{"id":"https://openalex.org/W2995192564","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.lb715","title":"Novel mechanisms to ATP\u2010dependent glucose uptake in skeletal muscle cells","display_name":"Novel mechanisms to ATP\u2010dependent glucose uptake in skeletal muscle cells","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2995192564","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.lb715","mag":"2995192564"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.26.1_supplement.lb715","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.lb715","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.lb715","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007107729","display_name":"Ces\u00e1r Osorio\u2010Fuentealba","orcid":"https://orcid.org/0000-0002-3653-9978","observed_orcids":["https://orcid.org/0000-0002-3653-9978"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CA","CL"],"is_corresponding":false,"raw_author_name":"Cesar Osorio-Fuentealba","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> CEMC. ICBM Facultad de Medicina Universidad de Chile Santiago Chile","<!--<label><sup>2</sup></label>--> Cell Biology Hospital for Sick Children Toronto ON Canada","1--> CEMC. ICBM Facultad de Medicina Universidad de Chile Santiago Chile","2--> Cell Biology Hospital for Sick Children Toronto ON Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> CEMC. ICBM Facultad de Medicina Universidad de Chile Santiago Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"<!--<label><sup>2</sup></label>--> Cell Biology Hospital for Sick Children Toronto ON Canada","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"1--> CEMC. ICBM Facultad de Medicina Universidad de Chile Santiago Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"2--> Cell Biology Hospital for Sick Children Toronto ON Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040659996","display_name":"Ariel Eduardo Contreras\u2010Ferrat","orcid":"https://orcid.org/0000-0002-5386-4131","observed_orcids":["https://orcid.org/0000-0002-5386-4131"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Ariel Contreras-Ferrat","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> CEMC. ICBM Facultad de Medicina Universidad de Chile Santiago Chile","1--> CEMC. ICBM Facultad de Medicina Universidad de Chile Santiago Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> CEMC. ICBM Facultad de Medicina Universidad de Chile Santiago Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"1--> CEMC. ICBM Facultad de Medicina Universidad de Chile Santiago Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064467789","display_name":"Amira Klip","orcid":"https://orcid.org/0000-0001-7906-0302","observed_orcids":["https://orcid.org/0000-0001-7906-0302"]},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Amira Klip","raw_affiliation_strings":["<!--<label><sup>2</sup></label>--> Cell Biology Hospital for Sick Children Toronto ON Canada","2--> Cell Biology Hospital for Sick Children Toronto ON Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>2</sup></label>--> Cell Biology Hospital for Sick Children Toronto ON Canada","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"2--> Cell Biology Hospital for Sick Children Toronto ON Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010563191","display_name":"Enrique Jaimovich","orcid":"https://orcid.org/0000-0002-4938-7176","observed_orcids":["https://orcid.org/0000-0002-4938-7176"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Enrique Jaimovich","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> CEMC. ICBM Facultad de Medicina Universidad de Chile Santiago Chile","1--> CEMC. ICBM Facultad de Medicina Universidad de Chile Santiago Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> CEMC. ICBM Facultad de Medicina Universidad de Chile Santiago Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"1--> CEMC. ICBM Facultad de Medicina Universidad de Chile Santiago Chile","institution_ids":["https://openalex.org/I69737025"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atp","display_name":"ATP","score":0.6800000071525574},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.972000002861023},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9850000143051147},{"id":"https://openalex.org/keywords/glut4-translocation","display_name":"GLUT4 translocation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.7360000014305115},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/as160","display_name":"AS160","score":0.9449999928474426},{"id":"https://openalex.org/keywords/pi3kgamma","display_name":"PI3K\u03b3","score":0.8880000114440918},{"id":"https://openalex.org/keywords/electrical-stimulation","display_name":"electrical stimulation","score":0.6069999933242798},{"id":"https://openalex.org/keywords/muscle-contraction","display_name":"muscle contraction","score":0.7549999952316284},{"id":"https://openalex.org/keywords/extracellular-atp","display_name":"extracellular ATP","score":0.7179999947547913},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.5820000171661377},{"id":"https://openalex.org/keywords/myotubes","display_name":"myotubes","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C2776188179","wikidata":"https://www.wikidata.org/wiki/Q24768727","display_name":"GLUT4","level":4,"score":0.880975604057312},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.7310776710510254},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6992774605751038},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.6434183716773987},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6418780088424683},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5297350287437439},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.5186454653739929},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5077096223831177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5024988651275635},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.47391852736473083},{"id":"https://openalex.org/C2776912716","wikidata":"https://www.wikidata.org/wiki/Q4042503","display_name":"LY294002","level":4,"score":0.4598013758659363},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4387591481208801},{"id":"https://openalex.org/C2778308172","wikidata":"https://www.wikidata.org/wiki/Q423565","display_name":"Wortmannin","level":4,"score":0.42834362387657166},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4247719645500183},{"id":"https://openalex.org/C89200155","wikidata":"https://www.wikidata.org/wiki/Q7547717","display_name":"Snf3","level":4,"score":0.4236436188220978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.356514036655426},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2660428583621979},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.13938447833061218},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08975541591644287}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.26.1_supplement.lb715","doi":"https://doi.org/10.1096/fasebj.26.1_supplement.lb715","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.26.1_supplement.lb715","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W795000478","https://openalex.org/W2163600797","https://openalex.org/W1876850819","https://openalex.org/W2040466763","https://openalex.org/W1963503219","https://openalex.org/W191749779","https://openalex.org/W2317321657","https://openalex.org/W2338085700","https://openalex.org/W2225322781","https://openalex.org/W2149331803"],"abstract_inverted_index":{"Contraction":[0],"and":[1,8,38,65,76,125,136,145,170,185,198,200],"insulin":[2,67,90,135,152,189],"stimulate":[3],"glucose":[4,60,140,154,181,203],"influx":[5],"into":[6],"muscle,":[7,37],"contraction":[9,27],"further":[10],"sensitizes":[11],"muscle":[12,50,63,206],"to":[13,24,55,84,151,188,202],"insulin.":[14],"Insulin":[15],"signals":[16,28],"via":[17,183],"\u03b1,\u03b2":[18],"class":[19],"I":[20],"phosphatidylinositol":[21],"3\u2010kinase":[22],"(PI3K\u03b1,\u03b2)":[23],"Akt,":[25],"but":[26],"remain":[29],"elusive.":[30],"Interestingly,":[31],"ATP":[32,45,58,96,137,148,179,186],"is":[33],"released":[34],"by":[35,115,196],"contracting":[36],"it":[39],"was":[40,54,106,113,129],"recently":[41],"reported":[42],"that":[43],"extracellular":[44],"can":[46],"act":[47],"auto/paracrinely":[48],"on":[49],"cells.":[51,121],"Our":[52],"aim":[53],"investigate":[56],"if":[57],"induces":[59],"uptake":[61,155,182,204],"in":[62,108,118],"cells":[64],"promotes":[66],"action.":[68,190],"Rat":[69],"primary":[70],"myotubes":[71],"transiently":[72],"transfected":[73],"with":[74,131],"GLUT4myc":[75,81],"L6":[77],"myoblasts":[78],"stably":[79],"expressing":[80],"were":[82],"exposed":[83],"9s":[85],"6V":[86],"electric":[87],"stimulation":[88],"(ES);":[89],"(100":[91,97],"nM,":[92],"5":[93],"min)":[94],"or":[95,167,178],"uM,":[98],"5min).":[99],"Uptake":[100],"of":[101,123,160],"the":[102,173],"fluorescent":[103],"hexose":[104],"2NBDG":[105],"assayed":[107],"real":[109],"time.":[110],"Surface":[111],"GLUT4":[112,142],"measured":[114],"anti\u2010myc":[116],"antibodies":[117],"fixed,":[119],"unpermeabilizad":[120],"Phosphorylation":[122],"Akt":[124,144,161,171,199],"its":[126],"target":[127],"AS160":[128,146],"detected":[130],"site\u2010specific":[132],"antibodies.":[133],"ES,":[134],"each":[138],"stimulated":[139],"uptake,":[141],"translocation,":[143],"phosphorylation.":[147],"added":[149],"prior":[150],"increased":[153],"beyond":[156],"insulin's":[157],"effect.":[158],"Inhibitors":[159],"(AktVIII),":[162],"PI3K\u03b1\u2013\u03b3":[163],"(LY294002),":[164],"PI3K\u03b3":[165,169],"(AS605240)":[166],"dominant\u2010negative":[168],"inhibited":[172],"ATP\u2010effect.":[174],"In":[175],"sum,":[176],"ES":[177],"promote":[180],"GLUT4,":[184],"adds":[187],"These":[191],"effects":[192],"may":[193],"be":[194],"mediated":[195],"PI3\u2010K\u03b3":[197],"contribute":[201],"during":[205],"activity.":[207],"Support:":[208],"FONDAP":[209],"15010006,":[210],"AT\u201024100067,":[211],"CIHR\u2010MT12601.":[212]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}