{"id":"https://openalex.org/W2994906232","doi":"https://doi.org/10.1016/j.jor.2019.12.008","title":"Tranexamic acid is toxic on human chondrocytes, in vitro","display_name":"Tranexamic acid is toxic on human chondrocytes, in vitro","publication_year":2019,"publication_date":"2019-12-18","ids":{"openalex":"https://openalex.org/W2994906232","doi":"https://doi.org/10.1016/j.jor.2019.12.008","mag":"2994906232","pmid":"https://pubmed.ncbi.nlm.nih.gov/32021047","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6994788"},"language":"en","primary_location":{"id":"doi:10.1016/j.jor.2019.12.008","doi":"https://doi.org/10.1016/j.jor.2019.12.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jor.2019.12.008","pdf_url":null,"source":{"id":"https://openalex.org/S2764834445","display_name":"Journal of Orthopaedics","issn_l":"0972-978X","issn":["0972-978X","2589-9082"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6994788/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032969938","display_name":"Benjamin Jacob","orcid":"https://orcid.org/0000-0002-1269-6231","observed_orcids":["https://orcid.org/0000-0002-1269-6231"]},"institutions":[{"id":"https://openalex.org/I4210096773","display_name":"Waldkrankenhaus Rudolf Elle","ror":"https://ror.org/00v2d0427","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210096773"]},{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Benjamin Jacob","raw_affiliation_strings":["Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany","institution_ids":["https://openalex.org/I4210096773","https://openalex.org/I4210134900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056483776","display_name":"Nadja Kloss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096773","display_name":"Waldkrankenhaus Rudolf Elle","ror":"https://ror.org/00v2d0427","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210096773"]},{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nadja Kloss","raw_affiliation_strings":["Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany","institution_ids":["https://openalex.org/I4210096773","https://openalex.org/I4210134900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034066072","display_name":"Sabrina B\u00f6hle","orcid":"https://orcid.org/0000-0002-6976-8953","observed_orcids":["https://orcid.org/0000-0002-6976-8953"]},"institutions":[{"id":"https://openalex.org/I4210096773","display_name":"Waldkrankenhaus Rudolf Elle","ror":"https://ror.org/00v2d0427","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210096773"]},{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabrina B\u00f6hle","raw_affiliation_strings":["Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany","institution_ids":["https://openalex.org/I4210096773","https://openalex.org/I4210134900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000860610","display_name":"Julia Kirschberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096773","display_name":"Waldkrankenhaus Rudolf Elle","ror":"https://ror.org/00v2d0427","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210096773"]},{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Kirschberg","raw_affiliation_strings":["Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany","institution_ids":["https://openalex.org/I4210096773","https://openalex.org/I4210134900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051095875","display_name":"Timo Zippelius","orcid":"https://orcid.org/0000-0003-2166-268X","observed_orcids":["https://orcid.org/0000-0003-2166-268X"]},"institutions":[{"id":"https://openalex.org/I4210096773","display_name":"Waldkrankenhaus Rudolf Elle","ror":"https://ror.org/00v2d0427","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210096773"]},{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Timo Zippelius","raw_affiliation_strings":["Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2166-268X","affiliations":[{"raw_affiliation_string":"Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany","institution_ids":["https://openalex.org/I4210096773","https://openalex.org/I4210134900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059483147","display_name":"Markus Heinecke","orcid":"https://orcid.org/0000-0003-2955-0471","observed_orcids":["https://orcid.org/0000-0003-2955-0471"]},"institutions":[{"id":"https://openalex.org/I4210096773","display_name":"Waldkrankenhaus Rudolf Elle","ror":"https://ror.org/00v2d0427","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210096773"]},{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Heinecke","raw_affiliation_strings":["Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany","institution_ids":["https://openalex.org/I4210096773","https://openalex.org/I4210134900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036431511","display_name":"Georg Matziolis","orcid":"https://orcid.org/0000-0002-5105-5875","observed_orcids":["https://orcid.org/0000-0002-5105-5875"]},"institutions":[{"id":"https://openalex.org/I4210096773","display_name":"Waldkrankenhaus Rudolf Elle","ror":"https://ror.org/00v2d0427","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210096773"]},{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Georg Matziolis","raw_affiliation_strings":["Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany","institution_ids":["https://openalex.org/I4210096773","https://openalex.org/I4210134900"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067844615","display_name":"Eric R\u00f6hner","orcid":"https://orcid.org/0000-0001-8329-294X","observed_orcids":["https://orcid.org/0000-0001-8329-294X"]},"institutions":[{"id":"https://openalex.org/I4210096773","display_name":"Waldkrankenhaus Rudolf Elle","ror":"https://ror.org/00v2d0427","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210096773"]},{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Eric R\u00f6hner","raw_affiliation_strings":["Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic Professorship of the University Hospital Jena, Orthopaedic Department of the Waldkliniken Eisenberg, 07607, Eisenberg, Germany","institution_ids":["https://openalex.org/I4210096773","https://openalex.org/I4210134900"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067844615"],"corresponding_institution_ids":["https://openalex.org/I4210096773","https://openalex.org/I4210134900"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":2.0277,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.85385367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"20","issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.14509999752044678,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tranexamic-acid","display_name":"tranexamic acid","score":1.0},{"id":"https://openalex.org/keywords/human-chondrocytes","display_name":"human chondrocytes","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.7789999842643738},{"id":"https://openalex.org/keywords/hemiarthroplasty","display_name":"hemiarthroplasty","score":0.8740000128746033},{"id":"https://openalex.org/keywords/unicompartmental-knee-arthroplasty","display_name":"unicompartmental knee arthroplasty","score":0.9959999918937683},{"id":"https://openalex.org/keywords/knee-joint","display_name":"knee joint","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2779637338","wikidata":"https://www.wikidata.org/wiki/Q418666","display_name":"Tranexamic acid","level":3,"score":0.8113225698471069},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7702552676200867},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6506363749504089},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.41972553730010986},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3608419895172119},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3347296118736267},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2140892744064331},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14961424469947815},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14020872116088867},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13252893090248108},{"id":"https://openalex.org/C2991743468","wikidata":"https://www.wikidata.org/wiki/Q166019","display_name":"Blood loss","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jor.2019.12.008","doi":"https://doi.org/10.1016/j.jor.2019.12.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jor.2019.12.008","pdf_url":null,"source":{"id":"https://openalex.org/S2764834445","display_name":"Journal of Orthopaedics","issn_l":"0972-978X","issn":["0972-978X","2589-9082"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedics","raw_type":"journal-article"},{"id":"pmid:32021047","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32021047","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6994788","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6994788/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Orthop","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6994788","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6994788/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Orthop","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1841792193","https://openalex.org/W1903132268","https://openalex.org/W1940864944","https://openalex.org/W2052300945","https://openalex.org/W2086028994","https://openalex.org/W2090906057","https://openalex.org/W2101320065","https://openalex.org/W2129128511","https://openalex.org/W2167084145","https://openalex.org/W2332665646","https://openalex.org/W2365289258","https://openalex.org/W2406579921","https://openalex.org/W2510275732","https://openalex.org/W2535621537","https://openalex.org/W2583814326","https://openalex.org/W2621421374","https://openalex.org/W2766088603","https://openalex.org/W2767587106","https://openalex.org/W2794041149","https://openalex.org/W2911010072","https://openalex.org/W2936329974","https://openalex.org/W4247907436"],"related_works":["https://openalex.org/W2794041149","https://openalex.org/W7066109214","https://openalex.org/W2406579921","https://openalex.org/W3081615362","https://openalex.org/W2936329974","https://openalex.org/W7123675791","https://openalex.org/W4386498899","https://openalex.org/W4280543929","https://openalex.org/W4389078059","https://openalex.org/W2583814326"],"abstract_inverted_index":{"The":[0,57],"aim":[1],"of":[2,10,17,72,76],"this":[3],"study":[4],"was":[5,22,37],"to":[6,39],"examine":[7],"toxic":[8],"effects":[9],"tranexamic":[11],"acid":[12],"(TXA)":[13],"on":[14],"the":[15,70,77],"viability":[16],"human":[18,26,33,63],"chondrocytes.":[19,27],"Our":[20],"hypothesis":[21],"that":[23,60],"TXA":[24,36,61,73],"damages":[25,62],"Chondrocytes":[28],"were":[29,43],"cultured":[30],"from":[31],"donated":[32],"knee":[34,81],"joints.":[35],"added":[38],"these":[40],"cultures.":[41],"Toxicity":[42],"analyzed":[44],"by":[45],"using":[46],"LDH":[47],"und":[48],"XTT":[49],"Elisa":[50],"assays,":[51],"light":[52],"microscopy":[53],"and":[54],"fluorescence":[55],"microscopy.":[56],"results":[58],"show":[59],"chondrocytes":[64],"in":[65,74,83],"vitro.":[66],"We":[67],"cannot":[68],"recommend":[69],"use":[71],"hemiarthroplasty":[75],"hip":[78],"or":[79],"unicompartmental":[80],"arthroplasty":[82],"higher":[84],"concentrations.":[85]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-26T00:00:00"}
