{"id":"https://openalex.org/W2995147355","doi":"https://doi.org/10.1063/1.5131856","title":"Influence of the cofactor structure on the photophysical processes initiating signal transduction in a phototropin-derived LOV domain","display_name":"Influence of the cofactor structure on the photophysical processes initiating signal transduction in a phototropin-derived LOV domain","publication_year":2019,"publication_date":"2019-12-18","ids":{"openalex":"https://openalex.org/W2995147355","doi":"https://doi.org/10.1063/1.5131856","mag":"2995147355","pmid":"https://pubmed.ncbi.nlm.nih.gov/31864253"},"language":"en","primary_location":{"id":"doi:10.1063/1.5131856","doi":"https://doi.org/10.1063/1.5131856","is_oa":false,"landing_page_url":"https://doi.org/10.1063/1.5131856","pdf_url":null,"source":{"id":"https://openalex.org/S77047749","display_name":"The Journal of Chemical Physics","issn_l":"0021-9606","issn":["0021-9606","1089-7690","1520-9032"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320257","host_organization_name":"American Institute of Physics","host_organization_lineage":["https://openalex.org/P4310320257"],"host_organization_lineage_names":["American Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Chemical Physics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083560305","display_name":"Sabine Richert","orcid":"https://orcid.org/0000-0002-2990-974X","observed_orcids":["https://orcid.org/0000-0002-2990-974X"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Richert","raw_affiliation_strings":["Institute of Physical Chemistry, University of Freiburg 1 , Albertstr. 21, 79104 Freiburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2990-974X","affiliations":[{"raw_affiliation_string":"Institute of Physical Chemistry, University of Freiburg 1 , Albertstr. 21, 79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394934","display_name":"Jing Chen","orcid":"https://orcid.org/0000-0002-8942-9537","observed_orcids":["https://orcid.org/0000-0002-8942-9537"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jing Chen","raw_affiliation_strings":["Institute of Physical Chemistry, University of Freiburg 1 , Albertstr. 21, 79104 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physical Chemistry, University of Freiburg 1 , Albertstr. 21, 79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088968993","display_name":"Nils Pompe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nils Pompe","raw_affiliation_strings":["Institute of Physical Chemistry, University of Freiburg 1 , Albertstr. 21, 79104 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physical Chemistry, University of Freiburg 1 , Albertstr. 21, 79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007480725","display_name":"Valentin Radtke","orcid":"https://orcid.org/0000-0002-5547-1278","observed_orcids":["https://orcid.org/0000-0002-5547-1278"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Valentin Radtke","raw_affiliation_strings":["Institute of Inorganic and Analytical Chemistry, University of Freiburg 2 , Albertstr. 21, 79104 Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Inorganic and Analytical Chemistry, University of Freiburg 2 , Albertstr. 21, 79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058813011","display_name":"Boris lllarionov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Boris lllarionov","raw_affiliation_strings":["Hamburg School of Food Science, University of Hamburg 3 , Grindelallee 117, 20146 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamburg School of Food Science, University of Hamburg 3 , Grindelallee 117, 20146 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006304159","display_name":"Markus J. Fischer","orcid":"https://orcid.org/0000-0001-7243-4199","observed_orcids":["https://orcid.org/0000-0001-7243-4199"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Fischer","raw_affiliation_strings":["Hamburg School of Food Science, University of Hamburg 3 , Grindelallee 117, 20146 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hamburg School of Food Science, University of Hamburg 3 , Grindelallee 117, 20146 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068798153","display_name":"Adelbert Bacher","orcid":"https://orcid.org/0000-0001-5174-4139","observed_orcids":["https://orcid.org/0000-0001-5174-4139"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Adelbert Bacher","raw_affiliation_strings":["Institute of Organic Chemistry and Biochemistry, Technical University of Munich 4 , Lichtenbergstr. 4, 85748 Garching, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Organic Chemistry and Biochemistry, Technical University of Munich 4 , Lichtenbergstr. 4, 85748 Garching, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101911083","display_name":"Stefan Weber","orcid":"https://orcid.org/0000-0003-4090-7435","observed_orcids":["https://orcid.org/0000-0003-4090-7435"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Weber","raw_affiliation_strings":["Institute of Physical Chemistry, University of Freiburg 1 , Albertstr. 21, 79104 Freiburg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-4090-7435","affiliations":[{"raw_affiliation_string":"Institute of Physical Chemistry, University of Freiburg 1 , Albertstr. 21, 79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.6608,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.65561647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"151","issue":"23","first_page":"235102","last_page":"235102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11129","display_name":"Photochemistry and Electron Transfer Studies","score":0.5830000042915344,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11129","display_name":"Photochemistry and Electron Transfer Studies","score":0.5830000042915344,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.3458999991416931,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.03449999913573265,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phototropin","display_name":"phototropin","score":0.7829999923706055},{"id":"https://openalex.org/keywords/lov-domain","display_name":"LOV domain","score":0.968999981880188},{"id":"https://openalex.org/keywords/flavin-mononucleotide","display_name":"flavin mononucleotide","score":0.8989999890327454},{"id":"https://openalex.org/keywords/blue-light-photoreceptor","display_name":"blue-light photoreceptor","score":0.7730000019073486},{"id":"https://openalex.org/keywords/excited-state-photochemistry","display_name":"excited-state photochemistry","score":0.777999997138977},{"id":"https://openalex.org/keywords/electron-transfer","display_name":"electron transfer","score":0.7390000224113464},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7649999856948853},{"id":"https://openalex.org/keywords/avena-sativa","display_name":"Avena sativa","score":0.847000002861023},{"id":"https://openalex.org/keywords/flavoprotein","display_name":"flavoprotein","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C33318195","wikidata":"https://www.wikidata.org/wiki/Q417930","display_name":"Phototropin","level":5,"score":0.9331998229026794},{"id":"https://openalex.org/C33093398","wikidata":"https://www.wikidata.org/wiki/Q174337","display_name":"Flavin group","level":3,"score":0.9056731462478638},{"id":"https://openalex.org/C2777427158","wikidata":"https://www.wikidata.org/wiki/Q376061","display_name":"Flavin mononucleotide","level":4,"score":0.7868597507476807},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.7422291040420532},{"id":"https://openalex.org/C144543706","wikidata":"https://www.wikidata.org/wiki/Q85754737","display_name":"Cryptochrome","level":4,"score":0.714520275592804},{"id":"https://openalex.org/C71995715","wikidata":"https://www.wikidata.org/wiki/Q78574842","display_name":"Flavoprotein","level":3,"score":0.7077762484550476},{"id":"https://openalex.org/C192468462","wikidata":"https://www.wikidata.org/wiki/Q533543","display_name":"Chromophore","level":2,"score":0.6635765433311462},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5737616419792175},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.5097751021385193},{"id":"https://openalex.org/C73978554","wikidata":"https://www.wikidata.org/wiki/Q772919","display_name":"Intersystem crossing","level":4,"score":0.4505109488964081},{"id":"https://openalex.org/C181500209","wikidata":"https://www.wikidata.org/wiki/Q215328","display_name":"Excited state","level":2,"score":0.4435213506221771},{"id":"https://openalex.org/C33062035","wikidata":"https://www.wikidata.org/wiki/Q3296863","display_name":"Singlet state","level":3,"score":0.27950650453567505},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09573546051979065},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06909379363059998},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1063/1.5131856","doi":"https://doi.org/10.1063/1.5131856","is_oa":false,"landing_page_url":"https://doi.org/10.1063/1.5131856","pdf_url":null,"source":{"id":"https://openalex.org/S77047749","display_name":"The Journal of Chemical Physics","issn_l":"0021-9606","issn":["0021-9606","1089-7690","1520-9032"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320257","host_organization_name":"American Institute of Physics","host_organization_lineage":["https://openalex.org/P4310320257"],"host_organization_lineage_names":["American Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Chemical Physics","raw_type":"journal-article"},{"id":"pmid:31864253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31864253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of chemical physics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1279010855","display_name":null,"funder_award_id":"RTG-1976","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G787536658","display_name":null,"funder_award_id":"INST 39/928-1 FUGG","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1207844576","https://openalex.org/W1581703093","https://openalex.org/W1902408092","https://openalex.org/W1964789752","https://openalex.org/W1965025889","https://openalex.org/W1967580645","https://openalex.org/W1972888996","https://openalex.org/W1978971052","https://openalex.org/W1983373264","https://openalex.org/W1999693045","https://openalex.org/W2006080412","https://openalex.org/W2008160964","https://openalex.org/W2009333693","https://openalex.org/W2021571134","https://openalex.org/W2022205840","https://openalex.org/W2026411487","https://openalex.org/W2031904472","https://openalex.org/W2032521268","https://openalex.org/W2032661660","https://openalex.org/W2035433344","https://openalex.org/W2036131768","https://openalex.org/W2053087708","https://openalex.org/W2054811648","https://openalex.org/W2060836111","https://openalex.org/W2063221585","https://openalex.org/W2075157926","https://openalex.org/W2075880454","https://openalex.org/W2077174748","https://openalex.org/W2080981650","https://openalex.org/W2097768784","https://openalex.org/W2099469237","https://openalex.org/W2110075655","https://openalex.org/W2111663819","https://openalex.org/W2113086708","https://openalex.org/W2129349897","https://openalex.org/W2135726588","https://openalex.org/W2137347727","https://openalex.org/W2146051607","https://openalex.org/W2168836416","https://openalex.org/W2173035231","https://openalex.org/W2327260608","https://openalex.org/W2330290939","https://openalex.org/W2331467333","https://openalex.org/W2341752324","https://openalex.org/W2406712131","https://openalex.org/W2538897271","https://openalex.org/W2564386346","https://openalex.org/W2620805952","https://openalex.org/W2995120264"],"related_works":["https://openalex.org/W2038981441","https://openalex.org/W2113086708","https://openalex.org/W2026411487","https://openalex.org/W2044241959","https://openalex.org/W2168836416","https://openalex.org/W2406712131","https://openalex.org/W2110075655","https://openalex.org/W2033363996","https://openalex.org/W1986585269","https://openalex.org/W2184477005"],"abstract_inverted_index":{"Due":[0],"to":[1,78,99,112],"their":[2,32],"biological":[3],"importance,":[4],"the":[5,16,38,49,63,71,82,86,90,117,129,138,148,155,159,164,186,189,199,202,210,223],"photochemistry":[6,83,120],"of":[7,55,74,84,89,121,125,128,147,154,163,185,188,195,201,222],"blue-light":[8,21],"photoreceptor":[9],"proteins":[10],"has":[11],"been":[12],"studied":[13],"extensively":[14],"over":[15],"last":[17],"few":[18],"decades.":[19],"Most":[20],"photoreceptors,":[22],"such":[23],"as":[24,31,178,180],"cryptochromes":[25],"and":[26,76,80,145,161,173,207],"phototropins,":[27],"utilize":[28],"flavin":[29,131,149,191,224],"chromophores":[30],"cofactors.":[33],"After":[34],"irradiation":[35],"with":[36,43,193],"light,":[37],"chromophore":[39],"undergoes":[40],"electron":[41,174],"transfer":[42],"nearby":[44],"redox-active":[45],"amino-acid":[46],"residues":[47],"within":[48],"protein,":[50],"whereby":[51],"this":[52],"first":[53],"step":[54],"signal":[56,95],"transduction":[57,96],"may":[58],"be":[59,100,214],"initiated":[60],"either":[61],"from":[62,108],"flavin's":[64],"excited":[65,91,118,204],"singlet":[66],"or":[67],"triplet":[68],"state.":[69],"Despite":[70],"collective":[72],"effort":[73],"theoreticians":[75],"experimentalists":[77],"characterize":[79],"understand":[81],"flavoproteins,":[85],"mechanistic":[87],"details":[88],"state":[92,119,205],"processes":[93],"initiating":[94],"are":[97,167],"yet":[98],"revealed.":[101],"Here,":[102],"we":[103],"use":[104],"a":[105],"light-oxygen-voltage-sensing":[106],"domain":[107],"Avena":[109],"sativa":[110],"phototropin":[111],"get":[113],"additional":[114],"insight":[115],"into":[116],"flavoproteins.":[122],"The":[123,151,183],"influence":[124],"structural":[126,220],"variations":[127],"cofactor":[130],"mononucleotide":[132],"(FMN)":[133],"is":[134],"explored":[135],"by":[136,169,217],"varying":[137],"methyl":[139],"substitution":[140],"pattern":[141],"in":[142,158],"positions":[143],"7":[144],"8":[146],"core.":[150,225],"photophysical":[152],"properties":[153,187],"FMN":[156,196],"derivatives,":[157],"absence":[160],"presence":[162],"protein":[165],"environment,":[166],"investigated":[168],"UV-vis":[170],"absorption,":[171],"fluorescence,":[172],"paramagnetic":[175],"resonance":[176],"spectroscopies":[177],"well":[179],"cyclic":[181],"voltammetry.":[182],"comparison":[184],"modified":[190],"cofactors":[192],"those":[194],"shows":[197],"that":[198],"rates":[200],"different":[203],"reactions,":[206],"therefore":[208],"also":[209],"singlet/triplet":[211],"yields,":[212],"can":[213],"modulated":[215],"substantially":[216],"only":[218],"minor":[219],"modifications":[221]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2019-12-26T00:00:00"}