{"id":"https://openalex.org/W2994872689","doi":"https://doi.org/10.3390/ijms21010062","title":"Folic Acid Decreases Astrocyte Apoptosis by Preventing Oxidative Stress-Induced Telomere Attrition","display_name":"Folic Acid Decreases Astrocyte Apoptosis by Preventing Oxidative Stress-Induced Telomere Attrition","publication_year":2019,"publication_date":"2019-12-20","ids":{"openalex":"https://openalex.org/W2994872689","doi":"https://doi.org/10.3390/ijms21010062","mag":"2994872689","pmid":"https://pubmed.ncbi.nlm.nih.gov/31861819","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6981374"},"language":"en","primary_location":{"id":"doi:10.3390/ijms21010062","doi":"https://doi.org/10.3390/ijms21010062","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms21010062","pdf_url":"https://www.mdpi.com/1422-0067/21/1/62/pdf?version=1576832833","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/21/1/62/pdf?version=1576832833","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100320246","display_name":"Wen Li","orcid":"https://orcid.org/0009-0008-3930-6302","observed_orcids":["https://orcid.org/0009-0008-3930-6302"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Li","raw_affiliation_strings":["Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin 300070, China","Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China","Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin 300070, China","institution_ids":[]},{"raw_affiliation_string":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046042187","display_name":"Yue Ma","orcid":"https://orcid.org/0000-0002-1980-7520","observed_orcids":["https://orcid.org/0000-0002-1980-7520"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Ma","raw_affiliation_strings":["Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008280331","display_name":"Zhenshu Li","orcid":"https://orcid.org/0000-0002-0117-653X","observed_orcids":["https://orcid.org/0000-0002-0117-653X","https://orcid.org/0009-0005-2575-5412"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenshu Li","raw_affiliation_strings":["Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072529549","display_name":"Xin Lv","orcid":"https://orcid.org/0000-0001-7033-7328","observed_orcids":["https://orcid.org/0000-0001-7033-7328"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Lv","raw_affiliation_strings":["Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104652186","display_name":"Xinyan Wang","orcid":"https://orcid.org/0000-0002-0665-2750","observed_orcids":["https://orcid.org/0000-0002-0665-2750"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyan Wang","raw_affiliation_strings":["Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030818917","display_name":"Dezheng Zhou","orcid":"https://orcid.org/0000-0002-0425-6965","observed_orcids":["https://orcid.org/0000-0002-0425-6965"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dezheng Zhou","raw_affiliation_strings":["Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088149597","display_name":"Suhui Luo","orcid":"https://orcid.org/0000-0001-8396-323X","observed_orcids":["https://orcid.org/0000-0001-8396-323X"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suhui Luo","raw_affiliation_strings":["Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin 300070, China","Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China","Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin 300070, China","institution_ids":[]},{"raw_affiliation_string":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051332838","display_name":"John Xavier Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John X. Wilson","raw_affiliation_strings":["Department of Exercise and Nutrition Sciences, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14214-8028, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise and Nutrition Sciences, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14214-8028, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103059565","display_name":"Guowei Huang","orcid":"https://orcid.org/0000-0002-0664-403X","observed_orcids":["https://orcid.org/0000-0002-0664-403X","https://orcid.org/0000-0002-0346-6303"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guowei Huang","raw_affiliation_strings":["Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin 300070, China","Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China","Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China"],"raw_orcid":"https://orcid.org/0000-0002-0664-403X","affiliations":[{"raw_affiliation_string":"Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin 300070, China","institution_ids":[]},{"raw_affiliation_string":"Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin 300070, China","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103059565"],"corresponding_institution_ids":["https://openalex.org/I5740404"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1824},"fwci":3.5998,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.93426067,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"21","issue":"1","first_page":"62","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":1.0},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8220000267028809},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8389999866485596},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.9959999918937683},{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.8920000195503235},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.9049999713897705},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9919999837875366},{"id":"https://openalex.org/keywords/folate-deficiency","display_name":"folate deficiency","score":0.9459999799728394},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.8220275044441223},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8199245929718018},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7132026553153992},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.5439566969871521},{"id":"https://openalex.org/C2780553607","wikidata":"https://www.wikidata.org/wiki/Q684868","display_name":"Attrition","level":2,"score":0.482781320810318},{"id":"https://openalex.org/C2992130864","wikidata":"https://www.wikidata.org/wiki/Q127060","display_name":"Folic acid","level":2,"score":0.4707682132720947},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45780205726623535},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44123563170433044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3445287346839905},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29273903369903564},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2619103193283081},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2065512239933014},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16952303051948547},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.13981711864471436},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.0},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014803","descriptor_name":"Vitamin B Complex","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms21010062","doi":"https://doi.org/10.3390/ijms21010062","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms21010062","pdf_url":"https://www.mdpi.com/1422-0067/21/1/62/pdf?version=1576832833","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5953458","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6981374","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6981374","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6981374","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:31861819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31861819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms21010062","doi":"https://doi.org/10.3390/ijms21010062","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ijms21010062","pdf_url":"https://www.mdpi.com/1422-0067/21/1/62/pdf?version=1576832833","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G128855036","display_name":null,"funder_award_id":"81602849","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G22045536","display_name":"\u57fa\u4e8e\u7aef\u7c92\u53f6\u9178\u5bf9\u795e\u7ecf\u7ec6\u80de\u51cb\u4ea1\u53ca\u5ef6\u7f13\u8001\u5e74\u4eba\u8ba4\u77e5\u51cf\u9000\u7684\u4f5c\u7528\u53ca\u673a\u5236\u7814\u7a76","funder_award_id":"81730091","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6738043051","display_name":null,"funder_award_id":"2017QNRC001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8868019885","display_name":null,"funder_award_id":"19JCQNJC11700","funder_id":"https://openalex.org/F4320323993","funder_display_name":"Natural Science Foundation of Tianjin City"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323993","display_name":"Natural Science Foundation of Tianjin City","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2994872689.pdf","grobid_xml":"https://content.openalex.org/works/W2994872689.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1813361552","https://openalex.org/W1967318479","https://openalex.org/W1996983517","https://openalex.org/W2009357228","https://openalex.org/W2018615256","https://openalex.org/W2026761826","https://openalex.org/W2043223000","https://openalex.org/W2043951267","https://openalex.org/W2076945218","https://openalex.org/W2089657261","https://openalex.org/W2125339708","https://openalex.org/W2177939130","https://openalex.org/W2203006631","https://openalex.org/W2206099919","https://openalex.org/W2295075830","https://openalex.org/W2327617960","https://openalex.org/W2439976878","https://openalex.org/W2464372340","https://openalex.org/W2529677616","https://openalex.org/W2551729681","https://openalex.org/W2560024581","https://openalex.org/W2596498307","https://openalex.org/W2747964283","https://openalex.org/W2767087329","https://openalex.org/W2771633394","https://openalex.org/W2777245553","https://openalex.org/W2795121593","https://openalex.org/W2804159257","https://openalex.org/W2885026421","https://openalex.org/W2900987624","https://openalex.org/W2902170211","https://openalex.org/W2903528140","https://openalex.org/W2907531390","https://openalex.org/W2912326177","https://openalex.org/W2919044883","https://openalex.org/W2919734852","https://openalex.org/W2946740283"],"related_works":["https://openalex.org/W3190831292","https://openalex.org/W3180434743","https://openalex.org/W2110588833","https://openalex.org/W4381804800","https://openalex.org/W1970761373","https://openalex.org/W2986343991","https://openalex.org/W2144224011","https://openalex.org/W1985256504","https://openalex.org/W2043223000","https://openalex.org/W2352948433"],"abstract_inverted_index":{"Astrocytes":[0],"are":[1],"the":[2,8,19,28,32],"most":[3],"widely":[4],"distributed":[5],"cells":[6],"in":[7,18,168],"brain,":[9],"and":[10,103,120,134,146,160,185,192],"astrocyte":[11,39,57],"apoptosis":[12,40,58,167],"may":[13,177],"play":[14],"an":[15],"important":[16],"role":[17],"pathogenesis":[20],"of":[21,31,54,67,77],"neurodegenerative":[22],"diseases.":[23],"Folate":[24],"is":[25,41],"required":[26],"for":[27,71,173],"normal":[29],"development":[30],"nervous":[33],"system,":[34],"but":[35,149],"its":[36],"effect":[37,176],"on":[38],"unclear.":[42],"In":[43,136,162],"this":[44,174],"study,":[45],"we":[46],"hypothesized":[47],"that":[48,111,179],"folic":[49,78,112,138,164,180],"acid":[50,79,113,139,165,181],"(the":[51],"therapeutic":[52],"form":[53],"folate)":[55],"decreases":[56],"by":[59],"preventing":[60],"oxidative":[61,101,132,158,183,190],"stress-induced":[62],"telomere":[63,104,121,147,193],"attrition.":[64,194],"Primary":[65],"cultures":[66],"astrocytes":[68],"were":[69,106],"incubated":[70],"12":[72],"days":[73],"with":[74],"various":[75],"concentrations":[76],"(0-40":[80],"\u03bcmol/L),":[81],"then":[82],"cell":[83,118,144],"proliferation,":[84,119,145],"apoptosis,":[85],"intracellular":[86,89,93,116,142],"folate":[87],"concentration,":[88,92,127,153],"homocysteine":[90],"(Hcy)":[91],"reactive":[94],"oxygen":[95],"species":[96],"(ROS)":[97],"levels,":[98,129,155],"telomeric":[99,130,156,188],"DNA":[100,131,157,189],"damage,":[102,133,159],"length":[105,148],"determined.":[107],"The":[108,170],"results":[109],"showed":[110],"deficiency":[114],"decreased":[115,151,182],"folate,":[117,143],"length,":[122],"whereas":[123],"it":[124,150],"increased":[125,141],"Hcy":[126,152],"ROS":[128,154],"apoptosis.":[135,161],"contrast,":[137],"dose-dependently":[140],"conclusion,":[163],"inhibited":[166],"astrocytes.":[169],"underlying":[171],"mechanism":[172],"protective":[175],"be":[178],"stress":[184],"thereby":[186],"prevented":[187],"damage":[191]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-26T00:00:00"}