{"id":"https://openalex.org/W2994936780","doi":"https://doi.org/10.1186/s12920-019-0616-2","title":"High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome","display_name":"High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome","publication_year":2019,"publication_date":"2019-11-27","ids":{"openalex":"https://openalex.org/W2994936780","doi":"https://doi.org/10.1186/s12920-019-0616-2","mag":"2994936780","pmid":"https://pubmed.ncbi.nlm.nih.gov/31775754","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6882360"},"language":"en","primary_location":{"id":"doi:10.1186/s12920-019-0616-2","doi":"https://doi.org/10.1186/s12920-019-0616-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12920-019-0616-2","pdf_url":"https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/s12920-019-0616-2","source":{"id":"https://openalex.org/S119250532","display_name":"BMC Medical Genomics","issn_l":"1755-8794","issn":["1755-8794"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/s12920-019-0616-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075879530","display_name":"Liviu-Ionut Moldovan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Liviu-Ionut Moldovan","raw_affiliation_strings":["Department of Molecular Biology and Genetics (MBG), Aarhus University, DK-8000, Aarhus, Denmark","Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics (MBG), Aarhus University, DK-8000, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080899662","display_name":"Thomas B. Hansen","orcid":"https://orcid.org/0000-0002-7573-9657","observed_orcids":["https://orcid.org/0000-0002-7573-9657"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Thomas Birkballe Hansen","raw_affiliation_strings":["Department of Molecular Biology and Genetics (MBG), Aarhus University, DK-8000, Aarhus, Denmark","Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-7573-9657","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics (MBG), Aarhus University, DK-8000, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087651926","display_name":"Morten Trillingsgaard Ven\u00f8","orcid":"https://orcid.org/0000-0002-4754-5193","observed_orcids":["https://orcid.org/0000-0002-4754-5193"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Morten Trillingsgaard Ven\u00f8","raw_affiliation_strings":["Department of Molecular Biology and Genetics (MBG), Aarhus University, DK-8000, Aarhus, Denmark","Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics (MBG), Aarhus University, DK-8000, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064464662","display_name":"Trine Line Hauge Okholm","orcid":"https://orcid.org/0000-0002-2779-4029","observed_orcids":["https://orcid.org/0000-0002-2779-4029"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Trine Line Hauge Okholm","raw_affiliation_strings":["Department of Molecular Medicine (MOMA), Aarhus University Hospital, DK-8200, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine (MOMA), Aarhus University Hospital, DK-8200, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059821476","display_name":"Thomas Levin Andersen","orcid":"https://orcid.org/0000-0002-6981-7276","observed_orcids":["https://orcid.org/0000-0002-6981-7276"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801498763"]},{"id":"https://openalex.org/I4210091196","display_name":"Vejle Sygehus","ror":"https://ror.org/00e8ar137","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I4210091196","https://openalex.org/I4210142184"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Thomas Levin Andersen","raw_affiliation_strings":["Clinical Cell Biology, Department of Pathology, Vejle Hospital and Odense University Hospital, DK-5000, Odense, Denmark","Clinical Cell Biology, Research Unit of Pathology, Department of Clinical Research, University of Southern Denmark, DK-5000, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Cell Biology, Department of Pathology, Vejle Hospital and Odense University Hospital, DK-5000, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763","https://openalex.org/I4210091196"]},{"raw_affiliation_string":"Clinical Cell Biology, Research Unit of Pathology, Department of Clinical Research, University of Southern Denmark, DK-5000, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061697262","display_name":"Henrik Hager","orcid":"https://orcid.org/0000-0002-3164-9190","observed_orcids":["https://orcid.org/0000-0002-3164-9190"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I4210091196","display_name":"Vejle Sygehus","ror":"https://ror.org/00e8ar137","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I4210091196","https://openalex.org/I4210142184"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Henrik Hager","raw_affiliation_strings":["Department of Clinical Research and Department of Molecular Medicine, University of Southern Denmark, DK-5000, Odense, Denmark","Department of Clinical Pathology, Vejle Hospital, DK-7100, Vejle, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research and Department of Molecular Medicine, University of Southern Denmark, DK-5000, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Department of Clinical Pathology, Vejle Hospital, DK-7100, Vejle, Denmark","institution_ids":["https://openalex.org/I4210091196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035700990","display_name":"Lars Iversen","orcid":"https://orcid.org/0000-0003-1816-4508","observed_orcids":["https://orcid.org/0000-0003-1816-4508","https://orcid.org/0000-0003-3096-1526"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lars Iversen","raw_affiliation_strings":["Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark","Department of Dermatology, Aarhus University Hospital, DK-8000 Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-1816-4508","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Dermatology, Aarhus University Hospital, DK-8000 Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072940644","display_name":"J\u00f8rgen Kjems","orcid":"https://orcid.org/0000-0003-4128-9317","observed_orcids":["https://orcid.org/0000-0003-4128-9317"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"J\u00f8rgen Kjems","raw_affiliation_strings":["Department of Molecular Biology and Genetics (MBG), Aarhus University, DK-8000, Aarhus, Denmark","Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics (MBG), Aarhus University, DK-8000, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064644319","display_name":"Claus Johansen","orcid":"https://orcid.org/0000-0002-5665-5212","observed_orcids":["https://orcid.org/0000-0002-5665-5212"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Claus Johansen","raw_affiliation_strings":["Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark","Department of Dermatology, Aarhus University Hospital, DK-8000 Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Dermatology, Aarhus University Hospital, DK-8000 Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001431960","display_name":"Lasse S. Kristensen","orcid":"https://orcid.org/0000-0002-5980-7939","observed_orcids":["https://orcid.org/0000-0002-5980-7939"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lasse Sommer Kristensen","raw_affiliation_strings":["Department of Molecular Biology and Genetics (MBG), Aarhus University, DK-8000, Aarhus, Denmark","Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-5980-7939","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics (MBG), Aarhus University, DK-8000, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2145,"currency":"USD","value_usd":2145},"apc_paid":{"value":2145,"currency":"USD","value_usd":2145},"fwci":3.2627,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.937872,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"174","last_page":"174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psoriasis","display_name":"psoriasis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/circular-rna","display_name":"circular RNA","score":0.7919999957084656},{"id":"https://openalex.org/keywords/plaque-psoriasis","display_name":"plaque psoriasis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/lesional-skin","display_name":"lesional skin","score":0.7689999938011169},{"id":"https://openalex.org/keywords/non-lesional-skin","display_name":"non-lesional skin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/microrna-binding-sites","display_name":"microRNA binding sites","score":0.7739999890327454},{"id":"https://openalex.org/keywords/microrna-expression","display_name":"microRNA expression","score":0.8840000033378601},{"id":"https://openalex.org/keywords/epidermis","display_name":"epidermis","score":0.796999990940094},{"id":"https://openalex.org/keywords/dermis","display_name":"dermis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/circrna-biogenesis","display_name":"circRNA biogenesis","score":0.6700000166893005},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.8009999990463257},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.7627898454666138},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.6754788756370544},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5207933783531189},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5000691413879395},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4784710109233856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44146138429641724},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3449128270149231},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3297044336795807},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29734182357788086},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.28178972005844116},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18758365511894226},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10800158977508545}],"mesh":[{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12920-019-0616-2","doi":"https://doi.org/10.1186/s12920-019-0616-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12920-019-0616-2","pdf_url":"https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/s12920-019-0616-2","source":{"id":"https://openalex.org/S119250532","display_name":"BMC Medical Genomics","issn_l":"1755-8794","issn":["1755-8794"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genomics","raw_type":"journal-article"},{"id":"doi:10.1101/581066","doi":"https://doi.org/10.1101/581066","is_oa":true,"landing_page_url":"https://doi.org/10.1101/581066","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/03/21/581066.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:31775754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31775754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical genomics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6882360","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6882360/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Med Genomics","raw_type":"Text"},{"id":"pmh:oai:sdu.dk:openaire/6f24e84c-88e1-4989-9195-204bc2f90091","doi":null,"is_oa":true,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/6f24e84c-88e1-4989-9195-204bc2f90091","pdf_url":"https://findresearcher.sdu.dk/ws/files/157300135/Open_Access_Version.pdf","source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Moldovan, L I, Hansen, T B, Ven\u00f8, M T, Okholm, T L H, Andersen, T L, Hager, H, Iversen, L, Kjems, J, Johansen, C & Kristensen, L S 2019, 'High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome', BMC Medical Genomics, vol. 12, 174. https://doi.org/10.1186/s12920-019-0616-2","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:e128b91bc28446c18746bdc4ef495a04","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e128b91bc28446c18746bdc4ef495a04","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Genomics, Vol 12, Iss 1, Pp 1-17 (2019)","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:openaire/491620ad-b7b5-45e3-82ea-436d0479d255","doi":null,"is_oa":true,"landing_page_url":"https://www.scopus.com/pages/publications/85075752478","pdf_url":null,"source":{"id":"https://openalex.org/S4306400063","display_name":"Scopus (Elsevier)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Moldovan, L-I, Hansen, T B, Ven\u00f8, M T, Okholm, T L H, Andersen, T L, Hager, H, Iversen, L, Kjems, J, Johansen, C & Kristensen, L S 2019, 'High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome', BMC Medical Genomics, vol. 12, no. 1, 174. https://doi.org/10.1186/s12920-019-0616-2","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12920-019-0616-2","doi":"https://doi.org/10.1186/s12920-019-0616-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12920-019-0616-2","pdf_url":"https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/s12920-019-0616-2","source":{"id":"https://openalex.org/S119250532","display_name":"BMC Medical Genomics","issn_l":"1755-8794","issn":["1755-8794"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1927241001","display_name":null,"funder_award_id":"00013393","funder_id":"https://openalex.org/F4320310490","funder_display_name":"Villum Fonden"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8377215115","display_name":"circular RNA Biology Training Network: from biogenesis to biomarkers","funder_award_id":"721890","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320310490","display_name":"Villum Fonden","ror":"https://ror.org/007ww2d15"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2994936780.pdf","grobid_xml":"https://content.openalex.org/works/W2994936780.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1966557314","https://openalex.org/W1968813912","https://openalex.org/W1981220178","https://openalex.org/W1981726010","https://openalex.org/W1991082489","https://openalex.org/W1991320836","https://openalex.org/W2004484880","https://openalex.org/W2007207147","https://openalex.org/W2010461414","https://openalex.org/W2019230794","https://openalex.org/W2034305079","https://openalex.org/W2051615060","https://openalex.org/W2058835062","https://openalex.org/W2064165694","https://openalex.org/W2080090843","https://openalex.org/W2092706476","https://openalex.org/W2100667488","https://openalex.org/W2103657395","https://openalex.org/W2105423509","https://openalex.org/W2110884132","https://openalex.org/W2115662330","https://openalex.org/W2116830437","https://openalex.org/W2126938291","https://openalex.org/W2138207763","https://openalex.org/W2147806662","https://openalex.org/W2162674813","https://openalex.org/W2194134194","https://openalex.org/W2209325576","https://openalex.org/W2279994616","https://openalex.org/W2316171452","https://openalex.org/W2341291028","https://openalex.org/W2531297636","https://openalex.org/W2545636599","https://openalex.org/W2586325787","https://openalex.org/W2597894202","https://openalex.org/W2602367484","https://openalex.org/W2625817416","https://openalex.org/W2625910148","https://openalex.org/W2744268790","https://openalex.org/W2762768829","https://openalex.org/W2764294957","https://openalex.org/W2766512489","https://openalex.org/W2767112290","https://openalex.org/W2767973858","https://openalex.org/W2769746516","https://openalex.org/W2779261153","https://openalex.org/W2779615732","https://openalex.org/W2806044202","https://openalex.org/W2885733344","https://openalex.org/W2889334297","https://openalex.org/W2890808906","https://openalex.org/W2895554567","https://openalex.org/W2911717630","https://openalex.org/W2942134847","https://openalex.org/W2951344785","https://openalex.org/W2952916470","https://openalex.org/W2967043226","https://openalex.org/W2968993120","https://openalex.org/W3039773043","https://openalex.org/W4249483860"],"related_works":["https://openalex.org/W6939111737","https://openalex.org/W2944487547","https://openalex.org/W2895554567","https://openalex.org/W3031928008","https://openalex.org/W4293800002","https://openalex.org/W3162034575","https://openalex.org/W4297991381","https://openalex.org/W4405952571","https://openalex.org/W7008609410","https://openalex.org/W7119505346"],"abstract_inverted_index":{"BACKGROUND:":[0],"Psoriasis":[1],"is":[2,17,305],"a":[3,31,43,69,75,162,306,309],"chronic":[4,23],"inflammatory":[5,24,238],"skin":[6,25,130,170,232,262,286],"disease":[7,313],"characterized":[8],"by":[9,184],"hyperproliferation":[10],"and":[11,65,94,112,127,146,156,260,284,291,341],"abnormal":[12],"differentiation":[13],"of":[14,19,37,47,71,80,84,165,196,202,211,222,237,281,311,326],"keratinocytes.":[15],"It":[16],"one":[18],"the":[20,78,90,121,154,182,194,197,247,256,276,300,312,324,331],"most":[21],"prevalent":[22],"conditions":[26],"in":[27,77,92,115,124,168,213,250,268,299,336],"adults":[28],"worldwide,":[29],"with":[30,50,133,266,289],"considerable":[32],"negative":[33],"impact":[34],"on":[35,255,330],"quality":[36],"life.":[38],"Circular":[39],"RNAs":[40,72],"(circRNAs)":[41],"are":[42,295],"recently":[44],"identified":[45],"type":[46],"non-coding":[48],"RNA":[49,113],"diverse":[51],"cellular":[52],"functions":[53],"related":[54],"to":[55,88,95,99,119,152,172,181,218,225,315],"their":[56,203],"exceptional":[57],"stability.":[58],"In":[59,136],"particular,":[60],"some":[61],"circRNAs":[62,198,212,257,294,332],"can":[63],"bind":[64],"regulate":[66],"microRNAs":[67],"(miRNAs),":[68],"group":[70],"that":[73,177,193,246,293,323],"play":[74],"role":[76],"pathogenesis":[79],"psoriasis.":[81],"The":[82,208],"aim":[83],"this":[85,178,304],"study":[86,153],"was":[87,150,215],"characterize":[89],"circRNAome":[91],"psoriasis":[93,134,214,290],"assess":[96],"potential":[97],"correlations":[98],"miRNA":[100,252,269,327,337],"expression":[101,123,167,220,270,338],"patterns.":[102,271],"METHODS:":[103],"We":[104,160,175,190,273],"used":[105,151],"high-throughput":[106],"RNA-sequencing":[107],"(RNA-seq),":[108],"NanoString":[109,143],"nCounter":[110,144],"technology":[111,145],"chromogenic":[114],"situ":[116],"hybridization":[117],"(CISH)":[118],"profile":[120],"circRNA":[122,166,227,279],"paired":[125,282],"lesional":[126,169,231,259,283,301,340],"non-lesional":[128,173,261,285,342],"psoriatic":[129],"from":[131,287],"patients":[132,288],"vulgaris.":[135],"addition,":[137],"799":[138],"miRNAs":[139],"were":[140,199],"profiled":[141],"using":[142],"laser":[147,186],"capture":[148,187],"microdissection":[149],"dermis":[155],"epidermis":[157,183],"separately.":[158],"RESULTS:":[159],"found":[161,192,320],"substantial":[163],"down-regulation":[164],"compared":[171],"skin.":[174,343],"observed":[176,209,245],"mainly":[179],"applies":[180],"analyzing":[185],"microdissected":[188],"tissues.":[189],"also":[191],"majority":[195],"downregulated":[200],"independently":[201],"corresponding":[204],"linear":[205],"host":[206],"genes.":[207],"downregulation":[210],"neither":[216],"due":[217],"altered":[219],"levels":[221],"factors":[223],"known":[224],"affect":[226],"biogenesis,":[228],"nor":[229],"because":[230],"contained":[233],"an":[234],"increased":[235],"number":[236],"cells":[239],"such":[240],"as":[241],"lymphocytes.":[242],"Finally,":[243],"we":[244,319],"overall":[248],"differences":[249,267,335],"available":[251],"binding":[253,328],"sites":[254,329],"between":[258,339],"did":[263],"not":[264],"correlate":[265],"CONCLUSIONS:":[272],"have":[274],"performed":[275],"first":[277],"genome-wide":[278],"profiling":[280],"revealed":[292],"much":[296],"less":[297],"abundant":[298],"samples.":[302],"Whether":[303],"cause":[307],"or":[308],"consequence":[310],"remains":[314],"be":[316],"revealed,":[317],"however,":[318],"no":[321],"evidence":[322],"loss":[325],"could":[333],"explain":[334]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-26T00:00:00"}