{"id":"https://openalex.org/W2995122052","doi":"https://doi.org/10.1016/j.comtox.2019.100115","title":"Population Life-course exposure to health effects model (PLETHEM): An R package for PBPK modeling","display_name":"Population Life-course exposure to health effects model (PLETHEM): An R package for PBPK modeling","publication_year":2019,"publication_date":"2019-12-13","ids":{"openalex":"https://openalex.org/W2995122052","doi":"https://doi.org/10.1016/j.comtox.2019.100115","mag":"2995122052"},"language":"en","primary_location":{"id":"doi:10.1016/j.comtox.2019.100115","doi":"https://doi.org/10.1016/j.comtox.2019.100115","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.comtox.2019.100115","pdf_url":null,"source":{"id":"https://openalex.org/S2898548427","display_name":"Computational Toxicology","issn_l":"2468-1113","issn":["2468-1113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030997657","display_name":"Salil N. Pendse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salil N. Pendse","raw_affiliation_strings":["ScitoVation, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ScitoVation, Durham, NC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006713637","display_name":"Alina Efremenko","orcid":"https://orcid.org/0000-0002-9439-2118","observed_orcids":["https://orcid.org/0000-0002-9439-2118"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alina Efremenko","raw_affiliation_strings":["ScitoVation, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ScitoVation, Durham, NC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030740405","display_name":"C. Eric Hack","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Eric Hack","raw_affiliation_strings":["ScitoVation, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ScitoVation, Durham, NC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003647626","display_name":"Marjory Moreau","orcid":"https://orcid.org/0009-0001-3701-2377","observed_orcids":["https://orcid.org/0009-0001-3701-2377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marjory Moreau","raw_affiliation_strings":["ScitoVation, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ScitoVation, Durham, NC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010189424","display_name":"Pankajini Mallick","orcid":"https://orcid.org/0000-0001-9438-7987","observed_orcids":["https://orcid.org/0000-0001-9438-7987"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pankajini Mallick","raw_affiliation_strings":["ScitoVation, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ScitoVation, Durham, NC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021936943","display_name":"Michael W. Dzierlenga","orcid":"https://orcid.org/0000-0001-7010-6191","observed_orcids":["https://orcid.org/0000-0001-7010-6191"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Dzierlenga","raw_affiliation_strings":["ScitoVation, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ScitoVation, Durham, NC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027265917","display_name":"Chantel I. Nicolas","orcid":"https://orcid.org/0000-0003-2061-5830","observed_orcids":["https://orcid.org/0000-0003-2061-5830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chantel I. Nicolas","raw_affiliation_strings":["ScitoVation, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ScitoVation, Durham, NC, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082658584","display_name":"Miyoung Yoon","orcid":"https://orcid.org/0000-0002-3653-3488","observed_orcids":["https://orcid.org/0000-0002-3653-3488"]},"institutions":[{"id":"https://openalex.org/I4403928214","display_name":"ToxStrategies LLC (United States)","ror":"https://ror.org/02cfpj844","country_code":"US","type":"company","lineage":["https://openalex.org/I4403928214"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miyoung Yoon","raw_affiliation_strings":["ScitoVation, Durham, NC, USA","ToxStrategies, Cary, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ScitoVation, Durham, NC, USA","institution_ids":[]},{"raw_affiliation_string":"ToxStrategies, Cary, NC, USA","institution_ids":["https://openalex.org/I4403928214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002591537","display_name":"Harvey J. Clewell III M.A.","orcid":"https://orcid.org/0000-0002-2253-9045","observed_orcids":["https://orcid.org/0000-0002-2253-9045"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harvey J. Clewell","raw_affiliation_strings":["Ramboll, Research Triangle Park, NC, USA","ScitoVation, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ramboll, Research Triangle Park, NC, USA","institution_ids":[]},{"raw_affiliation_string":"ScitoVation, Durham, NC, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089032817","display_name":"Patrick D. McMullen","orcid":"https://orcid.org/0000-0002-9635-932X","observed_orcids":["https://orcid.org/0000-0002-9635-932X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Patrick D. McMullen","raw_affiliation_strings":["ScitoVation, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ScitoVation, Durham, NC, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089032817"],"corresponding_institution_ids":[],"apc_list":{"value":3870,"currency":"USD","value_usd":3870},"apc_paid":null,"fwci":4.1522,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.93797478,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"100115","last_page":"100115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.3986999988555908,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.3986999988555908,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.14059999585151672,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.07989999651908875,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/physiologically-based-pharmacokinetic-model","display_name":"physiologically based pharmacokinetic modeling","score":0.9710000157356262},{"id":"https://openalex.org/keywords/alternatives-to-animal-testing","display_name":"alternatives to animal testing","score":0.9049999713897705},{"id":"https://openalex.org/keywords/exposure-assessment","display_name":"exposure assessment","score":0.6359999775886536},{"id":"https://openalex.org/keywords/life-course-exposure","display_name":"life course exposure","score":0.5149999856948853},{"id":"https://openalex.org/keywords/internal-radiation-exposure","display_name":"internal radiation exposure","score":0.45399999618530273},{"id":"https://openalex.org/keywords/in-vitro-in-vivo-extrapolation","display_name":"in vitro-in vivo extrapolation","score":0.640999972820282},{"id":"https://openalex.org/keywords/qsar","display_name":"QSAR","score":0.7129999995231628},{"id":"https://openalex.org/keywords/monte-carlo-simulation","display_name":"Monte Carlo simulation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/life-stage-sensitivity","display_name":"life stage sensitivity","score":0.6480000019073486},{"id":"https://openalex.org/keywords/r-package","display_name":"R package","score":0.5550000071525574},{"id":"https://openalex.org/keywords/open-source-software","display_name":"open source software","score":0.6079999804496765},{"id":"https://openalex.org/keywords/risk-assessment","display_name":"risk assessment","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.9464963674545288},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6492589712142944},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5639657378196716},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.4230271279811859},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26233625411987305},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.1836220622062683},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11476603150367737},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10684600472450256},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.09100010991096497},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.comtox.2019.100115","doi":"https://doi.org/10.1016/j.comtox.2019.100115","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.comtox.2019.100115","pdf_url":null,"source":{"id":"https://openalex.org/S2898548427","display_name":"Computational Toxicology","issn_l":"2468-1113","issn":["2468-1113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Toxicology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1539454494","https://openalex.org/W1867975073","https://openalex.org/W1879339955","https://openalex.org/W1963675326","https://openalex.org/W1970868126","https://openalex.org/W1973903568","https://openalex.org/W1982273835","https://openalex.org/W1982484840","https://openalex.org/W1988861488","https://openalex.org/W2009673602","https://openalex.org/W2026496625","https://openalex.org/W2055481443","https://openalex.org/W2061152607","https://openalex.org/W2075288278","https://openalex.org/W2082201195","https://openalex.org/W2096127677","https://openalex.org/W2109634874","https://openalex.org/W2117322959","https://openalex.org/W2121891867","https://openalex.org/W2131259606","https://openalex.org/W2132047249","https://openalex.org/W2132441900","https://openalex.org/W2147168021","https://openalex.org/W2148699693","https://openalex.org/W2306190993","https://openalex.org/W2313989261","https://openalex.org/W2319688352","https://openalex.org/W2397032297","https://openalex.org/W2557304814","https://openalex.org/W2593641295","https://openalex.org/W2734700870","https://openalex.org/W2979892379","https://openalex.org/W4246713397","https://openalex.org/W6820202108"],"related_works":["https://openalex.org/W2889634707","https://openalex.org/W3007818070","https://openalex.org/W2494777962","https://openalex.org/W3130395633","https://openalex.org/W4402137067","https://openalex.org/W7211891723","https://openalex.org/W4386479488","https://openalex.org/W2062411053","https://openalex.org/W4386479632","https://openalex.org/W6980698318"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}
