{"id":"https://openalex.org/W2995146830","doi":"https://doi.org/10.1021/acs.jmedchem.9b00796","title":"Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators","display_name":"Synthesis and Pharmacological Characterization of Conformationally Restricted Retigabine Analogues as Novel Neuronal Kv7 Channel Activators","publication_year":2019,"publication_date":"2019-12-09","ids":{"openalex":"https://openalex.org/W2995146830","doi":"https://doi.org/10.1021/acs.jmedchem.9b00796","mag":"2995146830","pmid":"https://pubmed.ncbi.nlm.nih.gov/31815462"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.9b00796","doi":"https://doi.org/10.1021/acs.jmedchem.9b00796","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.9b00796","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2995146830"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00796","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020033317","display_name":"Carmine Ostacolo","orcid":"https://orcid.org/0000-0003-3715-8680","observed_orcids":["https://orcid.org/0000-0003-3715-8680"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carmine Ostacolo","raw_affiliation_strings":["Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3715-8680","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021427652","display_name":"Francesco Miceli","orcid":"https://orcid.org/0000-0002-5393-1402","observed_orcids":["https://orcid.org/0000-0002-5393-1402"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Miceli","raw_affiliation_strings":["Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040913282","display_name":"Veronica Di Sarno","orcid":"https://orcid.org/0000-0002-1397-5240","observed_orcids":["https://orcid.org/0000-0002-1397-5240"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Veronica Di Sarno","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079671054","display_name":"Piera Nappi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Piera Nappi","raw_affiliation_strings":["Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074044188","display_name":"Nunzio Iraci","orcid":"https://orcid.org/0000-0002-1359-8684","observed_orcids":["https://orcid.org/0000-0002-1359-8684"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nunzio Iraci","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1359-8684","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031203360","display_name":"Maria Virginia Soldovieri","orcid":"https://orcid.org/0000-0002-3601-9374","observed_orcids":["https://orcid.org/0000-0002-3601-9374"]},"institutions":[{"id":"https://openalex.org/I129627893","display_name":"University of Molise","ror":"https://ror.org/04z08z627","country_code":"IT","type":"education","lineage":["https://openalex.org/I129627893"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Virginia Soldovieri","raw_affiliation_strings":["Department of Medicine and Health Science V. Tiberio, University of Molise, Via F. de Sanctis, 86100 Campobasso, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Health Science V. Tiberio, University of Molise, Via F. de Sanctis, 86100 Campobasso, Italy","institution_ids":["https://openalex.org/I129627893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003767871","display_name":"Tania Ciaglia","orcid":"https://orcid.org/0000-0002-6592-4373","observed_orcids":["https://orcid.org/0000-0002-6592-4373"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Tania Ciaglia","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072561516","display_name":"Paolo Ambrosino","orcid":"https://orcid.org/0000-0002-7761-5551","observed_orcids":["https://orcid.org/0000-0002-7761-5551"]},"institutions":[{"id":"https://openalex.org/I16337185","display_name":"University of Sannio","ror":"https://ror.org/04vc81p87","country_code":"IT","type":"education","lineage":["https://openalex.org/I16337185"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Ambrosino","raw_affiliation_strings":["Department of Science and Technology (DST), University of Sannio, Via Port\u2019Arsa 11, 82100 Benevento, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Science and Technology (DST), University of Sannio, Via Port\u2019Arsa 11, 82100 Benevento, Italy","institution_ids":["https://openalex.org/I16337185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047003794","display_name":"Vincenzo Vestuto","orcid":"https://orcid.org/0000-0002-3603-5526","observed_orcids":["https://orcid.org/0000-0002-3603-5526"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Vestuto","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079482269","display_name":"Anna Lauritano","orcid":"https://orcid.org/0000-0001-6788-5999","observed_orcids":["https://orcid.org/0000-0001-6788-5999"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Lauritano","raw_affiliation_strings":["Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050213616","display_name":"Simona Musella","orcid":"https://orcid.org/0000-0001-8312-4241","observed_orcids":["https://orcid.org/0000-0001-8312-4241"]},"institutions":[{"id":"https://openalex.org/I4210120965","display_name":"European Biomedical Research Institute of Salerno","ror":"https://ror.org/02aqtvv10","country_code":"IT","type":"other","lineage":["https://openalex.org/I4210120965"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona Musella","raw_affiliation_strings":["European Biomedical Research Center (EBRIS), Via Salvatore de Renzi, 3, 84125 Salerno, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Biomedical Research Center (EBRIS), Via Salvatore de Renzi, 3, 84125 Salerno, Salerno, Italy","institution_ids":["https://openalex.org/I4210120965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054372400","display_name":"Giacomo Pepe","orcid":"https://orcid.org/0000-0002-7561-2023","observed_orcids":["https://orcid.org/0000-0002-7561-2023"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giacomo Pepe","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7561-2023","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040050950","display_name":"Manuela Giovanna Basilicata","orcid":"https://orcid.org/0000-0003-2736-1044","observed_orcids":["https://orcid.org/0000-0003-2736-1044"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Manuela Giovanna Basilicata","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043164400","display_name":"Michele Manfra","orcid":"https://orcid.org/0000-0002-3320-972X","observed_orcids":["https://orcid.org/0000-0002-3320-972X"]},"institutions":[{"id":"https://openalex.org/I20272500","display_name":"University of Basilicata","ror":"https://ror.org/03tc05689","country_code":"IT","type":"education","lineage":["https://openalex.org/I20272500"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Manfra","raw_affiliation_strings":["Department of Science, University of Basilicata, Via dell\u2019Ateneo Lucano 10, 85100 Potenza, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Science, University of Basilicata, Via dell\u2019Ateneo Lucano 10, 85100 Potenza, Italy","institution_ids":["https://openalex.org/I20272500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029898397","display_name":"Diego Romano Perinelli","orcid":"https://orcid.org/0000-0002-7686-4150","observed_orcids":["https://orcid.org/0000-0002-7686-4150"]},"institutions":[{"id":"https://openalex.org/I112859197","display_name":"Universit\u00e0 di Camerino","ror":"https://ror.org/0005w8d69","country_code":"IT","type":"education","lineage":["https://openalex.org/I112859197"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Diego Romano Perinelli","raw_affiliation_strings":["School of Pharmacy, University of Camerino, Via Gentile III da Varano, 62032 Camerino, Macerata, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Camerino, Via Gentile III da Varano, 62032 Camerino, Macerata, Italy","institution_ids":["https://openalex.org/I112859197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040940946","display_name":"Ettore Novellino","orcid":"https://orcid.org/0000-0002-2181-2142","observed_orcids":["https://orcid.org/0000-0002-2181-2142"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ettore Novellino","raw_affiliation_strings":["Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2181-2142","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069089232","display_name":"Alessia Bertamino","orcid":"https://orcid.org/0000-0002-5482-6276","observed_orcids":["https://orcid.org/0000-0002-5482-6276"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessia Bertamino","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5482-6276","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050246182","display_name":"Isabel Maria Gomez-Monterrey","orcid":"https://orcid.org/0000-0001-6688-2606","observed_orcids":["https://orcid.org/0000-0001-6688-2606","https://orcid.org/0000-0003-0001-8748"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Isabel M. Gomez-Monterrey","raw_affiliation_strings":["Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6688-2606","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074768676","display_name":"Pietro Campiglia","orcid":"https://orcid.org/0000-0002-1069-2181","observed_orcids":["https://orcid.org/0000-0002-1069-2181"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Pietro Campiglia","raw_affiliation_strings":["Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1069-2181","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057579624","display_name":"Maurizio Taglialatela","orcid":"https://orcid.org/0000-0002-8202-0560","observed_orcids":["https://orcid.org/0000-0002-8202-0560"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Maurizio Taglialatela","raw_affiliation_strings":["Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, 80131 Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8202-0560","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via Pansini, 5, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5057579624","https://openalex.org/A5074768676"],"corresponding_institution_ids":["https://openalex.org/I131729948","https://openalex.org/I71267560"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.2368,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.77259965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"63","issue":"1","first_page":"163","last_page":"185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kv7-potassium-channels","display_name":"Kv7 potassium channels","score":0.8980000019073486},{"id":"https://openalex.org/keywords/conformationally-restricted-compounds","display_name":"conformationally restricted compounds","score":0.8980000019073486},{"id":"https://openalex.org/keywords/kv7-2","display_name":"Kv7.2","score":0.8159999847412109},{"id":"https://openalex.org/keywords/kv7-3","display_name":"Kv7.3","score":0.9919999837875366},{"id":"https://openalex.org/keywords/kv7-4","display_name":"Kv7.4","score":0.9909999966621399},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.4869999885559082},{"id":"https://openalex.org/keywords/chemical-stability","display_name":"chemical stability","score":0.6570000052452087},{"id":"https://openalex.org/keywords/binding-sites","display_name":"binding sites","score":0.4410000145435333},{"id":"https://openalex.org/keywords/pharmacophore","display_name":"pharmacophore","score":0.5479999780654907},{"id":"https://openalex.org/keywords/heteromeric-channels","display_name":"heteromeric channels","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9297389388084412},{"id":"https://openalex.org/C2776104367","wikidata":"https://www.wikidata.org/wiki/Q5891451","display_name":"Homomeric","level":4,"score":0.8732423782348633},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.6955232620239258},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.4808114767074585},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.47804147005081177},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.44281908869743347},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.4122496247291565},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3800666332244873},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.2061225175857544},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15086522698402405},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13701316714286804},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.10311433672904968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002219","descriptor_name":"Carbamates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010655","descriptor_name":"Phenylenediamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051658","descriptor_name":"KCNQ2 Potassium Channel","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051658","descriptor_name":"KCNQ2 Potassium Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051658","descriptor_name":"KCNQ2 Potassium Channel","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D051659","descriptor_name":"KCNQ3 Potassium Channel","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051659","descriptor_name":"KCNQ3 Potassium Channel","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1021/acs.jmedchem.9b00796","doi":"https://doi.org/10.1021/acs.jmedchem.9b00796","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.9b00796","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:31815462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31815462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unibas.it:11563/140523","doi":null,"is_oa":true,"landing_page_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00796","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00796","source":{"id":"https://openalex.org/S4377196360","display_name":"CINECA IRIS Institutional Research Information System (University of Basilicata)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20272500","host_organization_name":"University of Basilicata","host_organization_lineage":["https://openalex.org/I20272500"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unicampania.it:11591/543591","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11591/543591","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unimol.it:11695/90767","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11695/90767","pdf_url":null,"source":{"id":"https://openalex.org/S7407055127","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi del Molise","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubblicazioni.unicam.it:11581/496131","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11581/496131","pdf_url":null,"source":{"id":"https://openalex.org/S4306400819","display_name":"Unicam Scientific Publications (University of Camerino)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I112859197","host_organization_name":"Universit\u00e0 di Camerino","host_organization_lineage":["https://openalex.org/I112859197"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:iris.unibas.it:11563/140523","doi":null,"is_oa":true,"landing_page_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00796","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00796","source":{"id":"https://openalex.org/S4377196360","display_name":"CINECA IRIS Institutional Research Information System (University of Basilicata)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20272500","host_organization_name":"University of Basilicata","host_organization_lineage":["https://openalex.org/I20272500"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1364686276","display_name":null,"funder_award_id":"PRIN 2017YH3SXK","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G1459312295","display_name":null,"funder_award_id":"6-CSPUNINA-120","funder_id":"https://openalex.org/F4320309590","funder_display_name":"Universit\u00e0 degli Studi di Napoli Federico II"},{"id":"https://openalex.org/G1924149161","display_name":null,"funder_award_id":"GGP15113","funder_id":"https://openalex.org/F4320321179","funder_display_name":"Fondazione Telethon"},{"id":"https://openalex.org/G1991871361","display_name":null,"funder_award_id":"6\u2010CSP\u2010UNINA\u2010120","funder_id":"https://openalex.org/F4320309746","funder_display_name":"Compagnia di San Paolo"},{"id":"https://openalex.org/G5136116722","display_name":null,"funder_award_id":"PRIN 2017ALCR7C","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G7089318580","display_name":null,"funder_award_id":"GR\u20102016\u201002363337","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G8110728490","display_name":null,"funder_award_id":"2014 RBSI1444EM","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"}],"funders":[{"id":"https://openalex.org/F4320309590","display_name":"Universit\u00e0 degli Studi di Napoli Federico II","ror":"https://ror.org/05290cv24"},{"id":"https://openalex.org/F4320309746","display_name":"Compagnia di San Paolo","ror":"https://ror.org/00d1b1c41"},{"id":"https://openalex.org/F4320321179","display_name":"Fondazione Telethon","ror":"https://ror.org/04xraxn18"},{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1208303706","https://openalex.org/W1591329553","https://openalex.org/W1638684638","https://openalex.org/W1887681162","https://openalex.org/W1892342982","https://openalex.org/W1963298781","https://openalex.org/W1965607248","https://openalex.org/W1974809694","https://openalex.org/W1982297609","https://openalex.org/W1982816693","https://openalex.org/W1989048848","https://openalex.org/W1991601482","https://openalex.org/W1993790948","https://openalex.org/W1999491936","https://openalex.org/W2000815209","https://openalex.org/W2007912489","https://openalex.org/W2009134867","https://openalex.org/W2011005691","https://openalex.org/W2011379762","https://openalex.org/W2019959711","https://openalex.org/W2023459069","https://openalex.org/W2028105139","https://openalex.org/W2031220839","https://openalex.org/W2038786052","https://openalex.org/W2039105527","https://openalex.org/W2048754034","https://openalex.org/W2051381895","https://openalex.org/W2052127460","https://openalex.org/W2057949033","https://openalex.org/W2071358460","https://openalex.org/W2076622810","https://openalex.org/W2079373480","https://openalex.org/W2083954616","https://openalex.org/W2089221017","https://openalex.org/W2104937561","https://openalex.org/W2106383417","https://openalex.org/W2106882534","https://openalex.org/W2127457810","https://openalex.org/W2129153475","https://openalex.org/W2130004182","https://openalex.org/W2137263523","https://openalex.org/W2142318256","https://openalex.org/W2144993965","https://openalex.org/W2159579442","https://openalex.org/W2162891493","https://openalex.org/W2164439848","https://openalex.org/W2168858520","https://openalex.org/W2169119723","https://openalex.org/W2172086450","https://openalex.org/W2302590860","https://openalex.org/W2337718384","https://openalex.org/W2461435401","https://openalex.org/W2510865085","https://openalex.org/W2524353190","https://openalex.org/W2620982682","https://openalex.org/W2765769421","https://openalex.org/W2801273514","https://openalex.org/W2810796788","https://openalex.org/W2883140356","https://openalex.org/W2891731802","https://openalex.org/W2905025247","https://openalex.org/W2909765711","https://openalex.org/W2915308044","https://openalex.org/W2918867724","https://openalex.org/W2922427931","https://openalex.org/W2934454224","https://openalex.org/W2944151862","https://openalex.org/W2988704366"],"related_works":["https://openalex.org/W7072192112","https://openalex.org/W4292004335","https://openalex.org/W7057298980","https://openalex.org/W6981000060","https://openalex.org/W7203995508","https://openalex.org/W2047928870","https://openalex.org/W4409668907","https://openalex.org/W4401577374","https://openalex.org/W2159579442","https://openalex.org/W2032320802"],"abstract_inverted_index":{"Kv7":[0,27,40,157],"K":[1],"+":[2],"channels":[3],"represent":[4],"attractive":[5],"pharmacological":[6],"targets":[7],"for":[8,54,74,111,147],"the":[9,25,50,107,115,133,138,148],"treatment":[10],"of":[11,24,124,150],"different":[12],"neurological":[13],"disorders,":[14],"including":[15],"epilepsy.":[16],"In":[17,80],"this":[18],"paper,":[19],"42":[20],"conformationally":[21],"restricted":[22],"analogues":[23],"prototypical":[26],"activator":[28],"retigabine":[29,45],"have":[30],"been":[31],"synthesized":[32],"and":[33,86,96,126,155],"tested":[34],"by":[35,58],"electrophysiological":[36],"patch-clamp":[37],"experiments":[38],"as":[39],"agonists.":[41,158],"When":[42],"compared":[43,82],"to":[44,83],"(0.93":[46],"\u00b1":[47,62,77],"0.43":[48],"\u03bcM),":[49],"EC":[51],"50":[52],"s":[53],"Kv7.2":[55],"current":[56],"enhancements":[57],"compound":[59],"23a":[60,85,125],"(0.08":[61],"0.04":[63],"\u03bcM)":[64],"were":[65],"lower,":[66],"whereas":[67],"no":[68],"change":[69],"in":[70,92,128],"potency":[71,91],"was":[72],"observed":[73],"24a":[75,87,127],"(0.63":[76],"0.07":[78],"\u03bcM).":[79],"addition,":[81],"retigabine,":[84],"showed":[88],"also":[89],"higher":[90],"activating":[93],"heteromeric":[94],"Kv7.2/Kv7.3":[95],"homomeric":[97],"Kv7.4":[98],"channels.":[99],"Molecular":[100],"modeling":[101],"studies":[102,119],"provided":[103],"new":[104],"insights":[105],"into":[106],"chemical":[108,122],"features":[109],"required":[110],"optimal":[112],"interaction":[113],"at":[114],"binding":[116],"site.":[117],"Stability":[118],"evidenced":[120],"improved":[121],"stability":[123],"comparison":[129],"with":[130],"retigabine.":[131],"Overall,":[132],"present":[134],"results":[135],"highlight":[136],"that":[137],"N":[139],"5-alkylamidoindole":[140],"moiety":[141],"provides":[142],"a":[143],"suitable":[144],"pharmacophoric":[145],"scaffold":[146],"design":[149],"chemically":[151],"stable,":[152],"highly":[153],"potent":[154],"selective":[156]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2019-12-26T00:00:00"}
