{"id":"https://openalex.org/W2995117221","doi":"https://doi.org/10.1016/j.critrevonc.2019.102859","title":"RAS and BRAF in the foreground for non-small cell lung cancer and colorectal cancer: Similarities and main differences for prognosis and therapies","display_name":"RAS and BRAF in the foreground for non-small cell lung cancer and colorectal cancer: Similarities and main differences for prognosis and therapies","publication_year":2019,"publication_date":"2019-12-17","ids":{"openalex":"https://openalex.org/W2995117221","doi":"https://doi.org/10.1016/j.critrevonc.2019.102859","mag":"2995117221","pmid":"https://pubmed.ncbi.nlm.nih.gov/31927392"},"language":"en","primary_location":{"id":"doi:10.1016/j.critrevonc.2019.102859","doi":"https://doi.org/10.1016/j.critrevonc.2019.102859","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.critrevonc.2019.102859","pdf_url":null,"source":{"id":"https://openalex.org/S185233701","display_name":"Critical Reviews in Oncology/Hematology","issn_l":"1040-8428","issn":["1040-8428","1879-0461"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Oncology/Hematology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/10442/18093","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057918579","display_name":"Ioanna Giopanou","orcid":"https://orcid.org/0000-0003-4393-7517","observed_orcids":["https://orcid.org/0000-0003-4393-7517"]},"institutions":[{"id":"https://openalex.org/I4210127711","display_name":"National Hellenic Research Foundation","ror":"https://ror.org/033m02g29","country_code":"GR","type":"funder","lineage":["https://openalex.org/I4210127711"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Ioanna Giopanou","raw_affiliation_strings":["Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece. Electronic address: giopanou@eie.gr","Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece"],"raw_orcid":"https://orcid.org/0000-0003-4393-7517","affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece. Electronic address: giopanou@eie.gr","institution_ids":["https://openalex.org/I4210127711"]},{"raw_affiliation_string":"Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece","institution_ids":["https://openalex.org/I4210127711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110208256","display_name":"Alexandros Pintzas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127711","display_name":"National Hellenic Research Foundation","ror":"https://ror.org/033m02g29","country_code":"GR","type":"funder","lineage":["https://openalex.org/I4210127711"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Alexandros Pintzas","raw_affiliation_strings":["Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece. Electronic address: apint@eie.gr","Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece. Electronic address: apint@eie.gr","institution_ids":["https://openalex.org/I4210127711"]},{"raw_affiliation_string":"Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece","institution_ids":["https://openalex.org/I4210127711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057918579","https://openalex.org/A5110208256"],"corresponding_institution_ids":["https://openalex.org/I4210127711"],"apc_list":{"value":2750,"currency":"USD","value_usd":2750},"apc_paid":null,"fwci":0.436,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.44001533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"146","issue":null,"first_page":"102859","last_page":"102859"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.08619999885559082,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.035999998450279236,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.7590000033378601},{"id":"https://openalex.org/keywords/braf","display_name":"BRAF","score":0.9940000176429749},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.7350000143051147},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/targeted-therapy-resistance","display_name":"targeted therapy resistance","score":0.8899999856948853},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.7521436214447021},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7282474637031555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.70412278175354},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5720507502555847},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4651551842689514},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4605731964111328},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45390522480010986}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.critrevonc.2019.102859","doi":"https://doi.org/10.1016/j.critrevonc.2019.102859","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.critrevonc.2019.102859","pdf_url":null,"source":{"id":"https://openalex.org/S185233701","display_name":"Critical Reviews in Oncology/Hematology","issn_l":"1040-8428","issn":["1040-8428","1879-0461"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Oncology/Hematology","raw_type":"journal-article"},{"id":"pmid:31927392","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31927392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in oncology/hematology","raw_type":"Journal Article"},{"id":"pmh:oai:https://helios.eie.gr:10442/18093","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10442/18093","pdf_url":null,"source":{"id":"https://openalex.org/S4306402248","display_name":"National Hellenic Research Foundation Helios Repository (National Hellenic Research Foundation)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210127711","host_organization_name":"National Hellenic Research Foundation","host_organization_lineage":["https://openalex.org/I4210127711"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical reviews in oncology/hematology, 146, 102859, (2020-02)","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:https://helios.eie.gr:10442/18093","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10442/18093","pdf_url":null,"source":{"id":"https://openalex.org/S4306402248","display_name":"National Hellenic Research Foundation Helios Repository (National Hellenic Research Foundation)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210127711","host_organization_name":"National Hellenic Research Foundation","host_organization_lineage":["https://openalex.org/I4210127711"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Critical reviews in oncology/hematology, 146, 102859, (2020-02)","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321917","display_name":"General Secretariat for Research and Technology","ror":"https://ror.org/04yeh8h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":118,"referenced_works":["https://openalex.org/W1134514068","https://openalex.org/W1157613785","https://openalex.org/W1578083272","https://openalex.org/W1846586690","https://openalex.org/W1888056807","https://openalex.org/W1922733886","https://openalex.org/W1948677875","https://openalex.org/W1965905026","https://openalex.org/W1973106178","https://openalex.org/W1978044919","https://openalex.org/W1985318741","https://openalex.org/W1990376228","https://openalex.org/W2002226820","https://openalex.org/W2012006000","https://openalex.org/W2013191667","https://openalex.org/W2014881369","https://openalex.org/W2018530122","https://openalex.org/W2021043497","https://openalex.org/W2039924299","https://openalex.org/W2041919461","https://openalex.org/W2044468942","https://openalex.org/W2045509446","https://openalex.org/W2047433619","https://openalex.org/W2062547449","https://openalex.org/W2079015343","https://openalex.org/W2081269875","https://openalex.org/W2081747183","https://openalex.org/W2095201384","https://openalex.org/W2096387850","https://openalex.org/W2100738068","https://openalex.org/W2110682589","https://openalex.org/W2114784462","https://openalex.org/W2116265446","https://openalex.org/W2121389354","https://openalex.org/W2123531506","https://openalex.org/W2125210959","https://openalex.org/W2126423964","https://openalex.org/W2128447158","https://openalex.org/W2128937710","https://openalex.org/W2129429534","https://openalex.org/W2130948044","https://openalex.org/W2132545630","https://openalex.org/W2136362397","https://openalex.org/W2141801755","https://openalex.org/W2146437121","https://openalex.org/W2146737519","https://openalex.org/W2147001311","https://openalex.org/W2152454229","https://openalex.org/W2158797210","https://openalex.org/W2160147190","https://openalex.org/W2160586729","https://openalex.org/W2161821474","https://openalex.org/W2163523622","https://openalex.org/W2163774814","https://openalex.org/W2165097702","https://openalex.org/W2165741055","https://openalex.org/W2166191933","https://openalex.org/W2169460814","https://openalex.org/W2170138574","https://openalex.org/W2170226272","https://openalex.org/W2172010139","https://openalex.org/W2233032895","https://openalex.org/W2237484459","https://openalex.org/W2273990438","https://openalex.org/W2277124765","https://openalex.org/W2293531514","https://openalex.org/W2347201611","https://openalex.org/W2397294595","https://openalex.org/W2409383155","https://openalex.org/W2472619494","https://openalex.org/W2473420009","https://openalex.org/W2474854223","https://openalex.org/W2508893577","https://openalex.org/W2539051713","https://openalex.org/W2560322684","https://openalex.org/W2560449737","https://openalex.org/W2567564314","https://openalex.org/W2582545871","https://openalex.org/W2600831328","https://openalex.org/W2603066322","https://openalex.org/W2605109438","https://openalex.org/W2613467753","https://openalex.org/W2613593356","https://openalex.org/W2614986146","https://openalex.org/W2724448237","https://openalex.org/W2752625590","https://openalex.org/W2762186461","https://openalex.org/W2767380222","https://openalex.org/W2771414687","https://openalex.org/W2773200589","https://openalex.org/W2777461561","https://openalex.org/W2789374297","https://openalex.org/W2789558317","https://openalex.org/W2790910108","https://openalex.org/W2791721408","https://openalex.org/W2805661833","https://openalex.org/W2887268833","https://openalex.org/W2889517321","https://openalex.org/W2898735291","https://openalex.org/W2904683700","https://openalex.org/W2911127189","https://openalex.org/W2921071349","https://openalex.org/W2921784091","https://openalex.org/W2921911119","https://openalex.org/W2939976956","https://openalex.org/W2964344676","https://openalex.org/W2971457693","https://openalex.org/W2972509427","https://openalex.org/W2974805185","https://openalex.org/W2976334328","https://openalex.org/W2980634998","https://openalex.org/W2985951973","https://openalex.org/W2987342757","https://openalex.org/W2991035944","https://openalex.org/W3164126191","https://openalex.org/W6683994117","https://openalex.org/W6712470323","https://openalex.org/W6770245339"],"related_works":["https://openalex.org/W1942560962","https://openalex.org/W2904683700","https://openalex.org/W4382806815","https://openalex.org/W6920909823","https://openalex.org/W2909106823","https://openalex.org/W1992183621","https://openalex.org/W3157291855","https://openalex.org/W7097652190","https://openalex.org/W2107519248","https://openalex.org/W2012478862"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-26T00:00:00"}