{"id":"https://openalex.org/W2994569236","doi":"https://doi.org/10.21769/bioprotoc.3439","title":"Mapping the Mechanome\u2013A Protocol for Simultaneous Live Imaging and Quantitative Analysis of Cell Mechanoadaptation and Ingression","display_name":"Mapping the Mechanome\u2013A Protocol for Simultaneous Live Imaging and Quantitative Analysis of Cell Mechanoadaptation and Ingression","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2994569236","doi":"https://doi.org/10.21769/bioprotoc.3439","mag":"2994569236","pmid":"https://pubmed.ncbi.nlm.nih.gov/33654934","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7853984"},"language":"en","primary_location":{"id":"doi:10.21769/bioprotoc.3439","doi":"https://doi.org/10.21769/bioprotoc.3439","is_oa":true,"landing_page_url":"https://doi.org/10.21769/bioprotoc.3439","pdf_url":"https://bio-protocol.org/pdf/Bio-protocol3439.pdf","source":{"id":"https://openalex.org/S4210179406","display_name":"BIO-PROTOCOL","issn_l":"2331-8325","issn":["2331-8325"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320252","host_organization_name":"American Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/P4310320252"],"host_organization_lineage_names":["American Academy of Arts and Sciences"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BIO-PROTOCOL","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://bio-protocol.org/pdf/Bio-protocol3439.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068598204","display_name":"Vina D. L. Putra","orcid":"https://orcid.org/0000-0002-0688-2468","observed_orcids":["https://orcid.org/0000-0002-0688-2468"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Vina Putra","raw_affiliation_strings":["MechBio Team, Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MechBio Team, Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031751030","display_name":"Iman Jalilian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Iman Jalilian","raw_affiliation_strings":["Department of Cell Biology, Yale University, New Haven, USA","MechBio Team, Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Yale University, New Haven, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"MechBio Team, Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085446249","display_name":"Madeline Campbell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Madeline Campbell","raw_affiliation_strings":["MechBio Team, Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MechBio Team, Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070609220","display_name":"Kate Poole","orcid":"https://orcid.org/0000-0003-0879-6093","observed_orcids":["https://orcid.org/0000-0003-0879-6093"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210098306","display_name":"EMBL Australia","ror":"https://ror.org/00yx5cw48","country_code":"AU","type":"government","lineage":["https://openalex.org/I4210098306"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kate Poole","raw_affiliation_strings":["Cellular Mechanotransduction Group, EMBL Australia Node in Single Molecule Science, School of Medical Sciences, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Mechanotransduction Group, EMBL Australia Node in Single Molecule Science, School of Medical Sciences, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210098306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002429612","display_name":"Renee Megan Whan","orcid":"https://orcid.org/0000-0002-6664-6344","observed_orcids":["https://orcid.org/0000-0002-6664-6344"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4405259150","display_name":"Mark Wainwright Analytical Centre","ror":"https://ror.org/01trzbr20","country_code":"AU","type":"facility","lineage":["https://openalex.org/I31746571","https://openalex.org/I4405259150"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Renee Whan","raw_affiliation_strings":["Mark Wainwright Analytical Centre, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mark Wainwright Analytical Centre, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4405259150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036700052","display_name":"Florence Tomasetig","orcid":"https://orcid.org/0000-0002-6827-9453","observed_orcids":["https://orcid.org/0000-0002-6827-9453"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4405259150","display_name":"Mark Wainwright Analytical Centre","ror":"https://ror.org/01trzbr20","country_code":"AU","type":"facility","lineage":["https://openalex.org/I31746571","https://openalex.org/I4405259150"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Florence Tomasetig","raw_affiliation_strings":["Mark Wainwright Analytical Centre, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mark Wainwright Analytical Centre, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4405259150"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004319969","display_name":"Melissa L. Knothe Tate","orcid":"https://orcid.org/0000-0002-3552-2525","observed_orcids":["https://orcid.org/0000-0002-3552-2525"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Melissa Knothe Tate","raw_affiliation_strings":["MechBio Team, Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MechBio Team, Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004319969"],"corresponding_institution_ids":["https://openalex.org/I31746571"],"apc_list":null,"apc_paid":null,"fwci":0.1324,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.46179254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"9","issue":"23","first_page":"e3439","last_page":"e3439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanoadaptation","display_name":"mechanical adaptation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/mechanobiology","display_name":"mechanobiology","score":0.8930000066757202},{"id":"https://openalex.org/keywords/stem-cells","display_name":"stem cells","score":0.6809999942779541},{"id":"https://openalex.org/keywords/live-cell-imaging","display_name":"live-cell imaging","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cell-tracking","display_name":"cell tracking","score":0.5},{"id":"https://openalex.org/keywords/actin","display_name":"actin","score":0.6370000243186951},{"id":"https://openalex.org/keywords/tubulin","display_name":"tubulin","score":0.996999979019165},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.6869999766349792},{"id":"https://openalex.org/keywords/nuclear-volume","display_name":"nuclear volume","score":0.6200000047683716},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/c3h10t1-2-cells","display_name":"C3H10T1/2 cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/neuroblastoma-cells","display_name":"neuroblastoma cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cell-ingression","display_name":"cell ingression","score":0.7590000033378601},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.8320000171661377},{"id":"https://openalex.org/keywords/lineage-commitment","display_name":"lineage commitment","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C2780171871","wikidata":"https://www.wikidata.org/wiki/Q6804676","display_name":"Mechanobiology","level":2,"score":0.7117729783058167},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6606273055076599},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6484726667404175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6365022659301758},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6033374071121216},{"id":"https://openalex.org/C15526883","wikidata":"https://www.wikidata.org/wiki/Q6657126","display_name":"Live cell imaging","level":3,"score":0.5734460949897766},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.47789323329925537},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4430139362812042},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.328941285610199},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13641926646232605},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12366893887519836}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.21769/bioprotoc.3439","doi":"https://doi.org/10.21769/bioprotoc.3439","is_oa":true,"landing_page_url":"https://doi.org/10.21769/bioprotoc.3439","pdf_url":"https://bio-protocol.org/pdf/Bio-protocol3439.pdf","source":{"id":"https://openalex.org/S4210179406","display_name":"BIO-PROTOCOL","issn_l":"2331-8325","issn":["2331-8325"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320252","host_organization_name":"American Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/P4310320252"],"host_organization_lineage_names":["American Academy of Arts and Sciences"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BIO-PROTOCOL","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7853984","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7853984","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bio Protoc","raw_type":"Text"},{"id":"pmid:33654934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33654934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bio-protocol","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cb2296df83c548109ff16a6e7fb337e3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/cb2296df83c548109ff16a6e7fb337e3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bio-Protocol, Vol 9, Iss 23 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.21769/bioprotoc.3439","doi":"https://doi.org/10.21769/bioprotoc.3439","is_oa":true,"landing_page_url":"https://doi.org/10.21769/bioprotoc.3439","pdf_url":"https://bio-protocol.org/pdf/Bio-protocol3439.pdf","source":{"id":"https://openalex.org/S4210179406","display_name":"BIO-PROTOCOL","issn_l":"2331-8325","issn":["2331-8325"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320252","host_organization_name":"American Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/P4310320252"],"host_organization_lineage_names":["American Academy of Arts and Sciences"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BIO-PROTOCOL","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320319755","display_name":"Analytical Center for the Government of the Russian Federation","ror":"https://ror.org/01zwzc219"},{"id":"https://openalex.org/F4320320965","display_name":"University of New South Wales","ror":"https://ror.org/03r8z3t63"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2994569236.pdf","grobid_xml":"https://content.openalex.org/works/W2994569236.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W92152433","https://openalex.org/W222677860","https://openalex.org/W1481395611","https://openalex.org/W1525071054","https://openalex.org/W1585217303","https://openalex.org/W1872647657","https://openalex.org/W1967474814","https://openalex.org/W1968272833","https://openalex.org/W1970671651","https://openalex.org/W1975553175","https://openalex.org/W1980821201","https://openalex.org/W1980873499","https://openalex.org/W1995946343","https://openalex.org/W1999173314","https://openalex.org/W2003948204","https://openalex.org/W2004148494","https://openalex.org/W2022590623","https://openalex.org/W2035483677","https://openalex.org/W2037390556","https://openalex.org/W2050813185","https://openalex.org/W2051094099","https://openalex.org/W2058036222","https://openalex.org/W2060015784","https://openalex.org/W2068799496","https://openalex.org/W2072501343","https://openalex.org/W2075470662","https://openalex.org/W2088429452","https://openalex.org/W2089202108","https://openalex.org/W2093351508","https://openalex.org/W2103202783","https://openalex.org/W2105872854","https://openalex.org/W2115592755","https://openalex.org/W2117023190","https://openalex.org/W2126092026","https://openalex.org/W2138435864","https://openalex.org/W2142430509","https://openalex.org/W2142817949","https://openalex.org/W2145123926","https://openalex.org/W2149966352","https://openalex.org/W2167135785","https://openalex.org/W2171232910","https://openalex.org/W2402631817","https://openalex.org/W2408227741","https://openalex.org/W2461967856","https://openalex.org/W2478854880","https://openalex.org/W2530790582","https://openalex.org/W2623014782","https://openalex.org/W2725388488","https://openalex.org/W2760415787","https://openalex.org/W2767369251","https://openalex.org/W2920927997","https://openalex.org/W2952409381","https://openalex.org/W2989740905","https://openalex.org/W2999507022","https://openalex.org/W4255280766"],"related_works":["https://openalex.org/W2999507022","https://openalex.org/W2239693865","https://openalex.org/W2292167808","https://openalex.org/W2022590623","https://openalex.org/W2530790582","https://openalex.org/W4405133459","https://openalex.org/W4413447741","https://openalex.org/W4389829965","https://openalex.org/W6889828707","https://openalex.org/W2599924083"],"abstract_inverted_index":{"Mechanomics,":[0],"the":[1,34,37,150,185,215,218,229,232],"mechanics":[2],"equivalent":[3],"of":[4,13,23,33,39,63,73,79,96,117,128,156,180,184,217,224],"genomics,":[5],"is":[6],"a":[7,24,144,163,169],"burgeoning":[8],"field":[9],"studying":[10],"mechanical":[11,21,82],"modulation":[12],"stem":[14,51,98,139,160,225],"cell":[15,71,146,173,226],"behavior":[16],"and":[17,30,47,56,83,94,102,107,115,119,126,130,142,200,220,234],"lineage":[18,193],"commitment.Analogous":[19],"to":[20,42,91,152,213,231],"testing":[22],"living":[25],"material":[26],"as":[27,53,122,124],"it":[28],"adapts":[29],"evolves,":[31],"mapping":[32,216],"mechanome":[35,219],"necessitates":[36],"development":[38],"new":[40],"protocols":[41,90,111,177],"assess":[43],"changes":[44,80],"in":[45,49,66,81,100,133,143,162,168,171],"structure":[46],"function":[48],"live":[50,70,97,109],"cells":[52,68,75,99,129,140,161,186],"they":[54],"adapt":[55],"differentiate.Previous":[57],"techniques":[58],"have":[59],"relied":[60],"on":[61],"imaging":[62,72,110],"cellular":[64,230],"structures":[65],"fixed":[67],"and/or":[69],"single":[74],"with":[76],"separate":[77],"studies":[78],"biological":[84],"properties.Here":[85],"we":[86,105,148],"present":[87],"two":[88],"complementary":[89],"study":[92,155,179],"mechanobiology":[93],"mechanoadaptation":[95,121,183],"adherent":[101,134],"motile":[103,164],"contexts.First,":[104],"developed":[106],"tested":[108],"for":[112],"simultaneous":[113],"visualization":[114],"tracking":[116,192],"actin":[118],"tubulin":[120],"well":[123],"shape":[125],"volume":[127],"their":[131],"nuclei":[132],"model":[135],"embryonic":[136],"murine":[137],"mesenchymal":[138,159],"(C3H/10T1/2)":[141],"neuroblastoma":[145],"line.Then":[147],"applied":[149],"protocol":[151],"enable":[153,178],"quantitative":[154],"primary":[157],"human":[158],"state,":[165],"e.g.,":[166],"ingression":[167],"three-dimensional,":[170],"vitro":[172],"culture":[174],"model.Together,":[175],"these":[176],"emergent":[181],"structural":[182],"own":[187],"cytoskeletal":[188],"machiner":[189],"y":[190],"while":[191],"commitment":[194],"using":[195],"phenotypic":[196],"(quantitative":[197],"morphology":[198],"measures)":[199],"genotypic":[201],"(e.g.,":[202],"reverse":[203],"transcription":[204],"Polymerase":[205],"Chain":[206],"Reaction,":[207],"rtPCR)":[208],"methods.These":[209],"tools":[210],"are":[211],"expected":[212],"facilitate":[214],"incipient":[221],"mechanistic":[222],"understanding":[223],"mechanobiology,":[227],"from":[228],"tissue":[233],"organ":[235],"length":[236],"scales.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-12-13T00:00:00"}
