{"id":"https://openalex.org/W299500345","doi":null,"title":"Experimental canine distemper virus-induced lymphoid depletion.","display_name":"Experimental canine distemper virus-induced lymphoid depletion.","publication_year":1974,"publication_date":"1974-01-01","ids":{"openalex":"https://openalex.org/W299500345","mag":"299500345","pmid":"https://pubmed.ncbi.nlm.nih.gov/4809312","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1910729"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1910729","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1910729","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1910729","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"B McCullough","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B McCullough","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017737032","display_name":"Steven G. Krakowka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Krakowka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113576852","display_name":"Adalbert Koestner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Koestner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.17,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.9491357,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"74","issue":"1","first_page":"155","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/canine-distemper-virus","display_name":"canine distemper virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lymphoid-depletion","display_name":"lymphoid depletion","score":0.8960000276565552},{"id":"https://openalex.org/keywords/lymphocyte-count","display_name":"lymphocyte count","score":0.6700000166893005},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.828000009059906},{"id":"https://openalex.org/keywords/cns-lesions","display_name":"central nervous system lesions","score":0.8809999823570251},{"id":"https://openalex.org/keywords/thymic-atrophy","display_name":"thymic atrophy","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hassall-s-corpuscles","display_name":"Hassall's corpuscles","score":0.9549999833106995},{"id":"https://openalex.org/keywords/viral-nucleoprotein","display_name":"viral nucleoprotein","score":0.9160000085830688},{"id":"https://openalex.org/keywords/germinal-center","display_name":"germinal center","score":0.7070000171661377},{"id":"https://openalex.org/keywords/neurological-signs","display_name":"neurological signs","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2776040883","wikidata":"https://www.wikidata.org/wiki/Q601037","display_name":"Canine distemper","level":3,"score":0.9327691793441772},{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.7215202450752258},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.699159562587738},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.6867722868919373},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.6384578347206116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6058154106140137},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.581423282623291},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5385544896125793},{"id":"https://openalex.org/C2780451601","wikidata":"https://www.wikidata.org/wiki/Q25306","display_name":"Carnivora","level":2,"score":0.5314608812332153},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.48708274960517883},{"id":"https://openalex.org/C2776894844","wikidata":"https://www.wikidata.org/wiki/Q1197437","display_name":"Fissipedia","level":2,"score":0.4127143621444702},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28852152824401855},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2541365623474121},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.17038759589195251},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.14109405875205994},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.10722047090530396}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004216","descriptor_name":"Distemper","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D004216","descriptor_name":"Distemper","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004216","descriptor_name":"Distemper","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004217","descriptor_name":"Distemper Virus, Canine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005856","descriptor_name":"Germ-Free Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008212","descriptor_name":"Lymphocyte Depletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008231","descriptor_name":"Lymphopenia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008231","descriptor_name":"Lymphopenia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009698","descriptor_name":"Nucleoproteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1910729","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1910729","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:4809312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4809312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:299500345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4809312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1910729","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1910729","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W15669480","https://openalex.org/W190823870","https://openalex.org/W264805675","https://openalex.org/W1523441186","https://openalex.org/W2035516779","https://openalex.org/W2044773497","https://openalex.org/W2061863401","https://openalex.org/W2070060562","https://openalex.org/W2137710059","https://openalex.org/W2152593233","https://openalex.org/W2231808528","https://openalex.org/W2289718531","https://openalex.org/W2338684119","https://openalex.org/W2396437677","https://openalex.org/W2397440942","https://openalex.org/W2404462059","https://openalex.org/W2415288905","https://openalex.org/W4301437020"],"related_works":["https://openalex.org/W87228942","https://openalex.org/W2027434548","https://openalex.org/W2461811216","https://openalex.org/W2361877095","https://openalex.org/W2146005472","https://openalex.org/W2012790256","https://openalex.org/W2046654507","https://openalex.org/W2025104164","https://openalex.org/W1238321163","https://openalex.org/W1985200471"],"abstract_inverted_index":{"Thirty-four":[0],"gnotobiotic":[1],"dogs":[2,21,27,38,52,75,95,114,140,146,174,198,207,239],"were":[3,22,28,39,57,83,117,133,150,156,171,194,211,233],"used":[4],"to":[5,33,69,71,86,120],"study":[6],"the":[7,17,47,98,124,136,163,197,204],"effects":[8],"of":[9,46,51,112,123,145,147,165,175,199,203,206,208,216,224,238,240],"R252":[10,55],"canine":[11],"distemper":[12],"virus":[13],"(CDV)":[14],"infection":[15,90],"on":[16],"lymphoid":[18,159,192],"system.":[19],"Twenty-one":[20],"inoculated":[23,34],"parenterally,":[24],"and":[25,82,152,184,219],"6":[26],"infected":[29,53,139],"by":[30,106,188],"contact":[31],"exposure":[32],"littermates.":[35],"Seven":[36],"littermate":[37],"maintained":[40],"as":[41],"uninfected":[42,217],"controls.":[43],"The":[44,65,93,143],"means":[45],"absolute":[48],"lymphocyte":[49,66,104],"counts":[50,67,105],"with":[54,79],"CDV":[56],"significantly":[58,212],"decreased":[59,172],"for":[60],"7":[61,74],"weeks":[62,108],"after":[63,89,109],"infection.":[64,110],"failed":[68],"return":[70],"normal":[72,103],"in":[73,135,158,173,182,196,235],"which":[76,96],"became":[77],"moribund":[78],"neurologic":[80],"signs":[81],"sacrificed":[84],"27":[85],"47":[87],"days":[88],"(group":[91,115,141],"I).":[92],"19":[94],"survived":[97],"12-week":[99],"observation":[100],"period":[101],"had":[102],"8":[107],"Five":[111],"these":[113],"II)":[116],"subsequently":[118],"found":[119,195,234],"have":[121],"demyelination":[122],"central":[125],"nervous":[126],"system":[127],"(CNS),":[128],"while":[129],"no":[130],"CNS":[131],"lesions":[132,193],"demonstrated":[134,181],"remaining":[137],"14":[138],"III).":[142],"thymuses":[144,205,237],"group":[148,176,200,209,241],"I":[149],"atrophic":[151],"their":[153],"lymph":[154,185],"nodes":[155],"depleted":[157],"cells.":[160],"In":[161],"addition,":[162],"number":[164],"Hassall's":[166,225],"corpuscles":[167,226],"per":[168,227],"thymic":[169,228],"lobule":[170],"I.":[177],"Viral":[178],"nucleoprotein":[179],"was":[180],"thymus":[183],"node":[186],"cells":[187],"electron":[189],"microscopy.":[190],"No":[191],"II.":[201],"Some":[202],"III":[210],"larger":[213],"than":[214],"those":[215],"controls,":[218],"they":[220],"contained":[221],"increased":[222],"numbers":[223],"lobule.":[229],"Further,":[230],"germinal":[231],"centers":[232],"two":[236],"III.":[242]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}