40,55,114,123],"ABCC4/MRP4":[32],"gene":[33,64],"encoding":[34],"ATP-binding":[36],"cassette":[37],"(ABC)":[38],"transporter":[39],"individuals.":[42],"loss":[44],"PEL":[46,67,136,143],"expression":[47,133],"on":[48],"ABCC4-CRISPR-Cas9":[49],"K562":[50],"cells":[51,57,81],"its":[53],"overexpression":[54],"ABCC4-transfected":[56],"provided":[58],"evidence":[59],"that":[60,120],"ABCC4":[61,72,113,125,141],"underlying":[65],"group":[69],"antigen.":[70,137],"Although":[71],"important":[75],"cyclic":[76],"nucleotide":[77],"exporter,":[78],"red":[79],"from":[82],"ABCC4null/PEL-negative":[83],"individuals":[84,103],"exhibited":[85],"normal":[87],"guanosine":[88],"3',5'-cyclic":[89],"monophosphate":[90],"level,":[91],"suggesting":[92],"compensatory":[94],"mechanism":[95],"by":[96],"other":[97],"erythroid":[98],"ABC":[99],"transporters.":[100],"Interestingly,":[101],"showed":[104,119],"impaired":[106],"platelet":[107,115],"aggregation,":[108],"confirming":[109],"role":[111],"for":[112,154],"function.":[116],"Finally,":[117],"loss-of-function":[121],"mutations":[122],"gene,":[126],"associated":[127],"leukemia":[129,155],"outcome,":[130],"altered":[131],"In":[138],"addition":[139],"to":[140],"genotyping,":[142],"phenotyping":[144],"could":[145],"open":[146],"new":[148],"way":[149],"toward":[150],"drug":[151],"dose":[152],"adjustment":[153],"treatment.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}
