{"id":"https://openalex.org/W2995106932","doi":"https://doi.org/10.1161/strokeaha.119.027225","title":"Risk of Intracranial Hemorrhage Following Intravenous tPA (Tissue-Type Plasminogen Activator) for Acute Stroke Is Low in Children","display_name":"Risk of Intracranial Hemorrhage Following Intravenous tPA (Tissue-Type Plasminogen Activator) for Acute Stroke Is Low in Children","publication_year":2019,"publication_date":"2019-12-17","ids":{"openalex":"https://openalex.org/W2995106932","doi":"https://doi.org/10.1161/strokeaha.119.027225","mag":"2995106932","pmid":"https://pubmed.ncbi.nlm.nih.gov/31842706"},"language":"en","primary_location":{"id":"doi:10.1161/strokeaha.119.027225","doi":"https://doi.org/10.1161/strokeaha.119.027225","is_oa":false,"landing_page_url":"https://doi.org/10.1161/strokeaha.119.027225","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011874518","display_name":"Catherine Amlie\u2010Lefond","orcid":"https://orcid.org/0000-0002-3843-503X","observed_orcids":["https://orcid.org/0000-0002-3843-503X"]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Amlie-Lefond","raw_affiliation_strings":["From the Department of Neurology (C.A.-L., M.S.W., J.L.-E), Seattle Children\u2019s Hospital, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (C.A.-L., M.S.W., J.L.-E), Seattle Children\u2019s Hospital, WA","institution_ids":["https://openalex.org/I1295499534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047930377","display_name":"Dennis Shaw","orcid":"https://orcid.org/0000-0003-4007-6432","observed_orcids":["https://orcid.org/0000-0003-4007-6432"]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis W.W. Shaw","raw_affiliation_strings":["Department of Radiology (D.W.W.S.), Seattle Children\u2019s Hospital, WA","Dennis W.W. Shaw Department of Radiology (D.W.W.S.), Seattle Children's Hospital, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology (D.W.W.S.), Seattle Children\u2019s Hospital, WA","institution_ids":["https://openalex.org/I1295499534"]},{"raw_affiliation_string":"Dennis W.W. Shaw Department of Radiology (D.W.W.S.), Seattle Children's Hospital, WA","institution_ids":["https://openalex.org/I1295499534"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Cooper","raw_affiliation_strings":["Enterprise Analytics (A.C., D.B.), Seattle Children\u2019s Hospital, WA","Andrew Cooper Enterprise Analytics (A.C., D.B.), Seattle Children's Hospital, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enterprise Analytics (A.C., D.B.), Seattle Children\u2019s Hospital, WA","institution_ids":["https://openalex.org/I1295499534"]},{"raw_affiliation_string":"Andrew Cooper Enterprise Analytics (A.C., D.B.), Seattle Children's Hospital, WA","institution_ids":["https://openalex.org/I1295499534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087567621","display_name":"Mark S. Wainwright","orcid":"https://orcid.org/0000-0002-4736-7462","observed_orcids":["https://orcid.org/0000-0002-4736-7462"]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark S. Wainwright","raw_affiliation_strings":["From the Department of Neurology (C.A.-L., M.S.W., J.L.-E), Seattle Children\u2019s Hospital, WA","Mark S. Wainwright From the Department of Neurology (C.A.-L., M.S.W., J.L.-E), Seattle Children's Hospital, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (C.A.-L., M.S.W., J.L.-E), Seattle Children\u2019s Hospital, WA","institution_ids":["https://openalex.org/I1295499534"]},{"raw_affiliation_string":"Mark S. Wainwright From the Department of Neurology (C.A.-L., M.S.W., J.L.-E), Seattle Children's Hospital, WA","institution_ids":["https://openalex.org/I1295499534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071624312","display_name":"Adam Kirton","orcid":"https://orcid.org/0000-0001-5209-3374","observed_orcids":["https://orcid.org/0000-0001-5209-3374"]},"institutions":[{"id":"https://openalex.org/I2802127220","display_name":"Alberta Children's Hospital","ror":"https://ror.org/00sx29x36","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802127220"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Adam Kirton","raw_affiliation_strings":["Department of Neurology, Alberta Children\u2019s Hospital, Calgary, Canada (A.K.)","Adam Kirton Department of Neurology, Alberta Children's Hospital, Calgary, Canada (A.K.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Alberta Children\u2019s Hospital, Calgary, Canada (A.K.)","institution_ids":["https://openalex.org/I2802127220"]},{"raw_affiliation_string":"Adam Kirton Department of Neurology, Alberta Children's Hospital, Calgary, Canada (A.K.)","institution_ids":["https://openalex.org/I2802127220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014919793","display_name":"Ryan J. Felling","orcid":"https://orcid.org/0000-0002-0845-9356","observed_orcids":["https://orcid.org/0000-0002-0845-9356"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan J. Felling","raw_affiliation_strings":["Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD (R.J.F.)","Ryan J. Felling Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD (R.J.F.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD (R.J.F.)","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Ryan J. Felling Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD (R.J.F.)","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034282536","display_name":"Michael G. Abraham","orcid":"https://orcid.org/0000-0003-0407-654X","observed_orcids":["https://orcid.org/0000-0003-0407-654X"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G. Abraham","raw_affiliation_strings":["Department of Neurology, University of Kansas, Kansas City (M.G.A.)","Michael G. Abraham Department of Neurology, University of Kansas, Kansas City (M.G.A.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Kansas, Kansas City (M.G.A.)","institution_ids":["https://openalex.org/I146416000"]},{"raw_affiliation_string":"Michael G. Abraham Department of Neurology, University of Kansas, Kansas City (M.G.A.)","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055189711","display_name":"Mark Thomas Mackay","orcid":"https://orcid.org/0000-0002-3787-1112","observed_orcids":["https://orcid.org/0000-0002-3787-1112"]},"institutions":[{"id":"https://openalex.org/I1321649718","display_name":"Royal Children's Hospital","ror":"https://ror.org/02rktxt32","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1321649718"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark T. Mackay","raw_affiliation_strings":["Department of Neurology, The Royal Children\u2019s Hospital, Melbourne, VIC, Australia (M.T.M.)","Mark T. Mackay Department of Neurology, The Royal Children's Hospital, Melbourne, VIC, Australia (M.T.M.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Royal Children\u2019s Hospital, Melbourne, VIC, Australia (M.T.M.)","institution_ids":["https://openalex.org/I1321649718"]},{"raw_affiliation_string":"Mark T. Mackay Department of Neurology, The Royal Children's Hospital, Melbourne, VIC, Australia (M.T.M.)","institution_ids":["https://openalex.org/I1321649718"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012136791","display_name":"Michael Morgan Dowling","orcid":"https://orcid.org/0000-0001-5058-6589","observed_orcids":["https://orcid.org/0000-0001-5058-6589"]},"institutions":[{"id":"https://openalex.org/I1297463080","display_name":"Children's Medical Center","ror":"https://ror.org/02ndk3y82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1297463080"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael M. Dowling","raw_affiliation_strings":["Department of Neurology, Children\u2019s Medical Center at Dallas, TX (M.M.D.)","Michael M. Dowling Department of Neurology, Children's Medical Center at Dallas, TX (M.M.D.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Children\u2019s Medical Center at Dallas, TX (M.M.D.)","institution_ids":["https://openalex.org/I1297463080"]},{"raw_affiliation_string":"Michael M. Dowling Department of Neurology, Children's Medical Center at Dallas, TX (M.M.D.)","institution_ids":["https://openalex.org/I1297463080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045150370","display_name":"Marcela D. Torres","orcid":"https://orcid.org/0000-0002-7356-4910","observed_orcids":["https://orcid.org/0000-0002-7356-4910"]},"institutions":[{"id":"https://openalex.org/I4210090149","display_name":"Cook Children's Medical Center","ror":"https://ror.org/009z5t729","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210090149","https://openalex.org/I4210102753"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcela Torres","raw_affiliation_strings":["Department of Hematology, Cook Children\u2019s Medical Center, Fort Worth, TX (M.T.)","Marcela Torres Department of Hematology, Cook Children's Medical Center, Fort Worth, TX (M.T.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Cook Children\u2019s Medical Center, Fort Worth, TX (M.T.)","institution_ids":["https://openalex.org/I4210090149"]},{"raw_affiliation_string":"Marcela Torres Department of Hematology, Cook Children's Medical Center, Fort Worth, TX (M.T.)","institution_ids":["https://openalex.org/I4210090149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029988563","display_name":"Michael J. Rivkin","orcid":"https://orcid.org/0000-0003-3013-7107","observed_orcids":["https://orcid.org/0000-0003-3013-7107"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Rivkin","raw_affiliation_strings":["Department of Neurology, Boston Children\u2019s Hospital, MA (M.J.R.)","Michael J. Rivkin Department of Neurology, Boston Children's Hospital, MA (M.J.R.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Boston Children\u2019s Hospital, MA (M.J.R.)","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Michael J. Rivkin Department of Neurology, Boston Children's Hospital, MA (M.J.R.)","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066592938","display_name":"Er\u00edc F. Grabowski","orcid":"https://orcid.org/0000-0002-5242-963X","observed_orcids":["https://orcid.org/0000-0002-5242-963X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric F. Grabowski","raw_affiliation_strings":["Department of Pediatric Hematology-Oncology, Massachusetts General Hospital, Boston (E.F.G.)","Eric F. Grabowski Department of Pediatric Hematology-Oncology, Massachusetts General Hospital, Boston (E.F.G.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology-Oncology, Massachusetts General Hospital, Boston (E.F.G.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Eric F. Grabowski Department of Pediatric Hematology-Oncology, Massachusetts General Hospital, Boston (E.F.G.)","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100327218","display_name":"Sarah Lee","orcid":"https://orcid.org/0000-0002-8821-6636","observed_orcids":["https://orcid.org/0000-0002-8821-6636"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Lee","raw_affiliation_strings":["Department of Neurology, Stanford University, Palo Alto, CA (S.L.)","Sarah Lee Department of Neurology, Stanford University, Palo Alto, CA (S.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Stanford University, Palo Alto, CA (S.L.)","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Sarah Lee Department of Neurology, Stanford University, Palo Alto, CA (S.L.)","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039795632","display_name":"Jonathan E. Kurz","orcid":"https://orcid.org/0000-0002-2259-4263","observed_orcids":["https://orcid.org/0000-0002-2259-4263"]},"institutions":[{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan E. Kurz","raw_affiliation_strings":["Department of Neurology, Ann &amp; Robert H Lurie Children\u2019s Hospital of Chicago, IL (J.E.K.)","Jonathan E. Kurz Department of Neurology, Ann & Robert H Lurie Children's Hospital of Chicago, IL (J.E.K.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Ann &amp; Robert H Lurie Children\u2019s Hospital of Chicago, IL (J.E.K.)","institution_ids":["https://openalex.org/I1294278766"]},{"raw_affiliation_string":"Jonathan E. Kurz Department of Neurology, Ann & Robert H Lurie Children's Hospital of Chicago, IL (J.E.K.)","institution_ids":["https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085057399","display_name":"Hugh J. McMillan","orcid":"https://orcid.org/0000-0001-8927-2018","observed_orcids":["https://orcid.org/0000-0001-8927-2018"]},"institutions":[{"id":"https://openalex.org/I2799330578","display_name":"Children's Hospital of Eastern Ontario","ror":"https://ror.org/05nsbhw27","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799330578"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hugh J. McMillan","raw_affiliation_strings":["Department of Neurology, Children\u2019s Hospital of Eastern Ontario, Ottawa, Canada (H.J.M.)","Hugh J. McMillan Department of Neurology, Children's Hospital of Eastern Ontario, Ottawa, Canada (H.J.M.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Children\u2019s Hospital of Eastern Ontario, Ottawa, Canada (H.J.M.)","institution_ids":["https://openalex.org/I2799330578"]},{"raw_affiliation_string":"Hugh J. McMillan Department of Neurology, Children's Hospital of Eastern Ontario, Ottawa, Canada (H.J.M.)","institution_ids":["https://openalex.org/I2799330578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070709222","display_name":"Dwight Barry","orcid":"https://orcid.org/0000-0003-0938-6037","observed_orcids":["https://orcid.org/0000-0003-0938-6037"]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dwight Barry","raw_affiliation_strings":["Enterprise Analytics (A.C., D.B.), Seattle Children\u2019s Hospital, WA","Dwight Barry Enterprise Analytics (A.C., D.B.), Seattle Children's Hospital, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Enterprise Analytics (A.C., D.B.), Seattle Children\u2019s Hospital, WA","institution_ids":["https://openalex.org/I1295499534"]},{"raw_affiliation_string":"Dwight Barry Enterprise Analytics (A.C., D.B.), Seattle Children's Hospital, WA","institution_ids":["https://openalex.org/I1295499534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084726954","display_name":"Jacqueline Lee\u2010Eng","orcid":"https://orcid.org/0009-0005-9531-4452","observed_orcids":["https://orcid.org/0009-0005-9531-4452"]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline Lee-Eng","raw_affiliation_strings":["From the Department of Neurology (C.A.-L., M.S.W., J.L.-E), Seattle Children\u2019s Hospital, WA","Jacqueline Lee-Eng From the Department of Neurology (C.A.-L., M.S.W., J.L.-E), Seattle Children's Hospital, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Neurology (C.A.-L., M.S.W., J.L.-E), Seattle Children\u2019s Hospital, WA","institution_ids":["https://openalex.org/I1295499534"]},{"raw_affiliation_string":"Jacqueline Lee-Eng From the Department of Neurology (C.A.-L., M.S.W., J.L.-E), Seattle Children's Hospital, WA","institution_ids":["https://openalex.org/I1295499534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025606999","display_name":"Rebecca Ichord","orcid":"https://orcid.org/0000-0002-6863-0274","observed_orcids":["https://orcid.org/0000-0002-6863-0274"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca N. Ichord","raw_affiliation_strings":["Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia (R.N.I.)","Rebecca N. Ichord Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia (R.N.I.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia (R.N.I.)","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Rebecca N. Ichord Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia (R.N.I.)","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":14,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.9508,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.97018122,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"51","issue":"2","first_page":"542","last_page":"548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intravenous-tpa","display_name":"intravenous tPA","score":0.8289999961853027},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.9800000190734863},{"id":"https://openalex.org/keywords/intracranial-hemorrhage","display_name":"intracranial hemorrhage","score":0.8640000224113464},{"id":"https://openalex.org/keywords/symptomatic-intracranial-hemorrhage","display_name":"symptomatic intracranial hemorrhage","score":0.9150000214576721},{"id":"https://openalex.org/keywords/pediatric-stroke","display_name":"pediatric stroke","score":0.8519999980926514},{"id":"https://openalex.org/keywords/thrombolysis-safety","display_name":"thrombolysis safety","score":0.8560000061988831},{"id":"https://openalex.org/keywords/epistaxis","display_name":"epistaxis","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.962530255317688},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.7198644876480103},{"id":"https://openalex.org/C2779546523","wikidata":"https://www.wikidata.org/wiki/Q17143511","display_name":"Pediatric stroke","level":4,"score":0.6168878078460693},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6151810884475708},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.5698683261871338},{"id":"https://openalex.org/C2777094939","wikidata":"https://www.wikidata.org/wiki/Q1368943","display_name":"Intracerebral hemorrhage","level":3,"score":0.45306476950645447},{"id":"https://openalex.org/C2909817843","wikidata":"https://www.wikidata.org/wiki/Q575222","display_name":"Fibrinolytic agent","level":3,"score":0.42169833183288574},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.35386115312576294},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.32109731435775757},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.314372181892395},{"id":"https://openalex.org/C17624336","wikidata":"https://www.wikidata.org/wiki/Q461644","display_name":"Glasgow Coma Scale","level":2,"score":0.16673901677131653},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.14604035019874573},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.13295122981071472},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020300","descriptor_name":"Intracranial Hemorrhages","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020300","descriptor_name":"Intracranial Hemorrhages","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020300","descriptor_name":"Intracranial Hemorrhages","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/strokeaha.119.027225","doi":"https://doi.org/10.1161/strokeaha.119.027225","is_oa":false,"landing_page_url":"https://doi.org/10.1161/strokeaha.119.027225","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},{"id":"pmid:31842706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31842706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4099999964237213}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1996290607","https://openalex.org/W2003303029","https://openalex.org/W2005038503","https://openalex.org/W2015782836","https://openalex.org/W2030349406","https://openalex.org/W2073078878","https://openalex.org/W2083261663","https://openalex.org/W2118271588","https://openalex.org/W2131192729","https://openalex.org/W2137753851","https://openalex.org/W2159010777","https://openalex.org/W2160588825","https://openalex.org/W2162419383","https://openalex.org/W2168787997","https://openalex.org/W2171165037","https://openalex.org/W2292308933","https://openalex.org/W2525726046","https://openalex.org/W2617364419","https://openalex.org/W2911497402","https://openalex.org/W2945711427","https://openalex.org/W4255683973"],"related_works":["https://openalex.org/W2327082266","https://openalex.org/W2066951851","https://openalex.org/W4206801677","https://openalex.org/W2129575859","https://openalex.org/W4283798339","https://openalex.org/W4286489470","https://openalex.org/W2118271588","https://openalex.org/W2337130300","https://openalex.org/W4308467255","https://openalex.org/W2590960201"],"abstract_inverted_index":{"Background":[0],"and":[1,7,38,185,202,275],"Purpose-":[2],"Data":[3,74],"regarding":[4],"the":[5,167,178,271,282,290],"safety":[6,37,97],"efficacy":[8],"of":[9,32,41,51,154,208,213,243,260,293],"intravenous":[10,42,79,111,157,218,296],"tPA":[11,43,80,112,146,158,219,246,297],"(tissue-type":[12],"plasminogen":[13],"activator)":[14],"in":[15,27,44,62,170,247,298],"childhood":[16,46],"acute":[17,45,60,301],"arterial":[18,83,302],"ischemic":[19,84,303],"stroke":[20,61,85,201,229],"are":[21],"inadequate.":[22],"The":[23,240],"TIPS":[24,53,92],"trial":[25,40],"(Thrombolysis":[26],"Pediatric":[28],"Stroke;":[29],"National":[30,206],"Institutes":[31,207],"Health":[33,209],"grant":[34],"R01NS065848)-a":[35],"prospective":[36],"dose-finding":[39],"stroke-was":[47],"closed":[48],"for":[49,81,152,176],"lack":[50],"accrual.":[52],"sites":[54,93,100],"have":[55],"subsequently":[56],"treated":[57,77,109,216],"children":[58,76,106,190,236,248,299],"with":[59,64,78,110,140,183,200,217,300],"accordance":[63],"established":[65],"institutional":[66],"protocols":[67],"supporting":[68],"data":[69],"collection":[70],"on":[71,75,166],"outcomes.":[72],"Methods-":[73],"neuroimaging-confirmed":[82],"were":[86,101,108,215],"collected":[87],"retrospectively":[88],"from":[89],"16":[90],"former":[91],"to":[94,103,113,174,222],"establish":[95],"preliminary":[96],"data.":[98],"Participating":[99],"required":[102],"report":[104],"all":[105],"who":[107],"minimize":[114],"reporting":[115],"bias.":[116],"Symptomatic":[117],"intracranial":[118,137],"hemorrhage":[119,138],"(SICH)":[120],"was":[121,159,180],"defined":[122],"as":[123],"ECASS":[124],"(European":[125],"Cooperative":[126],"Acute":[127],"Stroke":[128,210],"Study)":[129],"II":[130],"parenchymal":[131],"hematoma":[132],"type":[133],"2":[134,221],"or":[135],"any":[136],"associated":[139],"neurological":[141],"deterioration":[142],"within":[143,220,307],"36":[144],"following":[145,156],"administration.":[147],"A":[148],"Bayesian":[149],"beta-binomial":[150],"model":[151,179],"risk":[153,168,242,272,283,292],"SICH":[155,244,294],"fit":[160,182],"using":[161],"a":[162,203,267,278],"prior":[163,261],"distribution":[164],"based":[165],"level":[169],"young":[171],"adults":[172],"(1.7%);":[173],"test":[175],"robustness,":[177],"also":[181],"uninformative":[184],"conservative":[186],"priors.":[187],"Results-":[188],"Twenty-six":[189],"(age":[191],"range,":[192],"1.1-17":[193],"years;":[194,197],"median,":[195],"14":[196,214],"12":[198],"boys)":[199],"median":[204],"pediatric":[205],"Scale":[211],"score":[212],"4.5":[223,308],"hours":[224,309],"(median,":[225],"3.0":[226],"hours)":[227],"after":[228,245,295,310],"onset.":[230],"No":[231],"patient":[232],"had":[233],"SICH.":[234],"Two":[235],"developed":[237],"epistaxis.":[238],"Conclusions-":[239],"estimated":[241],"is":[249,264,273,284,313],"2.1%":[250],"(95%":[251],"highest":[252],"posterior":[253],"density":[254],"interval,":[255],"0.0%-6.7%;":[256],"mode,":[257],"0.9%).":[258],"Regardless":[259],"assumption,":[262],"there":[263],"at":[265,276],"least":[266,277],"98%":[268],"chance":[269,280],"that":[270,281,289],"<15%":[274],"93%":[279],"<10%.":[285],"These":[286],"results":[287],"suggest":[288],"overall":[291],"stroke,":[304],"when":[305],"given":[306],"symptom":[311],"onset,":[312],"low.":[314]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":5}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
