{"id":"https://openalex.org/W2994772829","doi":"https://doi.org/10.1021/acs.chemrestox.9b00346","title":"CRISPR-Generated Nrf2a Loss- and Gain-of-Function Mutants Facilitate Mechanistic Analysis of Chemical Oxidative Stress-Mediated Toxicity in Zebrafish","display_name":"CRISPR-Generated Nrf2a Loss- and Gain-of-Function Mutants Facilitate Mechanistic Analysis of Chemical Oxidative Stress-Mediated Toxicity in Zebrafish","publication_year":2019,"publication_date":"2019-12-20","ids":{"openalex":"https://openalex.org/W2994772829","doi":"https://doi.org/10.1021/acs.chemrestox.9b00346","mag":"2994772829","pmid":"https://pubmed.ncbi.nlm.nih.gov/31858786","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7749997"},"language":"en","primary_location":{"id":"doi:10.1021/acs.chemrestox.9b00346","doi":"https://doi.org/10.1021/acs.chemrestox.9b00346","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.chemrestox.9b00346","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7749997","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091393492","display_name":"Margaret G. Mills","orcid":"https://orcid.org/0000-0002-0493-9408","observed_orcids":["https://orcid.org/0000-0002-0493-9408"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret G. Mills","raw_affiliation_strings":["Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 4225 Roosevelt Way NE, Seattle, Washington 98105, United States"],"raw_orcid":"https://orcid.org/0000-0002-0493-9408","affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 4225 Roosevelt Way NE, Seattle, Washington 98105, United States","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard Ramsden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Ramsden","raw_affiliation_strings":["Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 4225 Roosevelt Way NE, Seattle, Washington 98105, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 4225 Roosevelt Way NE, Seattle, Washington 98105, United States","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eva Y. Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eva Y. Ma","raw_affiliation_strings":["Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 4225 Roosevelt Way NE, Seattle, Washington 98105, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 4225 Roosevelt Way NE, Seattle, Washington 98105, United States","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110743987","display_name":"Jone Corrales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157394403","display_name":"Baylor University","ror":"https://ror.org/005781934","country_code":"US","type":"education","lineage":["https://openalex.org/I157394403"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jone Corrales","raw_affiliation_strings":["Department of Environmental Sciences, Baylor University, Baylor Sciences Building, One Bear Place #97266, Waco Texas 76798, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Sciences, Baylor University, Baylor Sciences Building, One Bear Place #97266, Waco Texas 76798, United States","institution_ids":["https://openalex.org/I157394403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089353817","display_name":"Lauren A. Kristofco","orcid":"https://orcid.org/0000-0003-2441-8463","observed_orcids":["https://orcid.org/0000-0003-2441-8463"]},"institutions":[{"id":"https://openalex.org/I157394403","display_name":"Baylor University","ror":"https://ror.org/005781934","country_code":"US","type":"education","lineage":["https://openalex.org/I157394403"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren A. Kristofco","raw_affiliation_strings":["Department of Environmental Sciences, Baylor University, Baylor Sciences Building, One Bear Place #97266, Waco Texas 76798, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Sciences, Baylor University, Baylor Sciences Building, One Bear Place #97266, Waco Texas 76798, United States","institution_ids":["https://openalex.org/I157394403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054843126","display_name":"W. Baylor Steele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157394403","display_name":"Baylor University","ror":"https://ror.org/005781934","country_code":"US","type":"education","lineage":["https://openalex.org/I157394403"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Baylor Steele","raw_affiliation_strings":["Department of Environmental Sciences, Baylor University, Baylor Sciences Building, One Bear Place #97266, Waco Texas 76798, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Sciences, Baylor University, Baylor Sciences Building, One Bear Place #97266, Waco Texas 76798, United States","institution_ids":["https://openalex.org/I157394403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035462737","display_name":"Gavin N. Saari","orcid":"https://orcid.org/0000-0002-3593-5127","observed_orcids":["https://orcid.org/0000-0002-3593-5127"]},"institutions":[{"id":"https://openalex.org/I157394403","display_name":"Baylor University","ror":"https://ror.org/005781934","country_code":"US","type":"education","lineage":["https://openalex.org/I157394403"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gavin N. Saari","raw_affiliation_strings":["Department of Environmental Sciences, Baylor University, Baylor Sciences Building, One Bear Place #97266, Waco Texas 76798, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Sciences, Baylor University, Baylor Sciences Building, One Bear Place #97266, Waco Texas 76798, United States","institution_ids":["https://openalex.org/I157394403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048086631","display_name":"Fjodor Melnikov","orcid":"https://orcid.org/0000-0003-3743-1376","observed_orcids":["https://orcid.org/0000-0003-3743-1376"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fjodor Melnikov","raw_affiliation_strings":["School of Forestry and Environmental Science, Yale University, 195 Prospect St., New Haven, Connecticut 06511, United States"],"raw_orcid":"https://orcid.org/0000-0003-3743-1376","affiliations":[{"raw_affiliation_string":"School of Forestry and Environmental Science, Yale University, 195 Prospect St., New Haven, Connecticut 06511, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037981549","display_name":"Jakub Kostal","orcid":"https://orcid.org/0000-0001-9727-0477","observed_orcids":["https://orcid.org/0000-0001-9727-0477"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jakub Kostal","raw_affiliation_strings":["Department of Chemistry, The George Washington University, Science & Engineering Hall, Suite 4000, 800 22nd St NW, Washington, DC 20052, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The George Washington University, Science & Engineering Hall, Suite 4000, 800 22nd St NW, Washington, DC 20052, United States","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023996574","display_name":"Terrance J. Kavanagh","orcid":"https://orcid.org/0000-0002-7213-103X","observed_orcids":["https://orcid.org/0000-0002-7213-103X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terrance J. Kavanagh","raw_affiliation_strings":["Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 4225 Roosevelt Way NE, Seattle, Washington 98105, United States"],"raw_orcid":"https://orcid.org/0000-0002-7213-103X","affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 4225 Roosevelt Way NE, Seattle, Washington 98105, United States","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044625101","display_name":"Julie Beth Zimmerman","orcid":"https://orcid.org/0000-0002-5392-312X","observed_orcids":["https://orcid.org/0000-0002-5392-312X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie B. Zimmerman","raw_affiliation_strings":["Department of Chemical and Environmental Engineering, Yale University, PO Box 208292, New Haven, Connecticut 06520, United States","School of Forestry and Environmental Science, Yale University, 195 Prospect St., New Haven, Connecticut 06511, United States"],"raw_orcid":"https://orcid.org/0000-0002-5392-312X","affiliations":[{"raw_affiliation_string":"Department of Chemical and Environmental Engineering, Yale University, PO Box 208292, New Haven, Connecticut 06520, United States","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"School of Forestry and Environmental Science, Yale University, 195 Prospect St., New Haven, Connecticut 06511, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009823543","display_name":"Adelina M. Voutchkova\u2010Kostal","orcid":"https://orcid.org/0000-0002-7016-5244","observed_orcids":["https://orcid.org/0000-0002-7016-5244"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adelina M. Voutchkova-Kostal","raw_affiliation_strings":["Department of Chemistry, The George Washington University, Science & Engineering Hall, Suite 4000, 800 22nd St NW, Washington, DC 20052, United States"],"raw_orcid":"https://orcid.org/0000-0002-7016-5244","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The George Washington University, Science & Engineering Hall, Suite 4000, 800 22nd St NW, Washington, DC 20052, United States","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021204825","display_name":"Bryan W. Brooks","orcid":"https://orcid.org/0000-0002-6277-9852","observed_orcids":["https://orcid.org/0000-0002-6277-9852"]},"institutions":[{"id":"https://openalex.org/I157394403","display_name":"Baylor University","ror":"https://ror.org/005781934","country_code":"US","type":"education","lineage":["https://openalex.org/I157394403"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan W. Brooks","raw_affiliation_strings":["Department of Environmental Sciences, Baylor University, Baylor Sciences Building, One Bear Place #97266, Waco Texas 76798, United States"],"raw_orcid":"https://orcid.org/0000-0002-6277-9852","affiliations":[{"raw_affiliation_string":"Department of Environmental Sciences, Baylor University, Baylor Sciences Building, One Bear Place #97266, Waco Texas 76798, United States","institution_ids":["https://openalex.org/I157394403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002354640","display_name":"Philip Coish","orcid":"https://orcid.org/0000-0002-3649-1636","observed_orcids":["https://orcid.org/0000-0002-3649-1636"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Coish","raw_affiliation_strings":["School of Forestry and Environmental Science, Yale University, 195 Prospect St., New Haven, Connecticut 06511, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Forestry and Environmental Science, Yale University, 195 Prospect St., New Haven, Connecticut 06511, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000494141","display_name":"Paul T. Anastas","orcid":"https://orcid.org/0000-0003-4777-5172","observed_orcids":["https://orcid.org/0000-0003-4777-5172"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul T. Anastas","raw_affiliation_strings":["School of Forestry and Environmental Science, Yale University, 195 Prospect St., New Haven, Connecticut 06511, United States","School of Public Health, Yale University, PO Box 208034, New Haven, Connecticut 06520, United States"],"raw_orcid":"https://orcid.org/0000-0003-4777-5172","affiliations":[{"raw_affiliation_string":"School of Forestry and Environmental Science, Yale University, 195 Prospect St., New Haven, Connecticut 06511, United States","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"School of Public Health, Yale University, PO Box 208034, New Haven, Connecticut 06520, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102751418","display_name":"Evan P. Gallagher","orcid":"https://orcid.org/0000-0002-1196-4222","observed_orcids":["https://orcid.org/0000-0002-1196-4222"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Evan Gallagher","raw_affiliation_strings":["Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 4225 Roosevelt Way NE, Seattle, Washington 98105, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, 4225 Roosevelt Way NE, Seattle, Washington 98105, United States","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5102751418"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.2481,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.50022315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"33","issue":"2","first_page":"426","last_page":"435"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6019999980926514},{"id":"https://openalex.org/keywords/chemical-toxicity","display_name":"chemical toxicity","score":0.6840000152587891},{"id":"https://openalex.org/keywords/zebrafish-mutants","display_name":"zebrafish mutants","score":0.8960000276565552},{"id":"https://openalex.org/keywords/loss-of-function-mutants","display_name":"loss-of-function mutants","score":0.890999972820282},{"id":"https://openalex.org/keywords/gain-of-function-mutants","display_name":"gain-of-function mutants","score":0.996999979019165},{"id":"https://openalex.org/keywords/antioxidant-response","display_name":"antioxidant response","score":0.7400000095367432},{"id":"https://openalex.org/keywords/tert-butyl-hydroperoxide","display_name":"tert-butyl hydroperoxide","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cumene-hydroperoxide","display_name":"cumene hydroperoxide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/carvone","display_name":"carvone","score":0.656000018119812},{"id":"https://openalex.org/keywords/glutathione-s-transferase-pi","display_name":"glutathione S-transferase pi","score":0.7960000038146973},{"id":"https://openalex.org/keywords/superoxide-dismutase-1","display_name":"superoxide dismutase 1","score":0.8560000061988831},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.7720000147819519},{"id":"https://openalex.org/keywords/crispr-gene-editing","display_name":"CRISPR gene editing","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.912423312664032},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7296572923660278},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6793617010116577},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5542018413543701},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.536311686038971},{"id":"https://openalex.org/C2779881523","wikidata":"https://www.wikidata.org/wiki/Q18026129","display_name":"GCLC","level":4,"score":0.4668254256248474},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.465869665145874},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.447967529296875},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.4322255849838257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33685576915740967},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3273305594921112},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3067549467086792},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.09412321448326111},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000073658","descriptor_name":"Loss of Function Mutation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000073658","descriptor_name":"Loss of Function Mutation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000073658","descriptor_name":"Loss of Function Mutation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000073658","descriptor_name":"Loss of Function Mutation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000073659","descriptor_name":"Gain of Function Mutation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000073659","descriptor_name":"Gain of Function Mutation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000073659","descriptor_name":"Gain of Function Mutation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000073659","descriptor_name":"Gain of Function Mutation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001555","descriptor_name":"Benzene Derivatives","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020122","descriptor_name":"tert-Butylhydroperoxide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D020122","descriptor_name":"tert-Butylhydroperoxide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D020122","descriptor_name":"tert-Butylhydroperoxide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D020122","descriptor_name":"tert-Butylhydroperoxide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064112","descriptor_name":"Clustered Regularly Interspaced Short Palindromic Repeats","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D064112","descriptor_name":"Clustered Regularly Interspaced Short Palindromic Repeats","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D064112","descriptor_name":"Clustered Regularly Interspaced Short Palindromic Repeats","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D064112","descriptor_name":"Clustered Regularly Interspaced Short Palindromic Repeats","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D064112","descriptor_name":"Clustered Regularly Interspaced Short Palindromic Repeats","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064112","descriptor_name":"Clustered Regularly Interspaced Short Palindromic Repeats","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064112","descriptor_name":"Clustered Regularly Interspaced Short Palindromic Repeats","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064112","descriptor_name":"Clustered Regularly Interspaced Short Palindromic Repeats","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.chemrestox.9b00346","doi":"https://doi.org/10.1021/acs.chemrestox.9b00346","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.chemrestox.9b00346","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},{"id":"pmid:31858786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31858786","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical research in toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7749997","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7749997","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Res Toxicol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7749997","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7749997","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Res Toxicol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3592810552","display_name":"Effects-Related Biomarkers of Environmental Neurotoxic Exposures","funder_award_id":"P42ES004696","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G5142799241","display_name":null,"funder_award_id":"CHE-1339637","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"},{"id":"https://openalex.org/G9000896837","display_name":"University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment","funder_award_id":"P30ES007033","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W66633716","https://openalex.org/W598738849","https://openalex.org/W643666707","https://openalex.org/W745874334","https://openalex.org/W805945966","https://openalex.org/W829805959","https://openalex.org/W1533811499","https://openalex.org/W1544328481","https://openalex.org/W1561096292","https://openalex.org/W1823204572","https://openalex.org/W1845508194","https://openalex.org/W1855877637","https://openalex.org/W1915704240","https://openalex.org/W1967692811","https://openalex.org/W1968045891","https://openalex.org/W1971535051","https://openalex.org/W1973882427","https://openalex.org/W1974972325","https://openalex.org/W1976709591","https://openalex.org/W1978529094","https://openalex.org/W1981601139","https://openalex.org/W1990598806","https://openalex.org/W1991631628","https://openalex.org/W1992033043","https://openalex.org/W1993204994","https://openalex.org/W1995445783","https://openalex.org/W2000751609","https://openalex.org/W2012022049","https://openalex.org/W2017224987","https://openalex.org/W2018888672","https://openalex.org/W2027085316","https://openalex.org/W2036297991","https://openalex.org/W2036336318","https://openalex.org/W2038612772","https://openalex.org/W2040042255","https://openalex.org/W2050512725","https://openalex.org/W2050794881","https://openalex.org/W2053471764","https://openalex.org/W2065540551","https://openalex.org/W2069159655","https://openalex.org/W2071137645","https://openalex.org/W2076405456","https://openalex.org/W2080952734","https://openalex.org/W2088082968","https://openalex.org/W2089097264","https://openalex.org/W2092482659","https://openalex.org/W2098567793","https://openalex.org/W2112853317","https://openalex.org/W2114681936","https://openalex.org/W2115338196","https://openalex.org/W2118150025","https://openalex.org/W2125349610","https://openalex.org/W2134285628","https://openalex.org/W2148242921","https://openalex.org/W2155117797","https://openalex.org/W2163292409","https://openalex.org/W2165167356","https://openalex.org/W2168395641","https://openalex.org/W2291881520","https://openalex.org/W2343277111","https://openalex.org/W2419239237","https://openalex.org/W2461902324","https://openalex.org/W2515118862","https://openalex.org/W2519529012","https://openalex.org/W2533524005","https://openalex.org/W2535167826","https://openalex.org/W2587986259","https://openalex.org/W2594396705","https://openalex.org/W2753995352","https://openalex.org/W2769077130","https://openalex.org/W2774073810","https://openalex.org/W2899622135","https://openalex.org/W2907571614","https://openalex.org/W2911910045","https://openalex.org/W2936452733","https://openalex.org/W2945113757","https://openalex.org/W2945352109","https://openalex.org/W4248078302"],"related_works":["https://openalex.org/W2907571614","https://openalex.org/W805945966","https://openalex.org/W2088082968","https://openalex.org/W7099004058","https://openalex.org/W1976709591","https://openalex.org/W2527814485","https://openalex.org/W2587986259","https://openalex.org/W2114681936","https://openalex.org/W2004574865","https://openalex.org/W4324144275"],"abstract_inverted_index":{"The":[0,92],"transcription":[1],"factor":[2],"Nrf2a":[3,37,85,95,113,170,227,284,299],"induces":[4],"a":[5,20,29,110],"cellular":[6],"antioxidant":[7,101,245],"response":[8],"and":[9,25,106,108,160,184,210,257,291],"provides":[10],"protection":[11],"against":[12,89,213],"chemical-induced":[13],"oxidative":[14,90],"stress,":[15],"as":[16,18,121,123],"well":[17,122],"playing":[19],"critical":[21],"role":[22,35,111,282],"in":[23,38,87,114,140,146,154,161,285],"development":[24,209],"disease.":[26],"Zebrafish":[27],"are":[28],"powerful":[30],"model":[31],"to":[32,79,167,176,200,241,248,269],"study":[33,294],"the":[34,84,100,115,128,177,188,204,214,229,236,271,281,286,293],"of":[36,63,69,75,83,99,118,131,180,192,208,216,226,231,238,273,277,283,288,295],"these":[39,119,262],"processes":[40],"but":[41],"have":[42],"been":[43],"limited":[44],"by":[45,133,158],"reliance":[46],"on":[47],"transient":[48],"gene":[49,275],"knockdown":[50],"techniques":[51],"or":[52,72],"mutants":[53,93,156,163,172,196,253],"with":[54],"only":[55],"partial":[56],"functional":[57],"alteration.":[58],"We":[59],"developed":[60],"several":[61],"lines":[62],"zebrafish":[64,252],"carrying":[65],"different":[66],"null":[67],"(loss":[68],"function,":[70,76],"LOF)":[71],"hyperactive":[73],"(gain":[74],"GOF)":[77],"mutations":[78],"facilitate":[80,270],"our":[81],"understanding":[82],"pathway":[86],"protecting":[88],"stress.":[91],"confirmed":[94],"dependence":[96],"for":[97,112,124],"induction":[98,130],"genes":[102],"gclc,":[103],"gstp,":[104],"prdx1,":[105],"gpx1a":[107],"identified":[109],"baseline":[116,151],"expression":[117,153],"genes,":[120],"sod1":[125],".":[126],"Specifically,":[127],"4-fold":[129],"gstp":[132,152],"tert":[134],"-butyl":[135],"hydroperoxide":[136,182],"(":[137],"t":[138,185],"BHP)":[139],"wild":[141,168],"type":[142],"fish":[143],"was":[144,164],"abolished":[145],"LOF":[147,162,171],"mutants.":[148],"In":[149,260],"addition,":[150],"GOF":[155,195,251],"increased":[157,174],"12.6-fold":[159],"0.8-fold":[165],"relative":[166],"type.":[169],"showed":[173],"sensitivity":[175],"acute":[178],"toxicity":[179,202,215,230,287],"cumene":[181],"(CHP)":[183],"BHP":[186],"throughout":[187],"first":[189,205],"4":[190,206,220],"days":[191,207],"development.":[193],"Conversely,":[194],"were":[197,211],"less":[198],"sensitive":[199],"CHP":[201],"during":[203],"protected":[212],"both":[217],"hydroperoxides":[218],"after":[219],"dpf.":[221],"Neither":[222],"gain":[223],"nor":[224],"loss":[225],"modulated":[228],"R":[232],"-(\u2212)-carvone":[233],"(CAR),":[234],"despite":[235],"ability":[237],"this":[239],"compound":[240],"potently":[242],"induce":[243],"Nrf2a-dependent":[244],"genes.":[246],"Similar":[247],"other":[249],"species,":[250],"exhibited":[254],"significant":[255],"growth":[256],"survival":[258],"defects.":[259],"summary,":[261],"new":[263],"genetic":[264],"tools":[265],"can":[266],"be":[267],"used":[268],"identification":[272],"downstream":[274],"targets":[276],"Nrf2a,":[278],"better":[279],"define":[280],"environmental":[289],"chemicals,":[290],"further":[292],"diseases":[296],"involving":[297],"altered":[298],"function.":[300]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-12-26T00:00:00"}
