{"id":"https://openalex.org/W2994797288","doi":"https://doi.org/10.3390/antiox9010016","title":"Piceatannol Increases Antioxidant Defense and Reduces Cell Death in Human Periodontal Ligament Fibroblast under Oxidative Stress","display_name":"Piceatannol Increases Antioxidant Defense and Reduces Cell Death in Human Periodontal Ligament Fibroblast under Oxidative Stress","publication_year":2019,"publication_date":"2019-12-23","ids":{"openalex":"https://openalex.org/W2994797288","doi":"https://doi.org/10.3390/antiox9010016","mag":"2994797288","pmid":"https://pubmed.ncbi.nlm.nih.gov/31878036","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7023480"},"language":"en","primary_location":{"id":"doi:10.3390/antiox9010016","doi":"https://doi.org/10.3390/antiox9010016","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/antiox9010016","pdf_url":"https://www.mdpi.com/2076-3921/9/1/16/pdf?version=1577102000","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-3921/9/1/16/pdf?version=1577102000","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030711946","display_name":"Fl\u00e1via P\u00f3voa da Costa","orcid":"https://orcid.org/0000-0002-5667-0754","observed_orcids":["https://orcid.org/0000-0002-5667-0754"]},"institutions":[{"id":"https://openalex.org/I4210144600","display_name":"Instituto Evandro Chagas","ror":"https://ror.org/04xk4hz96","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210144600"]},{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fl\u00e1via P\u00f3voa da Costa","raw_affiliation_strings":["Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Par\u00e1 (UFPA), Bel\u00e9m-Par\u00e1 66075-110, Brazil","Laboratory of Tissue Culture and Cytogenetics, Environment Section, Evandro Chagas Institute, Ananindeua-Par\u00e1 67030-000, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-5667-0754","affiliations":[{"raw_affiliation_string":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Par\u00e1 (UFPA), Bel\u00e9m-Par\u00e1 66075-110, Brazil","institution_ids":["https://openalex.org/I59606676"]},{"raw_affiliation_string":"Laboratory of Tissue Culture and Cytogenetics, Environment Section, Evandro Chagas Institute, Ananindeua-Par\u00e1 67030-000, Brazil","institution_ids":["https://openalex.org/I4210144600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087317683","display_name":"Bruna Puty","orcid":"https://orcid.org/0000-0001-5570-8530","observed_orcids":["https://orcid.org/0000-0001-5570-8530"]},"institutions":[{"id":"https://openalex.org/I4210144600","display_name":"Instituto Evandro Chagas","ror":"https://ror.org/04xk4hz96","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210144600"]},{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bruna Puty","raw_affiliation_strings":["Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Par\u00e1 (UFPA), Bel\u00e9m-Par\u00e1 66075-110, Brazil","Laboratory of Tissue Culture and Cytogenetics, Environment Section, Evandro Chagas Institute, Ananindeua-Par\u00e1 67030-000, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-5570-8530","affiliations":[{"raw_affiliation_string":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Par\u00e1 (UFPA), Bel\u00e9m-Par\u00e1 66075-110, Brazil","institution_ids":["https://openalex.org/I59606676"]},{"raw_affiliation_string":"Laboratory of Tissue Culture and Cytogenetics, Environment Section, Evandro Chagas Institute, Ananindeua-Par\u00e1 67030-000, Brazil","institution_ids":["https://openalex.org/I4210144600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028454377","display_name":"Lygia Sega Nogueira","orcid":"https://orcid.org/0000-0002-9464-3490","observed_orcids":["https://orcid.org/0000-0002-9464-3490"]},"institutions":[{"id":"https://openalex.org/I4210144600","display_name":"Instituto Evandro Chagas","ror":"https://ror.org/04xk4hz96","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210144600"]},{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lygia S. Nogueira","raw_affiliation_strings":["Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Par\u00e1 (UFPA), Bel\u00e9m-Par\u00e1 66075-110, Brazil","Laboratory of Tissue Culture and Cytogenetics, Environment Section, Evandro Chagas Institute, Ananindeua-Par\u00e1 67030-000, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-9464-3490","affiliations":[{"raw_affiliation_string":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Par\u00e1 (UFPA), Bel\u00e9m-Par\u00e1 66075-110, Brazil","institution_ids":["https://openalex.org/I59606676"]},{"raw_affiliation_string":"Laboratory of Tissue Culture and Cytogenetics, Environment Section, Evandro Chagas Institute, Ananindeua-Par\u00e1 67030-000, Brazil","institution_ids":["https://openalex.org/I4210144600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027110038","display_name":"Geovanni Pereira Mitre","orcid":"https://orcid.org/0000-0001-7011-0457","observed_orcids":["https://orcid.org/0000-0001-7011-0457"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Geovanni Pereira Mitre","raw_affiliation_strings":["Laboratory of Cell Culture, Faculty of Dentistry, Federal University of Par\u00e1 (UFPA), Bel\u00e9m-Par\u00e1 66075-110, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Culture, Faculty of Dentistry, Federal University of Par\u00e1 (UFPA), Bel\u00e9m-Par\u00e1 66075-110, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052629716","display_name":"S\u00e1vio Monteiro dos Santos","orcid":"https://orcid.org/0000-0002-0927-9680","observed_orcids":["https://orcid.org/0000-0002-0927-9680"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"S\u00e1vio Monteiro dos Santos","raw_affiliation_strings":["Laboratory of Oxidative Stress and Clinical Immunology, Faculty of Pharmacy, Federal University of Par\u00e1 (UFPA), Bel\u00e9m-Par\u00e1 66075-110, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Oxidative Stress and Clinical Immunology, Faculty of Pharmacy, Federal University of Par\u00e1 (UFPA), Bel\u00e9m-Par\u00e1 66075-110, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062073158","display_name":"Bruno Jos\u00e9 Brito Teixeira","orcid":"https://orcid.org/0000-0002-6583-4917","observed_orcids":["https://orcid.org/0000-0002-6583-4917"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bruno Jos\u00e9 Brito Teixeira","raw_affiliation_strings":["Center for Valorization of Amazonian Bioactive Compounds (CVACBA) & Federal University of Par\u00e1 UFPA, Bel\u00e9m-Par\u00e1 66075-110, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-6583-4917","affiliations":[{"raw_affiliation_string":"Center for Valorization of Amazonian Bioactive Compounds (CVACBA) & Federal University of Par\u00e1 UFPA, Bel\u00e9m-Par\u00e1 66075-110, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091188059","display_name":"Maria Sueli da Silva Kataoka","orcid":"https://orcid.org/0000-0001-9650-1034","observed_orcids":["https://orcid.org/0000-0001-9650-1034"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Sueli da Silva Kataoka","raw_affiliation_strings":["Laboratory of Cell Culture, Faculty of Dentistry, Federal University of Par\u00e1 (UFPA), Bel\u00e9m-Par\u00e1 66075-110, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Culture, Faculty of Dentistry, Federal University of Par\u00e1 (UFPA), Bel\u00e9m-Par\u00e1 66075-110, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035417445","display_name":"Manoela Domingues Martins","orcid":"https://orcid.org/0000-0001-8662-5965","observed_orcids":["https://orcid.org/0000-0001-8662-5965"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Manoela Domingues Martins","raw_affiliation_strings":["Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre 91509-900, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre 91509-900, RS, Brazil","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007822416","display_name":"Carlos Augusto Galv\u00e3o Barboza","orcid":"https://orcid.org/0000-0003-1979-9919","observed_orcids":["https://orcid.org/0000-0003-1979-9919"]},"institutions":[{"id":"https://openalex.org/I35046152","display_name":"Universidade Federal do Rio Grande do Norte","ror":"https://ror.org/04wn09761","country_code":"BR","type":"education","lineage":["https://openalex.org/I35046152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carlos Augusto Galv\u00e3o Barboza","raw_affiliation_strings":["Department of Morphology, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil","institution_ids":["https://openalex.org/I35046152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034615093","display_name":"Marta Chagas Monteiro","orcid":"https://orcid.org/0000-0002-3328-5650","observed_orcids":["https://orcid.org/0000-0002-3328-5650"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marta Chagas Monteiro","raw_affiliation_strings":["Laboratory of Oxidative Stress and Clinical Immunology, Faculty of Pharmacy, Federal University of Par\u00e1 (UFPA), Bel\u00e9m-Par\u00e1 66075-110, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-3328-5650","affiliations":[{"raw_affiliation_string":"Laboratory of Oxidative Stress and Clinical Immunology, Faculty of Pharmacy, Federal University of Par\u00e1 (UFPA), Bel\u00e9m-Par\u00e1 66075-110, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047936976","display_name":"Herve Louis Ghislain Rogez","orcid":"https://orcid.org/0000-0001-8925-8881","observed_orcids":["https://orcid.org/0000-0001-8925-8881"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Rogez","raw_affiliation_strings":["Center for Valorization of Amazonian Bioactive Compounds (CVACBA) & Federal University of Par\u00e1 UFPA, Bel\u00e9m-Par\u00e1 66075-110, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-8925-8881","affiliations":[{"raw_affiliation_string":"Center for Valorization of Amazonian Bioactive Compounds (CVACBA) & Federal University of Par\u00e1 UFPA, Bel\u00e9m-Par\u00e1 66075-110, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045169393","display_name":"Edivaldo Herculano Corr\u00eaa de Oliveira","orcid":"https://orcid.org/0000-0001-6315-3352","observed_orcids":["https://orcid.org/0000-0001-6315-3352"]},"institutions":[{"id":"https://openalex.org/I4210144600","display_name":"Instituto Evandro Chagas","ror":"https://ror.org/04xk4hz96","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210144600"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Edivaldo Herculano Corr\u00eaa de Oliveira","raw_affiliation_strings":["Laboratory of Tissue Culture and Cytogenetics, Environment Section, Evandro Chagas Institute, Ananindeua-Par\u00e1 67030-000, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-6315-3352","affiliations":[{"raw_affiliation_string":"Laboratory of Tissue Culture and Cytogenetics, Environment Section, Evandro Chagas Institute, Ananindeua-Par\u00e1 67030-000, Brazil","institution_ids":["https://openalex.org/I4210144600"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018144501","display_name":"Rafael Rodrigues Lima","orcid":"https://orcid.org/0000-0003-1486-4013","observed_orcids":["https://orcid.org/0000-0003-1486-4013"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Rafael Rodrigues Lima","raw_affiliation_strings":["Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Par\u00e1 (UFPA), Bel\u00e9m-Par\u00e1 66075-110, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-1486-4013","affiliations":[{"raw_affiliation_string":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Par\u00e1 (UFPA), Bel\u00e9m-Par\u00e1 66075-110, Brazil","institution_ids":["https://openalex.org/I59606676"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5018144501"],"corresponding_institution_ids":["https://openalex.org/I59606676"],"apc_list":{"value":1200,"currency":"CHF","value_usd":1216},"apc_paid":{"value":1200,"currency":"CHF","value_usd":1216},"fwci":1.9582,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.82856263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"16","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.41019999980926514,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.41019999980926514,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.2224999964237213,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.20509999990463257,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piceatannol","display_name":"piceatannol","score":1.0},{"id":"https://openalex.org/keywords/resveratrol-metabolites","display_name":"resveratrol metabolites","score":0.9390000104904175},{"id":"https://openalex.org/keywords/periodontal-ligament-fibroblasts","display_name":"periodontal ligament fibroblasts","score":0.9279999732971191},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.996999979019165},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.6779999732971191},{"id":"https://openalex.org/keywords/antioxidant-capacity","display_name":"antioxidant capacity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.906000018119812},{"id":"https://openalex.org/keywords/mitochondrial-atp-synthesis","display_name":"mitochondrial ATP production","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.9049999713897705},{"id":"https://openalex.org/keywords/periodontal-disease","display_name":"periodontal disease","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C2779746291","wikidata":"https://www.wikidata.org/wiki/Q7190608","display_name":"Piceatannol","level":3,"score":0.9762084484100342},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8065662384033203},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.7678386569023132},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6034083962440491},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5879408121109009},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.5607532858848572},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5186649560928345},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.45471876859664917},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.434938907623291},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4058111011981964},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.38252025842666626},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3809420168399811},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3599686026573181},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2674608826637268}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.3390/antiox9010016","doi":"https://doi.org/10.3390/antiox9010016","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/antiox9010016","pdf_url":"https://www.mdpi.com/2076-3921/9/1/16/pdf?version=1577102000","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6009523","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7023480","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31878036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31878036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7023480","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7023480/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants (Basel)","raw_type":"Text"},{"id":"pmh:oai:www.lume.ufrgs.br:10183/206376","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/206376","pdf_url":"http://hdl.handle.net/10183/206376","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"instacron:UFRGS","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:2650022","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/206376","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UFRGS","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:aeba898332be43458d87c0848bba5a36","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/aeba898332be43458d87c0848bba5a36","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antioxidants, Vol 9, Iss 1, p 16 (2019)","raw_type":"article"},{"id":"pmh:oai:patua.iec.gov.br:iec/4061","doi":null,"is_oa":true,"landing_page_url":"https://patua.iec.gov.br/handle/iec/4061","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:IEC","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.3390/antiox9010016","doi":"https://doi.org/10.3390/antiox9010016","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/antiox9010016","pdf_url":"https://www.mdpi.com/2076-3921/9/1/16/pdf?version=1577102000","source":{"id":"https://openalex.org/S2737566431","display_name":"Antioxidants","issn_l":"2076-3921","issn":["2076-3921"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320323207","display_name":"Funda\u00e7\u00e3o Amaz\u00f4nia Paraense de Amparo \u00e0 Pesquisa","ror":"https://ror.org/00ssgrj25"},{"id":"https://openalex.org/F4320324376","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818"},{"id":"https://openalex.org/F4320329820","display_name":"Banco Nacional de Desenvolvimento Econ\u00f4mico e Social","ror":"https://ror.org/0145x2c32"},{"id":"https://openalex.org/F4320331038","display_name":"Fundo Amaz\u00f4nia","ror":null},{"id":"https://openalex.org/F4320334115","display_name":"Pr\u00f3-Reitoria de Pesquisa e P\u00f3s-Gradua\u00e7\u00e3o, Universidade Federal do Par\u00e1","ror":null},{"id":"https://openalex.org/F4320337368","display_name":"Division of Graduate Education","ror":"https://ror.org/00whkrf32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2994797288.pdf","grobid_xml":"https://content.openalex.org/works/W2994797288.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W783745786","https://openalex.org/W1518189745","https://openalex.org/W1945428372","https://openalex.org/W1967265302","https://openalex.org/W1977240135","https://openalex.org/W1978792599","https://openalex.org/W1990132468","https://openalex.org/W1991875535","https://openalex.org/W2001992152","https://openalex.org/W2012991711","https://openalex.org/W2013432042","https://openalex.org/W2027143587","https://openalex.org/W2030817463","https://openalex.org/W2039507504","https://openalex.org/W2045363495","https://openalex.org/W2045818692","https://openalex.org/W2052813444","https://openalex.org/W2057587118","https://openalex.org/W2068934001","https://openalex.org/W2076112714","https://openalex.org/W2085087221","https://openalex.org/W2085580458","https://openalex.org/W2086623705","https://openalex.org/W2087156772","https://openalex.org/W2090678272","https://openalex.org/W2097147939","https://openalex.org/W2110378444","https://openalex.org/W2114738387","https://openalex.org/W2114918609","https://openalex.org/W2136127035","https://openalex.org/W2139177583","https://openalex.org/W2155754747","https://openalex.org/W2163365522","https://openalex.org/W2235693008","https://openalex.org/W2256742438","https://openalex.org/W2304644588","https://openalex.org/W2546457048","https://openalex.org/W2562455296","https://openalex.org/W2619401730","https://openalex.org/W2625536757","https://openalex.org/W2712187041","https://openalex.org/W2723222493","https://openalex.org/W2755080059","https://openalex.org/W2767392813","https://openalex.org/W2791767507","https://openalex.org/W2794183144","https://openalex.org/W2794304737","https://openalex.org/W2896612510","https://openalex.org/W2912931895","https://openalex.org/W2915879183","https://openalex.org/W2919021368","https://openalex.org/W2921347039","https://openalex.org/W2933553758","https://openalex.org/W2934673453","https://openalex.org/W2937336507","https://openalex.org/W2941311374","https://openalex.org/W2979123679","https://openalex.org/W4230982340"],"related_works":["https://openalex.org/W3168064186","https://openalex.org/W3113617053","https://openalex.org/W2645076091","https://openalex.org/W2150678424","https://openalex.org/W2953430439","https://openalex.org/W2803309400","https://openalex.org/W2001992152","https://openalex.org/W4382776903","https://openalex.org/W2052813444","https://openalex.org/W2501780455"],"abstract_inverted_index":{"Piceatannol":[0,167],"is":[1,6,34,54,246],"a":[2,8,191,247],"resveratrol":[3],"metabolite":[4],"that":[5],"considered":[7],"potent":[9,248],"antioxidant":[10,162,206,227,249],"and":[11,43,50,90,105,118,164,181,205,226],"cytoprotector":[12,75],"because":[13],"of":[14,25,30,78,87,176,188,193,208],"its":[15],"high":[16],"capacity":[17,207],"to":[18,37,71,130,170],"chelate/sequester":[19],"reactive":[20,31],"oxygen":[21,32],"species.":[22],"In":[23,65,190,243],"pathogenesis":[24],"periodontal":[26,80],"diseases,":[27],"the":[28,38,41,108,123,150,158,174,186,209,212,215],"imbalance":[29],"species":[33],"closely":[35],"related":[36],"disorder":[39],"in":[40,47,56,62,76,84,125,185,250],"cells":[42,234],"may":[44],"cause":[45],"changes":[46],"cellular":[48,203],"metabolism":[49,147,204,225],"mitochondrial":[51,155,236],"activity,":[52],"which":[53],"implicated":[55],"oxidative":[57,91,95],"stress":[58,92,96],"status":[59,148],"or":[60],"even":[61,184],"cell":[63,88,139,177,199],"death.":[64],"this":[66,68],"way,":[67],"study":[69,110],"aimed":[70],"evaluate":[72],"piceatannol":[73,126,196,219,230,245],"as":[74,98,238],"culture":[77],"human":[79],"ligament":[81],"fibroblasts":[82,216],"through":[83,157],"vitro":[85],"analyses":[86],"viability":[89,140,178,200],"parameters":[93,134],"after":[94],"induced":[97],"an":[99],"injury":[100],"simulator.":[101],"Fibroblasts":[102],"were":[103,138],"seeded":[104],"divided":[106],"into":[107],"following":[109,136],"groups:":[111],"control,":[112],"vehicle,":[113],"control":[114],"piceatannol,":[115],"H2O2":[116,119],"exposure,":[117],"exposure":[120,137],"combined":[121],"with":[122,218,253],"maintenance":[124,175],"ranging":[127],"from":[128,235],"0.1":[129,194],"20":[131],"\u03bcM.":[132],"The":[133],"analyzed":[135],"by":[141,149,240,264],"trypan":[142],"blue":[143],"exclusion":[144],"test,":[145],"general":[146],"3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium":[151],"bromide":[152],"(MTT)":[153],"method,":[154],"activity":[156],"ATP":[159,241],"production,":[160],"total":[161],"capacity,":[163,255],"reduced":[165],"gluthatione.":[166],"was":[168],"shown":[169],"be":[171],"cytoprotective":[172,254],"due":[173],"between":[179],"1":[180,221],"10":[182],"\u03bcM":[183,195,222],"presence":[187],"H2O2.":[189],"concentration":[192],"decreased":[197],"significantly":[198],"but":[201,256],"increased":[202],"fibroblasts.":[210],"On":[211],"other":[213],"hand,":[214],"treated":[217],"at":[220],"presented":[223],"low":[224,251],"capacity.":[228],"However,":[229],"did":[231],"not":[232,259],"protect":[233],"damage":[237,262],"measured":[239],"production.":[242],"summary,":[244],"concentrations":[252],"it":[257],"does":[258],"prevent":[260],"all":[261],"caused":[263],"hydrogen":[265],"peroxide.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-26T00:00:00"}
