{"id":"https://openalex.org/W2993983740","doi":null,"title":"[Therapeutic potential of vanadium in treating diabetes mellitus].","display_name":"[Therapeutic potential of vanadium in treating diabetes mellitus].","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2993983740","mag":"2993983740","pmid":"https://pubmed.ncbi.nlm.nih.gov/15632473"},"language":"ja","primary_location":{"id":"pmid:15632473","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15632473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101846331","display_name":"Hiromu Sakurai","orcid":"https://orcid.org/0000-0002-0933-2074","observed_orcids":["https://orcid.org/0000-0002-0933-2074"]},"institutions":[{"id":"https://openalex.org/I25998863","display_name":"Kyoto Pharmaceutical University","ror":"https://ror.org/01ytgve10","country_code":"JP","type":"education","lineage":["https://openalex.org/I25998863"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiromu Sakurai","raw_affiliation_strings":["Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan","Dept. of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan","institution_ids":["https://openalex.org/I25998863"]},{"raw_affiliation_string":"Dept. of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan","institution_ids":["https://openalex.org/I25998863"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101846331"],"corresponding_institution_ids":["https://openalex.org/I25998863"],"apc_list":null,"apc_paid":null,"fwci":0.6685,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.65960036,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"15","issue":"1","first_page":"49","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12136","display_name":"Vanadium and Halogenation Chemistry","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12136","display_name":"Vanadium and Halogenation Chemistry","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vanadium-complexes","display_name":"vanadium complexes","score":0.8730000257492065},{"id":"https://openalex.org/keywords/insulin-mimetic-agents","display_name":"insulin-mimetic agents","score":0.7749999761581421},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9160000085830688},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9549999833106995},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9769999980926514},{"id":"https://openalex.org/keywords/vanadate","display_name":"vanadate","score":0.6510000228881836},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.47099998593330383},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8069999814033508},{"id":"https://openalex.org/keywords/free-fatty-acid-release","display_name":"free fatty acid release","score":0.8019999861717224},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C2781116636","wikidata":"https://www.wikidata.org/wiki/Q426228","display_name":"Vanadate","level":2,"score":0.8059968948364258},{"id":"https://openalex.org/C504678139","wikidata":"https://www.wikidata.org/wiki/Q722","display_name":"Vanadium","level":2,"score":0.7419463396072388},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.7080002427101135},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6780322194099426},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6404584050178528},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6368795037269592},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6069692373275757},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6065662503242493},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.5034720301628113},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48895156383514404},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4875583052635193},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.4704253673553467},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45433810353279114},{"id":"https://openalex.org/C2776351790","wikidata":"https://www.wikidata.org/wiki/Q417351","display_name":"Oxalate","level":2,"score":0.4124263823032379},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3178936839103699},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29885134100914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13419866561889648},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.07617411017417908},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017968","descriptor_name":"Vanadium Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017968","descriptor_name":"Vanadium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017968","descriptor_name":"Vanadium Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15632473","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15632473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"Journal Article"},{"id":"mag:2993983740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15632473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W41516964","https://openalex.org/W58690323","https://openalex.org/W93053989","https://openalex.org/W1501473386","https://openalex.org/W1547733031","https://openalex.org/W1594144334","https://openalex.org/W2008492357","https://openalex.org/W2014707628","https://openalex.org/W2045562495","https://openalex.org/W2066613071","https://openalex.org/W2098511755","https://openalex.org/W2100604852","https://openalex.org/W2101503666","https://openalex.org/W2105894548","https://openalex.org/W2142099365","https://openalex.org/W2144930991","https://openalex.org/W2150891147","https://openalex.org/W2172421250","https://openalex.org/W2337485820","https://openalex.org/W2409360547","https://openalex.org/W2409679560","https://openalex.org/W2414044484","https://openalex.org/W2508997451","https://openalex.org/W2520211681","https://openalex.org/W2542822064","https://openalex.org/W2769671204","https://openalex.org/W2791309620","https://openalex.org/W2895903821","https://openalex.org/W2909894833","https://openalex.org/W2981617674","https://openalex.org/W2990840371","https://openalex.org/W3016852213","https://openalex.org/W3016940380","https://openalex.org/W3025259451","https://openalex.org/W3028330817","https://openalex.org/W3034225365","https://openalex.org/W3035467903","https://openalex.org/W3036451283","https://openalex.org/W3092541624","https://openalex.org/W3147479802","https://openalex.org/W6776928405"],"related_works":["https://openalex.org/W1967307772","https://openalex.org/W2157032178","https://openalex.org/W2013562553","https://openalex.org/W2233175606","https://openalex.org/W2067496936","https://openalex.org/W3202429515","https://openalex.org/W2092654177","https://openalex.org/W1987553535","https://openalex.org/W1978315699","https://openalex.org/W2107667026"],"abstract_inverted_index":{"The":[0],"patients":[1],"suffered":[2],"from":[3,166],"diabetes":[4],"mellitus":[5],"(DM)":[6],"are":[7],"increasing":[8],"year":[9,11],"by":[10,89],"through":[12],"the":[13,72,86,140,143,156,159,167,182,184],"world.":[14],"DM":[15,193],"is":[16],"classified":[17],"into":[18],"two":[19],"groups,":[20],"insulin-dependent":[21],"type":[22,26,63],"1":[23,64],"and":[24,37,82,104,169,175,191],"non-insulin-dependent":[25],"2.":[27],"Recent":[28],"research":[29],"has":[30,194],"demonstrated":[31],"that":[32],"vanadate":[33,53],"(VO3-,":[34],"oxidation":[35,40],"state+5)":[36],"vanadyl":[38,98,116],"(VO2+,":[39],"state+4)":[41],"both":[42],"mimic":[43],"various":[44],"actions":[45],"of":[46,75,85,142,158,161,186],"insulin":[47],"in":[48,107,146,170,178,189],"cellular":[49],"systems.":[50],"In":[51,91],"1985,":[52],"given":[54],"orally":[55,96,114,135],"as":[56,101],"a":[57,198],"drinking":[58],"water":[59],"to":[60,70,79,132,155],"streptozotocin-induced":[61],"hyperglycemic":[62],"diabetic":[65],"rats":[66],"(STZ-rats)":[67],"was":[68],"found":[69,131],"reduce":[71],"high":[73],"levels":[74,81],"blood":[76],"glucose":[77],"down":[78],"normal":[80],"ameliorated":[83],"many":[84],"aberrations":[87],"induced":[88],"hyperglycemia.":[90],"1990,":[92],"we":[93,111],"proposed":[94],"first":[95],"active":[97,115,136],"complexes":[99,106,117,125,188],"such":[100],"vanadyl-cysteine":[102],"methylester":[103],"vanadyl-oxalate":[105],"STZ-rats.":[108,179],"Since":[109],"then,":[110],"have":[112],"developed":[113],"with":[118,126,153],"different":[119],"coordination":[120,128],"modes.":[121],"Among":[122],"them,":[123],"vanadyl-picolinate":[124],"VO(N2O2)":[127],"mode":[129],"were":[130],"be":[133],"potent":[134],"insulin-mimetic":[137],"agents,":[138],"on":[139,145,181],"basis":[141],"results":[144],"vitro":[147],"test":[148],"using":[149],"isolated":[150],"rat":[151],"adipocytes":[152],"respect":[154],"inhibition":[157],"release":[160],"free":[162],"fatty":[163],"acids":[164],"(FFA)":[165],"cells":[168],"vivo":[171],"evaluation":[172],"(intraperitoneal":[173],"injection":[174],"oral":[176],"administration)":[177],"Based":[180],"results,":[183],"usefulness":[185],"vanadium":[187],"treating":[190],"preventing":[192],"been":[195],"revealed,":[196],"proposing":[197],"possible":[199],"action":[200],"mechanism.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2019-12-13T00:00:00"}