{"id":"https://openalex.org/W2994150391","doi":null,"title":"TELMISARTAN ALLEVIATES NITROSATIVE STRESS IN TURN DOPAMINERGIC DEGENERATION IN MICE MPTP MODEL OF PARKINSONISM\u2013BIOCHEMICAL AND HISTOPATHOLOGICAL EVIDENCES","display_name":"TELMISARTAN ALLEVIATES NITROSATIVE STRESS IN TURN DOPAMINERGIC DEGENERATION IN MICE MPTP MODEL OF PARKINSONISM\u2013BIOCHEMICAL AND HISTOPATHOLOGICAL EVIDENCES","publication_year":2015,"publication_date":"2015-04-15","ids":{"openalex":"https://openalex.org/W2994150391","mag":"2994150391"},"language":"en","primary_location":{"id":"mag:2994150391","doi":null,"is_oa":true,"landing_page_url":"https://innovareacademics.in/journals/index.php/ijpps/article/view/5827","pdf_url":null,"source":{"id":"https://openalex.org/S2764469077","display_name":"International Journal of Pharmacy and Pharmaceutical Sciences","issn_l":"0975-1491","issn":["0975-1491","2656-0097"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharmacy and Pharmaceutical Sciences","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://innovareacademics.in/journals/index.php/ijpps/article/view/5827","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103089275","display_name":"Sathiya Sekar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19926482","display_name":"Dr. M.G.R. Educational and Research Institute","ror":"https://ror.org/053hsst90","country_code":"IN","type":"education","lineage":["https://openalex.org/I19926482"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sathiya Sekar","raw_affiliation_strings":["Department of Biotechnology, Dr. M.G.R. Educational and Research Institute University, Chennai 600095, TN, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Dr. M.G.R. Educational and Research Institute University, Chennai 600095, TN, India","institution_ids":["https://openalex.org/I19926482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065120976","display_name":"Saravana Babu Chidambaram","orcid":"https://orcid.org/0000-0003-2357-056X","observed_orcids":["https://orcid.org/0000-0003-2357-056X","https://orcid.org/0000-0002-7952-7280"]},"institutions":[{"id":"https://openalex.org/I20107917","display_name":"Sri Ramachandra Institute of Higher Education and Research","ror":"https://ror.org/0108gdg43","country_code":"IN","type":"education","lineage":["https://openalex.org/I20107917"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saravana Babu Chidambaram","raw_affiliation_strings":["Centre for Toxicology and Developmental Research (CEFT), Sri Ramachandra University, Chennai 600 116, TN, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Toxicology and Developmental Research (CEFT), Sri Ramachandra University, Chennai 600 116, TN, India","institution_ids":["https://openalex.org/I20107917"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.428,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.62368058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":94},"biblio":{"volume":"7","issue":"6","first_page":"97","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telmisartan","display_name":"telmisartan","score":1.0},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mptp","display_name":"MPTP","score":0.7689999938011169},{"id":"https://openalex.org/keywords/nitrosative-stress","display_name":"nitrosative stress","score":0.8820000290870667},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.878000020980835},{"id":"https://openalex.org/keywords/dopaminergic-neuron-degeneration","display_name":"dopaminergic neuron loss","score":0.8659999966621399},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8930000066757202},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9049999713897705},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":1.0},{"id":"https://openalex.org/keywords/reduced-glutathione","display_name":"reduced glutathione","score":0.8809999823570251},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.7480000257492065},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.9900000095367432},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C2778674702","wikidata":"https://www.wikidata.org/wiki/Q239816","display_name":"MPTP","level":4,"score":0.9676077365875244},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7060768604278564},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6732124090194702},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6402895450592041},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5586430430412292},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.5241601467132568},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5080869197845459},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4785200357437134},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46983736753463745},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4602985978126526},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4593098759651184},{"id":"https://openalex.org/C2779716603","wikidata":"https://www.wikidata.org/wiki/Q733186","display_name":"Telmisartan","level":3,"score":0.4487648010253906},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40603601932525635},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3589528203010559},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.24520501494407654},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12546280026435852},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.05248335003852844},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2994150391","doi":null,"is_oa":true,"landing_page_url":"https://innovareacademics.in/journals/index.php/ijpps/article/view/5827","pdf_url":null,"source":{"id":"https://openalex.org/S2764469077","display_name":"International Journal of Pharmacy and Pharmaceutical Sciences","issn_l":"0975-1491","issn":["0975-1491","2656-0097"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharmacy and Pharmaceutical Sciences","raw_type":null}],"best_oa_location":{"id":"mag:2994150391","doi":null,"is_oa":true,"landing_page_url":"https://innovareacademics.in/journals/index.php/ijpps/article/view/5827","pdf_url":null,"source":{"id":"https://openalex.org/S2764469077","display_name":"International Journal of Pharmacy and Pharmaceutical Sciences","issn_l":"0975-1491","issn":["0975-1491","2656-0097"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharmacy and Pharmaceutical Sciences","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1503393361","https://openalex.org/W1531305298","https://openalex.org/W1539544057","https://openalex.org/W1791420399","https://openalex.org/W1966322594","https://openalex.org/W1970354788","https://openalex.org/W1971474539","https://openalex.org/W1979710783","https://openalex.org/W1990802251","https://openalex.org/W2003017246","https://openalex.org/W2005434075","https://openalex.org/W2008520631","https://openalex.org/W2009815108","https://openalex.org/W2013168439","https://openalex.org/W2018076136","https://openalex.org/W2018616136","https://openalex.org/W2036940243","https://openalex.org/W2042630261","https://openalex.org/W2062118842","https://openalex.org/W2065083920","https://openalex.org/W2069132215","https://openalex.org/W2076325033","https://openalex.org/W2082983835","https://openalex.org/W2085272860","https://openalex.org/W2093019685","https://openalex.org/W2106563803","https://openalex.org/W2107366065","https://openalex.org/W2128635872","https://openalex.org/W2137829901"],"related_works":["https://openalex.org/W2003017246","https://openalex.org/W7164997998","https://openalex.org/W4391576177","https://openalex.org/W7134033842","https://openalex.org/W3198627732","https://openalex.org/W7095931368","https://openalex.org/W2157199780","https://openalex.org/W3114059366","https://openalex.org/W2262022772","https://openalex.org/W4220993773"],"abstract_inverted_index":{"Objective:":[0],"Telmisartan":[2],"(TEL),":[3],"an":[4],"angiotensin":[5],"type":[6],"1":[7],"receptor":[8],"blocker,":[9],"exerts":[10,185],"neuroprotection":[11,186],"in":[12,44,65,89,128,145,171,210],"MPTP":[13,61,84,101,129,152,172],"induced":[14,191],"Parkinson\u2019s":[15],"disease.":[16],"The":[17,93,156,179,198],"present":[18,180],"study":[19,181],"was":[20,77,161],"aimed":[21],"to":[22,82],"investigate":[23],"its":[24],"effects":[25],"on":[26],"oxidative":[27,192],"stress":[28,193],"markers\u2013inducible":[29],"nitric":[30,36,189],"oxide":[31,37,190],"synthase":[32],"(":[33],"iNOS":[34,122],"),":[35],"(NO)":[38],"and":[39,86,103,119,125,142,147,194],"reduced":[40],"glutathione":[41],"(GSH)":[42],"content":[43,118],"C57BL/6J":[45,55],"mice":[46,56,131,154,173],"brain.":[47,155],"Methods:":[50],"Young":[52],"healthy":[53],"male":[54],"were":[57,95,105],"injected":[58],"intraperitoneally":[59],"with":[60,164],"at":[62,73],"80":[63],"mg/kg":[64,72],"two":[66,90],"divided":[67],"doses":[68],"(2":[69],"x":[70],"40":[71],"16h":[74],"interval).":[75],"TEL":[76,114,137,160,184,203],"administered":[78],"one":[79],"hour":[80],"prior":[81],"first":[83,100],"intoxication":[85],"thereafter":[87],"once":[88],"consecutive":[91],"days.":[92],"animals":[94],"sacrificed":[96],"48":[97],"h":[98],"after":[99],"injection":[102],"brains":[104],"collected":[106],"for":[107],"further":[108,162],"analysis.":[109],"Results:":[112],"administration":[115],"increased":[116,165],"GSH":[117],"decreased":[120,138],"expression":[124],"NO":[126],"level":[127],"intoxicated":[130,153],"brains.":[132,174],"Histopathological":[133],"evaluation":[134],"revealed":[135],"that":[136,183,202],"the":[139,195,211],"cytoplasmic":[140],"vacuolation":[141],"nuclear":[143],"pigmentation":[144],"striatal":[146],"substantial":[148],"nigral":[149],"regions":[150],"of":[151,159,213],"neuroprotective":[157],"effect":[158],"evidenced":[163],"neuronal":[166],"nuclei":[167],"(NeuN)":[168],"immune":[169],"fluorescence":[170],"Conclusion:":[177],"showed":[182],"by":[187],"suppressing":[188],"dopaminergic":[196],"degeneration.":[197],"above":[199],"findings":[200],"suggests":[201],"may":[204],"act":[205],"as":[206],"a":[207],"potential":[208],"target":[209],"management":[212],"PD.":[214]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-13T00:00:00"}
