{"id":"https://openalex.org/W2994014658","doi":null,"title":"[SERUM CONTENTS OF SUBSTANCE P, ENDOTHELIN-1 AND VASOACTIVE INTESTINAL PEPTIDE IN CHILDREN WITH RECURRENT BRONCHITIS AND VERTEBROBASILAR INSUFFICIENCY].","display_name":"[SERUM CONTENTS OF SUBSTANCE P, ENDOTHELIN-1 AND VASOACTIVE INTESTINAL PEPTIDE IN CHILDREN WITH RECURRENT BRONCHITIS AND VERTEBROBASILAR INSUFFICIENCY].","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W2994014658","mag":"2994014658","pmid":"https://pubmed.ncbi.nlm.nih.gov/31322514"},"language":"ru","primary_location":{"id":"pmid:31322514","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31322514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Georgian medical news","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084313249","display_name":"\u0422.\u0412. Slutskaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800491467","display_name":"Zaporizhzhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine","ror":"https://ror.org/009914361","country_code":"UA","type":"facility","lineage":["https://openalex.org/I2800491467"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"T Slutskaya","raw_affiliation_strings":["Zaporozhye Medical Academy of Postgraduate Education of Ministry of Health of Ukraine, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zaporozhye Medical Academy of Postgraduate Education of Ministry of Health of Ukraine, Ukraine","institution_ids":["https://openalex.org/I2800491467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037003335","display_name":"L.S. Ovcharenko","orcid":"https://orcid.org/0000-0001-9711-1329","observed_orcids":["https://orcid.org/0000-0001-9711-1329"]},"institutions":[{"id":"https://openalex.org/I2800491467","display_name":"Zaporizhzhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine","ror":"https://ror.org/009914361","country_code":"UA","type":"facility","lineage":["https://openalex.org/I2800491467"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"L Ovcharenko","raw_affiliation_strings":["Zaporozhye Medical Academy of Postgraduate Education of Ministry of Health of Ukraine, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zaporozhye Medical Academy of Postgraduate Education of Ministry of Health of Ukraine, Ukraine","institution_ids":["https://openalex.org/I2800491467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102809443","display_name":"A.O. Vertehel","orcid":"https://orcid.org/0000-0002-6314-1826","observed_orcids":["https://orcid.org/0000-0002-6314-1826"]},"institutions":[{"id":"https://openalex.org/I2800491467","display_name":"Zaporizhzhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine","ror":"https://ror.org/009914361","country_code":"UA","type":"facility","lineage":["https://openalex.org/I2800491467"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"A Vertehel","raw_affiliation_strings":["Zaporozhye Medical Academy of Postgraduate Education of Ministry of Health of Ukraine, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zaporozhye Medical Academy of Postgraduate Education of Ministry of Health of Ukraine, Ukraine","institution_ids":["https://openalex.org/I2800491467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073039472","display_name":"A.V. Kryazhev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800491467","display_name":"Zaporizhzhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine","ror":"https://ror.org/009914361","country_code":"UA","type":"facility","lineage":["https://openalex.org/I2800491467"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"A Kryazhev","raw_affiliation_strings":["Zaporozhye Medical Academy of Postgraduate Education of Ministry of Health of Ukraine, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zaporozhye Medical Academy of Postgraduate Education of Ministry of Health of Ukraine, Ukraine","institution_ids":["https://openalex.org/I2800491467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038968156","display_name":"I.V. Samokhin","orcid":"https://orcid.org/0000-0001-7644-1046","observed_orcids":["https://orcid.org/0000-0001-7644-1046"]},"institutions":[{"id":"https://openalex.org/I2800491467","display_name":"Zaporizhzhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine","ror":"https://ror.org/009914361","country_code":"UA","type":"facility","lineage":["https://openalex.org/I2800491467"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"I Samokhin","raw_affiliation_strings":["Zaporozhye Medical Academy of Postgraduate Education of Ministry of Health of Ukraine, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zaporozhye Medical Academy of Postgraduate Education of Ministry of Health of Ukraine, Ukraine","institution_ids":["https://openalex.org/I2800491467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2800491467"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"290","first_page":"48","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.0674000009894371,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13770","display_name":"Pediatric health and respiratory diseases","score":0.05119999870657921,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-bronchitis","display_name":"recurrent bronchitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vertebrobasilar-insufficiency","display_name":"vertebrobasilar insufficiency","score":0.921999990940094},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.9470000267028809},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/vasoactive-intestinal-peptide","display_name":"vasoactive intestinal peptide","score":0.996999979019165},{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.8970000147819519},{"id":"https://openalex.org/keywords/neurogenic-inflammation","display_name":"neurogenic inflammation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.531000018119812},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C8330315","wikidata":"https://www.wikidata.org/wiki/Q414964","display_name":"Vasoactive intestinal peptide","level":4,"score":0.9623221755027771},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.8759893774986267},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6746523380279541},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.6178817749023438},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6170099377632141},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5895158052444458},{"id":"https://openalex.org/C2779993553","wikidata":"https://www.wikidata.org/wiki/Q173022","display_name":"Bronchitis","level":2,"score":0.5641788840293884},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.524875819683075},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4727799892425537},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4439714252948761},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16043797135353088}],"mesh":[{"descriptor_ui":"D001991","descriptor_name":"Bronchitis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001991","descriptor_name":"Bronchitis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014660","descriptor_name":"Vasoactive Intestinal Peptide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014715","descriptor_name":"Vertebrobasilar Insufficiency","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014715","descriptor_name":"Vertebrobasilar Insufficiency","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:31322514","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31322514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Georgian medical news","raw_type":"Journal Article"},{"id":"mag:2994014658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31322514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2750965878","https://openalex.org/W2973009970","https://openalex.org/W2882990520","https://openalex.org/W3133632514","https://openalex.org/W2402441851","https://openalex.org/W2336192177","https://openalex.org/W2412747516","https://openalex.org/W2400137224","https://openalex.org/W2399365548","https://openalex.org/W2417904539"],"abstract_inverted_index":{"The":[0,42],"recurrent":[1],"bronchitis":[2,196],"(RB)":[3],"course":[4,198],"is":[5],"caused":[6],"by":[7,23,57],"the":[8,34,37,46,50,59,66,127,132,141,186,195],"bronchi":[9],"secretory-evacuation":[10,69],"mechanisms":[11],"state,":[12],"which":[13],"provide":[14],"clearance":[15],"from":[16],"pathogens.":[17],"This":[18],"mechanism":[19],"can":[20],"be":[21],"disrupted":[22],"vegetative":[24],"reflexes":[25],"and":[26,71,81,105,134,153,157,162,172,179,191],"neuropeptides":[27],"imbalance":[28,184],"that":[29],"develops":[30],"in":[31,53,140],"children":[32,54,86,102,111,120,142],"with":[33,55,103,112,121,131,144,177],"syndrome":[35],"of":[36,45,49,62,65,148,168,185],"vertebrobasilar":[38],"arterial":[39],"system":[40],"(SVBAS).":[41],"objective:":[43],"study":[44],"neurogenic":[47],"maintenance":[48],"RB":[51,104,115,122,178],"pathogenesis":[52],"SVBAS":[56,106,113,124,180],"studying":[58],"serum":[60,146,182],"content":[61,147,167],"substances":[63],"affecting":[64],"bronchial":[67],"mucosa":[68],"function":[70],"inflammatory":[72],"activity":[73],"(substance":[74],"P,":[75,189],"vasoactive":[76],"intestinal":[77],"peptide":[78],"-":[79,83,101,110,119],"VIP":[80,169,193],"endothelin-1":[82],"ET-1).":[84],"90":[85],"aged":[87],"7":[88],"to":[89],"11":[90],"years":[91],"were":[92,97],"examined,":[93],"3":[94,118],"observation":[95],"groups":[96],"formed:":[98],"Group":[99,108,117,128],"1":[100],"(n=30);":[107,116],"2":[109],"without":[114,123],"(n=30).":[125],"In":[126],"1,":[129],"compared":[130],"2nd":[133],"3rd,":[135],"there":[136],"was":[137],"an":[138],"increase":[139],"number":[143],"high":[145],"substance":[149,188],"P":[150],"(by":[151,160,170],"66.7%":[152],"50.0%,":[154],"respectively,":[155,164,174],"p<0.05)":[156],"ET":[158],"-1":[159],"23.3%":[161],"40.0%,":[163],"p<0.05),":[165],"low":[166],"46.7%":[171],"23.4%,":[173],"p<0.05).":[175],"Children":[176],"have":[181],"level":[183],"pro-inflammatory":[187],"ET-1":[190],"anti-inflammatory":[192],"as":[194],"severe":[197],"basis.":[199]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-13T00:00:00"}