{"id":"https://openalex.org/W2995170682","doi":"https://doi.org/10.1088/1757-899x/677/2/022074","title":"Synthesis of 1-methyl-3-(5-nitropyridin-2-yl) urea","display_name":"Synthesis of 1-methyl-3-(5-nitropyridin-2-yl) urea","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W2995170682","doi":"https://doi.org/10.1088/1757-899x/677/2/022074","mag":"2995170682"},"language":"en","primary_location":{"id":"doi:10.1088/1757-899x/677/2/022074","doi":"https://doi.org/10.1088/1757-899x/677/2/022074","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1757-899x/677/2/022074","pdf_url":"https://iopscience.iop.org/article/10.1088/1757-899X/677/2/022074/pdf","source":{"id":"https://openalex.org/S4210189194","display_name":"IOP Conference Series Materials Science and Engineering","issn_l":"1757-8981","issn":["1757-8981","1757-899X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IOP Conference Series: Materials Science and Engineering","raw_type":"journal-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://iopscience.iop.org/article/10.1088/1757-899X/677/2/022074/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074160031","display_name":"Binliang Zhang","orcid":"https://orcid.org/0009-0000-2555-3339","observed_orcids":["https://orcid.org/0009-0000-2555-3339"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Binliang Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072356660","display_name":"Luogen Lai","orcid":"https://orcid.org/0000-0002-6936-3737","observed_orcids":["https://orcid.org/0000-0002-6936-3737"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luogen Lai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Pan Feng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pan Feng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101832588","display_name":"Shan Xu","orcid":"https://orcid.org/0000-0002-0072-2156","observed_orcids":["https://orcid.org/0000-0002-0072-2156"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shan Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101832588"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14258483,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"677","issue":"2","first_page":"022074","last_page":"022074"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.5586000084877014,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.5586000084877014,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.24729999899864197,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.07400000095367432,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urea-synthesis","display_name":"urea synthesis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/nucleophilic-substitution","display_name":"nucleophilic substitution","score":0.8259999752044678},{"id":"https://openalex.org/keywords/synthetic-route-optimization","display_name":"synthetic route optimization","score":0.5950000286102295},{"id":"https://openalex.org/keywords/multistep-synthesis","display_name":"multistep synthesis","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.870780885219574},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.8083091974258423},{"id":"https://openalex.org/C178907741","wikidata":"https://www.wikidata.org/wiki/Q745930","display_name":"Nucleophile","level":3,"score":0.6538034677505493},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6353318095207214},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.5463961362838745},{"id":"https://openalex.org/C103319777","wikidata":"https://www.wikidata.org/wiki/Q1979695","display_name":"Proton NMR","level":2,"score":0.4397926926612854},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4103577136993408},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.39881932735443115},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3956451117992401},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.12027958035469055},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.06192025542259216},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1088/1757-899x/677/2/022074","doi":"https://doi.org/10.1088/1757-899x/677/2/022074","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1757-899x/677/2/022074","pdf_url":"https://iopscience.iop.org/article/10.1088/1757-899X/677/2/022074/pdf","source":{"id":"https://openalex.org/S4210189194","display_name":"IOP Conference Series Materials Science and Engineering","issn_l":"1757-8981","issn":["1757-8981","1757-899X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IOP Conference Series: Materials Science and Engineering","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1088/1757-899x/677/2/022074","doi":"https://doi.org/10.1088/1757-899x/677/2/022074","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1757-899x/677/2/022074","pdf_url":"https://iopscience.iop.org/article/10.1088/1757-899X/677/2/022074/pdf","source":{"id":"https://openalex.org/S4210189194","display_name":"IOP Conference Series Materials Science and Engineering","issn_l":"1757-8981","issn":["1757-8981","1757-899X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IOP Conference Series: Materials Science and Engineering","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2995170682.pdf","grobid_xml":"https://content.openalex.org/works/W2995170682.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W13260057","https://openalex.org/W1956497896","https://openalex.org/W1972422388","https://openalex.org/W1981603699","https://openalex.org/W2058578594","https://openalex.org/W2071078085","https://openalex.org/W2089831452"],"related_works":["https://openalex.org/W2958818973","https://openalex.org/W2380701592","https://openalex.org/W4283832506","https://openalex.org/W2034809074","https://openalex.org/W2188159330","https://openalex.org/W2754438320","https://openalex.org/W2130500977","https://openalex.org/W1010705226","https://openalex.org/W161619315","https://openalex.org/W2314507701"],"abstract_inverted_index":{"Abstract":[0],"1-methyl-3-(5-nitropyridin-2-yl)":[1,21],"urea":[2,22],"(8)":[3,23],"is":[4],"an":[5],"important":[6],"intermediate":[7],"for":[8,20],"small":[9],"molecule":[10],"anticancer":[11],"drugs.":[12],"A":[13],"rapid":[14],"and":[15],"high":[16,70],"yield":[17,64],"synthetic":[18,58],"method":[19,59],"was":[24,32,50,60,69],"established":[25],"in":[26],"this":[27],"work.":[28],"The":[29,62],"target":[30,48],"compound":[31],"synthesized":[33],"from":[34],"the":[35,47,57,66],"commercially":[36],"available":[37],"2-chloro-5":[38],"-nitropyridine":[39],"(5)":[40],"through":[41],"multi-step":[42],"nucleophilic":[43],"reactions.The":[44],"structure":[45],"of":[46,65],"product":[49],"confirmed":[51],"by":[52],"1H":[53],"NMR.":[54],"In":[55],"addition,":[56],"optimized.":[61],"total":[63],"four":[67],"steps":[68],"up":[71],"to":[72],"92%.":[73]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-12-26T00:00:00"}
