{"id":"https://openalex.org/W2994952016","doi":"https://doi.org/10.3389/fonc.2019.01458","title":"Current and Future Treatment Strategies for Rhabdomyosarcoma","display_name":"Current and Future Treatment Strategies for Rhabdomyosarcoma","publication_year":2019,"publication_date":"2019-12-20","ids":{"openalex":"https://openalex.org/W2994952016","doi":"https://doi.org/10.3389/fonc.2019.01458","mag":"2994952016","pmid":"https://pubmed.ncbi.nlm.nih.gov/31921698"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2019.01458","doi":"https://doi.org/10.3389/fonc.2019.01458","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2019.01458","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2019.01458/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2019.01458/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019443901","display_name":"Celine Y. Chen","orcid":"https://orcid.org/0000-0002-1579-024X","observed_orcids":["https://orcid.org/0000-0002-1579-024X"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Celine Chen","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002451015","display_name":"Heathcliff Dorado Garc\u00eda","orcid":"https://orcid.org/0000-0002-2578-3350","observed_orcids":["https://orcid.org/0000-0002-2578-3350"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heathcliff Dorado Garcia","raw_affiliation_strings":["Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002688480","display_name":"Monika Scheer","orcid":"https://orcid.org/0000-0002-0665-6268","observed_orcids":["https://orcid.org/0000-0002-0665-6268"]},"institutions":[{"id":"https://openalex.org/I4210113917","display_name":"Olgahospital","ror":"https://ror.org/01xet8208","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]},{"id":"https://openalex.org/I4210161485","display_name":"Klinikum Stuttgart","ror":"https://ror.org/059jfth35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210161485"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Monika Scheer","raw_affiliation_strings":["Pediatrics 5, Klinikum Stuttgart, Olgahospital, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics 5, Klinikum Stuttgart, Olgahospital, Stuttgart, Germany","institution_ids":["https://openalex.org/I4210113917","https://openalex.org/I4210161485"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002107117","display_name":"Anton George Henssen","orcid":"https://orcid.org/0000-0003-1534-778X","observed_orcids":["https://orcid.org/0000-0003-1534-778X"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Anton G. Henssen","raw_affiliation_strings":["Berlin Institute of Health, Berlin, Germany","Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Berlin Institute of Health, Berlin, Germany","institution_ids":["https://openalex.org/I4210139777"]},{"raw_affiliation_string":"Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Experimental and Clinical Research Center (ECRC) of the MDC and Charit\u00e9 Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I205582932","https://openalex.org/I7877124"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5002107117"],"corresponding_institution_ids":["https://openalex.org/I17937529","https://openalex.org/I205582932","https://openalex.org/I4210139777","https://openalex.org/I7877124"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":13.0224,"has_fulltext":true,"cited_by_count":172,"citation_normalized_percentile":{"value":0.99249587,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"9","issue":null,"first_page":"1458","last_page":"1458"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhabdomyosarcoma","display_name":"rhabdomyosarcoma","score":1.0},{"id":"https://openalex.org/keywords/pediatric-soft-tissue-sarcoma","display_name":"pediatric soft tissue sarcoma","score":0.9010000228881836},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7950000166893005},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/clinical-trial-development","display_name":"clinical trial development","score":0.6010000109672546},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7924072742462158},{"id":"https://openalex.org/C2780844630","wikidata":"https://www.wikidata.org/wiki/Q1898141","display_name":"Rhabdomyosarcoma","level":3,"score":0.7348069548606873},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6655192375183105},{"id":"https://openalex.org/C2778629024","wikidata":"https://www.wikidata.org/wiki/Q720020","display_name":"Soft tissue sarcoma","level":3,"score":0.5488609671592712},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.45504724979400635},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40570324659347534},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3961968421936035},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.3300107419490814},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25137537717819214},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23105713725090027},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2291552722454071}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fonc.2019.01458","doi":"https://doi.org/10.3389/fonc.2019.01458","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2019.01458","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2019.01458/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmid:31921698","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31921698","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mdc-berlin.de:18661","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mdc-berlin.de/18661/1/18661oa.pdf","pdf_url":"http://edoc.mdc-berlin.de/18661/1/18661oa.pdf","source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Review"},{"id":"pmh:oai:pubmedcentral.nih.gov:6933601","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6933601","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:025b8e17eb43450599d80e915a9839b6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/025b8e17eb43450599d80e915a9839b6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 9 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2019.01458","doi":"https://doi.org/10.3389/fonc.2019.01458","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2019.01458","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2019.01458/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6499999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8990464473","display_name":"Sequenzspezifische DNA Rekombination als Ursache genomischer Mutationen im Neuroblastom","funder_award_id":"398299703","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320329666","display_name":"Berlin Institute of Health","ror":"https://ror.org/0493xsw21"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2994952016.pdf","grobid_xml":"https://content.openalex.org/works/W2994952016.grobid-xml"},"referenced_works_count":189,"referenced_works":["https://openalex.org/W1486709967","https://openalex.org/W1503731208","https://openalex.org/W1504229479","https://openalex.org/W1507357096","https://openalex.org/W1512690422","https://openalex.org/W1523117612","https://openalex.org/W1527808522","https://openalex.org/W1547298604","https://openalex.org/W1558871366","https://openalex.org/W1565539350","https://openalex.org/W1566978183","https://openalex.org/W1602493743","https://openalex.org/W1693048258","https://openalex.org/W1758612015","https://openalex.org/W1824189202","https://openalex.org/W1864208984","https://openalex.org/W1905490737","https://openalex.org/W1906676875","https://openalex.org/W1914050662","https://openalex.org/W1926287352","https://openalex.org/W1927281193","https://openalex.org/W1931737153","https://openalex.org/W1939574960","https://openalex.org/W1950118853","https://openalex.org/W1966802202","https://openalex.org/W1968331107","https://openalex.org/W1971639718","https://openalex.org/W1974879801","https://openalex.org/W1985006583","https://openalex.org/W1986115996","https://openalex.org/W1986157370","https://openalex.org/W1990611116","https://openalex.org/W1994523262","https://openalex.org/W1998351962","https://openalex.org/W1999872588","https://openalex.org/W2003794063","https://openalex.org/W2004610844","https://openalex.org/W2006038974","https://openalex.org/W2006061944","https://openalex.org/W2007061536","https://openalex.org/W2010055897","https://openalex.org/W2014851856","https://openalex.org/W2016552156","https://openalex.org/W2020233730","https://openalex.org/W2020691941","https://openalex.org/W2028011921","https://openalex.org/W2032281778","https://openalex.org/W2033274316","https://openalex.org/W2043274355","https://openalex.org/W2044313879","https://openalex.org/W2049342310","https://openalex.org/W2057793681","https://openalex.org/W2057849896","https://openalex.org/W2059763709","https://openalex.org/W2061622036","https://openalex.org/W2061873102","https://openalex.org/W2062972691","https://openalex.org/W2063812976","https://openalex.org/W2067942082","https://openalex.org/W2072315137","https://openalex.org/W2078110289","https://openalex.org/W2081261283","https://openalex.org/W2081754396","https://openalex.org/W2083086786","https://openalex.org/W2087007084","https://openalex.org/W2087554245","https://openalex.org/W2088342479","https://openalex.org/W2093917816","https://openalex.org/W2094061902","https://openalex.org/W2094903176","https://openalex.org/W2095826876","https://openalex.org/W2096048988","https://openalex.org/W2096087550","https://openalex.org/W2096322385","https://openalex.org/W2096964142","https://openalex.org/W2097905432","https://openalex.org/W2100034382","https://openalex.org/W2101405991","https://openalex.org/W2103077999","https://openalex.org/W2103690933","https://openalex.org/W2107307464","https://openalex.org/W2107433579","https://openalex.org/W2109400179","https://openalex.org/W2112359031","https://openalex.org/W2112521155","https://openalex.org/W2112621891","https://openalex.org/W2113863686","https://openalex.org/W2115759102","https://openalex.org/W2117784457","https://openalex.org/W2117943725","https://openalex.org/W2119240302","https://openalex.org/W2119501563","https://openalex.org/W2125028197","https://openalex.org/W2127561752","https://openalex.org/W2127736279","https://openalex.org/W2127749855","https://openalex.org/W2127767887","https://openalex.org/W2127862779","https://openalex.org/W2128758225","https://openalex.org/W2137184839","https://openalex.org/W2138223668","https://openalex.org/W2138853528","https://openalex.org/W2139383226","https://openalex.org/W2139607880","https://openalex.org/W2140449207","https://openalex.org/W2142190381","https://openalex.org/W2143163879","https://openalex.org/W2144048410","https://openalex.org/W2144875629","https://openalex.org/W2145980885","https://openalex.org/W2147486937","https://openalex.org/W2149228256","https://openalex.org/W2152880836","https://openalex.org/W2152897456","https://openalex.org/W2155977618","https://openalex.org/W2156353875","https://openalex.org/W2156587036","https://openalex.org/W2156822604","https://openalex.org/W2157293741","https://openalex.org/W2160417212","https://openalex.org/W2171543679","https://openalex.org/W2176682109","https://openalex.org/W2180033414","https://openalex.org/W2238273397","https://openalex.org/W2239229810","https://openalex.org/W2243095616","https://openalex.org/W2272802268","https://openalex.org/W2288109457","https://openalex.org/W2318725321","https://openalex.org/W2325972250","https://openalex.org/W2404932476","https://openalex.org/W2410858260","https://openalex.org/W2470708296","https://openalex.org/W2474331216","https://openalex.org/W2503311213","https://openalex.org/W2515857015","https://openalex.org/W2529951711","https://openalex.org/W2557211863","https://openalex.org/W2559997659","https://openalex.org/W2560367415","https://openalex.org/W2561907259","https://openalex.org/W2572174216","https://openalex.org/W2597062310","https://openalex.org/W2609598144","https://openalex.org/W2626568103","https://openalex.org/W2692768525","https://openalex.org/W2752835339","https://openalex.org/W2756121549","https://openalex.org/W2766726178","https://openalex.org/W2767281692","https://openalex.org/W2777859145","https://openalex.org/W2781540560","https://openalex.org/W2788562722","https://openalex.org/W2790101734","https://openalex.org/W2790715303","https://openalex.org/W2791040072","https://openalex.org/W2791483720","https://openalex.org/W2792323180","https://openalex.org/W2803823444","https://openalex.org/W2806426467","https://openalex.org/W2806837101","https://openalex.org/W2807252943","https://openalex.org/W2807729510","https://openalex.org/W2809122047","https://openalex.org/W2811415290","https://openalex.org/W2885745841","https://openalex.org/W2888184319","https://openalex.org/W2891155482","https://openalex.org/W2892297790","https://openalex.org/W2892752271","https://openalex.org/W2898463166","https://openalex.org/W2910164268","https://openalex.org/W2913043165","https://openalex.org/W2942289486","https://openalex.org/W2946836513","https://openalex.org/W2951560509","https://openalex.org/W2953324065","https://openalex.org/W2956457862","https://openalex.org/W2961969123","https://openalex.org/W2963080170","https://openalex.org/W2970427574","https://openalex.org/W2973216672","https://openalex.org/W2975416164","https://openalex.org/W2976316026","https://openalex.org/W3137135981","https://openalex.org/W3139776026","https://openalex.org/W4239989216","https://openalex.org/W4241911458","https://openalex.org/W6713283507"],"related_works":["https://openalex.org/W4246679218","https://openalex.org/W2094855561","https://openalex.org/W2132781781","https://openalex.org/W228711004","https://openalex.org/W2883899332","https://openalex.org/W4301147166","https://openalex.org/W4366992003","https://openalex.org/W4312808698","https://openalex.org/W2503630697","https://openalex.org/W3010805179"],"abstract_inverted_index":{"Rhabdomyosarcoma":[0],"(RMS)":[1],"is":[2],"the":[3,24,60,72,94,122],"most":[4],"common":[5],"soft":[6],"tissue":[7],"sarcoma":[8],"in":[9,34,56,82],"children,":[10],"and":[11,39,63,109,115,121],"can":[12],"be":[13],"subcategorized":[14],"histologically":[15],"and/or":[16],"based":[17],"on":[18],"PAX-FOXO1":[19],"fusion":[20],"gene":[21],"status.":[22],"Over":[23],"last":[25],"four":[26],"decades,":[27],"there":[28],"have":[29,70],"been":[30],"no":[31],"significant":[32,54],"improvements":[33],"clinical":[35,83,118,128],"outcomes":[36],"for":[37,46,50,99,126],"advanced":[38],"metastatic":[40],"RMS":[41,68,100],"patients,":[42],"underscoring":[43],"a":[44],"need":[45],"new":[47],"treatment":[48],"options":[49],"these":[51,80],"groups.":[52],"Despite":[53],"advancements":[55],"our":[57],"understanding":[58],"of":[59,74,79],"genomic":[61],"landscape":[62],"underlying":[64],"biological":[65],"mechanisms":[66],"governing":[67],"that":[69],"informed":[71],"identification":[73],"novel":[75],"therapeutic":[76],"targets,":[77],"development":[78],"therapies":[81,108],"trials":[84],"has":[85],"lagged":[86],"far":[87],"behind.":[88],"In":[89],"this":[90],"review,":[91],"we":[92],"summarize":[93],"current":[95],"frontline":[96],"multi-modality":[97],"therapy":[98],"according":[101],"to":[102],"pediatric":[103],"protocols,":[104],"highlight":[105],"emerging":[106],"targeted":[107],"immunotherapies":[110],"identified":[111],"by":[112],"preclinical":[113],"studies,":[114],"discuss":[116],"early":[117],"trial":[119],"data":[120],"implications":[123],"they":[124],"hold":[125],"future":[127],"development.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":32},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":29},{"year":2021,"cited_by_count":36},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}