{"id":"https://openalex.org/W2995186254","doi":"https://doi.org/10.1145/3365966.3365978","title":"In silico Protein Structure Comparison of Conotoxins with VI/VII Cysteine Framework","display_name":"In silico Protein Structure Comparison of Conotoxins with VI/VII Cysteine Framework","publication_year":2019,"publication_date":"2019-10-17","ids":{"openalex":"https://openalex.org/W2995186254","doi":"https://doi.org/10.1145/3365966.3365978","mag":"2995186254"},"language":"en","primary_location":{"id":"doi:10.1145/3365966.3365978","doi":"https://doi.org/10.1145/3365966.3365978","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3365966.3365978","pdf_url":null,"source":{"id":"https://openalex.org/S7407087173","display_name":"International Conference on Computational Biology and Bioinformatics (ICCBB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2019 3rd International Conference on Computational Biology and Bioinformatics","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040456628","display_name":"Marineil C. Gomez","orcid":"https://orcid.org/0000-0001-6238-5709","observed_orcids":["https://orcid.org/0000-0001-6238-5709"]},"institutions":[{"id":"https://openalex.org/I137967721","display_name":"Map\u00faa University","ror":"https://ror.org/040rd2b57","country_code":"PH","type":"facility","lineage":["https://openalex.org/I137967721"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Marineil C. Gomez","raw_affiliation_strings":["School of Chemical, Biological and Materials Engineering and Sciences, Map\u00faa University Intramuros Manila"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical, Biological and Materials Engineering and Sciences, Map\u00faa University Intramuros Manila","institution_ids":["https://openalex.org/I137967721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021736983","display_name":"Riggs Anton D. Alvarico","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137967721","display_name":"Map\u00faa University","ror":"https://ror.org/040rd2b57","country_code":"PH","type":"facility","lineage":["https://openalex.org/I137967721"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Riggs Anton D. Alvarico","raw_affiliation_strings":["School of Chemical, Biological and Materials Engineering and Sciences, Map\u00faa University Intramuros Manila"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical, Biological and Materials Engineering and Sciences, Map\u00faa University Intramuros Manila","institution_ids":["https://openalex.org/I137967721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008386887","display_name":"Reincess E. Valbuena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137967721","display_name":"Map\u00faa University","ror":"https://ror.org/040rd2b57","country_code":"PH","type":"facility","lineage":["https://openalex.org/I137967721"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Reincess E. Valbuena","raw_affiliation_strings":["School of Chemical, Biological and Materials Engineering and Sciences, Map\u00faa University Intramuros Manila"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical, Biological and Materials Engineering and Sciences, Map\u00faa University Intramuros Manila","institution_ids":["https://openalex.org/I137967721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068274417","display_name":"Alisha Marcelle C. Aquino","orcid":"https://orcid.org/0009-0007-7644-5398","observed_orcids":["https://orcid.org/0009-0007-7644-5398"]},"institutions":[{"id":"https://openalex.org/I137967721","display_name":"Map\u00faa University","ror":"https://ror.org/040rd2b57","country_code":"PH","type":"facility","lineage":["https://openalex.org/I137967721"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Alisha Marcelle C. Aquino","raw_affiliation_strings":["School of Chemical, Biological and Materials Engineering and Sciences, Map\u00faa University Intramuros Manila"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical, Biological and Materials Engineering and Sciences, Map\u00faa University Intramuros Manila","institution_ids":["https://openalex.org/I137967721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045875608","display_name":"Andrea R. Matira","orcid":"https://orcid.org/0000-0003-2302-0824","observed_orcids":["https://orcid.org/0000-0003-2302-0824"]},"institutions":[{"id":"https://openalex.org/I137967721","display_name":"Map\u00faa University","ror":"https://ror.org/040rd2b57","country_code":"PH","type":"facility","lineage":["https://openalex.org/I137967721"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Andrea R. Matira","raw_affiliation_strings":["School of Chemical, Biological and Materials Engineering and Sciences, Map\u00faa University Intramuros Manila"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical, Biological and Materials Engineering and Sciences, Map\u00faa University Intramuros Manila","institution_ids":["https://openalex.org/I137967721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023945378","display_name":"Lemmuel Lara Tayo","orcid":"https://orcid.org/0000-0002-0869-2131","observed_orcids":["https://orcid.org/0000-0002-0869-2131"]},"institutions":[{"id":"https://openalex.org/I137967721","display_name":"Map\u00faa University","ror":"https://ror.org/040rd2b57","country_code":"PH","type":"facility","lineage":["https://openalex.org/I137967721"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Lemmuel L. Tayo","raw_affiliation_strings":["School of Chemical, Biological and Materials Engineering and Sciences, Map\u00faa University Intramuros Manila"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical, Biological and Materials Engineering and Sciences, Map\u00faa University Intramuros Manila","institution_ids":["https://openalex.org/I137967721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I137967721"],"apc_list":null,"apc_paid":null,"fwci":1.7317,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.94528268,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"52","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8593999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8593999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.11330000311136246,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conotoxins","display_name":"conotoxins","score":0.9959999918937683},{"id":"https://openalex.org/keywords/conopeptides","display_name":"conopeptides","score":0.7950000166893005},{"id":"https://openalex.org/keywords/omega-conotoxin","display_name":"omega-conotoxin","score":0.6850000023841858},{"id":"https://openalex.org/keywords/cone-snail-venom","display_name":"cone snail venom","score":0.7770000100135803},{"id":"https://openalex.org/keywords/protein-structure-comparison","display_name":"protein structure comparison","score":0.7279999852180481},{"id":"https://openalex.org/keywords/structural-alignment","display_name":"structural alignment","score":0.6420000195503235},{"id":"https://openalex.org/keywords/polypeptide-backbone","display_name":"polypeptide backbone","score":0.6240000128746033},{"id":"https://openalex.org/keywords/structure-based-design","display_name":"structure-based design","score":0.3160000145435333}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8251273036003113},{"id":"https://openalex.org/C175234850","wikidata":"https://www.wikidata.org/wiki/Q417238","display_name":"Conotoxin","level":3,"score":0.5844699144363403},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.5655105710029602},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4650273323059082},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4428376853466034},{"id":"https://openalex.org/C18051474","wikidata":"https://www.wikidata.org/wiki/Q899656","display_name":"Protein structure prediction","level":3,"score":0.43404263257980347},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42130953073501587},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.23474553227424622},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.16110900044441223},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1476355791091919},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14761418104171753},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06916552782058716},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3365966.3365978","doi":"https://doi.org/10.1145/3365966.3365978","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3365966.3365978","pdf_url":null,"source":{"id":"https://openalex.org/S7407087173","display_name":"International Conference on Computational Biology and Bioinformatics (ICCBB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2019 3rd International Conference on Computational Biology and Bioinformatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1588299405","https://openalex.org/W1977817462","https://openalex.org/W1980339275","https://openalex.org/W1989723044","https://openalex.org/W1989756167","https://openalex.org/W2010758923","https://openalex.org/W2035841324","https://openalex.org/W2064460771","https://openalex.org/W2094420790","https://openalex.org/W2097642323","https://openalex.org/W2114854952","https://openalex.org/W2117977572","https://openalex.org/W2163545771","https://openalex.org/W2295140893","https://openalex.org/W2441501804","https://openalex.org/W2512214264","https://openalex.org/W2520365883","https://openalex.org/W2534596046","https://openalex.org/W2590796243","https://openalex.org/W2626920341","https://openalex.org/W2739354616","https://openalex.org/W2770931749","https://openalex.org/W2794084717","https://openalex.org/W2908913255","https://openalex.org/W2913188636","https://openalex.org/W2926681452","https://openalex.org/W2968869035"],"related_works":["https://openalex.org/W2996490644","https://openalex.org/W2553334167","https://openalex.org/W4400864951","https://openalex.org/W2398125330","https://openalex.org/W2948050113","https://openalex.org/W2353322775","https://openalex.org/W3024234972","https://openalex.org/W4399256245","https://openalex.org/W2014408719","https://openalex.org/W2015432354"],"abstract_inverted_index":{"Conopeptides":[0],"are":[1,15,127],"small":[2],"disulfide-rich":[3],"peptides":[4],"isolated":[5],"from":[6],"the":[7,17,21,40,60,102,146,157],"venom":[8,22],"of":[9,20,33,84,132,160],"marine":[10],"cone":[11],"snails,":[12],"and":[13,31,35,53,88,124],"they":[14,79],"amongst":[16],"most":[18,69],"interesting":[19],"species.":[23],"In":[24],"this":[25,89],"paper,":[26],"in":[27,140],"silico":[28],"structural":[29],"models":[30,154],"alignments":[32],"\u03c9-conotoxin":[34],"different":[36,107,135],"pharmacological":[37,108,136],"family":[38],"with":[39,59,64,75,97,109,163],"same":[41,147],"cysteine":[42,148],"framework":[43,149],"(VI/VII)":[44],"will":[45],"be":[46,92,151],"discussed":[47],"using":[48],"computational":[49],"methods":[50],"--":[51],"FATCAT":[52],"POSA.":[54],"The":[55],"results":[56,118],"show":[57,138],"that":[58],"\u03c9-CTX":[61,65,93,98,110],"conopeptide":[62,90],"aligned":[63,96],"conopeptide,":[66],"it":[67],"would":[68,91,111],"likely":[70],"have":[71],"significantly":[72,116],"similar":[73,117],"structures":[74,133],"lower":[76],"RMSD":[77],"as":[78,82,153],"both":[80],"function":[81],"blockers":[83],"voltage-gated":[85],"calcium":[86],"channels,":[87],"MVIIA":[94,99],"1OMGA":[95],"1TTK.":[100],"On":[101],"other":[103],"hand,":[104],"having":[105],"compared":[106],"result":[112],"to":[113],"a":[114,161],"fewer":[115],"since":[119],"their":[120,141],"amino":[121],"acid":[122],"residues,":[123],"ion":[125],"channels":[126],"quite":[128],"different.":[129],"Multiple":[130],"alignment":[131],"across":[134],"families":[137],"similarities":[139],"polypeptide":[142,158],"backbone.":[143],"Hence,conotoxins":[144],"sharing":[145],"can":[150],"used":[152],"for":[155],"deducing":[156],"backbone":[159],"conotoxin":[162],"unknown":[164],"structure.":[165]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}