{"id":"https://openalex.org/W2994417240","doi":null,"title":"[Bone metabolism and cardiovascular function update. Role of vitamin D in the bone and vascular intercommunication].","display_name":"[Bone metabolism and cardiovascular function update. Role of vitamin D in the bone and vascular intercommunication].","publication_year":2014,"publication_date":"2014-07-01","ids":{"openalex":"https://openalex.org/W2994417240","mag":"2994417240","pmid":"https://pubmed.ncbi.nlm.nih.gov/24976055"},"language":"ja","primary_location":{"id":"pmid:24976055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24976055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102240936","display_name":"Toshio Okano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197065826","display_name":"Kobe Pharmaceutical University","ror":"https://ror.org/00088z429","country_code":"JP","type":"education","lineage":["https://openalex.org/I197065826"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshio Okano","raw_affiliation_strings":["Department of Hygienic Sciences, Kobe Pharmaceutical University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygienic Sciences, Kobe Pharmaceutical University, Japan","institution_ids":["https://openalex.org/I197065826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102240936"],"corresponding_institution_ids":["https://openalex.org/I197065826"],"apc_list":null,"apc_paid":null,"fwci":0.4358,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.64008528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"24","issue":"7","first_page":"45","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.76419997215271,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.76419997215271,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.23180000483989716,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13004","display_name":"Vitamin K Research Studies","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.9900000095367432},{"id":"https://openalex.org/keywords/vascular-calcification","display_name":"vascular calcification","score":0.8389999866485596},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.6729999780654907},{"id":"https://openalex.org/keywords/cardiovascular-function","display_name":"cardiovascular function","score":0.7789999842643738},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.6710000038146973},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.621999979019165},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.9340000152587891},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9139999747276306},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.9359999895095825},{"id":"https://openalex.org/keywords/calcium-metabolism","display_name":"calcium metabolism","score":0.8259999752044678},{"id":"https://openalex.org/keywords/dialysis-patients","display_name":"dialysis patients","score":0.7820000052452087},{"id":"https://openalex.org/keywords/bone-vascular-crosstalk","display_name":"bone-vascular crosstalk","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.7261569499969482},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.6848286986351013},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.6371103525161743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6140638589859009},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5775893926620483},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5611222982406616},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.5070452690124512},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.5048266053199768},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.4909403622150421},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.11610683798789978}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061205","descriptor_name":"Vascular Calcification","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24976055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24976055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"English Abstract"},{"id":"mag:2994417240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24976055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W41516964","https://openalex.org/W58690323","https://openalex.org/W93053989","https://openalex.org/W1501473386","https://openalex.org/W1547733031","https://openalex.org/W1594144334","https://openalex.org/W2008492357","https://openalex.org/W2014707628","https://openalex.org/W2045562495","https://openalex.org/W2066613071","https://openalex.org/W2098511755","https://openalex.org/W2100604852","https://openalex.org/W2101503666","https://openalex.org/W2105894548","https://openalex.org/W2142099365","https://openalex.org/W2144930991","https://openalex.org/W2150891147","https://openalex.org/W2172421250","https://openalex.org/W2337485820","https://openalex.org/W2409360547","https://openalex.org/W2409679560","https://openalex.org/W2414044484","https://openalex.org/W2508997451","https://openalex.org/W2520211681","https://openalex.org/W2542822064","https://openalex.org/W2769671204","https://openalex.org/W2791309620","https://openalex.org/W2895903821","https://openalex.org/W2909894833","https://openalex.org/W2981617674","https://openalex.org/W2990840371","https://openalex.org/W3016852213","https://openalex.org/W3016940380","https://openalex.org/W3025259451","https://openalex.org/W3028330817","https://openalex.org/W3034225365","https://openalex.org/W3035467903","https://openalex.org/W3036451283","https://openalex.org/W3092541624","https://openalex.org/W3147479802","https://openalex.org/W6776928405"],"related_works":["https://openalex.org/W2103153086","https://openalex.org/W2128749750","https://openalex.org/W2803795050","https://openalex.org/W2483149634","https://openalex.org/W3205345219","https://openalex.org/W2142338958","https://openalex.org/W4393352563","https://openalex.org/W2154915131","https://openalex.org/W2937584775","https://openalex.org/W2076388915"],"abstract_inverted_index":{"Vascular":[0],"calcification,":[1,30,64],"hypertension":[2],"and":[3,28,68,85,103,127,130,147],"cardiac":[4],"hypertrophy":[5],"have":[6,57],"been":[7,35,58],"often":[8],"complicated":[9],"in":[10,41,48,76,89,124,142],"osteoporotic":[11],"patients":[12],"with":[13],"low":[14],"bone":[15,26,126],"mass.":[16],"Since":[17],"there":[18],"are":[19],"many":[20],"similarities":[21],"among":[22],"the":[23,42,73,119,125,143],"processes":[24],"of":[25,44,118,121,145],"formation":[27],"vascular":[29,63,83,99,128],"vitamin":[31,51,80,122],"D":[32,52,81,123],"insufficiency":[33],"has":[34],"thought":[36],"to":[37,60],"be":[38,137],"deeply":[39],"involved":[40],"pathogenesis":[43],"these":[45],"diseases.":[46],"Indeed,":[47],"animal":[49],"studies,":[50,78],"receptor":[53],"gene":[54],"knockout":[55],"mice":[56],"shown":[59],"display":[61],"severe":[62],"high":[65],"blood":[66],"pressure,":[67],"left":[69],"ventricular":[70],"hypertrophy.":[71],"On":[72],"other":[74],"hand,":[75],"clinical":[77],"active":[79],"restores":[82],"calcification":[84],"improves":[86],"heart":[87],"function":[88],"dialysis":[90],"patients.":[91],"Whether":[92],"1,25":[93],"(OH)":[94],"\u2082D\u2083":[95],"acts":[96,106],"directly":[97],"on":[98,108],"smooth":[100],"muscle":[101],"cells":[102],"cardiomyocytes":[104],"or":[105],"indirectly":[107],"them":[109],"via":[110],"regulating":[111],"calcium":[112],"metabolism":[113],"remains":[114],"unclear.":[115],"The":[116],"elucidation":[117],"role":[120],"intercommunication":[129],"its":[131],"application":[132],"toward":[133],"drug":[134],"development":[135],"could":[136],"an":[138],"important":[139],"step":[140],"forward":[141],"realization":[144],"health":[146],"longevity":[148],"society.":[149]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2019-12-13T00:00:00"}