{"id":"https://openalex.org/W2994465274","doi":null,"title":"Current approaches in regenerative medicine for the treatment of diabetes: introducing CRISPR/CAS9 technology and the case for non-embryonic stem cell therapy.","display_name":"Current approaches in regenerative medicine for the treatment of diabetes: introducing CRISPR/CAS9 technology and the case for non-embryonic stem cell therapy.","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2994465274","mag":"2994465274","pmid":"https://pubmed.ncbi.nlm.nih.gov/30697454","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6334205"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5329498","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6334205","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6334205","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036530894","display_name":"Lauren Coombe","orcid":"https://orcid.org/0000-0002-7518-2326","observed_orcids":["https://orcid.org/0000-0002-7518-2326"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Coombe","raw_affiliation_strings":["Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center 3900 Reservoir Road NW, Washington DC 20007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center 3900 Reservoir Road NW, Washington DC 20007, USA","institution_ids":["https://openalex.org/I2799903593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079811128","display_name":"Aamir Kadri","orcid":"https://orcid.org/0000-0002-8037-7945","observed_orcids":["https://orcid.org/0000-0002-8037-7945"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aamir Kadri","raw_affiliation_strings":["Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center 3900 Reservoir Road NW, Washington DC 20007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center 3900 Reservoir Road NW, Washington DC 20007, USA","institution_ids":["https://openalex.org/I2799903593"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jessica Ferrer Martinez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Ferrer Martinez","raw_affiliation_strings":["Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center 3900 Reservoir Road NW, Washington DC 20007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center 3900 Reservoir Road NW, Washington DC 20007, USA","institution_ids":["https://openalex.org/I2799903593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089909448","display_name":"Vivas Tatachar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivas Tatachar","raw_affiliation_strings":["Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center 3900 Reservoir Road NW, Washington DC 20007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center 3900 Reservoir Road NW, Washington DC 20007, USA","institution_ids":["https://openalex.org/I2799903593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083808447","display_name":"G. Ian Gallicano","orcid":"https://orcid.org/0000-0001-8399-1556","observed_orcids":["https://orcid.org/0000-0001-8399-1556"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Ian Gallicano","raw_affiliation_strings":["Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center 3900 Reservoir Road NW, Washington DC 20007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center 3900 Reservoir Road NW, Washington DC 20007, USA","institution_ids":["https://openalex.org/I2799903593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2799903593"],"apc_list":null,"apc_paid":null,"fwci":0.7292,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.73280508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"7","issue":"5","first_page":"104","last_page":"113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.031599998474121094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8989999890327454},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.8799999952316284},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.9269999861717224},{"id":"https://openalex.org/keywords/crispr-cas9","display_name":"CRISPR/Cas9","score":0.8859999775886536},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/human-embryonic-stem-cells","display_name":"human embryonic stem cells","score":0.9729999899864197},{"id":"https://openalex.org/keywords/adult-stem-cells","display_name":"adult stem cells","score":0.7799999713897705},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.7250000238418579},{"id":"https://openalex.org/keywords/islet-regeneration","display_name":"islet regeneration","score":0.75},{"id":"https://openalex.org/keywords/somatic-cell-nuclear-transfer","display_name":"somatic cell nuclear transfer","score":0.9620000123977661},{"id":"https://openalex.org/keywords/stem-cell-ethics","display_name":"stem cell research ethics","score":0.7039999961853027},{"id":"https://openalex.org/keywords/pancreas-transplantation","display_name":"pancreas transplantation","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7809409499168396},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7688912153244019},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7096471190452576},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.6570112109184265},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5421943664550781},{"id":"https://openalex.org/C143441281","wikidata":"https://www.wikidata.org/wiki/Q5133858","display_name":"Clinical uses of mesenchymal stem cells","level":5,"score":0.48352885246276855},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.47811904549598694},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.47037142515182495},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.45776063203811646},{"id":"https://openalex.org/C2779389132","wikidata":"https://www.wikidata.org/wiki/Q1533033","display_name":"Stem-cell therapy","level":3,"score":0.45466700196266174},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.42821961641311646},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4253814220428467},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34861958026885986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3036189079284668},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29857245087623596},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2148805856704712},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06373810768127441},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:5329498","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6334205","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6334205","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6334205","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Stem Cells","raw_type":"Text"},{"id":"pmid:30697454","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30697454","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of stem cells","raw_type":"Journal Article"},{"id":"mag:2994465274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30697454","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5329498","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6334205","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1855140684","https://openalex.org/W1975582083","https://openalex.org/W2000415769","https://openalex.org/W2002358384","https://openalex.org/W2023295447","https://openalex.org/W2032472678","https://openalex.org/W2036682769","https://openalex.org/W2051570027","https://openalex.org/W2054570348","https://openalex.org/W2063135302","https://openalex.org/W2084223203","https://openalex.org/W2086943348","https://openalex.org/W2086948443","https://openalex.org/W2102414730","https://openalex.org/W2107975900","https://openalex.org/W2113690846","https://openalex.org/W2116962418","https://openalex.org/W2136331613","https://openalex.org/W2136430025","https://openalex.org/W2148890861","https://openalex.org/W2553768201","https://openalex.org/W2565689687","https://openalex.org/W2580656391","https://openalex.org/W2582801455","https://openalex.org/W2622166906","https://openalex.org/W2626822318","https://openalex.org/W2767609674"],"related_works":["https://openalex.org/W2166814643","https://openalex.org/W2171099032","https://openalex.org/W2046207030","https://openalex.org/W1911808314","https://openalex.org/W2553166446","https://openalex.org/W2790265474","https://openalex.org/W16755528","https://openalex.org/W7221239358","https://openalex.org/W1967314103","https://openalex.org/W2076362043"],"abstract_inverted_index":{"Type":[0],"1":[1],"diabetes":[2,119],"mellitus":[3],"(T1DM)":[4],"is":[5,100,116],"an":[6],"autoimmune":[7],"disorder":[8],"in":[9,192],"which":[10,110],"the":[11,48,71,82,126,157,169,182,189,216],"body":[12],"destroys":[13],"its":[14],"pancreatic":[15],"\u03b2":[16],"cells.":[17],"Since":[18],"these":[19,30,175],"cells":[20,31,93,133,138,143,146,151],"are":[21,59],"responsible":[22],"for":[23,81,118,128,220],"insulin":[24,38],"production,":[25],"dysfunction":[26],"or":[27,144],"destruction":[28],"of":[29,50,73,84,88,98,112,162,184],"necessitates":[32],"blood":[33],"glucose":[34],"control":[35],"through":[36],"exogenous":[37],"shots.":[39],"Curative":[40],"treatment":[41,83],"involves":[42],"pancreas":[43],"transplantation,":[44],"but":[45,102],"due":[46],"to":[47,91,108,147],"incidence":[49],"transplant":[51],"rejection":[52],"and":[53,66,94,104,140,152,160,165,171,177,209],"complications":[54],"associated":[55],"with":[56,68,96],"immunosuppression,":[57],"alternatives":[58],"being":[60],"explored.":[61],"Despite":[62],"facing":[63],"clinical":[64],"challenges":[65],"issues":[67],"public":[69,172],"perception,":[70],"field":[72],"regenerative":[74],"stem":[75,113,132,137,142,185,199,213],"cell":[76,114,186,200,205],"therapy":[77],"shows":[78],"great":[79],"promise":[80],"diabetes.":[85,222],"The":[86],"idea":[87],"harnessing":[89],"pluripotency":[90],"derive":[92],"tissues":[95],"characteristics":[97],"choice":[99],"astounding":[101],"feasible,":[103],"this":[105,122,193],"review":[106],"seeks":[107],"determine":[109],"method":[111],"derivation":[115],"preferable":[117],"treatment.":[120],"In":[121],"report,":[123],"we":[124,166,195],"outline":[125],"methods":[127,176],"deriving":[129],"human":[130],"embryonic":[131],"(hESCs),":[134],"induced":[135],"pluripotent":[136],"(iPSCs),":[139],"adult":[141,210],"progenitor":[145],"generate":[148],"functional":[149],"islet":[150],"related":[153],"tissues.":[154],"We":[155],"discuss":[156],"specific":[158],"uses":[159],"advantages":[161],"each":[163],"method,":[164],"comment":[167],"on":[168],"ethics":[170],"perceptions":[173],"surrounding":[174],"how":[178],"they":[179],"may":[180],"affect":[181],"future":[183],"research.":[187],"For":[188],"reasons":[190],"outlined":[191],"paper,":[194],"believe":[196],"that":[197],"non-embryonic":[198],"lines,":[201,208],"including":[202],"iPSCs,":[203],"somatic":[204],"nuclear":[206],"transfer":[207],"tissue":[211],"derived":[212],"cells,":[214],"offer":[215],"highest":[217],"therapeutic":[218],"potential":[219],"treating":[221]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2019-12-13T00:00:00"}
