{"id":"https://openalex.org/W2995111334","doi":null,"title":"Physiology, NMDA Receptor","display_name":"Physiology, NMDA Receptor","publication_year":2018,"publication_date":"2018-10-27","ids":{"openalex":"https://openalex.org/W2995111334","mag":"2995111334"},"language":"en","primary_location":{"id":"mag:2995111334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30137779/","pdf_url":null,"source":{"id":"https://openalex.org/S4306530867","display_name":"StatPearls","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"StatPearls","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078964997","display_name":"Benjamin E. Jewett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin E. Jewett","raw_affiliation_strings":["Quillen College of Medicine, East Tennessee State University)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quillen College of Medicine, East Tennessee State University)","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090375120","display_name":"Bicky Thapa","orcid":"https://orcid.org/0000-0002-7636-8907","observed_orcids":["https://orcid.org/0000-0002-7636-8907"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bicky Thapa","raw_affiliation_strings":["Cleveland Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1955,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.40999443,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.9340000152587891},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9679999947547913},{"id":"https://openalex.org/keywords/memory-formation","display_name":"memory formation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":0.8650000095367432},{"id":"https://openalex.org/keywords/phencyclidine","display_name":"phencyclidine","score":0.984000027179718},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.8180000185966492},{"id":"https://openalex.org/keywords/drug-abuse","display_name":"drug abuse","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.8896021842956543},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.8351526856422424},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7129169702529907},{"id":"https://openalex.org/C2778851735","wikidata":"https://www.wikidata.org/wiki/Q407324","display_name":"Phencyclidine","level":4,"score":0.6371710300445557},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.606814980506897},{"id":"https://openalex.org/C156927020","wikidata":"https://www.wikidata.org/wiki/Q1187783","display_name":"Neurotransmitter receptor","level":3,"score":0.5183295011520386},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.47809240221977234},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4715205430984497},{"id":"https://openalex.org/C73009533","wikidata":"https://www.wikidata.org/wiki/Q1517140","display_name":"Long-term depression","level":5,"score":0.4705422520637512},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.4041941463947296},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32622072100639343},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3243183493614197},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1037701666355133}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2995111334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30137779/","pdf_url":null,"source":{"id":"https://openalex.org/S4306530867","display_name":"StatPearls","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"StatPearls","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W14748109","https://openalex.org/W92838330","https://openalex.org/W1635212197","https://openalex.org/W1769548618","https://openalex.org/W1841463848","https://openalex.org/W1965797477","https://openalex.org/W2008979655","https://openalex.org/W2009633157","https://openalex.org/W2052712042","https://openalex.org/W2078467762","https://openalex.org/W2104853108","https://openalex.org/W2107099794","https://openalex.org/W2122682406","https://openalex.org/W2138667563","https://openalex.org/W2154168677","https://openalex.org/W2525666831","https://openalex.org/W2626951440","https://openalex.org/W2755379397","https://openalex.org/W2800815779","https://openalex.org/W2803958441","https://openalex.org/W2807805342","https://openalex.org/W2810832877"],"related_works":["https://openalex.org/W179678603","https://openalex.org/W4230121107","https://openalex.org/W4235348330","https://openalex.org/W384219423","https://openalex.org/W4252466805","https://openalex.org/W2181883781","https://openalex.org/W7135561952","https://openalex.org/W2396106731","https://openalex.org/W1984160003","https://openalex.org/W1960244652"],"abstract_inverted_index":{"The":[0],"N-methyl-D-aspartate":[1],"(NMDA)":[2],"receptor":[3],"is":[4,26],"a":[5,27,46,53,59],"ligand":[6],"of":[7,35,58,61,81],"glutamate,":[8],"the":[9,14,33,56],"primary":[10],"excitatory":[11],"neurotransmitter":[12],"in":[13,22,45,55],"human":[15],"brain.":[16],"It":[17],"plays":[18],"an":[19],"integral":[20],"role":[21,54],"synaptic":[23],"plasticity,":[24],"which":[25],"neuronal":[28],"mechanism":[29],"believed":[30],"to":[31,42],"be":[32],"basis":[34],"memory":[36],"formation.":[37],"NMDA":[38,72],"receptors":[39],"also":[40],"appear":[41],"have":[43],"involvement":[44],"process":[47],"called":[48],"excitotoxicity.":[49],"Excitotoxicity":[50],"may":[51],"play":[52],"pathophysiology":[57],"variety":[60],"diseases":[62],"such":[63],"as":[64],"epilepsy":[65],"or":[66],"Alzheimer":[67],"disease.":[68],"Many":[69],"drugs":[70,80],"inhibit":[71],"receptors,":[73],"including":[74],"ketamine":[75],"and":[76],"phencyclidine,":[77],"two":[78],"common":[79],"abuse.":[82]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}