{"id":"https://openalex.org/W2994009208","doi":null,"title":"[Bone and calcium metabolism associated with malignancy. Clinical Characteristics and Treatment of Cancer Treatment Induced Bone Loss(CTIBL)in Breast Cancer.]","display_name":"[Bone and calcium metabolism associated with malignancy. Clinical Characteristics and Treatment of Cancer Treatment Induced Bone Loss(CTIBL)in Breast Cancer.]","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2994009208","mag":"2994009208","pmid":"https://pubmed.ncbi.nlm.nih.gov/30374009"},"language":"ja","primary_location":{"id":"pmid:30374009","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30374009","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014421519","display_name":"Tetsuya Taguchi","orcid":"https://orcid.org/0000-0003-0755-0550","observed_orcids":["https://orcid.org/0000-0003-0755-0550"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tetsuya Taguchi","raw_affiliation_strings":["Division of Endocrine & Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrine & Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014421519"],"corresponding_institution_ids":["https://openalex.org/I40677808"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"11","first_page":"1515","last_page":"1517"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.09300000220537186,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-treatment-induced-bone-loss","display_name":"cancer treatment-induced bone loss","score":0.8399999737739563},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9769999980926514},{"id":"https://openalex.org/keywords/aromatase-inhibitors","display_name":"aromatase inhibitors","score":0.9120000004768372},{"id":"https://openalex.org/keywords/adjuvant-endocrine-therapy","display_name":"adjuvant endocrine therapy","score":0.8989999890327454},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.5360000133514404},{"id":"https://openalex.org/keywords/fracture-prevention","display_name":"fracture prevention","score":0.7049999833106995},{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":0.9229999780654907},{"id":"https://openalex.org/keywords/bone-modifying-agents","display_name":"bone-modifying agents","score":0.7860000133514404},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8551698923110962},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8135983943939209},{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.7955937385559082},{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.6233865022659302},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6203920841217041},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5957860946655273},{"id":"https://openalex.org/C2778504769","wikidata":"https://www.wikidata.org/wiki/Q3040305","display_name":"Aromatase inhibitor","level":5,"score":0.559151828289032},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5117089748382568},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5019490718841553},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.45679688453674316},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.41914403438568115},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.4116540253162384},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37127798795700073}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047072","descriptor_name":"Aromatase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D047072","descriptor_name":"Aromatase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:30374009","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30374009","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"Journal Article"},{"id":"mag:2994009208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30374009","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W41516964","https://openalex.org/W58690323","https://openalex.org/W93053989","https://openalex.org/W1501473386","https://openalex.org/W1547733031","https://openalex.org/W1594144334","https://openalex.org/W2008492357","https://openalex.org/W2014707628","https://openalex.org/W2045562495","https://openalex.org/W2066613071","https://openalex.org/W2098511755","https://openalex.org/W2100604852","https://openalex.org/W2101503666","https://openalex.org/W2105894548","https://openalex.org/W2142099365","https://openalex.org/W2144930991","https://openalex.org/W2150891147","https://openalex.org/W2172421250","https://openalex.org/W2337485820","https://openalex.org/W2409360547","https://openalex.org/W2409679560","https://openalex.org/W2414044484","https://openalex.org/W2508997451","https://openalex.org/W2520211681","https://openalex.org/W2542822064","https://openalex.org/W2769671204","https://openalex.org/W2791309620","https://openalex.org/W2895903821","https://openalex.org/W2909894833","https://openalex.org/W2981617674","https://openalex.org/W2990840371","https://openalex.org/W3016852213","https://openalex.org/W3016940380","https://openalex.org/W3025259451","https://openalex.org/W3028330817","https://openalex.org/W3034225365","https://openalex.org/W3035467903","https://openalex.org/W3036451283","https://openalex.org/W3092541624","https://openalex.org/W3147479802","https://openalex.org/W6776928405"],"related_works":["https://openalex.org/W132346105","https://openalex.org/W3156226808","https://openalex.org/W4363645376","https://openalex.org/W2006131871","https://openalex.org/W2340859553","https://openalex.org/W2044330087","https://openalex.org/W2027856259","https://openalex.org/W3136769243","https://openalex.org/W1971653725","https://openalex.org/W3192850769"],"abstract_inverted_index":{"Breast":[0],"cancer":[1,31,68,123,142,162],"is":[2,32,57,173],"a":[3,33,91,106,170,176],"typical":[4,92],"hormone-dependent":[5],"tumor":[6,34],"and":[7,24,82,113,129],"at":[8],"the":[9,50,71,75,99,119,130],"time":[10],"of":[11,16,52,94,101,121,157,179],"diagnosis":[12],"more":[13],"than":[14],"60%":[15],"breast":[17,30,67,122,141,161],"cancers":[18],"are":[19,185],"positive":[20],"for":[21,27],"estrogen":[22,53],"receptors":[23],"estrogen(E)is":[25],"required":[26],"proliferation.":[28],"Since":[29],"easily":[35],"to":[36,43,78,109],"cause":[37],"micrometastasis,":[38],"adjuvant":[39],"hormonal":[40],"therapy(HT)for":[41],"5":[42],"10":[44],"years":[45],"after":[46],"surgery":[47],"that":[48],"suppresses":[49],"action":[51],"actively":[54],"prevents":[55],"recurrence":[56],"very":[58],"popular.":[59],"However,":[60],"HT":[61],"with":[62],"aromatase":[63,87],"inhibitor(AI)for":[64],"postoperative":[65],"postmenopausal":[66],"markedly":[69],"reduces":[70],"E":[72],"concentration":[73],"in":[74,127,139,152,163],"body,":[76],"leading":[77],"significant":[79,150],"bone":[80,89,102,111,153],"loss":[81],"fracture":[83,115],"as":[84,86,105,175],"known":[85],"inhibitor-induced":[88],"loss(AIBL),":[90],"example":[93],"CTIBL.":[95],"Under":[96],"these":[97],"circumstances,":[98],"usefulness":[100],"modifying":[103],"agents":[104],"supportive":[107],"therapy":[108],"increase":[110,151],"density":[112],"decrease":[114],"rate":[116],"without":[117],"interrupting":[118],"treatment":[120],"became":[124],"clear,":[125],"mainly":[126],"Europe":[128],"United":[131],"States.":[132],"And":[133],"recently,":[134],"our":[135],"study":[136],"revealed":[137],"even":[138],"Japanese":[140],"patients":[143],"denosumab":[144],"injection":[145],"every":[146],"6":[147],"months":[148],"showed":[149],"density.":[154],"The":[155],"number":[156,172],"women":[158],"suffering":[159],"from":[160],"Japan":[164],"reaches":[165],"approximately":[166],"90,000":[167],"per":[168],"year,":[169],"considerable":[171],"estimated":[174],"preliminary":[177],"group":[178],"CTIBL,":[180],"so":[181],"early":[182],"appropriate":[183],"measures":[184],"desired.":[186]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2019-12-13T00:00:00"}