{"id":"https://openalex.org/W2994766078","doi":"https://doi.org/10.1002/jia2.25423","title":"Directly observed therapy and risk of unfavourable tuberculosis treatment outcomes among an international cohort of people living with HIV in low\u2010 and middle\u2010income countries","display_name":"Directly observed therapy and risk of unfavourable tuberculosis treatment outcomes among an international cohort of people living with HIV in low\u2010 and middle\u2010income countries","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W2994766078","doi":"https://doi.org/10.1002/jia2.25423","mag":"2994766078","pmid":"https://pubmed.ncbi.nlm.nih.gov/31814312","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6900483"},"language":"en","primary_location":{"id":"doi:10.1002/jia2.25423","doi":"https://doi.org/10.1002/jia2.25423","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jia2.25423","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jia2.25423","source":{"id":"https://openalex.org/S66330005","display_name":"Journal of the International AIDS Society","issn_l":"1758-2652","issn":["1758-2652"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320728","host_organization_name":"International AIDS Society","host_organization_lineage":["https://openalex.org/P4310320728"],"host_organization_lineage_names":["International AIDS Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jia2.25423","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074591388","display_name":"April Christine Pettit","orcid":"https://orcid.org/0000-0001-8832-0866","observed_orcids":["https://orcid.org/0000-0001-8832-0866"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"April C Pettit","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","Vanderbilt Tuberculosis Center, Nashville, TN, USA"],"raw_orcid":"https://orcid.org/0000-0001-8832-0866","affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt Tuberculosis Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003593760","display_name":"Cathy A. Jenkins","orcid":"https://orcid.org/0000-0001-7217-2985","observed_orcids":["https://orcid.org/0000-0001-7217-2985"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cathy A Jenkins","raw_affiliation_strings":["Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085744275","display_name":"Meridith L Blevins","orcid":"https://orcid.org/0000-0002-3861-9859","observed_orcids":["https://orcid.org/0000-0002-3861-9859"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meridith Blevins Peratikos","raw_affiliation_strings":["Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071521824","display_name":"Marcel Yotebieng","orcid":"https://orcid.org/0000-0003-2110-2631","observed_orcids":["https://orcid.org/0000-0003-2110-2631"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcel Yotebieng","raw_affiliation_strings":["College of Public Health, The Ohio State University, Columbus, OH, USA"],"raw_orcid":"https://orcid.org/0000-0003-2110-2631","affiliations":[{"raw_affiliation_string":"College of Public Health, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003450734","display_name":"Lameck Oteko Diero","orcid":"https://orcid.org/0000-0001-9717-3570","observed_orcids":["https://orcid.org/0000-0001-9717-3570"]},"institutions":[{"id":"https://openalex.org/I4210158668","display_name":"AMPATH","ror":"https://ror.org/049nx2j30","country_code":"KE","type":"healthcare","lineage":["https://openalex.org/I4210158668"]}],"countries":["KE"],"is_corresponding":false,"raw_author_name":"Lameck Diero","raw_affiliation_strings":["Academic Model Providing Access To Healthcare (AMPATH), Eldoret, Kenya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Model Providing Access To Healthcare (AMPATH), Eldoret, Kenya","institution_ids":["https://openalex.org/I4210158668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020631194","display_name":"Cuong Duy","orcid":"https://orcid.org/0000-0002-1565-642X","observed_orcids":["https://orcid.org/0000-0002-1565-642X"]},"institutions":[{"id":"https://openalex.org/I4210152634","display_name":"B\u1ea1ch Mai Hospital","ror":"https://ror.org/05ecec111","country_code":"VN","type":"healthcare","lineage":["https://openalex.org/I4210152634"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Cuong D Do","raw_affiliation_strings":["Bach Mai Hospital, Hanoi, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bach Mai Hospital, Hanoi, Vietnam","institution_ids":["https://openalex.org/I4210152634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064903621","display_name":"Jeremy L. Ross","orcid":"https://orcid.org/0000-0003-3183-2451","observed_orcids":["https://orcid.org/0000-0003-3183-2451"]},"institutions":[{"id":"https://openalex.org/I2802687840","display_name":"American Foundation for AIDS Research","ror":"https://ror.org/02jesmk44","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802687840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Ross","raw_affiliation_strings":["TREAT Asia/amfAR \u2013 The Foundation for AIDS Research Bangkok Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TREAT Asia/amfAR \u2013 The Foundation for AIDS Research Bangkok Thailand","institution_ids":["https://openalex.org/I2802687840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087601006","display_name":"Valdilea Gon\u00e7alves Veloso","orcid":"https://orcid.org/0000-0002-6622-3165","observed_orcids":["https://orcid.org/0000-0002-6622-3165"]},"institutions":[{"id":"https://openalex.org/I4405286924","display_name":"Instituto Nacional de Infectologia Evandro Chagas","ror":"https://ror.org/03jw34240","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4405286924","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Valdilea G Veloso","raw_affiliation_strings":["Instituto Nacional de Infectologia Evandro Chagas Funda\u00e7\u00e3o Oswaldo Cruz Rio de Janeiro RJ Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Infectologia Evandro Chagas Funda\u00e7\u00e3o Oswaldo Cruz Rio de Janeiro RJ Brazil","institution_ids":["https://openalex.org/I4405286924","https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056167060","display_name":"Denise Hawerlander","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Denise Hawerlander","raw_affiliation_strings":["Centre Int\u00e9gr\u00e9 de Recherches Biocliniques d'Abidjan CIRBA Abidjan C\u00f4te d'Ivoire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Int\u00e9gr\u00e9 de Recherches Biocliniques d'Abidjan CIRBA Abidjan C\u00f4te d'Ivoire","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090028970","display_name":"Olivier Marcy","orcid":"https://orcid.org/0000-0003-3350-112X","observed_orcids":["https://orcid.org/0000-0003-3350-112X"]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210106115","display_name":"Bordeaux Population Health","ror":"https://ror.org/00xzzba89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210106115"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Marcy","raw_affiliation_strings":["Centre INSERM U1219, Bordeaux Population Health, University of Bordeaux, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre INSERM U1219, Bordeaux Population Health, University of Bordeaux, Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210106115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048891443","display_name":"Bryan E. Shepherd","orcid":"https://orcid.org/0000-0002-3758-5992","observed_orcids":["https://orcid.org/0000-0002-3758-5992"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan E Shepherd","raw_affiliation_strings":["Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058001657","display_name":"Lukas Fenner","orcid":"https://orcid.org/0000-0003-3309-4835","observed_orcids":["https://orcid.org/0000-0003-3309-4835"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I4210135124","display_name":"Institute of Social and Preventive Medicine","ror":"https://ror.org/038esz880","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2802229882","https://openalex.org/I4210135124","https://openalex.org/I4210149340","https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lukas Fenner","raw_affiliation_strings":["Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I4210135124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076748422","display_name":"Timothy R. Sterling","orcid":"https://orcid.org/0000-0002-4822-6979","observed_orcids":["https://orcid.org/0000-0002-4822-6979"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy R Sterling","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","Vanderbilt Tuberculosis Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt Tuberculosis Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5074591388"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"],"apc_list":{"value":2400,"currency":"USD","value_usd":2400},"apc_paid":{"value":2400,"currency":"USD","value_usd":2400},"fwci":0.1958,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.56276338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"22","issue":"12","first_page":"e25423","last_page":"e25423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-associated-tuberculosis","display_name":"HIV-associated tuberculosis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/directly-observed-therapy","display_name":"directly observed therapy","score":0.9670000076293945},{"id":"https://openalex.org/keywords/self-administered-treatment","display_name":"self-administered therapy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/tuberculosis-treatment-outcomes","display_name":"tuberculosis treatment outcomes","score":0.7480000257492065},{"id":"https://openalex.org/keywords/tuberculosis-mortality","display_name":"tuberculosis mortality","score":0.7879999876022339},{"id":"https://openalex.org/keywords/continuation-phase","display_name":"continuation phase","score":0.6140000224113464},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.8930000066757202},{"id":"https://openalex.org/keywords/low-and-middle-income-countries","display_name":"low- and middle-income countries","score":0.9020000100135803},{"id":"https://openalex.org/keywords/risk-factors-for-poor-outcome","display_name":"risk factors for poor outcome","score":0.6690000295639038},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.5590000152587891},{"id":"https://openalex.org/keywords/hiv-tb-co-infection","display_name":"HIV/TB coinfection","score":0.4650000035762787},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.36500000953674316}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9229944348335266},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.7452966570854187},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5725293159484863},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5613782405853271},{"id":"https://openalex.org/C2909923361","wikidata":"https://www.wikidata.org/wiki/Q2339584","display_name":"Directly Observed Therapy","level":3,"score":0.5524932742118835},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4306502640247345},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.42829132080078125},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4150155484676361},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3802010416984558},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3221462368965149},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2363356649875641},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003906","descriptor_name":"Developing Countries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011203","descriptor_name":"Poverty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023801","descriptor_name":"Directly Observed Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":13,"locations":[{"id":"doi:10.1002/jia2.25423","doi":"https://doi.org/10.1002/jia2.25423","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jia2.25423","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jia2.25423","source":{"id":"https://openalex.org/S66330005","display_name":"Journal of the International AIDS Society","issn_l":"1758-2652","issn":["1758-2652"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320728","host_organization_name":"International AIDS Society","host_organization_lineage":["https://openalex.org/P4310320728"],"host_organization_lineage_names":["International AIDS Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5873599","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6900483","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6900483","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6900483","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Int AIDS Soc","raw_type":"Text"},{"id":"pmid:31814312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31814312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"Journal Article"},{"id":"pmh:oai:www.arca.fiocruz.br:icict/38792","doi":null,"is_oa":true,"landing_page_url":"https://www.arca.fiocruz.br/handle/icict/38792","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da FIOCRUZ (ARCA)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:doi:10.7892/boris.137050","doi":null,"is_oa":false,"landing_page_url":"https://boris-portal.unibe.ch/handle/20.500.12422/184617","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"pmh:oai:HAL:hal-03169049v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.archives-ouvertes.fr/hal-03169049","pdf_url":null,"source":{"id":"https://openalex.org/S4377196329","display_name":"HAL Portal Artxiker (Hindustan Aeronautics Limited (India))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210088939","host_organization_name":"Hindustan Aeronautics Limited (India)","host_organization_lineage":["https://openalex.org/I4210088939"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1473-5571","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-03169049v2","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-03169049v2/document","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"AIDS. Official journal of the international AIDS Society, 2019, 22 (12), pp.e25423. ⟨10.1002/jia2.25423⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:2319873","doi":null,"is_oa":true,"landing_page_url":"https://www.arca.fiocruz.br/handle/icict/38792","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da FIOCRUZ (ARCA)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:arca.fiocruz.br:icict/38792","doi":null,"is_oa":true,"landing_page_url":"https://arca.fiocruz.br/handle/icict/38792","pdf_url":null,"source":{"id":"https://openalex.org/S7407055450","display_name":"Arca - Reposit\u00f3rio Institucional da Fiocruz","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:boris.unibe.ch:137050","doi":null,"is_oa":true,"landing_page_url":"https://boris.unibe.ch/137050/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401086","display_name":"Bern Open Repository and Information System (University of Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118564535","host_organization_name":"University of Bern","host_organization_lineage":["https://openalex.org/I118564535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:oskar-bordeaux.fr:20.500.12278/10235","doi":null,"is_oa":true,"landing_page_url":"https://oskar-bordeaux.fr/handle/20.500.12278/10235","pdf_url":null,"source":{"id":"https://openalex.org/S4306402569","display_name":"Oskar-Bordeaux (Universite de Bordeaux)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I15057530","host_organization_name":"Universit\u00e9 de Bordeaux","host_organization_lineage":["https://openalex.org/I15057530"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article de revue"},{"id":"doi:10.7892/boris.137050","doi":"https://doi.org/10.7892/boris.137050","is_oa":true,"landing_page_url":"https://doi.org/10.7892/boris.137050","pdf_url":null,"source":{"id":"https://openalex.org/S7407053152","display_name":"Open Access CRIS of the University of Bern","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1002/jia2.25423","doi":"https://doi.org/10.1002/jia2.25423","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jia2.25423","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jia2.25423","source":{"id":"https://openalex.org/S66330005","display_name":"Journal of the International AIDS Society","issn_l":"1758-2652","issn":["1758-2652"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320728","host_organization_name":"International AIDS Society","host_organization_lineage":["https://openalex.org/P4310320728"],"host_organization_lineage_names":["International AIDS Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G14153761","display_name":"Tuberculosis Risk and Highly Active Antiretroviral Therapy Initiation","funder_award_id":"K08AI104352","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2611662874","display_name":null,"funder_award_id":"AID-623-A-12-0001","funder_id":"https://openalex.org/F4320306115","funder_display_name":"United States Agency for International Development"},{"id":"https://openalex.org/G6375457957","display_name":"leDEA Networks Coordinating Center at Vanderbilt","funder_award_id":"U01AI096186","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7773456091","display_name":"The Vanderbilt Institute for Clinical and Translational Research (VICTR)","funder_award_id":"UL1TR000445","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000076998","display_name":"Tennessee Center for AIDS Research (TN-CFAR)","funder_award_id":"P30AI110527","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000873063","display_name":"IeDEA Asia-Pacific Research Collaboration","funder_award_id":"U01AI069907","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000888500","display_name":"Central Africa International Epidemiology databases to Evaluate AIDS","funder_award_id":"U01AI096299","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000897956","display_name":"East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium","funder_award_id":"U01AI069911","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000903780","display_name":"Caribbean, Central, and South America network for HIV Epidemiology (CCASAnet)","funder_award_id":"U01AI069923","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000906750","display_name":"International Epidemiology Databases to EvaluateAIDS (IeDEA) Renewal 4","funder_award_id":"U01AI069919","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000915114","display_name":"International epidemiology Databases to Evaluate AIDS (IeDEA) Southern Africa.","funder_award_id":"U01AI069924","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306115","display_name":"United States Agency for International Development","ror":"https://ror.org/01n6e6j62"},{"id":"https://openalex.org/F4320310979","display_name":"U.S. President\u2019s Emergency Plan for AIDS Relief","ror":"https://ror.org/025g6sc95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2994766078.pdf","grobid_xml":"https://content.openalex.org/works/W2994766078.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1878724292","https://openalex.org/W1931371138","https://openalex.org/W1964361983","https://openalex.org/W1990993788","https://openalex.org/W1996971859","https://openalex.org/W2018179591","https://openalex.org/W2093274439","https://openalex.org/W2100383609","https://openalex.org/W2101963972","https://openalex.org/W2109728564","https://openalex.org/W2110818436","https://openalex.org/W2111815088","https://openalex.org/W2113559481","https://openalex.org/W2117226950","https://openalex.org/W2117344292","https://openalex.org/W2123717316","https://openalex.org/W2124084123","https://openalex.org/W2151102304","https://openalex.org/W2158224318","https://openalex.org/W2167575493","https://openalex.org/W2346255608","https://openalex.org/W2409466655","https://openalex.org/W2413772593","https://openalex.org/W2467319939","https://openalex.org/W2484377507","https://openalex.org/W2550887784","https://openalex.org/W2895784427","https://openalex.org/W2977290983","https://openalex.org/W2983448774","https://openalex.org/W3009705041","https://openalex.org/W4290773045"],"related_works":["https://openalex.org/W3121049015","https://openalex.org/W4416801155","https://openalex.org/W4244178826","https://openalex.org/W2417256753","https://openalex.org/W2806094404","https://openalex.org/W2977290983","https://openalex.org/W2800737385","https://openalex.org/W2426986967","https://openalex.org/W1964361983","https://openalex.org/W4387078936"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"Identification":[2],"of":[3,37,72,128,141,156,158,171,278,289,307,317,330],"persons":[4],"living":[5,44,291],"with":[6,33,45,54,64,85,180,221,275,292,313],"human":[7],"immunodeficiency":[8],"virus":[9],"(HIV)\u2010associated":[10],"tuberculosis":[11],"(TB)":[12],"at":[13,132,257],"increased":[14],"risk":[15,36],"for":[16],"unfavourable":[17,38,172,187,222,279,318],"TB":[18,39,87,106,111,114,173,182,188,223,258,280,294,319,334],"outcomes":[19,41,108,189,224,321,335],"would":[20],"inform":[21],"efforts":[22],"to":[23,29,96,103,122,230,233,252,269,323],"improve":[24],"such":[25],"outcomes.":[26,175,282],"We":[27,76],"sought":[28],"identify":[30],"factors":[31],"associated":[32,220,274,312],"a":[34,55,78,314],"decreased":[35,276,315],"treatment":[40,107,115,150,174,242,281,320],"among":[42,82,336],"people":[43,290],"HIV\u2010infection":[46],"(PLHIV)":[47],"in":[48,88,199,208,213,295],"low\u2010":[49],"and":[50,91,113,136,149,203,254],"middle\u2010income":[51],"countries":[52],"(LMIC),":[53],"specific":[56],"focus":[57],"on":[58,333],"directly":[59],"observed":[60],"therapy":[61,66,309],"(DOT)":[62],"compared":[63,232,322],"self\u2010administered":[65],"(SAT)":[67],"during":[68,110,240,303],"the":[69,92,133,168,200,209,214,304,328],"continuation":[70,210,215,305],"phase":[71,202,216,300,306],"anti\u2010TB":[73,241,308],"therapy.":[74],"Methods":[75],"conducted":[77],"retrospective":[79],"cohort":[80,288],"study":[81],"adults":[83,179],"diagnosed":[84],"HIV\u2010associated":[86,181,293],"Africa,":[89],"Asia":[90],"Americas":[93],"from":[94,101],"2012":[95,102],"2013;":[97],"data":[98],"were":[99,119,271],"collected":[100],"2016.":[104],"Unfavourable":[105],"(death":[109],"treatment,":[112],"failure":[116],"or":[117],"recurrence)":[118],"defined":[120,137,161],"according":[121],"World":[123],"Health":[124],"Organization":[125],"criteria.":[126],"Receipt":[127],"DOT":[129,142,148,159,198,207,212,302,332],"was":[130,160,217,310],"obtained":[131],"site":[134],"level":[135],"as":[138,162],"\u22655":[139],"days":[140],"per":[143],"week.":[144],"The":[145],"person":[146],"administering":[147],"location":[151],"varied":[152],"by":[153],"site.":[154],"Lack":[155],"receipt":[157],"SAT.":[163,234,324],"Multivariable":[164],"logistic":[165],"regression":[166],"estimated":[167],"adjusted":[169],"odds":[170,277,316],"Results":[176],"Among":[177],"1862":[178],"included,":[183],"252":[184],"(13.5%)":[185],"had":[186],"(226":[190],"deaths,":[191],"26":[192],"recurrences/failures).":[193],"Overall,":[194],"1825":[195],"(98%)":[196],"received":[197,206,298],"intensive":[201,299],"1617":[204],"(87%)":[205],"phase.":[211],"not":[218,311],"significantly":[219],"(aOR":[225],"1.43,":[226],"95%":[227,249,266],"CI":[228,250,267],"0.86":[229],"2.38)":[231],"Body":[235],"mass":[236],"index":[237],"(BMI)":[238],"change":[239],"(per":[243],"2":[244],"units":[245],"increase,":[246],"aOR":[247,264],"0.74,":[248],"0.68":[251],"0.82)":[253],"CD4+":[255],"count":[256],"diagnosis":[259],"(200":[260],"vs.":[261],"50":[262],"cells/\u00b5L,":[263],"0.54,":[265],"0.39":[268],"0.73)":[270],"both":[272],"independently":[273],"Conclusions":[283],"In":[284],"this":[285],"large,":[286],"international":[287],"LMIC":[296],"who":[297],"DOT,":[301],"Randomized":[325],"trials":[326],"evaluating":[327],"effect":[329],"continuation\u2010phase":[331],"PLHIV":[337],"are":[338],"needed.":[339]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2019-12-26T00:00:00"}