{"id":"https://openalex.org/W2994937594","doi":"https://doi.org/10.1158/1538-7445.panca19-a18","title":"Abstract A18: Angiotensin receptor blockers normalize the pancreatic ductal adenocarcinoma stroma by reprogramming carcinoma-associated fibroblasts","display_name":"Abstract A18: Angiotensin receptor blockers normalize the pancreatic ductal adenocarcinoma stroma by reprogramming carcinoma-associated fibroblasts","publication_year":2019,"publication_date":"2019-12-13","ids":{"openalex":"https://openalex.org/W2994937594","doi":"https://doi.org/10.1158/1538-7445.panca19-a18","mag":"2994937594"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.panca19-a18","doi":"https://doi.org/10.1158/1538-7445.panca19-a18","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca19-a18","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Liu","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044970408","display_name":"William W. Ho","orcid":"https://orcid.org/0000-0002-1272-8184","observed_orcids":["https://orcid.org/0000-0002-1272-8184","https://orcid.org/0000-0002-1755-833X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William W. Ho","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061240871","display_name":"Kamila Naxerova","orcid":"https://orcid.org/0000-0001-7744-5110","observed_orcids":["https://orcid.org/0000-0001-7744-5110"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kamila Naxerova","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011749534","display_name":"Jelena Grahovac","orcid":"https://orcid.org/0000-0003-1430-8682","observed_orcids":["https://orcid.org/0000-0003-1430-8682"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jelena Grahovac","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021812533","display_name":"Hadi\u00a0Tavakoli Nia","orcid":"https://orcid.org/0000-0003-1970-9901","observed_orcids":["https://orcid.org/0000-0003-1970-9901"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hadi Nia","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062724957","display_name":"Ivy X. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivy Chen","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088266280","display_name":"Jessica M. Posada","orcid":"https://orcid.org/0000-0002-9056-0735","observed_orcids":["https://orcid.org/0000-0002-9056-0735"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica M. Posada","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064632694","display_name":"Daniel Hendrik Schanne","orcid":"https://orcid.org/0000-0001-5189-0507","observed_orcids":["https://orcid.org/0000-0001-5189-0507"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel H. Schanne","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055058026","display_name":"Matthias Pinter","orcid":"https://orcid.org/0000-0002-7260-532X","observed_orcids":["https://orcid.org/0000-0002-7260-532X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthias Pinter","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055468745","display_name":"Jonathan A. Crain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Crain","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070879013","display_name":"Xialong Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xialong Qi","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088474933","display_name":"Jeffrey William Clark","orcid":"https://orcid.org/0000-0001-9524-3600","observed_orcids":["https://orcid.org/0000-0001-9524-3600"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey W. Clark","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044225007","display_name":"Theodore Sunki Hong","orcid":"https://orcid.org/0000-0001-8481-6581","observed_orcids":["https://orcid.org/0000-0001-8481-6581"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore S. Hong","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070720153","display_name":"David P. Ryan","orcid":"https://orcid.org/0000-0002-9685-673X","observed_orcids":["https://orcid.org/0000-0002-9685-673X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David P. Ryan","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021963513","display_name":"Peigen Huang","orcid":"https://orcid.org/0000-0002-3184-6493","observed_orcids":["https://orcid.org/0000-0002-3184-6493"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peigen Huang","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051782291","display_name":"Keith D. Lillemoe","orcid":"https://orcid.org/0009-0004-5057-3875","observed_orcids":["https://orcid.org/0009-0004-5057-3875","https://orcid.org/0000-0003-4283-8437"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith D. Lillemoe","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111915471","display_name":"Carlos Fern\u00e1ndez-del Castillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Fern\u00e1ndez-Del Castillo","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061627885","display_name":"Cristina Rosa Ferrone","orcid":"https://orcid.org/0000-0002-6295-1085","observed_orcids":["https://orcid.org/0000-0002-6295-1085"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina R Ferrone","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087598197","display_name":"Michael Downes","orcid":"https://orcid.org/0000-0002-6351-9585","observed_orcids":["https://orcid.org/0000-0002-6351-9585"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Downes","raw_affiliation_strings":["2Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA","institution_ids":["https://openalex.org/I1307098950","https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087519016","display_name":"Ronald M. Evans","orcid":"https://orcid.org/0000-0002-9986-5965","observed_orcids":["https://orcid.org/0000-0002-9986-5965"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald M. Evans","raw_affiliation_strings":["2Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA","institution_ids":["https://openalex.org/I1307098950","https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038972103","display_name":"Vikram Deshpande","orcid":"https://orcid.org/0000-0003-4230-9308","observed_orcids":["https://orcid.org/0000-0003-4230-9308"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikram Deshpande","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027437473","display_name":"Yves Boucher","orcid":"https://orcid.org/0000-0002-0334-3012","observed_orcids":["https://orcid.org/0000-0002-0334-3012","https://orcid.org/0000-0001-6182-0860"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yves Boucher","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":null,"display_name":"Rakesh K. Jain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rakesh K. Jain","raw_affiliation_strings":["1Massachusetts General Hospital, Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Massachusetts General Hospital, Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"24_Supplement","first_page":"A18","last_page":"A18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9620000123977661},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.9919999837875366},{"id":"https://openalex.org/keywords/desmoplasia","display_name":"desmoplasia","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8989999890327454},{"id":"https://openalex.org/keywords/angiotensin-receptor-1","display_name":"angiotensin receptor 1","score":0.8740000128746033},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.7689999938011169},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7960000038146973},{"id":"https://openalex.org/keywords/fibroblast-activation-protein","display_name":"fibroblast activation protein","score":0.6679999828338623},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.9110000133514404},{"id":"https://openalex.org/keywords/fibroblast-reprogramming","display_name":"fibroblast reprogramming","score":0.5519999861717224},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2781005279","wikidata":"https://www.wikidata.org/wiki/Q5264825","display_name":"Desmoplasia","level":4,"score":0.9278144240379333},{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.7294691801071167},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7092710733413696},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.6182824373245239},{"id":"https://openalex.org/C123915805","wikidata":"https://www.wikidata.org/wiki/Q15332826","display_name":"Angiotensin II receptor type 1","level":4,"score":0.47305503487586975},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46467074751853943},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.46177661418914795},{"id":"https://openalex.org/C104849204","wikidata":"https://www.wikidata.org/wiki/Q24778533","display_name":"Angiotensin receptor","level":4,"score":0.4485255777835846},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4409894645214081},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4380026161670685},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4211077094078064},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3917188048362732},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3901413381099701},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2583649158477783}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.panca19-a18","doi":"https://doi.org/10.1158/1538-7445.panca19-a18","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.panca19-a18","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416643923","https://openalex.org/W2343016965","https://openalex.org/W7148910371","https://openalex.org/W4411506657","https://openalex.org/W2563124588","https://openalex.org/W2998162429","https://openalex.org/W1573445593","https://openalex.org/W7124231250","https://openalex.org/W2280591849","https://openalex.org/W4396680230"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"resistance":[2],"to":[3,14,75,165,194],"therapy":[4],"in":[5,12,55,84,113,134,152,161,182,269,307,358,382,468],"pancreatic":[6,448],"ductal":[7,449],"adenocarcinoma":[8,450],"(PDAC)":[9],"is":[10],"due":[11],"part":[13],"carcinoma-associated":[15,454],"fibroblasts":[16,455],"(CAFs)":[17],"that":[18,32,91,119,200,265,306,346,372],"produce":[19],"a":[20,76,114,279],"highly":[21],"desmoplastic":[22],"and":[23,42,44,48,51,150,177,189,243,245,254,298,312,322,328,334,341,364,378,470],"proinflammatory":[24],"tumor":[25,285,310,359],"microenvironment":[26],"(TME).":[27],"Our":[28],"laboratory":[29],"has":[30],"shown":[31],"the":[33,40,49,103,120,167,178,201,209,214,232,238,247,259,274,283,309,317,348,380,447,460],"angiotensin":[34,124,239],"receptor":[35,240,444],"blocker":[36],"(ARB)":[37],"losartan":[38,92,315],"reduces":[39],"CAF-density":[41],"desmoplasia,":[43],"improves":[45],"vascular":[46],"perfusion,":[47],"uptake":[50],"efficacy":[52],"of":[53,58,123,169,172,204,211,234,249,262,282,339,350,459],"drugs":[54],"animal":[56],"models":[57],"PDAC":[59,87,136,154,184,296],"(Diop-Frimpong":[60],"et":[61,66,107,139],"al.,":[62,67,108,140],"PNAS":[63],"2011;":[64],"Chauhan":[65],"Nature":[68],"Comm":[69],"2013).":[70],"These":[71,369],"preclinical":[72],"findings":[73],"led":[74],"phase":[77],"II":[78],"trial":[79],"at":[80],"Massachusetts":[81],"General":[82],"Hospital":[83],"locally":[85],"advanced":[86],"patients,":[88],"which":[89],"showed":[90],"combined":[93],"with":[94,130,192,300],"neoadjuvant-FOLFIRINOX":[95],"chemotherapy":[96],"followed":[97],"by":[98,452],"chemoradiation":[99],"more":[100],"than":[101],"doubled":[102],"resection":[104],"rate":[105],"(Murphy":[106],"JAMA":[109],"Oncology":[110],"2019).":[111],"Moreover,":[112],"retrospective":[115],"analysis,":[116],"we":[117,158,277],"found":[118,199],"chronic":[121,170,202],"use":[122,171,203],"system":[125],"inhibitors":[126],"was":[127],"independently":[128],"associated":[129],"longer":[131],"overall":[132],"survival":[133],"nonmetastatic":[135],"patients":[137,188,190],"(Liu":[138],"Clin":[141],"Cancer":[142,481],"Res":[143,482],"2017).":[144],"However,":[145,229],"how":[146],"ARBs":[147,193,205,230,256,266,373],"affect":[148],"CAFs":[149,212,235,250],"desmoplasia":[151,268],"human":[153,270],"remains":[155],"unknown.":[156],"Here":[157],"performed":[159,278],"immunohistochemistry":[160],"formalin-fixed,":[162],"paraffin-embedded":[163],"sections":[164],"examine":[166],"effect":[168],"ARB":[173],"on":[174,464],"CAF":[175],"phenotypes":[176],"extracellular":[179],"matrix":[180],"(ECM)":[181],"resected":[183],"samples":[185],"from":[186,292],"untreated":[187],"treated":[191,299],"control":[195],"their":[196],"hypertension.":[197],"We":[198],"did":[206],"not":[207,357],"reduce":[208,267],"density":[210],"expressing":[213,236,251],"fibroblast":[215],"activation":[216],"protein":[217],"(FAP),":[218],"\u03b1-smooth":[219],"muscle":[220,365],"actin":[221],"(\u03b1-SMA),":[222],"or":[223],"platelet-derived":[224,323],"growth":[225,324],"factor":[226,325],"receptor-beta":[227],"alone.":[228],"increased":[231],"fraction":[233,248],"both":[237,252,308],"1":[241],"(AT1)":[242],"\u03b1-SMA":[244],"decreased":[246],"AT1":[253],"FAP.":[255],"also":[257],"reduced":[258,330,361],"intratumoral":[260],"levels":[261],"hyaluronan,":[263],"suggesting":[264],"PDAC.":[271,383],"To":[272],"reveal":[273],"underlying":[275],"mechanisms,":[276],"transcriptomic":[280],"analysis":[281],"bulk":[284,311],"as":[286,288],"well":[287],"\u03b1-SMA+":[289,313,355,376],"cells":[290,377],"isolated":[291],"mice":[293],"bearing":[294],"orthotopic":[295],"tumors":[297],"losartan.":[301],"Gene":[302,337],"expression":[303],"profiling":[304],"revealed":[305],"cells,":[314],"\u201cnormalized\u201d":[316],"ECM/cytoskeleton":[318],"interaction,":[319],"glycosaminoglycan":[320],"metabolism":[321],"gene":[326,331,367],"sets,":[327],"significantly":[329],"transcripts":[332],"ofS100A8":[333],"S100A9":[335,342],".":[336],"products":[338],"S100A8":[340],"are":[343],"S100":[344],"proteins":[345],"stimulate":[347],"development":[349],"myeloid-derived":[351],"suppressor":[352],"cells.":[353],"In":[354],"cells\u2014but":[356],"bulk\u2014losartan":[360],"cell":[362],"cycle":[363],"contraction":[366],"sets.":[368],"results":[370],"suggest":[371],"can":[374],"reprogram":[375],"normalize":[379,446],"TME":[381],"Citation":[384],"Format:":[385],"Hao":[386],"Liu,":[387],"William":[388],"W.":[389,412],"Ho,":[390],"Kamila":[391],"Naxerova,":[392],"Jelena":[393],"Grahovac,":[394],"Hadi":[395],"Nia,":[396],"Ivy":[397],"Chen,":[398],"Jessica":[399],"M.":[400,434],"Posada,":[401],"Daniel":[402],"H.":[403],"Schanne,":[404],"Matthias":[405],"Pinter,":[406],"Jonathan":[407],"Crain,":[408],"Xialong":[409],"Qi,":[410],"Jeffrey":[411],"Clark,":[413],"Theodore":[414],"S.":[415],"Hong,":[416],"David":[417],"P.":[418],"Ryan,":[419],"Peigen":[420],"Huang,":[421],"Keith":[422],"D.":[423],"Lillemoe,":[424],"Carlos":[425],"Fern\u00e1ndez-Del":[426],"Castillo,":[427],"Cristina":[428],"R":[429],"Ferrone,":[430],"Michael":[431],"Downes,":[432],"Ronald":[433],"Evans,":[435],"Vikram":[436],"Deshpande,":[437],"Yves":[438],"Boucher,":[439],"Rakesh":[440],"K.":[441],"Jain.":[442],"Angiotensin":[443],"blockers":[445],"stroma":[451],"reprogramming":[453],"[abstract].":[456],"In:":[457],"Proceedings":[458],"AACR":[461],"Special":[462],"Conference":[463],"Pancreatic":[465],"Cancer:":[466],"Advances":[467],"Science":[469],"Clinical":[471],"Care;":[472],"2019":[473],"Sept":[474],"6-9;":[475],"Boston,":[476],"MA.":[477],"Philadelphia":[478],"(PA):":[479],"AACR;":[480],"2019;79(24":[483],"Suppl):Abstract":[484],"nr":[485],"A18.":[486]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-12-26T00:00:00"}
