{"id":"https://openalex.org/W2994590934","doi":null,"title":"Theophylline inhibits free oxygen radicals production by human monocytes via phosphodiesterase inhibition.","display_name":"Theophylline inhibits free oxygen radicals production by human monocytes via phosphodiesterase inhibition.","publication_year":2007,"publication_date":"2007-11-01","ids":{"openalex":"https://openalex.org/W2994590934","mag":"2994590934","pmid":"https://pubmed.ncbi.nlm.nih.gov/18204120"},"language":"en","primary_location":{"id":"pmid:18204120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18204120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080173835","display_name":"Joanna Chorostowska\u2010Wynimko","orcid":"https://orcid.org/0000-0003-1743-2961","observed_orcids":["https://orcid.org/0000-0003-1743-2961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Chorostowska-Wynimko","raw_affiliation_strings":["Laboratory of Molecular Diagnostics, Department of Lung Diseases, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland. j.chorostowska@igichp.edu.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Diagnostics, Department of Lung Diseases, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland. j.chorostowska@igichp.edu.pl","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110030220","display_name":"J Ku\u015b","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Kus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086525582","display_name":"Ewa Skopi\u0144ska-R\u00f3\u017cewska","orcid":"https://orcid.org/0000-0001-7033-5867","observed_orcids":["https://orcid.org/0000-0001-7033-5867"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Skopi\u0144ska-R\u00f3zewska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0792,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.81735334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"58 Suppl 5","issue":"Pt 1","first_page":"95","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.6937999725341797,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.6937999725341797,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.25099998712539673,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/theophylline","display_name":"theophylline","score":1.0},{"id":"https://openalex.org/keywords/phosphodiesterase-inhibition","display_name":"phosphodiesterase inhibition","score":0.8140000104904175},{"id":"https://openalex.org/keywords/human-monocytes","display_name":"human monocytes","score":0.7519999742507935},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.7229999899864197},{"id":"https://openalex.org/keywords/oxygen-free-radicals","display_name":"oxygen free radicals","score":0.8349999785423279},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.5419999957084656},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8510000109672546},{"id":"https://openalex.org/keywords/papaverine","display_name":"papaverine","score":0.8080000281333923},{"id":"https://openalex.org/keywords/adenosine-receptor-antagonists","display_name":"adenosine receptor antagonists","score":0.8320000171661377},{"id":"https://openalex.org/keywords/adenosine-a1-receptor","display_name":"adenosine A1 receptor","score":0.6890000104904175},{"id":"https://openalex.org/keywords/adenosine-a2-receptor","display_name":"adenosine A2 receptor","score":0.8989999890327454},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C2778095195","wikidata":"https://www.wikidata.org/wiki/Q407308","display_name":"Theophylline","level":2,"score":0.8334097862243652},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7196515202522278},{"id":"https://openalex.org/C2780634109","wikidata":"https://www.wikidata.org/wiki/Q18350222","display_name":"Adenosine receptor antagonist","level":5,"score":0.6713546514511108},{"id":"https://openalex.org/C67907053","wikidata":"https://www.wikidata.org/wiki/Q356147","display_name":"Adenosine receptor","level":4,"score":0.6533105373382568},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.6476985216140747},{"id":"https://openalex.org/C2778870864","wikidata":"https://www.wikidata.org/wiki/Q3083725","display_name":"Zymosan","level":3,"score":0.608557939529419},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5684831738471985},{"id":"https://openalex.org/C2776202631","wikidata":"https://www.wikidata.org/wiki/Q471763","display_name":"Aminophylline","level":2,"score":0.535060465335846},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.5314413905143738},{"id":"https://openalex.org/C2776952824","wikidata":"https://www.wikidata.org/wiki/Q410374","display_name":"Papaverine","level":2,"score":0.48824408650398254},{"id":"https://openalex.org/C2776766087","wikidata":"https://www.wikidata.org/wiki/Q418251","display_name":"Phosphodiesterase inhibitor","level":2,"score":0.4611940383911133},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4104878604412079},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3749060034751892},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.35557886958122253},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21763277053833008},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16715025901794434},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.1628325879573822},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13692200183868408},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09725004434585571},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07946616411209106}],"mesh":[{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010208","descriptor_name":"Papaverine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010726","descriptor_name":"Phosphodiesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014970","descriptor_name":"Xanthines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043682","descriptor_name":"Receptor, Adenosine A1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043683","descriptor_name":"Receptors, Adenosine A2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058916","descriptor_name":"Adenosine A1 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058917","descriptor_name":"Adenosine A2 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18204120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18204120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"mag:2994590934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18204120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2153062771","https://openalex.org/W2406534885","https://openalex.org/W2406673820","https://openalex.org/W2164508592","https://openalex.org/W1906051669","https://openalex.org/W1600482","https://openalex.org/W2323573074","https://openalex.org/W2335346964","https://openalex.org/W63815849","https://openalex.org/W2001606944"],"abstract_inverted_index":{"Recent":[0],"evidence":[1],"suggests":[2],"that":[3,55,146],"theophylline,":[4],"apart":[5],"from":[6,14],"bronchodilatation,":[7],"derives":[8],"its":[9],"therapeutic":[10,149],"activity":[11,52,157],"in":[12,23,34,57,148],"asthma":[13],"anti-inflammatory":[15],"effects.":[16],"Free":[17],"oxygen":[18],"radicals":[19],"play":[20],"important":[21],"role":[22],"the":[24,43,63,82,91],"perpetuation":[25],"of":[26,46,59,65,76,84,93],"inflammatory":[27],"processes":[28],"underlying":[29],"bronchoconstriction":[30],"and":[31,53,70,103,108,128,135,150],"airway":[32],"hyperresponsiveness":[33],"asthmatics.":[35],"In":[36],"our":[37],"previous":[38],"studies,":[39],"we":[40],"have":[41],"analyzed":[42],"immunomodulatory":[44],"effects":[45,92],"theophylline":[47,56,85,147],"on":[48,87,115],"human":[49,88,154],"monocyte":[50,155],"metabolic":[51,156],"showed":[54],"doses":[58],"5-20":[60],"microg/ml":[61],"inhibited":[62],"process":[64],"zymosan-induced":[66,133],"activation,":[67],"decreasing":[68],"total":[69,134],"maximum":[71,136],"O2-":[72,116,137],"production.":[73,138],"The":[74,139],"aim":[75],"present":[77],"study":[78],"was":[79,142],"to":[80],"analyze":[81],"mechanism":[83],"action":[86],"monocytes.":[89],"Therefore,":[90],"papaverine--a":[94],"phosphodiesterase":[95,99,159],"inhibitor,":[96,101],"LAS":[97,129],"31025--selective":[98],"IV":[100],"8-phenyltheophylline--A1":[102],"A2":[104],"adenosine":[105],"receptors":[106],"antagonist,":[107],"8-cyclopenthyl-1,":[109],"3":[110],"dipropylxanthine--selective":[111],"A1":[112],"receptor":[113,121],"antagonist":[114,122],"release":[117],"were":[118],"assessed.":[119],"Adenosine":[120],"exerted":[123],"no":[124],"influence,":[125],"while":[126],"papaverine":[127],"31025":[130],"suppressed":[131],"spontaneous,":[132],"suppressant":[140],"effect":[141],"concentration-dependent.":[143],"We":[144],"conclude":[145],"subtherapeutic":[151],"concentrations":[152],"suppresses":[153],"via":[158],"inhibition.":[160]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-13T00:00:00"}