{"id":"https://openalex.org/W2995103161","doi":null,"title":"High-dose Clozapine Withdrawal: A Case Report and Timeline of a Single Potential Withdrawal Seizure.","display_name":"High-dose Clozapine Withdrawal: A Case Report and Timeline of a Single Potential Withdrawal Seizure.","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2995103161","mag":"2995103161","pmid":"https://pubmed.ncbi.nlm.nih.gov/31832260","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6850498"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6850498","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6850498","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Clin Neurosci","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6850498","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039989368","display_name":"Megan K. Skelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102265","display_name":"New York State Office of Mental Health","ror":"https://ror.org/01b2wv937","country_code":"US","type":"government","lineage":["https://openalex.org/I1334095494","https://openalex.org/I4210102265"]},{"id":"https://openalex.org/I4210132958","display_name":"Buffalo Psychiatric Center","ror":"https://ror.org/042hsjs98","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210132958"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan K Skelly","raw_affiliation_strings":["Drs. Skelly, Demler, and Lee are with the State University at Buffalo (SUNY) School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacy Practice in Buffalo, New York","Drs. Demler and Lee are also with New York State Office of Mental Health, Buffalo Psychiatric Center in Buffalo, New York","SUNY School of Medicine, Department of Psychiatry (Demler) and Department of Medicine (Lee) in Buffalo, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drs. Skelly, Demler, and Lee are with the State University at Buffalo (SUNY) School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacy Practice in Buffalo, New York","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Drs. Demler and Lee are also with New York State Office of Mental Health, Buffalo Psychiatric Center in Buffalo, New York","institution_ids":["https://openalex.org/I4210102265","https://openalex.org/I4210132958"]},{"raw_affiliation_string":"SUNY School of Medicine, Department of Psychiatry (Demler) and Department of Medicine (Lee) in Buffalo, New York","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084779374","display_name":"Tammie Lee Demler","orcid":"https://orcid.org/0000-0002-3794-9610","observed_orcids":["https://orcid.org/0000-0002-3794-9610"]},"institutions":[{"id":"https://openalex.org/I4210102265","display_name":"New York State Office of Mental Health","ror":"https://ror.org/01b2wv937","country_code":"US","type":"government","lineage":["https://openalex.org/I1334095494","https://openalex.org/I4210102265"]},{"id":"https://openalex.org/I4210132958","display_name":"Buffalo Psychiatric Center","ror":"https://ror.org/042hsjs98","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210132958"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tammie Lee Demler","raw_affiliation_strings":["Drs. Skelly, Demler, and Lee are with the State University at Buffalo (SUNY) School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacy Practice in Buffalo, New York","Drs. Demler and Lee are also with New York State Office of Mental Health, Buffalo Psychiatric Center in Buffalo, New York","SUNY School of Medicine, Department of Psychiatry (Demler) and Department of Medicine (Lee) in Buffalo, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drs. Skelly, Demler, and Lee are with the State University at Buffalo (SUNY) School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacy Practice in Buffalo, New York","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Drs. Demler and Lee are also with New York State Office of Mental Health, Buffalo Psychiatric Center in Buffalo, New York","institution_ids":["https://openalex.org/I4210102265","https://openalex.org/I4210132958"]},{"raw_affiliation_string":"SUNY School of Medicine, Department of Psychiatry (Demler) and Department of Medicine (Lee) in Buffalo, New York","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":null,"display_name":"Claudia Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102265","display_name":"New York State Office of Mental Health","ror":"https://ror.org/01b2wv937","country_code":"US","type":"government","lineage":["https://openalex.org/I1334095494","https://openalex.org/I4210102265"]},{"id":"https://openalex.org/I4210132958","display_name":"Buffalo Psychiatric Center","ror":"https://ror.org/042hsjs98","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210132958"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia Lee","raw_affiliation_strings":["Drs. Skelly, Demler, and Lee are with the State University at Buffalo (SUNY) School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacy Practice in Buffalo, New York","Drs. Demler and Lee are also with New York State Office of Mental Health, Buffalo Psychiatric Center in Buffalo, New York","SUNY School of Medicine, Department of Psychiatry (Demler) and Department of Medicine (Lee) in Buffalo, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drs. Skelly, Demler, and Lee are with the State University at Buffalo (SUNY) School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacy Practice in Buffalo, New York","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Drs. Demler and Lee are also with New York State Office of Mental Health, Buffalo Psychiatric Center in Buffalo, New York","institution_ids":["https://openalex.org/I4210102265","https://openalex.org/I4210132958"]},{"raw_affiliation_string":"SUNY School of Medicine, Department of Psychiatry (Demler) and Department of Medicine (Lee) in Buffalo, New York","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7293,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.71628722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"16","issue":"7-08","first_page":"22","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11921","display_name":"Electroconvulsive Therapy Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":0.9819999933242798},{"id":"https://openalex.org/keywords/drug-withdrawal","display_name":"drug withdrawal","score":0.6460000276565552},{"id":"https://openalex.org/keywords/withdrawal-seizures","display_name":"withdrawal seizures","score":0.7129999995231628},{"id":"https://openalex.org/keywords/antipsychotic-discontinuation","display_name":"antipsychotic discontinuation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.8429999947547913},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8547228574752808},{"id":"https://openalex.org/C2780864610","wikidata":"https://www.wikidata.org/wiki/Q221361","display_name":"Clozapine","level":3,"score":0.8531262874603271},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.840316891670227},{"id":"https://openalex.org/C73787029","wikidata":"https://www.wikidata.org/wiki/Q7104929","display_name":"Orthostatic vital signs","level":3,"score":0.599197506904602},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5957385301589966},{"id":"https://openalex.org/C2777495988","wikidata":"https://www.wikidata.org/wiki/Q217111","display_name":"Bradycardia","level":4,"score":0.5661143064498901},{"id":"https://openalex.org/C2778062832","wikidata":"https://www.wikidata.org/wiki/Q498902","display_name":"Drug withdrawal","level":3,"score":0.5354666113853455},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.48607876896858215},{"id":"https://openalex.org/C2780325297","wikidata":"https://www.wikidata.org/wiki/Q834047","display_name":"Schizoaffective disorder","level":3,"score":0.4630695879459381},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.4552004933357239},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.4339723289012909},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.33959510922431946},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.3314381241798401},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2610699534416199},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.23500549793243408},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22248327732086182},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:6850498","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6850498","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Clin Neurosci","raw_type":"Text"},{"id":"pmid:31832260","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31832260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovations in clinical neuroscience","raw_type":"Case Reports"},{"id":"mag:2995103161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31832260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6850498","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6850498","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Clin Neurosci","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W36453299","https://openalex.org/W186127170","https://openalex.org/W1951378015","https://openalex.org/W1988400695","https://openalex.org/W1995585472","https://openalex.org/W2000143568","https://openalex.org/W2007529171","https://openalex.org/W2007589067","https://openalex.org/W2015677498","https://openalex.org/W2048424833","https://openalex.org/W2060710508","https://openalex.org/W2081525292","https://openalex.org/W2089286338","https://openalex.org/W2099190385","https://openalex.org/W2137941062","https://openalex.org/W2144435474","https://openalex.org/W2144588282","https://openalex.org/W2154929433","https://openalex.org/W2316544418","https://openalex.org/W2413047072","https://openalex.org/W2600053469"],"related_works":["https://openalex.org/W7163988350","https://openalex.org/W4412602558","https://openalex.org/W2105011038","https://openalex.org/W2078378610","https://openalex.org/W2137941062","https://openalex.org/W2321928131","https://openalex.org/W1987859687","https://openalex.org/W2007589067","https://openalex.org/W4387248360","https://openalex.org/W2007529171"],"abstract_inverted_index":{"Clozapine,":[0],"a":[1,72,88,100,111],"second-generation":[2],"antipsychotic":[3],"(SGA),":[4],"is":[5,58],"known":[6,97],"for":[7],"its":[8,66],"superior":[9],"efficacy":[10],"in":[11,87,115],"the":[12,59],"treatment":[13],"of":[14,49,74,104],"refractory":[15],"schizophrenia.":[16],"Clozapine's":[17],"hallmark":[18],"side":[19,102],"effects":[20],"are":[21],"well-known,":[22],"including,":[23],"but":[24],"not":[25,107],"limited":[26],"to,":[27],"drug-induced":[28],"seizures":[29],"associated":[30],"with":[31,90],"daily":[32],"goal":[33],"doses":[34],"greater":[35],"than":[36],"600mg":[37],"and":[38,53],"rapid":[39,67],"dose":[40],"escalation,":[41],"which":[42],"can":[43,63],"also":[44],"contribute":[45],"to":[46,98],"significant":[47],"risk":[48],"orthostatic":[50],"hypotension,":[51],"bradycardia,":[52],"syncope.":[54],"However,":[55],"less":[56],"well-known":[57],"potential":[60],"withdrawal":[61,113],"that":[62,77],"occur":[64],"from":[65],"discontinuation.":[68],"Here,":[69],"we":[70],"describe":[71],"case":[73],"seizure-like":[75],"activity":[76],"occurred":[78],"72":[79],"hours":[80],"after":[81],"an":[82],"abrupt":[83],"high-dose":[84],"clozapine":[85],"discontinuation":[86],"patient":[89],"schizoaffective":[91],"disorder,":[92],"bipolar":[93],"type.":[94],"Seizures,":[95],"although":[96],"be":[99,108],"high-serum-concentration-dependent":[101],"effect":[103],"clozapine,":[105],"could":[106],"excluded":[109],"as":[110],"possible":[112],"syndrome":[114],"this":[116],"patient.":[117]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2019-12-26T00:00:00"}
