{"id":"https://openalex.org/W2994037520","doi":"https://doi.org/10.1159/000504604","title":"Skeletal Muscle Mass Influences Tolerability and Prognosis in Hepatocellular Carcinoma Patients Treated with Lenvatinib","display_name":"Skeletal Muscle Mass Influences Tolerability and Prognosis in Hepatocellular Carcinoma Patients Treated with Lenvatinib","publication_year":2019,"publication_date":"2019-12-06","ids":{"openalex":"https://openalex.org/W2994037520","doi":"https://doi.org/10.1159/000504604","mag":"2994037520","pmid":"https://pubmed.ncbi.nlm.nih.gov/32399433","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7206580"},"language":"en","primary_location":{"id":"doi:10.1159/000504604","doi":"https://doi.org/10.1159/000504604","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000504604","pdf_url":"https://www.karger.com/Article/Pdf/504604","source":{"id":"https://openalex.org/S2764970739","display_name":"Liver Cancer","issn_l":"1664-5553","issn":["1664-5553","2235-1795"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.karger.com/Article/Pdf/504604","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084731951","display_name":"Haruki Uojima","orcid":"https://orcid.org/0000-0003-1719-1352","observed_orcids":["https://orcid.org/0000-0003-1719-1352"]},"institutions":[{"id":"https://openalex.org/I4210151342","display_name":"Shonan Kamakura General Hospital","ror":"https://ror.org/03xz3hj66","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210151342"]},{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruki Uojima","raw_affiliation_strings":["Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan","Department of Gastroenterology, Shonan Kamakura General Hospital, Kamakura, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"Department of Gastroenterology, Shonan Kamakura General Hospital, Kamakura, Japan","institution_ids":["https://openalex.org/I4210151342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028068047","display_name":"Makoto Chuma","orcid":"https://orcid.org/0000-0002-0963-9172","observed_orcids":["https://orcid.org/0000-0002-0963-9172"]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]},{"id":"https://openalex.org/I4210099218","display_name":"Yokohama City University Hospital","ror":"https://ror.org/010hfy465","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099218"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Chuma","raw_affiliation_strings":["Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan","institution_ids":["https://openalex.org/I2802180866","https://openalex.org/I4210099218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019871387","display_name":"Yoshiaki Tanaka","orcid":"https://orcid.org/0000-0003-0073-869X","observed_orcids":["https://orcid.org/0000-0003-0073-869X"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiaki Tanaka","raw_affiliation_strings":["Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018258244","display_name":"Hisashi Hidaka","orcid":"https://orcid.org/0000-0002-4151-5663","observed_orcids":["https://orcid.org/0000-0002-4151-5663"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisashi Hidaka","raw_affiliation_strings":["Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042231482","display_name":"Takahide Nakazawa","orcid":"https://orcid.org/0000-0003-1980-2591","observed_orcids":["https://orcid.org/0000-0003-1980-2591"]},"institutions":[{"id":"https://openalex.org/I4210109991","display_name":"Kanazawa Municipal Hospital","ror":"https://ror.org/018jgg490","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210109991"]},{"id":"https://openalex.org/I4405253767","display_name":"Inazawa Municipal Hospital","ror":"https://ror.org/0128bs295","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405253767"]},{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahide Nakazawa","raw_affiliation_strings":["Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan","Nakazawa Medical Clinic, Sagamihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"Nakazawa Medical Clinic, Sagamihara, Japan","institution_ids":["https://openalex.org/I4210109991","https://openalex.org/I4405253767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112241581","display_name":"Shogo Iwabuchi","orcid":"https://orcid.org/0009-0009-5136-553X","observed_orcids":["https://orcid.org/0009-0009-5136-553X"]},"institutions":[{"id":"https://openalex.org/I4405254078","display_name":"Shonan Fujisawa Tokusyukai Hospital","ror":"https://ror.org/01crjdg76","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405254078"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shogo Iwabuchi","raw_affiliation_strings":["Department of Gastroenterology, Shonan Fujisawa Tokushukai Hospital, Fujisawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Shonan Fujisawa Tokushukai Hospital, Fujisawa, Japan","institution_ids":["https://openalex.org/I4405254078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034675205","display_name":"Satoshi Kobayashi","orcid":"https://orcid.org/0000-0002-2535-6586","observed_orcids":["https://orcid.org/0000-0002-2535-6586"]},"institutions":[{"id":"https://openalex.org/I4387152949","display_name":"Kanagawa Cancer Center","ror":"https://ror.org/00aapa202","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4387152949"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Kobayashi","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Medical Oncology, Kanagawa Cancer Center, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Medical Oncology, Kanagawa Cancer Center, Yokohama, Japan","institution_ids":["https://openalex.org/I4387152949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028671386","display_name":"Nobuhiro Hattori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163917720","display_name":"St. Marianna University School of Medicine","ror":"https://ror.org/043axf581","country_code":"JP","type":"education","lineage":["https://openalex.org/I163917720"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuhiro Hattori","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan","institution_ids":["https://openalex.org/I163917720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021826951","display_name":"Katsuaki Ogushi","orcid":"https://orcid.org/0000-0001-7968-8933","observed_orcids":["https://orcid.org/0000-0001-7968-8933"]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]},{"id":"https://openalex.org/I4210099218","display_name":"Yokohama City University Hospital","ror":"https://ror.org/010hfy465","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099218"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuaki Ogushi","raw_affiliation_strings":["Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan","institution_ids":["https://openalex.org/I2802180866","https://openalex.org/I4210099218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101457577","display_name":"Manabu Morimoto","orcid":"https://orcid.org/0000-0002-3940-9634","observed_orcids":["https://orcid.org/0000-0002-3940-9634","https://orcid.org/0009-0006-7576-7187"]},"institutions":[{"id":"https://openalex.org/I4387152949","display_name":"Kanagawa Cancer Center","ror":"https://ror.org/00aapa202","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4387152949"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Manabu Morimoto","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Medical Oncology, Kanagawa Cancer Center, Yokohama, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3940-9634","affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Medical Oncology, Kanagawa Cancer Center, Yokohama, Japan","institution_ids":["https://openalex.org/I4387152949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079940937","display_name":"Tatehiro Kagawa","orcid":"https://orcid.org/0000-0002-3442-1423","observed_orcids":["https://orcid.org/0000-0002-3442-1423","https://orcid.org/0000-0002-5959-913X"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]},{"id":"https://openalex.org/I4210115139","display_name":"Tokai University Hospital","ror":"https://ror.org/01gvmn480","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210115139"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatehiro Kagawa","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan","institution_ids":["https://openalex.org/I1314466530","https://openalex.org/I4210115139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101436780","display_name":"Katsuaki Tanaka","orcid":"https://orcid.org/0000-0003-4989-2073","observed_orcids":["https://orcid.org/0000-0003-4989-2073"]},"institutions":[{"id":"https://openalex.org/I4210132840","display_name":"Japanese Red Cross Hadano Hospital","ror":"https://ror.org/0406qcr55","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210132840"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuaki Tanaka","raw_affiliation_strings":["Department of Gastroenterology, Japanese Red Cross Hadano Hospital, Hadano, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Japanese Red Cross Hadano Hospital, Hadano, Japan","institution_ids":["https://openalex.org/I4210132840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039549002","display_name":"Makoto Kako","orcid":"https://orcid.org/0000-0002-6447-8471","observed_orcids":["https://orcid.org/0000-0002-6447-8471"]},"institutions":[{"id":"https://openalex.org/I4210151342","display_name":"Shonan Kamakura General Hospital","ror":"https://ror.org/03xz3hj66","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210151342"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Kako","raw_affiliation_strings":["Department of Gastroenterology, Shonan Kamakura General Hospital, Kamakura, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Shonan Kamakura General Hospital, Kamakura, Japan","institution_ids":["https://openalex.org/I4210151342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068425977","display_name":"Wasaburo Koizumi","orcid":"https://orcid.org/0000-0001-9972-1083","observed_orcids":["https://orcid.org/0000-0001-9972-1083"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Wasaburo Koizumi","raw_affiliation_strings":["Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan","institution_ids":["https://openalex.org/I64189623"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":5.3458,"has_fulltext":true,"cited_by_count":96,"citation_normalized_percentile":{"value":0.96647245,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"9","issue":"2","first_page":"193","last_page":"206"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.925000011920929},{"id":"https://openalex.org/keywords/lenvatinib","display_name":"lenvatinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/skeletal-muscle-mass","display_name":"skeletal muscle mass","score":0.9750000238418579},{"id":"https://openalex.org/keywords/skeletal-muscle-index","display_name":"skeletal muscle index","score":0.9039999842643738},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/treatment-tolerability","display_name":"treatment tolerability","score":0.7210000157356262},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8830000162124634},{"id":"https://openalex.org/keywords/drug-withdrawal","display_name":"drug withdrawal","score":0.7099999785423279},{"id":"https://openalex.org/keywords/time-to-treatment-failure","display_name":"time to treatment failure","score":0.8830000162124634},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8757336735725403},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.8482345342636108},{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.7115696668624878},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6919295191764832},{"id":"https://openalex.org/C2776264508","wikidata":"https://www.wikidata.org/wiki/Q6523413","display_name":"Lenvatinib","level":4,"score":0.6769422292709351},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6604130268096924},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5516029596328735},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.525574266910553},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.4910752773284912},{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.14800149202346802}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1159/000504604","doi":"https://doi.org/10.1159/000504604","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000504604","pdf_url":"https://www.karger.com/Article/Pdf/504604","source":{"id":"https://openalex.org/S2764970739","display_name":"Liver Cancer","issn_l":"1664-5553","issn":["1664-5553","2235-1795"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Cancer","raw_type":"journal-article"},{"id":"pmid:32399433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32399433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7206580","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7206580/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1159/000504604","doi":"https://doi.org/10.1159/000504604","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000504604","pdf_url":"https://www.karger.com/Article/Pdf/504604","source":{"id":"https://openalex.org/S2764970739","display_name":"Liver Cancer","issn_l":"1664-5553","issn":["1664-5553","2235-1795"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2994037520.pdf","grobid_xml":"https://content.openalex.org/works/W2994037520.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1788749837","https://openalex.org/W1834228192","https://openalex.org/W1987519248","https://openalex.org/W1994193851","https://openalex.org/W2035523314","https://openalex.org/W2037048755","https://openalex.org/W2046000826","https://openalex.org/W2079586464","https://openalex.org/W2148227350","https://openalex.org/W2152963742","https://openalex.org/W2268912046","https://openalex.org/W2397305960","https://openalex.org/W2406223713","https://openalex.org/W2492424475","https://openalex.org/W2492645252","https://openalex.org/W2502954640","https://openalex.org/W2505846117","https://openalex.org/W2528882804","https://openalex.org/W2560499218","https://openalex.org/W2579821162","https://openalex.org/W2625736993","https://openalex.org/W2763128199","https://openalex.org/W2787358630","https://openalex.org/W2789297669","https://openalex.org/W2887077258","https://openalex.org/W2921177108","https://openalex.org/W4210955410","https://openalex.org/W4295126505","https://openalex.org/W4324262440"],"related_works":["https://openalex.org/W4225921116","https://openalex.org/W3005164841","https://openalex.org/W4406202541","https://openalex.org/W4402922122","https://openalex.org/W3121929873","https://openalex.org/W4386098900","https://openalex.org/W4391024989","https://openalex.org/W4210612187","https://openalex.org/W2997344920","https://openalex.org/W4392565404"],"abstract_inverted_index":{"Background:":[0],"Low":[1],"skeletal":[2,28,82,241],"muscle":[3,29,68,83,242,258],"mass":[4,30,69,243,259],"is":[5,31,244],"significantly":[6,216],"associated":[7,245],"with":[8,33,39,44,62,65,148,246,275],"severe":[9,116,149,250],"adverse":[10],"events":[11],"(AEs)":[12],"from":[13,94],"chemotherapy,":[14],"and":[15,35,75,123,130,139,144,157,162,186,191,201,206,219,252,255,269],"low":[16,90,109],"tolerability":[17,34,268],"leads":[18],"to":[19,24,115,126,152,271],"decreased":[20],"survival.":[21],"We":[22,58,104],"aimed":[23],"investigate":[25],"whether":[26],"body":[27],"correlated":[32],"prognosis":[36,270],"in":[37,56,79,118,154,183,198,211,223,273],"patients":[38,61,141,274],"hepatocellular":[40],"carcinoma":[41],"(HCC)":[42],"treated":[43,64],"lenvatinib.":[45,66],"Methods:":[46],"This":[47],"multicenter,":[48],"retrospective":[49],"study":[50],"was":[51,70,189,204],"conducted":[52],"at":[53],"five":[54],"locations":[55],"Japan.":[57],"included":[59],"100":[60],"HCC":[63],"Skeletal":[67,257],"measured":[71],"by":[72],"computed":[73],"tomography":[74],"normalized":[76],"for":[77,89,229,267],"height":[78],"m2":[80],"as":[81,263],"index":[84],"(SMI).":[85],"The":[86,135,165,180,195],"assessment":[87],"criteria":[88,97],"SMI":[91,110],"were":[92,142,160],"taken":[93],"the":[95,99,106,119,155,174,184,199,212,224,247],"sarcopenia":[96],"of":[98,102,108,137,249],"Japan":[100],"Society":[101],"Hepatology.":[103],"investigated":[105],"influence":[107],"on":[111,124],"drug":[112],"withdrawal":[113,171],"due":[114],"AEs":[117,150,251],"first":[120],"2":[121],"months":[122],"time":[125],"treatment":[127],"failure":[128],"(TTF)":[129],"overall":[131],"survival":[132],"(OS).":[133],"Results:":[134],"numbers":[136],"high-":[138,156],"low-SMI":[140,158,166,213],"41":[143],"59,":[145],"respectively.":[146,164,194,209],"Those":[147],"leading":[151],"withdraw":[153],"groups":[159,188,203],"7":[161],"23,":[163],"group":[167,176,214,226],"had":[168],"a":[169,264],"higher":[170],"rate":[172],"than":[173,221],"high-SMI":[175,187,202,225],"(p":[177],"=":[178,233,237],"0.042).":[179],"median":[181,196],"TTF":[182,220,254],"low-":[185,200],"139":[190],"230":[192],"days,":[193,208],"OS":[197,218],"264":[205],"353":[207],"Patients":[210],"experienced":[215],"worse":[217,253],"those":[222],"(log-rank":[227],"test":[228],"trend:":[230],"TTF,":[231],"p":[232,236],"0.010;":[234],"OS,":[235],"0.021).":[238],"Conclusion:":[239],"Decreased":[240],"occurrence":[248],"OS.":[256],"can":[260],"be":[261],"used":[262],"predictive":[265],"marker":[266],"lenvatinib":[272],"HCC.":[276]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-12-13T00:00:00"}
