{"id":"https://openalex.org/W2994483572","doi":null,"title":"Protective effect of Co-enzyme Q10 on seizure, short term spatial memory and oxidative stress in induced-epileptic rats","display_name":"Protective effect of Co-enzyme Q10 on seizure, short term spatial memory and oxidative stress in induced-epileptic rats","publication_year":2014,"publication_date":"2014-03-01","ids":{"openalex":"https://openalex.org/W2994483572","mag":"2994483572"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:0a7e49b24edb4f1492e95afb408ff3f2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0a7e49b24edb4f1492e95afb408ff3f2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0645\u062c\u0644\u0647 \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u0639\u0644\u0648\u0645 \u067e\u0632\u0634\u06a9\u06cc \u06af\u0631\u06af\u0627\u0646, Vol 16, Iss 1, Pp 14-21 (2014)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/0a7e49b24edb4f1492e95afb408ff3f2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073707783","display_name":"Tourandokht Baluchnejadmojarad","orcid":"https://orcid.org/0000-0002-2703-728X","observed_orcids":["https://orcid.org/0000-0002-2703-728X"]},"institutions":[{"id":"https://openalex.org/I161106909","display_name":"Iran University of Medical Sciences","ror":"https://ror.org/03w04rv71","country_code":"IR","type":"education","lineage":["https://openalex.org/I161106909"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Baluchnejadmojarad T","raw_affiliation_strings":["\n             Professor, Department of Physiology, School of Medicine, Iran University of Medical Sciences,Tehran, Iran    \n\t"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\n             Professor, Department of Physiology, School of Medicine, Iran University of Medical Sciences,Tehran, Iran    \n\t","institution_ids":["https://openalex.org/I161106909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070346344","display_name":"Mehrdad Roghani","orcid":"https://orcid.org/0000-0002-9209-8484","observed_orcids":["https://orcid.org/0000-0002-9209-8484"]},"institutions":[{"id":"https://openalex.org/I119025939","display_name":"Shahed University","ror":"https://ror.org/01e8ff003","country_code":"IR","type":"education","lineage":["https://openalex.org/I119025939"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Roghani M","raw_affiliation_strings":["\n             Professor, Neurophysiology Research Center, Shahed University,Tehran, Iran    \n\t"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\n             Professor, Neurophysiology Research Center, Shahed University,Tehran, Iran    \n\t","institution_ids":["https://openalex.org/I119025939"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.40357794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.13770000636577606,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coenzyme-q10","display_name":"coenzyme Q10","score":0.8820000290870667},{"id":"https://openalex.org/keywords/temporal-lobe-epilepsy","display_name":"temporal lobe epilepsy","score":0.8640000224113464},{"id":"https://openalex.org/keywords/kainic-acid-induced-epilepsy","display_name":"kainic acid-induced epilepsy","score":0.9589999914169312},{"id":"https://openalex.org/keywords/seizures","display_name":"seizures","score":0.7139999866485596},{"id":"https://openalex.org/keywords/spatial-short-term-memory","display_name":"spatial short-term memory","score":0.9629999995231628},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9520000219345093},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9539999961853027},{"id":"https://openalex.org/keywords/nitrite","display_name":"nitrite","score":0.9670000076293945},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.781262993812561},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.6130537390708923},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.45780467987060547},{"id":"https://openalex.org/C2779334592","wikidata":"https://www.wikidata.org/wiki/Q6279182","display_name":"Epileptic seizure","level":3,"score":0.4542350172996521},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.43444114923477173},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3126908540725708},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2914564609527588},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2866339087486267},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1295655369758606},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:0a7e49b24edb4f1492e95afb408ff3f2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0a7e49b24edb4f1492e95afb408ff3f2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0645\u062c\u0644\u0647 \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u0639\u0644\u0648\u0645 \u067e\u0632\u0634\u06a9\u06cc \u06af\u0631\u06af\u0627\u0646, Vol 16, Iss 1, Pp 14-21 (2014)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:0a7e49b24edb4f1492e95afb408ff3f2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0a7e49b24edb4f1492e95afb408ff3f2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0645\u062c\u0644\u0647 \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u0639\u0644\u0648\u0645 \u067e\u0632\u0634\u06a9\u06cc \u06af\u0631\u06af\u0627\u0646, Vol 16, Iss 1, Pp 14-21 (2014)","raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W238106794","https://openalex.org/W1583585930","https://openalex.org/W1607065540","https://openalex.org/W1616682748","https://openalex.org/W1911339081","https://openalex.org/W1938152176","https://openalex.org/W1967751169","https://openalex.org/W1976940800","https://openalex.org/W1983221766","https://openalex.org/W1988905501","https://openalex.org/W1994101711","https://openalex.org/W1995186464","https://openalex.org/W1995444099","https://openalex.org/W2000828660","https://openalex.org/W2001817718","https://openalex.org/W2002111965","https://openalex.org/W2006457855","https://openalex.org/W2013911972","https://openalex.org/W2013926783","https://openalex.org/W2014545614","https://openalex.org/W2015380328","https://openalex.org/W2016293448","https://openalex.org/W2017245711","https://openalex.org/W2026048677","https://openalex.org/W2030030552","https://openalex.org/W2031575360","https://openalex.org/W2037288337","https://openalex.org/W2043830456","https://openalex.org/W2045871887","https://openalex.org/W2055031312","https://openalex.org/W2059223526","https://openalex.org/W2066375606","https://openalex.org/W2078333644","https://openalex.org/W2084464741","https://openalex.org/W2090309274","https://openalex.org/W2093238337","https://openalex.org/W2099956125","https://openalex.org/W2103946141","https://openalex.org/W2111680392","https://openalex.org/W2119873134","https://openalex.org/W2128635872","https://openalex.org/W2134855793","https://openalex.org/W2158884281","https://openalex.org/W2171471740","https://openalex.org/W2273901538","https://openalex.org/W2407221497","https://openalex.org/W2417192910","https://openalex.org/W2480598026","https://openalex.org/W3188106608"],"related_works":["https://openalex.org/W2098792305","https://openalex.org/W2068623125","https://openalex.org/W2891319058","https://openalex.org/W3119381293","https://openalex.org/W2058896104","https://openalex.org/W2943220478","https://openalex.org/W3042529371","https://openalex.org/W2500857469","https://openalex.org/W2046420682","https://openalex.org/W4236168947"],"abstract_inverted_index":{"Background":[0],"and":[1,20,41,74,102,135,165,193,198],"Objective:":[2],"Temporal":[3],"lobe":[4],"epilepsy":[5,12],"is":[6],"the":[7,29],"most":[8],"common":[9],"type":[10],"of":[11,31,47,91,125,131,137,147,154,182,191],"in":[13,45,95,106,115,127,202],"human.":[14],"Patients":[15],"suffer":[16],"from":[17],"spontaneous":[18,104,155],"seizures":[19,105,156,192],"memory":[21,40,197],"deficiency.":[22],"This":[23],"study":[24],"was":[25,81],"done":[26],"to":[27,142],"assess":[28],"effect":[30,175],"Co-enzyme":[32],"Q10":[33],"(CoQ10)":[34],"administration":[35,111],"on":[36,176],"seizure,":[37],"short-term":[38,195],"spatial":[39,196],"stress":[42,200],"oxidative":[43,199],"indices":[44,201],"hippocampus":[46],"kainic":[48,78,92,109,183],"acid-induced":[49],"epilepsy.":[50],"Methods:":[51],"In":[52],"this":[53],"experimental":[54],"study,":[55],"48":[56],"male":[57],"rats":[58,149,186],"were":[59],"randomly":[60],"allocated":[61],"into":[62,123],"six":[63],"groups:":[64],"sham-operated":[65],"CoQ10":[66,71,80,151,158,188],"(10":[67],"mg/kg/bw)-treated":[68],"SH":[69],"kainate":[70,148],"(2,":[72],"5":[73],"10":[75],"mg/kg/bw)":[76],"treated":[77],"acid.":[79],"intraperitoneally":[82],"administered":[83],"daily":[84],"for":[85],"one":[86],"week":[87],"before":[88],"intra-hippocampal":[89],"injection":[90],"acid":[93,99,110,184],"(4\u00b5g/kg/bw)":[94],"animals.":[96,107],"Results:":[97],"Kainic":[98],"induced":[100],"chronic":[101],"acute":[103],"Also,":[108],"caused":[112],"a":[113],"reduction":[114],"alternational":[116,160],"behavior":[117,161],"rate":[118,153,190],"(consecutive":[119],"or":[120],"serially":[121],"entrance":[122],"all":[124],"arms":[126],"triplet":[128],"set),":[129],"increasing":[130],"malondialdehide,":[132],"nitrite":[133,166],"level":[134,168],"decreasing":[136],"superoxide":[138,177],"dismutase":[139,178],"activity":[140],"compared":[141],"sham":[143],"group":[144],"(P<0.05).":[145,157,169],"Pre-treatment":[146,181],"with":[150,187],"decreased":[152,163],"increased":[159],"rate,":[162],"malondialdehide":[164],"serum":[167],"But":[170],"it":[171],"had":[172],"no":[173],"significant":[174],"activity.":[179],"Conclusion:":[180],"exposed":[185],"reduced":[189],"improved":[194],"rats.":[203]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2019-12-13T00:00:00"}