{"id":"https://openalex.org/W2995019236","doi":"https://doi.org/10.1021/acs.analchem.9b03450","title":"Fluorescence Polarization-Based Rapid Detection System for Salivary Biomarkers Using Modified DNA Aptamers Containing Base-Appended Bases","display_name":"Fluorescence Polarization-Based Rapid Detection System for Salivary Biomarkers Using Modified DNA Aptamers Containing Base-Appended Bases","publication_year":2019,"publication_date":"2019-12-19","ids":{"openalex":"https://openalex.org/W2995019236","doi":"https://doi.org/10.1021/acs.analchem.9b03450","mag":"2995019236","pmid":"https://pubmed.ncbi.nlm.nih.gov/31855403"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.9b03450","doi":"https://doi.org/10.1021/acs.analchem.9b03450","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.analchem.9b03450","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.9b03450","source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.9b03450","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005234927","display_name":"Hirotaka Minagawa","orcid":"https://orcid.org/0000-0001-6888-3741","observed_orcids":["https://orcid.org/0000-0001-6888-3741"]},"institutions":[{"id":"https://openalex.org/I4405275943","display_name":"NEC Solution Innovators, Ltd. (Japan)","ror":"https://ror.org/04k1qqg60","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275943"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotaka Minagawa","raw_affiliation_strings":["NEC Solution Innovators, Ltd. , 1-18-7, Shinkiba, Koto-ku , ,","NEC Solution Innovators, Ltd., 1-18-7, Shinkiba, Koto-ku, Tokyo 136-8627, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NEC Solution Innovators, Ltd. , 1-18-7, Shinkiba, Koto-ku , ,","institution_ids":["https://openalex.org/I4405275943"]},{"raw_affiliation_string":"NEC Solution Innovators, Ltd., 1-18-7, Shinkiba, Koto-ku, Tokyo 136-8627, Japan","institution_ids":["https://openalex.org/I4405275943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038541019","display_name":"Akihisa Shimizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405275943","display_name":"NEC Solution Innovators, Ltd. (Japan)","ror":"https://ror.org/04k1qqg60","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275943"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihisa Shimizu","raw_affiliation_strings":["NEC Solution Innovators, Ltd. , 1-18-7, Shinkiba, Koto-ku , ,","NEC Solution Innovators, Ltd., 1-18-7, Shinkiba, Koto-ku, Tokyo 136-8627, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NEC Solution Innovators, Ltd. , 1-18-7, Shinkiba, Koto-ku , ,","institution_ids":["https://openalex.org/I4405275943"]},{"raw_affiliation_string":"NEC Solution Innovators, Ltd., 1-18-7, Shinkiba, Koto-ku, Tokyo 136-8627, Japan","institution_ids":["https://openalex.org/I4405275943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033203894","display_name":"Yuka Kataoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuka Kataoka","raw_affiliation_strings":["Nihon University , , 3-25-40 Sakurajosui, Setagaya-ku , ,","Graduate School of Integrated Basic Sciences, Nihon University, 3-25-40 Sakurajosui, Setagaya-ku, Tokyo 156-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nihon University , , 3-25-40 Sakurajosui, Setagaya-ku , ,","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Graduate School of Integrated Basic Sciences, Nihon University, 3-25-40 Sakurajosui, Setagaya-ku, Tokyo 156-8550, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017667026","display_name":"Masayasu Kuwahara","orcid":"https://orcid.org/0000-0002-0810-4627","observed_orcids":["https://orcid.org/0000-0002-0810-4627"]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masayasu Kuwahara","raw_affiliation_strings":["Nihon University , , 3-25-40 Sakurajosui, Setagaya-ku , ,","Graduate School of Integrated Basic Sciences, Nihon University, 3-25-40 Sakurajosui, Setagaya-ku, Tokyo 156-8550, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0810-4627","affiliations":[{"raw_affiliation_string":"Nihon University , , 3-25-40 Sakurajosui, Setagaya-ku , ,","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Graduate School of Integrated Basic Sciences, Nihon University, 3-25-40 Sakurajosui, Setagaya-ku, Tokyo 156-8550, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003957159","display_name":"Shintaro Kato","orcid":"https://orcid.org/0000-0001-6240-1326","observed_orcids":["https://orcid.org/0000-0001-6240-1326"]},"institutions":[{"id":"https://openalex.org/I4405275943","display_name":"NEC Solution Innovators, Ltd. (Japan)","ror":"https://ror.org/04k1qqg60","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275943"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shintaro Kato","raw_affiliation_strings":["NEC Solution Innovators, Ltd. , 1-18-7, Shinkiba, Koto-ku , ,","NEC Solution Innovators, Ltd., 1-18-7, Shinkiba, Koto-ku, Tokyo 136-8627, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NEC Solution Innovators, Ltd. , 1-18-7, Shinkiba, Koto-ku , ,","institution_ids":["https://openalex.org/I4405275943"]},{"raw_affiliation_string":"NEC Solution Innovators, Ltd., 1-18-7, Shinkiba, Koto-ku, Tokyo 136-8627, Japan","institution_ids":["https://openalex.org/I4405275943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046018209","display_name":"Katsunori Horii","orcid":"https://orcid.org/0000-0003-0783-2080","observed_orcids":["https://orcid.org/0000-0003-0783-2080"]},"institutions":[{"id":"https://openalex.org/I4405275943","display_name":"NEC Solution Innovators, Ltd. (Japan)","ror":"https://ror.org/04k1qqg60","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275943"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsunori Horii","raw_affiliation_strings":["NEC Solution Innovators, Ltd. , 1-18-7, Shinkiba, Koto-ku , ,","NEC Solution Innovators, Ltd., 1-18-7, Shinkiba, Koto-ku, Tokyo 136-8627, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NEC Solution Innovators, Ltd. , 1-18-7, Shinkiba, Koto-ku , ,","institution_ids":["https://openalex.org/I4405275943"]},{"raw_affiliation_string":"NEC Solution Innovators, Ltd., 1-18-7, Shinkiba, Koto-ku, Tokyo 136-8627, Japan","institution_ids":["https://openalex.org/I4405275943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061556330","display_name":"Ikuo Shiratori","orcid":"https://orcid.org/0000-0003-3713-4910","observed_orcids":["https://orcid.org/0000-0003-3713-4910"]},"institutions":[{"id":"https://openalex.org/I4405275943","display_name":"NEC Solution Innovators, Ltd. (Japan)","ror":"https://ror.org/04k1qqg60","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275943"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Ikuo Shiratori","raw_affiliation_strings":["NEC Solution Innovators, Ltd. , 1-18-7, Shinkiba, Koto-ku , ,","NEC Solution Innovators, Ltd., 1-18-7, Shinkiba, Koto-ku, Tokyo 136-8627, Japan"],"raw_orcid":"https://orcid.org/0000-0003-3713-4910","affiliations":[{"raw_affiliation_string":"NEC Solution Innovators, Ltd. , 1-18-7, Shinkiba, Koto-ku , ,","institution_ids":["https://openalex.org/I4405275943"]},{"raw_affiliation_string":"NEC Solution Innovators, Ltd., 1-18-7, Shinkiba, Koto-ku, Tokyo 136-8627, Japan","institution_ids":["https://openalex.org/I4405275943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005783169","display_name":"Iwao Waga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405275943","display_name":"NEC Solution Innovators, Ltd. (Japan)","ror":"https://ror.org/04k1qqg60","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275943"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Iwao Waga","raw_affiliation_strings":["NEC Solution Innovators, Ltd. , 1-18-7, Shinkiba, Koto-ku , ,","NEC Solution Innovators, Ltd., 1-18-7, Shinkiba, Koto-ku, Tokyo 136-8627, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NEC Solution Innovators, Ltd. , 1-18-7, Shinkiba, Koto-ku , ,","institution_ids":["https://openalex.org/I4405275943"]},{"raw_affiliation_string":"NEC Solution Innovators, Ltd., 1-18-7, Shinkiba, Koto-ku, Tokyo 136-8627, Japan","institution_ids":["https://openalex.org/I4405275943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017667026","https://openalex.org/A5061556330"],"corresponding_institution_ids":["https://openalex.org/I104946051","https://openalex.org/I4405275943"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":0.873,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.6863114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"92","issue":"2","first_page":"1780","last_page":"1787"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-aptamers","display_name":"DNA aptamers","score":0.7940000295639038},{"id":"https://openalex.org/keywords/fluorescence-polarization","display_name":"fluorescence polarization","score":0.4560000002384186},{"id":"https://openalex.org/keywords/salivary-biomarkers","display_name":"salivary biomarkers","score":0.9480000138282776},{"id":"https://openalex.org/keywords/secretory-iga","display_name":"secretory IgA","score":0.9350000023841858},{"id":"https://openalex.org/keywords/salivary-amylase","display_name":"salivary amylase","score":0.8790000081062317},{"id":"https://openalex.org/keywords/stress-markers","display_name":"stress symptoms","score":0.6779999732971191},{"id":"https://openalex.org/keywords/aptamer-binding-affinity","display_name":"aptamer binding affinity","score":0.7839999794960022},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"point-of-care testing","score":0.7139999866485596},{"id":"https://openalex.org/keywords/saliva-analysis","display_name":"saliva testing","score":0.33399999141693115}],"concepts":[{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.9560495615005493},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8870415091514587},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.817541241645813},{"id":"https://openalex.org/C111357860","wikidata":"https://www.wikidata.org/wiki/Q903807","display_name":"Fluorescence anisotropy","level":3,"score":0.6007701754570007},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4789077043533325},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.46388062834739685},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4119286835193634},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.4101371169090271},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40095940232276917},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3683333992958069},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.35277754068374634},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.11956056952476501},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07001164555549622},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D005454","descriptor_name":"Fluorescence Polarization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007071","descriptor_name":"Immunoglobulin A, Secretory","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020349","descriptor_name":"Surface Plasmon Resonance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.analchem.9b03450","doi":"https://doi.org/10.1021/acs.analchem.9b03450","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.analchem.9b03450","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.9b03450","source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:31855403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31855403","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/acs.analchem.9b03450","doi":"https://doi.org/10.1021/acs.analchem.9b03450","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.analchem.9b03450","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.9b03450","source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8355424456","display_name":null,"funder_award_id":"AS2525029M","funder_id":"https://openalex.org/F4320338117","funder_display_name":"Adaptable and Seamless Technology Transfer Program through Target-Driven R and D"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320338117","display_name":"Adaptable and Seamless Technology Transfer Program through Target-Driven R and D","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2995019236.pdf"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W560853235","https://openalex.org/W1492747384","https://openalex.org/W1621386139","https://openalex.org/W1989439371","https://openalex.org/W1995763457","https://openalex.org/W2002953155","https://openalex.org/W2011306933","https://openalex.org/W2020997268","https://openalex.org/W2021028637","https://openalex.org/W2024379106","https://openalex.org/W2027940369","https://openalex.org/W2031396071","https://openalex.org/W2033105713","https://openalex.org/W2067876164","https://openalex.org/W2079321730","https://openalex.org/W2079338546","https://openalex.org/W2084373725","https://openalex.org/W2098432074","https://openalex.org/W2104525153","https://openalex.org/W2125068643","https://openalex.org/W2135995702","https://openalex.org/W2148237300","https://openalex.org/W2281860958","https://openalex.org/W2290548509","https://openalex.org/W2313063104","https://openalex.org/W2321761631","https://openalex.org/W2328158587","https://openalex.org/W2529390643","https://openalex.org/W2550847225","https://openalex.org/W2559051818","https://openalex.org/W2593838155","https://openalex.org/W2611458958","https://openalex.org/W2614821510","https://openalex.org/W2625478887","https://openalex.org/W2753337544","https://openalex.org/W2769331629","https://openalex.org/W2793939127","https://openalex.org/W2907822139"],"related_works":["https://openalex.org/W7118352256","https://openalex.org/W3116412619","https://openalex.org/W2593838155","https://openalex.org/W2027009484","https://openalex.org/W2040333447","https://openalex.org/W4214840550","https://openalex.org/W4320921240","https://openalex.org/W7128009076","https://openalex.org/W4223982570","https://openalex.org/W2888417101"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"field":[2],"of":[3,9,48,96,100,127,153,168,188],"care":[4],"testing":[5],"toward":[6],"the":[7,41,46,73,81,91,101,109,118,125,142,149,154],"analysis":[8],"blood":[10],"and":[11,78,93,148,170,175],"saliva":[12,134,193],"lacks":[13],"nowadays":[14],"simple":[15,129,186],"test":[16,187],"techniques":[17,162],"for":[18,132],"biomarkers.":[19],"In":[20],"this":[21],"study,":[22],"we":[23,44],"have":[24],"developed":[25],"a":[26,33,37,63,128,164,184],"novel":[27],"nucleobase":[28],"analog,":[29],"Ugu,":[30],"which":[31,58],"is":[32,179],"uracil":[34],"derivative":[35],"bearing":[36],"guanine":[38],"base":[39],"at":[40],"5-position.":[42],"Moreover,":[43],"attempted":[45],"development":[47,126],"aptamers":[49],"that":[50,72,183],"can":[51,194],"bind":[52],"to":[53,80,90,117],"secretory":[54],"immunoglobulin":[55],"A":[56],"(SIgA),":[57],"has":[59],"been":[60],"examined":[61],"as":[62],"stress":[64,189],"marker":[65],"in":[66,191],"human":[67,97,133,144,192],"saliva.":[68],"It":[69,178],"was":[70,139],"observed":[71],"acquired":[74],"aptamer":[75,102,121],"binds":[76],"strongly":[77,181],"selectively":[79],"SIgA":[82],"dimer":[83],"(Kd":[84,112],"=":[85,113],"13.6":[86],"nM)":[87],"without":[88,198],"binding":[89,110],"IgG":[92],"IgA":[94],"monomers":[95],"serum.":[98],"Reduction":[99],"length":[103],"(41":[104],"mer)":[105],"successfully":[106],"improved":[107],"4-fold":[108],"affinity":[111],"3.7":[114],"nM),":[115],"compared":[116],"original,":[119],"longer":[120],"(78":[122],"mer).":[123],"Furthermore,":[124],"detection":[130],"system":[131],"samples":[135],"by":[136],"fluorescence":[137],"polarization":[138],"investigated,":[140],"using":[141],"reported":[143],"salivary":[145],"\u03b1-amylase":[146],"(sAA)":[147],"SIgA-binding":[150],"aptamer.":[151],"Comparison":[152],"present":[155],"method":[156],"with":[157],"conventional":[158],"enzyme-linked":[159],"immunosorbent":[160],"assay":[161],"highlighted":[163],"significant":[165],"Pearson\u2019s":[166],"correlation":[167],"0.94":[169],"0.83":[171],"when":[172],"targeting":[173],"sAA":[174],"SIgA,":[176],"respectively.":[177],"thus":[180],"suggested":[182],"new":[185],"markers":[190],"be":[195],"quantified":[196],"quickly":[197],"bound/free":[199],"(B/F)":[200],"separation.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-26T00:00:00"}