{"id":"https://openalex.org/W2995176879","doi":"https://doi.org/10.1158/1538-7445.panca19-c41","title":"Abstract C41: Establishment of a novel mouse model of pancreatic squamous carcinoma","display_name":"Abstract C41: Establishment of a novel mouse model of pancreatic squamous carcinoma","publication_year":2019,"publication_date":"2019-12-13","ids":{"openalex":"https://openalex.org/W2995176879","doi":"https://doi.org/10.1158/1538-7445.panca19-c41","mag":"2995176879"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.panca19-c41","doi":"https://doi.org/10.1158/1538-7445.panca19-c41","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca19-c41","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Filipa Pinto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Filipa Pinto","raw_affiliation_strings":["1Boston University, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Boston University, Boston, MA,","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078936000","display_name":"T\u00e1chira Pichardo","orcid":"https://orcid.org/0000-0001-7377-8065","observed_orcids":["https://orcid.org/0000-0001-7377-8065"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tachira Pichardo","raw_affiliation_strings":["1Boston University, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Boston University, Boston, MA,","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031615602","display_name":"Adrien Leu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrien Leu","raw_affiliation_strings":["2University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046953707","display_name":"Makoto Senoo","orcid":"https://orcid.org/0000-0002-0155-0683","observed_orcids":["https://orcid.org/0000-0002-0155-0683"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Makoto Senoo","raw_affiliation_strings":["1Boston University, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Boston University, Boston, MA,","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"24_Supplement","first_page":"C41","last_page":"C41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.7910000085830688},{"id":"https://openalex.org/keywords/deltanp63alpha","display_name":"\u0394Np63\u03b1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/p63-isoforms","display_name":"p63 isoforms","score":0.9490000009536743},{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.7919999957084656},{"id":"https://openalex.org/keywords/conditional-transgenic-mice","display_name":"conditional transgenic mice","score":0.7080000042915344},{"id":"https://openalex.org/keywords/squamous-differentiation","display_name":"squamous differentiation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/tumor-suppressor-function","display_name":"tumor suppressor function","score":0.44999998807907104},{"id":"https://openalex.org/keywords/pancreatic-carcinogenesis","display_name":"pancreatic carcinogenesis","score":0.4830000102519989},{"id":"https://openalex.org/keywords/cytokeratin-18","display_name":"cytokeratin 18","score":0.550000011920929},{"id":"https://openalex.org/keywords/keratin-14","display_name":"keratin 14","score":0.48899999260902405},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.3160000145435333},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.3059999942779541},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.5199999809265137},{"id":"https://openalex.org/keywords/tumor-infiltrating-t-cells","display_name":"tumor-infiltrating T cells","score":0.4050000011920929},{"id":"https://openalex.org/keywords/tumor-infiltrating-macrophages","display_name":"tumor-infiltrating macrophages","score":0.699999988079071},{"id":"https://openalex.org/keywords/tumor-infiltrating-neutrophils","display_name":"tumor-infiltrating neutrophils","score":0.703000009059906},{"id":"https://openalex.org/keywords/tumor-infiltrating-b-cells","display_name":"tumor-infiltrating B cells","score":0.6399999856948853},{"id":"https://openalex.org/keywords/tumor-infiltrating-dendritic-cells","display_name":"tumor-infiltrating dendritic cells","score":0.6970000267028809},{"id":"https://openalex.org/keywords/tumor-infiltrating-nk-cells","display_name":"tumor-infiltrating NK cells","score":0.6159999966621399},{"id":"https://openalex.org/keywords/tumor-infiltrating-treg-cells","display_name":"tumor-infiltrating Treg cells","score":0.6320000290870667},{"id":"https://openalex.org/keywords/tumor-infiltrating-myeloid-cells","display_name":"tumor-infiltrating myeloid cells","score":0.6980000138282776},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.5879999995231628},{"id":"https://openalex.org/keywords/tumor-infiltrating-fibroblasts","display_name":"tumor-infiltrating fibroblasts","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7933000922203064},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6107500791549683},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5699447393417358},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49936413764953613},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4755503833293915},{"id":"https://openalex.org/C144369459","wikidata":"https://www.wikidata.org/wiki/Q182517","display_name":"CA19-9","level":4,"score":0.45504701137542725},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.44044622778892517},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.42670297622680664},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3930628299713135},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38718608021736145},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3634330630302429},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3478412330150604},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3422369956970215},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09704691171646118}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.panca19-c41","doi":"https://doi.org/10.1158/1538-7445.panca19-c41","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca19-c41","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2082288541","https://openalex.org/W2110598677","https://openalex.org/W2059722556","https://openalex.org/W2321230979","https://openalex.org/W2327831016","https://openalex.org/W2393196544","https://openalex.org/W1909630905","https://openalex.org/W2037689247","https://openalex.org/W2901608487","https://openalex.org/W2740134880"],"abstract_inverted_index":{"Abstract":[0],"Pancreatic":[1,461],"cancer":[2],"is":[3,57,174,187,201,362],"a":[4,16,103,134,141,170,204,296,326,333,444],"lethal":[5],"malignancy":[6],"with":[7,169,278],"the":[8,23,31,35,63,75,90,98,108,123,137,145,194,252,256,284,287,313,317,320,339,342,349,366,374,381,398,402,418,426,456],"highest":[9],"mortality":[10],"rate":[11,19],"among":[12,66],"all":[13,26,53,67],"cancers":[14,95,149,179,208,237],"and":[15,60,77,96,316,416,466],"5-year":[17],"survival":[18],"of":[20,28,37,52,79,93,110,122,147,163,167,197,206,209,232,235,249,258,286,319,322,341,351,359,368,373,380,429,443,448,455],"9%":[21],"in":[22,136,177,190,199,203,220,230,251,283,376,464],"US.":[24],"Among":[25],"subtypes":[27],"pancreatic":[29,54,68,80,94,111,148,178,222,236,253,259,297,307,352,369,390,430,449],"cancers,":[30,55,192],"molecular":[32,91,419],"mechanisms":[33,420],"underlying":[34],"development":[36,109,146,350],"squamous":[38,46,81,210,233,260,308,334,370,391,427,450],"carcinomas":[39,392],"are":[40,83,217,225],"not":[41,218,346,363],"well":[42],"understood.":[43],"While":[44,185],"pure":[45],"carcinoma":[47,82,309,451],"makes":[48],"up":[49],"only":[50],"0.05-5%":[51],"it":[56,157],"very":[58],"aggressive":[59],"leads":[61],"to":[62,73,107,348,409,425],"worst":[64],"prognosis":[65],"cancers.":[69],"However,":[70],"animal":[71,414],"models":[72],"study":[74,115],"initiation":[76],"progression":[78],"lacking.":[84],"Genetic":[85],"studies":[86],"have":[87,267],"recently":[88],"revealed":[89],"signature":[92],"identified":[97,133],"transcription":[99],"factor":[100,143],"p63":[101,138,168,186,198,215,395,423],"as":[102,140,310],"candidate":[104],"that":[105,161,246,303,355],"contributes":[106,424],"carcinomas.":[112,261,371],"In":[113],"one":[114],"(Bailey":[116,180],"et":[117,151,181,239,291,385],"al.,":[118,152,182,240,292,386],"Nature":[119,183],"2016;47-52),":[120],"upregulation":[121],"p63-mediated":[124],"transcriptional":[125],"network":[126],"was":[127],"reported.":[128],"Another":[129],"genome-wide":[130],"analysis":[131],"has":[132,158],"SNP":[135],"gene":[139],"risk":[142],"for":[144,365],"(Childs":[150],"Nat":[153],"Genet":[154],"2015;911-6).":[155],"Furthermore,":[156],"been":[159],"shown":[160],"expression":[162,248,321,358],"TAp63,":[164],"an":[165],"isoform":[166,196],"tumor":[171],"suppressor":[172],"function,":[173],"frequently":[175],"suppressed":[176],"2016;47-52).":[184],"rarely":[188],"mutated":[189],"human":[191,207],"\u0394Np63\u03b1,":[193],"predominant":[195],"epithelia,":[200],"overexpressed":[202],"variety":[205],"cell":[211,329,336],"origin.":[212],"Notably,":[213],"although":[214],"proteins":[216],"expressed":[219,226],"normal":[221],"cells,":[223],"they":[224],"at":[227],"high":[228],"levels":[229],"areas":[231],"differentiation":[234],"(Basturk":[238],"Modern":[241],"Pathol":[242],"2005;1193-8).":[243],"We":[244,407],"hypothesize":[245],"aberrant":[247],"\u0394Np63\u03b1":[250,275,360],"epithelia":[254],"drives":[255],"tumorigenesis":[257],"To":[262],"test":[263],"this":[264],"hypothesis,":[265],"we":[266],"created":[268],"transgenic":[269],"(Tg)":[270],"mice":[271,282,305,375],"conditionally":[272],"expressing":[273],"ectopic":[274],"upon":[276],"crossing":[277],"tissue/cell":[279],"type-specific":[280],"Cre-Tg":[281],"presence":[285],"K-rasG12D":[288],"mutation":[289,344],"(Hingorani":[290],"Cancer":[293,477],"Cell":[294],"2003;437-50),":[295],"cancer-promoting":[298],"factor.":[299],"Our":[300],"data":[301],"show":[302],"Pdx1Cre:KrasG12D:\u0394Np63\u03b1-Tg":[304],"develop":[306],"determined":[311],"by":[312,421],"cellular":[314],"morphology":[315],"shift":[318],"cytokeratin":[323],"8":[324],"(K8),":[325],"pan-pancreatic":[327],"epithelial":[328,335],"marker,":[330],"into":[331],"K5,":[332],"marker.":[337],"Interestingly,":[338],"absence":[340],"K-ras":[343],"did":[345],"lead":[347],"tumors,":[353],"indicating":[354],"de":[356],"novo":[357],"alone":[361],"sufficient":[364],"generation":[367],"None":[372],"our":[377,412],"control":[378],"cohort":[379],"Pdx1Cre:KrasG12D:p53+/-":[382],"genotype":[383],"(Bardeesy":[384],"PNAS":[387],"2006;5947-52)":[388],"developed":[389],"or":[393],"showed":[394],"expression,":[396],"emphasizing":[397],"functional":[399],"differences":[400],"between":[401],"two":[403],"p53":[404],"family":[405],"members.":[406],"aim":[408],"further":[410],"characterize":[411],"novel":[413,445],"model":[415,447],"determine":[417],"which":[422],"pathogenesis":[428],"cancer.":[431],"Citation":[432],"Format:":[433],"Filipa":[434],"Pinto,":[435],"Tachira":[436],"Pichardo,":[437],"Adrien":[438],"Leu,":[439],"Makoto":[440],"Senoo.":[441],"Establishment":[442],"mouse":[446],"[abstract].":[452],"In:":[453],"Proceedings":[454],"AACR":[457],"Special":[458],"Conference":[459],"on":[460],"Cancer:":[462],"Advances":[463],"Science":[465],"Clinical":[467],"Care;":[468],"2019":[469],"Sept":[470],"6-9;":[471],"Boston,":[472],"MA.":[473],"Philadelphia":[474],"(PA):":[475],"AACR;":[476],"Res":[478],"2019;79(24":[479],"Suppl):Abstract":[480],"nr":[481],"C41.":[482]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2019-12-26T00:00:00"}
