{"id":"https://openalex.org/W2995067605","doi":null,"title":"Melanocortin-4 receptor in subthalamic nucleus is involved in the modulation of nociception.","display_name":"Melanocortin-4 receptor in subthalamic nucleus is involved in the modulation of nociception.","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2995067605","mag":"2995067605","pmid":"https://pubmed.ncbi.nlm.nih.gov/30245921","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6146155"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5096200","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6146155","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6146155","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110741513","display_name":"Dongji Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong-Ji Han","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, PR China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074243377","display_name":"Zhigang He","orcid":"https://orcid.org/0000-0002-8999-9345","observed_orcids":["https://orcid.org/0000-0002-8999-9345"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Gang He","raw_affiliation_strings":["Department of Emergency Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, Hubei, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, Hubei, PR China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100764013","display_name":"Hui Yang","orcid":"https://orcid.org/0000-0001-6498-5126","observed_orcids":["https://orcid.org/0000-0001-6498-5126"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Yang","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, PR China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"7","issue":"4","first_page":"76","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.06509999930858612,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanocortin-4-receptor","display_name":"melanocortin-4 receptor","score":0.9860000014305115},{"id":"https://openalex.org/keywords/subthalamic-nucleus","display_name":"subthalamic nucleus","score":0.9779999852180481},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.9700000286102295},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.8539999723434448},{"id":"https://openalex.org/keywords/pain-modulation","display_name":"pain modulation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"deep brain stimulation","score":0.925000011920929},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9430000185966492},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C2777319143","wikidata":"https://www.wikidata.org/wiki/Q2270424","display_name":"Subthalamic nucleus","level":5,"score":0.8793178200721741},{"id":"https://openalex.org/C2779004600","wikidata":"https://www.wikidata.org/wiki/Q18357784","display_name":"Opioidergic","level":5,"score":0.8336784839630127},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6754964590072632},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.5907927751541138},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.5763659477233887},{"id":"https://openalex.org/C2779993316","wikidata":"https://www.wikidata.org/wiki/Q6591465","display_name":"Melanocortin","level":3,"score":0.45247024297714233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3707093894481659},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.3538997173309326},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.31305480003356934},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.2916796803474426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28889620304107666},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24841096997261047},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:5096200","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6146155","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30245921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30245921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical and experimental immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6146155","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6146155/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Clin Exp Immunol","raw_type":"Text"},{"id":"mag:2995067605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30245921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5096200","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6146155","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W172019495","https://openalex.org/W188954790","https://openalex.org/W348119250","https://openalex.org/W1481847427","https://openalex.org/W1571292123","https://openalex.org/W1967559082","https://openalex.org/W1971317721","https://openalex.org/W1980997499","https://openalex.org/W1991280533","https://openalex.org/W1994965203","https://openalex.org/W2011997796","https://openalex.org/W2013885507","https://openalex.org/W2052604407","https://openalex.org/W2056955842","https://openalex.org/W2066972000","https://openalex.org/W2067639934","https://openalex.org/W2070448790","https://openalex.org/W2077598827","https://openalex.org/W2078977548","https://openalex.org/W2086991865","https://openalex.org/W2103677924","https://openalex.org/W2142372791","https://openalex.org/W2171639664","https://openalex.org/W2235421817","https://openalex.org/W2245932772","https://openalex.org/W2332943006","https://openalex.org/W2346508484","https://openalex.org/W2402382240","https://openalex.org/W2514635071","https://openalex.org/W2593967302","https://openalex.org/W2600601560","https://openalex.org/W2604153523","https://openalex.org/W2619194893","https://openalex.org/W2769743050","https://openalex.org/W2983530065","https://openalex.org/W3022056926"],"related_works":["https://openalex.org/W7154752778","https://openalex.org/W4400003191","https://openalex.org/W2889016666","https://openalex.org/W2245932772","https://openalex.org/W2073477437","https://openalex.org/W2103677924","https://openalex.org/W7151423576","https://openalex.org/W2077598827","https://openalex.org/W3164227357","https://openalex.org/W2025693001"],"abstract_inverted_index":{"Deep":[0],"brain":[1],"stimulation":[2,8],"of":[3,12,25,54,70,82,89,111,122,124],"the":[4,20,37,42,55,76,97,102,109,115],"subthalamic":[5,116],"nucleus":[6,117],"(STN-DBS)":[7],"produces":[9],"significant":[10],"improvement":[11],"overall":[13],"pain":[14],"related":[15],"to":[16,108],"Parkinson":[17],"disease;":[18],"however,":[19],"mechanisms":[21],"underlying":[22],"analgesic":[23],"effects":[24],"STN-DBS":[26],"are":[27],"still":[28],"unknown.":[29],"This":[30],"report":[31],"describes":[32],"direct":[33,93],"neuroanatomical":[34,94],"evidence":[35,95],"for":[36,96,129],"central":[38,98],"melanocortinergic-opioidergic":[39,99,112],"circuits":[40,113],"in":[41,57,101,114],"STN.":[43],"We":[44],"investigated":[45],"melanocortin-4":[46],"receptor":[47,51],"(MC4R)":[48],"and":[49,72,79],"mu-opioid":[50],"(MOR)-positive":[52],"expression":[53],"STN":[56,77,103],"MC4R-GFP":[58],"transgenic":[59],"mice":[60],"using":[61],"fluorescence":[62],"immunohistochemical":[63],"detection.":[64],"Immunohistochemistry":[65],"showed":[66,92],"a":[67,119],"large":[68],"number":[69],"MC4R-GFP-":[71],"MOR-positive":[73],"neurons":[74,84],"within":[75],"region,":[78],"approximately":[80],"50%":[81],"MC4R-GFP-positive":[83],"coexpressed":[85],"MOR.":[86],"The":[87],"results":[88],"this":[90],"study":[91],"signaling":[100],"region.":[104],"These":[105],"findings":[106],"contribute":[107],"view":[110],"as":[118],"reliable":[120],"source":[121],"modulating":[123],"nociception":[125],"with":[126],"therapeutic":[127],"potential":[128],"alleviating":[130],"pain.":[131]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-26T00:00:00"}