{"id":"https://openalex.org/W2994816474","doi":"https://doi.org/10.1038/s41598-019-55371-9","title":"Pannexin 3 ER Ca2+ channel gating is regulated by phosphorylation at the Serine 68 residue in osteoblast differentiation","display_name":"Pannexin 3 ER Ca2+ channel gating is regulated by phosphorylation at the Serine 68 residue in osteoblast differentiation","publication_year":2019,"publication_date":"2019-12-10","ids":{"openalex":"https://openalex.org/W2994816474","doi":"https://doi.org/10.1038/s41598-019-55371-9","mag":"2994816474","pmid":"https://pubmed.ncbi.nlm.nih.gov/31822768","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6904572"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-019-55371-9","doi":"https://doi.org/10.1038/s41598-019-55371-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-55371-9","pdf_url":"https://www.nature.com/articles/s41598-019-55371-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-019-55371-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054682806","display_name":"Masaki Ishikawa","orcid":"https://orcid.org/0000-0003-3276-9474","observed_orcids":["https://orcid.org/0000-0003-3276-9474"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masaki Ishikawa","raw_affiliation_strings":["Department of Pediatric Dentistry, Tohoku University Graduate School of Dentistry, Sendai, 980-8576, Japan","Operative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan. ishikawamas@dent.tohoku.ac.jp","Operative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Dentistry, Tohoku University Graduate School of Dentistry, Sendai, 980-8576, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Operative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan. ishikawamas@dent.tohoku.ac.jp","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Operative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143833406","display_name":"Geneva Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geneva Williams","raw_affiliation_strings":["Molecular Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Philadelphia, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075804905","display_name":"Patricia Forcinito","orcid":"https://orcid.org/0000-0001-9754-9881","observed_orcids":["https://orcid.org/0000-0001-9754-9881"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Forcinito","raw_affiliation_strings":["Molecular Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Philadelphia, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100881514","display_name":"Momoko Ishikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Momoko Ishikawa","raw_affiliation_strings":["Department of Pediatric Dentistry, Tohoku University Graduate School of Dentistry, Sendai, 980-8576, Japan","Operative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan. ishikawamas@dent.tohoku.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Dentistry, Tohoku University Graduate School of Dentistry, Sendai, 980-8576, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Operative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan. ishikawamas@dent.tohoku.ac.jp","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061680685","display_name":"Ryan J. Petrie","orcid":"https://orcid.org/0000-0001-9780-4969","observed_orcids":["https://orcid.org/0000-0001-9780-4969"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan J. Petrie","raw_affiliation_strings":["Department of Biology, Drexel University, Philadelphia, PA, 19104, USA"],"raw_orcid":"https://orcid.org/0000-0001-9780-4969","affiliations":[{"raw_affiliation_string":"Department of Biology, Drexel University, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022379915","display_name":"Kan Saito","orcid":"https://orcid.org/0000-0002-2151-6204","observed_orcids":["https://orcid.org/0000-0002-2151-6204"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kan Saito","raw_affiliation_strings":["Department of Pediatric Dentistry, Tohoku University Graduate School of Dentistry, Sendai, 980-8576, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Dentistry, Tohoku University Graduate School of Dentistry, Sendai, 980-8576, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083569724","display_name":"Satoshi Fukumoto","orcid":"https://orcid.org/0000-0002-5046-6891","observed_orcids":["https://orcid.org/0000-0002-5046-6891"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Fukumoto","raw_affiliation_strings":["Department of Pediatric Dentistry, Tohoku University Graduate School of Dentistry, Sendai, 980-8576, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Dentistry, Tohoku University Graduate School of Dentistry, Sendai, 980-8576, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102398216","display_name":"Yoshihiko Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoshihiko Yamada","raw_affiliation_strings":["Molecular Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Philadelphia, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5054682806","https://openalex.org/A5100881514"],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":{"value":1790,"currency":"USD","value_usd":1790},"fwci":0.5788,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.62791199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"18759","last_page":"18759"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.2483000010251999,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.2483000010251999,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.21060000360012054,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.1665000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pannexin-3","display_name":"pannexin 3","score":0.9139999747276306},{"id":"https://openalex.org/keywords/panx3","display_name":"Panx3","score":0.7120000123977661},{"id":"https://openalex.org/keywords/channel-gating","display_name":"channel gating","score":0.8920000195503235},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8799999952316284},{"id":"https://openalex.org/keywords/atp","display_name":"ATP","score":0.5889999866485596},{"id":"https://openalex.org/keywords/osterix","display_name":"Osterix","score":0.9359999895095825},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9829999804496765},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.8109999895095825},{"id":"https://openalex.org/keywords/growth-plate","display_name":"growth plate","score":0.921999990940094},{"id":"https://openalex.org/keywords/c2c12-myoblasts","display_name":"C2C12 myoblasts","score":0.6980000138282776},{"id":"https://openalex.org/keywords/fret-microscopy","display_name":"FRET imaging","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7444700598716736},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.7203723192214966},{"id":"https://openalex.org/C127992366","wikidata":"https://www.wikidata.org/wiki/Q410332","display_name":"Pannexin","level":5,"score":0.6265219449996948},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6242836713790894},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.5902411937713623},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5569968819618225},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5229226350784302},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.4718501567840576},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23921775817871094},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.23849564790725708},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2342630922794342},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.18376806378364563},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.060636967420578},{"id":"https://openalex.org/C2780228694","wikidata":"https://www.wikidata.org/wiki/Q423489","display_name":"Connexin","level":4,"score":0.05215185880661011},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000076182","descriptor_name":"Sp7 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002413","descriptor_name":"Cations, Divalent","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-019-55371-9","doi":"https://doi.org/10.1038/s41598-019-55371-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-55371-9","pdf_url":"https://www.nature.com/articles/s41598-019-55371-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6904572","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6904572","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:31822768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31822768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e14a8df8dd96459289fba90afc698f76","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e14a8df8dd96459289fba90afc698f76","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-019-55371-9","doi":"https://doi.org/10.1038/s41598-019-55371-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-55371-9","pdf_url":"https://www.nature.com/articles/s41598-019-55371-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1363107111","display_name":null,"funder_award_id":"DE000483-24","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G1858986227","display_name":"Pannexin 3 provides bone marrow niche for B- and T cell differentiation.","funder_award_id":"19K22698","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2151830567","display_name":null,"funder_award_id":"DE000483-25","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G2383216761","display_name":null,"funder_award_id":"16H05514","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G2407514977","display_name":"Cartilage and Bone Development and Disease","funder_award_id":"ZIADE000483","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G5482965816","display_name":null,"funder_award_id":"LS010","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G5749857184","display_name":"The development of anti-inflammatory and regenerative medicine for periodontitis: application of Pannexin 3 signaling pathways.","funder_award_id":"16H05514","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6219142797","display_name":null,"funder_award_id":"DE000483-24","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G6454081989","display_name":"Regulation of epithelial polarization to regenerate tooth","funder_award_id":"26670880","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6858058510","display_name":null,"funder_award_id":"DE000483-26","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G7220699285","display_name":null,"funder_award_id":"26670880","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G7746244764","display_name":null,"funder_award_id":"DE000483-25","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G8162053085","display_name":null,"funder_award_id":"LS010","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8459306770","display_name":null,"funder_award_id":"DE000483-26","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G8896986005","display_name":"Cartilage Development and Disease","funder_award_id":"Z01DE000483","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2994816474.pdf","grobid_xml":"https://content.openalex.org/works/W2994816474.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1599277155","https://openalex.org/W1834171181","https://openalex.org/W1982322107","https://openalex.org/W1988978438","https://openalex.org/W1990564843","https://openalex.org/W1995117011","https://openalex.org/W2005784286","https://openalex.org/W2016665408","https://openalex.org/W2017612052","https://openalex.org/W2019015469","https://openalex.org/W2020435230","https://openalex.org/W2022023926","https://openalex.org/W2031422633","https://openalex.org/W2036553406","https://openalex.org/W2037755817","https://openalex.org/W2042259903","https://openalex.org/W2043794217","https://openalex.org/W2045201777","https://openalex.org/W2047960556","https://openalex.org/W2048537844","https://openalex.org/W2064315055","https://openalex.org/W2068487087","https://openalex.org/W2069466450","https://openalex.org/W2072542349","https://openalex.org/W2075086629","https://openalex.org/W2085082795","https://openalex.org/W2085474187","https://openalex.org/W2085780740","https://openalex.org/W2104285627","https://openalex.org/W2104357869","https://openalex.org/W2106427960","https://openalex.org/W2115836236","https://openalex.org/W2118108909","https://openalex.org/W2121299956","https://openalex.org/W2125951597","https://openalex.org/W2127114287","https://openalex.org/W2131426434","https://openalex.org/W2134454787","https://openalex.org/W2137283585","https://openalex.org/W2137563421","https://openalex.org/W2138977093","https://openalex.org/W2148785089","https://openalex.org/W2149352571","https://openalex.org/W2151966001","https://openalex.org/W2152266406","https://openalex.org/W2156090275","https://openalex.org/W2163056759","https://openalex.org/W2170704593","https://openalex.org/W2171863507","https://openalex.org/W2255891477","https://openalex.org/W2323286511","https://openalex.org/W2336045548","https://openalex.org/W2343938601","https://openalex.org/W2552793361","https://openalex.org/W2612496804"],"related_works":["https://openalex.org/W4245917097","https://openalex.org/W4390653572","https://openalex.org/W3178589820","https://openalex.org/W7213928420","https://openalex.org/W2047960556","https://openalex.org/W2042837372","https://openalex.org/W2951150642","https://openalex.org/W2607908162","https://openalex.org/W2424297402","https://openalex.org/W6927158779"],"abstract_inverted_index":{"Abstract":[0],"Pannexin":[1],"3":[2],"(Panx3)":[3],"is":[4,44,165],"a":[5,87],"regulator":[6],"of":[7,29,48,67,81,103,161,172],"bone":[8,101],"formation.":[9],"Panx3":[10,31,40,93,125,132,151,162,174],"forms":[11],"three":[12],"distinct":[13],"functional":[14],"channels:":[15],"hemichannels,":[16],"gap":[17],"junctions,":[18],"and":[19,83,100,138,145],"endoplasmic":[20],"reticulum":[21],"(ER)":[22],"Ca2+":[23,42,127,176],"channels.":[24],"However,":[25],"the":[26,30,39,49,59,65,104,116,120,150,159,170,173],"gating":[27,171],"mechanisms":[28],"channels":[32],"remain":[33],"unclear.":[34],"Here,":[35],"we":[36],"show":[37],"that":[38,149],"ER":[41,117,126,175],"channel":[43,128,152,177],"modulated":[45],"by":[46,135],"phosphorylation":[47,62,160],"serine":[50],"68":[51],"residue":[52],"(Ser68)":[53],"to":[54,69,74,156,178],"promote":[55,179],"osteoblast":[56,77],"differentiation.":[57],"Among":[58],"17":[60],"candidate":[61],"sites":[63],"identified,":[64],"mutation":[66,122],"Ser68":[68,88,130,164],"Ala":[70],"(Ser68Ala)":[71],"was":[72,94,113,133,154],"sufficient":[73],"inhibit":[75],"Panx3-mediated":[76],"differentiation":[78],"via":[79],"reduction":[80],"Osterix":[82],"ALP":[84],"expression.":[85],"Using":[86],"phospho-specific":[89],"antibody":[90],"(P-Panx3)":[91],"revealed":[92,148],"phosphorylated":[95,134],"in":[96],"prehypertrophic,":[97],"hypertrophic":[98],"chondrocytes,":[99],"areas":[102],"newborn":[105],"growth":[106],"plate.":[107],"In":[108],"osteogenic":[109],"C2C12":[110],"cells,":[111],"P-Panx3":[112],"located":[114],"on":[115,131],"membranes.":[118],"Importantly,":[119],"Ser68Ala":[121],"only":[123],"affected":[124],"function.":[129],"ATP":[136],"stimulation":[137],"PI3K/Akt":[139],"signaling.":[140],"Finally,":[141],"real-time":[142],"FRET":[143],"imaging":[144],"ratio":[146],"analysis":[147],"conformation":[153],"sensitive":[155],"ATP.":[157],"Together,":[158],"at":[163],"an":[166],"essential":[167],"step":[168],"controlling":[169],"osteogenesis.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-26T00:00:00"}
