{"id":"https://openalex.org/W2994845901","doi":"https://doi.org/10.1177/0004867419894067","title":"Lithium vs valproate in the maintenance treatment of bipolar I disorder: A post- hoc analysis of a randomized double-blind placebo-controlled trial","display_name":"Lithium vs valproate in the maintenance treatment of bipolar I disorder: A post- hoc analysis of a randomized double-blind placebo-controlled trial","publication_year":2019,"publication_date":"2019-12-17","ids":{"openalex":"https://openalex.org/W2994845901","doi":"https://doi.org/10.1177/0004867419894067","mag":"2994845901","pmid":"https://pubmed.ncbi.nlm.nih.gov/31845587"},"language":"en","primary_location":{"id":"doi:10.1177/0004867419894067","doi":"https://doi.org/10.1177/0004867419894067","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0004867419894067","pdf_url":null,"source":{"id":"https://openalex.org/S179943861","display_name":"Australian & New Zealand Journal of Psychiatry","issn_l":"0004-8674","issn":["0004-8674","1440-1614"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Australian & New Zealand Journal of Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010147631","display_name":"Mehar G Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mehar G Kang","raw_affiliation_strings":["School of Medicine, Queen\u2019s University, Kingston, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Queen\u2019s University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100772064","display_name":"Hong Qian","orcid":"https://orcid.org/0000-0003-1455-1893","observed_orcids":["https://orcid.org/0000-0003-1455-1893"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hong Qian","raw_affiliation_strings":["Centre for Health Evaluation & Outcome Sciences, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Health Evaluation & Outcome Sciences, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013753892","display_name":"Kamyar Keramatian","orcid":"https://orcid.org/0000-0003-4958-6025","observed_orcids":["https://orcid.org/0000-0003-4958-6025"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kamyar Keramatian","raw_affiliation_strings":["Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070814968","display_name":"Trisha Chakrabarty","orcid":"https://orcid.org/0000-0002-2262-8697","observed_orcids":["https://orcid.org/0000-0002-2262-8697"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Trisha Chakrabarty","raw_affiliation_strings":["Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003813624","display_name":"Gayatri Saraf","orcid":"https://orcid.org/0000-0002-9767-2270","observed_orcids":["https://orcid.org/0000-0002-9767-2270"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gayatri Saraf","raw_affiliation_strings":["Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090658899","display_name":"Raymond Wing Moon Lam","orcid":"https://orcid.org/0000-0001-7142-4669","observed_orcids":["https://orcid.org/0000-0001-7142-4669"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Raymond W Lam","raw_affiliation_strings":["Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023506411","display_name":"Hubert Wong","orcid":"https://orcid.org/0000-0001-8840-4509","observed_orcids":["https://orcid.org/0000-0001-8840-4509"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hubert Wong","raw_affiliation_strings":["School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035147009","display_name":"Lakshmi N. Yatham","orcid":"https://orcid.org/0000-0002-7405-0954","observed_orcids":["https://orcid.org/0000-0002-7405-0954"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Lakshmi N Yatham","raw_affiliation_strings":["Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":"https://orcid.org/0000-0002-7405-0954","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035147009"],"corresponding_institution_ids":["https://openalex.org/I141945490"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":1.4509,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.79043789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"54","issue":"3","first_page":"298","last_page":"307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bipolar-i-disorder","display_name":"bipolar I disorder","score":0.8529999852180481},{"id":"https://openalex.org/keywords/lithium","display_name":"lithium","score":0.9629999995231628},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":1.0},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.7239999771118164},{"id":"https://openalex.org/keywords/mood-stabilizers","display_name":"mood stabilizers","score":0.7519999742507935},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.9649999737739563},{"id":"https://openalex.org/keywords/adjunctive-antipsychotic-therapy","display_name":"adjunctive antipsychotic therapy","score":0.8550000190734863},{"id":"https://openalex.org/keywords/depression-prevention","display_name":"depression prevention","score":0.7440000176429749},{"id":"https://openalex.org/keywords/monotherapy","display_name":"monotherapy","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2776809841","wikidata":"https://www.wikidata.org/wiki/Q185935","display_name":"Mania","level":4,"score":0.7287707328796387},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6908062100410461},{"id":"https://openalex.org/C2780550438","wikidata":"https://www.wikidata.org/wiki/Q2622367","display_name":"Mood stabilizer","level":4,"score":0.6536213159561157},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.5771262645721436},{"id":"https://openalex.org/C2776921671","wikidata":"https://www.wikidata.org/wiki/Q758295","display_name":"Atypical antipsychotic","level":4,"score":0.5760475993156433},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.5663553476333618},{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.5504117012023926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5269073843955994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5140015482902527},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5114337801933289},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.48065245151519775},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.459231972694397},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.44450095295906067},{"id":"https://openalex.org/C2780634440","wikidata":"https://www.wikidata.org/wiki/Q408535","display_name":"Quetiapine","level":3,"score":0.41950350999832153},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.41481322050094604},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.18426185846328735},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002170","descriptor_name":"Canada","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018020","descriptor_name":"Lithium Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018692","descriptor_name":"Antimanic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055502","descriptor_name":"Secondary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/0004867419894067","doi":"https://doi.org/10.1177/0004867419894067","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0004867419894067","pdf_url":null,"source":{"id":"https://openalex.org/S179943861","display_name":"Australian & New Zealand Journal of Psychiatry","issn_l":"0004-8674","issn":["0004-8674","1440-1614"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Australian & New Zealand Journal of Psychiatry","raw_type":"journal-article"},{"id":"pmid:31845587","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31845587","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Australian and New Zealand journal of psychiatry","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320338069","display_name":"Institute of Neurosciences, Mental Health and Addiction","ror":"https://ror.org/043tfr230"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1980863823","https://openalex.org/W1984344128","https://openalex.org/W1994114163","https://openalex.org/W2012476442","https://openalex.org/W2030034545","https://openalex.org/W2041184765","https://openalex.org/W2094421505","https://openalex.org/W2096353016","https://openalex.org/W2107363582","https://openalex.org/W2114613490","https://openalex.org/W2119895840","https://openalex.org/W2121552371","https://openalex.org/W2124044664","https://openalex.org/W2128264233","https://openalex.org/W2130040176","https://openalex.org/W2136125265","https://openalex.org/W2158010896","https://openalex.org/W2163640551","https://openalex.org/W2166079129","https://openalex.org/W2167659819","https://openalex.org/W2213525431","https://openalex.org/W2730406007","https://openalex.org/W2792027821","https://openalex.org/W2792245820"],"related_works":["https://openalex.org/W2017951033","https://openalex.org/W2053505895","https://openalex.org/W1583228078","https://openalex.org/W4231774701","https://openalex.org/W2010520341","https://openalex.org/W2003524716","https://openalex.org/W2476726472","https://openalex.org/W2950242224","https://openalex.org/W2163640551","https://openalex.org/W7213918518"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Lithium":[1],"and":[2,40,84,113,211],"valproate":[3,39,83,112,140],"are":[4,234],"commonly":[5],"used":[6,199],"either":[7,45],"in":[8,11,16,46,49,107,123,142,168,191,203,225],"monotherapy":[9,47,141,167,201],"or":[10,48,82,100,202],"combination":[12,50,204],"with":[13,51,74,80,130,157,205,231],"atypical":[14,52,86,95,134,161,206],"antipsychotics":[15],"maintenance":[17,238],"treatment":[18,79],"of":[19,38,133,160],"bipolar":[20],"I":[21],"disorder;":[22],"however,":[23],"their":[24],"comparative":[25],"efficacy":[26,37,108,192,226],"is":[27],"not":[28,180,187],"well":[29],"understood.":[30],"This":[31],"study":[32,185,209],"aimed":[33],"to":[34,92,125,139,165,236],"compare":[35],"the":[36,194],"lithium":[41,81,114,156,166],"on":[42],"mood":[43,127,145],"stability":[44],"antipsychotics.":[53,207],"METHODS:":[54],"We":[55],"performed":[56],"a":[57,64],"post":[58],"hoc":[59],"analysis":[60],"using":[61],"data":[62],"from":[63,218],"52-week":[65],"randomized":[66,91],"double-blind,":[67],"placebo-controlled":[68],"trial,":[69],"that":[70],"recruited":[71],"159":[72],"patients":[73],"recently":[75],"remitted":[76],"mania":[77,170],"during":[78],"adjunctive":[85,94],"antipsychotic":[87,96,135,162],"therapy.":[88],"Patients":[89],"were":[90,109],"discontinue":[93],"at":[97],"0,":[98],"24":[99,131,158],"52":[101],"weeks.":[102],"RESULTS:":[103],"No":[104],"significant":[105,189],"differences":[106,190],"observed":[110],"between":[111,193],"(hazard":[115,147,171],"ratio:":[116,148,172],"0.99;":[117],"95%":[118,150,174],"confidence":[119,151,175],"interval:":[120,152,176],"[0.66,":[121],"1.48])":[122],"time":[124],"any":[126,144],"event.":[128],"Valproate":[129],"weeks":[132,159],"was":[136,163],"significantly":[137],"superior":[138,164],"preventing":[143,169],"relapse":[146],"0.46;":[149],"[0.22,":[153],"0.97])":[154],"while":[155],"0.27;":[173],"[0.09,":[177],"0.85])":[178],"but":[179],"depression.":[181],"CONCLUSION:":[182],"Overall,":[183],"this":[184],"did":[186],"find":[188],"two":[195],"mood-stabilizing":[196],"agents":[197],"when":[198],"as":[200],"However,":[208],"design":[210],"small":[212],"sample":[213],"size":[214],"might":[215],"have":[216],"precluded":[217],"detecting":[219],"an":[220],"effect":[221],"if":[222],"true":[223],"difference":[224],"existed.":[227],"Further":[228],"head-to-head":[229],"investigations":[230],"stratified":[232],"designs":[233],"needed":[235],"evaluate":[237],"therapies.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-26T00:00:00"}