{"id":"https://openalex.org/W2994487263","doi":null,"title":"DNA Binding Domains of LEDGF: Contribution of the Two Helix\u2013 Turn\u2013Helix (HTH) and One Zinc Finger\u2013Like Domains to the Trans\u2013activation potential of LEDGF","display_name":"DNA Binding Domains of LEDGF: Contribution of the Two Helix\u2013 Turn\u2013Helix (HTH) and One Zinc Finger\u2013Like Domains to the Trans\u2013activation potential of LEDGF","publication_year":2004,"publication_date":"2004-05-01","ids":{"openalex":"https://openalex.org/W2994487263","mag":"2994487263"},"language":"en","primary_location":{"id":"mag:2994487263","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2405911","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101836695","display_name":"Dhirendra P. Singh","orcid":"https://orcid.org/0000-0003-3311-2191","observed_orcids":["https://orcid.org/0000-0003-3311-2191"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dhirendra P. Singh","raw_affiliation_strings":["Ophthalmology, University of Nebraska Medical Center, Omaha, NE"],"raw_orcid":"https://orcid.org/0000-0003-3311-2191","affiliations":[{"raw_affiliation_string":"Ophthalmology, University of Nebraska Medical Center, Omaha, NE","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072279870","display_name":"Eri Kubo","orcid":"https://orcid.org/0000-0001-6789-9311","observed_orcids":["https://orcid.org/0000-0001-6789-9311"]},"institutions":[{"id":"https://openalex.org/I111966504","display_name":"University of Fukui","ror":"https://ror.org/00msqp585","country_code":"JP","type":"education","lineage":["https://openalex.org/I111966504"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eri Kubo","raw_affiliation_strings":["Ophthalmology, Univ of Fukui, Fukui, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6789-9311","affiliations":[{"raw_affiliation_string":"Ophthalmology, Univ of Fukui, Fukui, Japan","institution_ids":["https://openalex.org/I111966504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021530758","display_name":"Toshimichi Shinohara","orcid":"https://orcid.org/0000-0002-7197-9039","observed_orcids":["https://orcid.org/0000-0002-7197-9039"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toshimichi Shinohara","raw_affiliation_strings":["Ophthalmology, University of Nebraska Medical Center, Omaha, NE"],"raw_orcid":"https://orcid.org/0000-0002-7197-9039","affiliations":[{"raw_affiliation_string":"Ophthalmology, University of Nebraska Medical Center, Omaha, NE","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113447456","display_name":"L T Chylack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L T Chylack","raw_affiliation_strings":["Center for Ophthalmic Research, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Ophthalmic Research, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111912416","display_name":"N. Fatma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Fatma","raw_affiliation_strings":["Ophthalmology, University of Nebraska Medical Center, Omaha, NE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, University of Nebraska Medical Center, Omaha, NE","institution_ids":["https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29252936,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"13","first_page":"393","last_page":"393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ledgf","display_name":"LEDGF","score":0.9739999771118164},{"id":"https://openalex.org/keywords/dna-binding-domain","display_name":"DNA-binding domain","score":0.5849999785423279},{"id":"https://openalex.org/keywords/helix-turn-helix","display_name":"helix-turn-helix","score":0.7879999876022339},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.8617176413536072},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.8151919841766357},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.5108796954154968},{"id":"https://openalex.org/C85641259","wikidata":"https://www.wikidata.org/wiki/Q290042","display_name":"Turn (biochemistry)","level":2,"score":0.4623170495033264},{"id":"https://openalex.org/C199487717","wikidata":"https://www.wikidata.org/wiki/Q24786260","display_name":"Helix-turn-helix","level":5,"score":0.4498056173324585},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.42679399251937866},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3989366292953491},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.3878651261329651},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.373968243598938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3382628262042999},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30985742807388306},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.12924453616142273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12762042880058289},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10691320896148682},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2994487263","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2405911","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1984598132","https://openalex.org/W2042625748","https://openalex.org/W2740513813","https://openalex.org/W2526931630","https://openalex.org/W6960031406","https://openalex.org/W1147884308","https://openalex.org/W2766344869","https://openalex.org/W168194700","https://openalex.org/W2137026617","https://openalex.org/W2977894246"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2019-12-13T00:00:00"}