{"id":"https://openalex.org/W2993971785","doi":null,"title":"[Bazedoxifene as a new-generation SERM].","display_name":"[Bazedoxifene as a new-generation SERM].","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2993971785","mag":"2993971785","pmid":"https://pubmed.ncbi.nlm.nih.gov/21187592"},"language":"ja","primary_location":{"id":"pmid:21187592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21187592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102971912","display_name":"Hiroaki Ohta","orcid":"https://orcid.org/0000-0003-2490-3442","observed_orcids":["https://orcid.org/0000-0003-2490-3442"]},"institutions":[{"id":"https://openalex.org/I79072001","display_name":"International University of Health and Welfare","ror":"https://ror.org/053d3tv41","country_code":"JP","type":"education","lineage":["https://openalex.org/I79072001"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroaki Ohta","raw_affiliation_strings":["International University of Health and Welfare/Sanno Medical Center, Women's Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International University of Health and Welfare/Sanno Medical Center, Women's Medical Center","institution_ids":["https://openalex.org/I79072001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102971912"],"corresponding_institution_ids":["https://openalex.org/I79072001"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"1","first_page":"34","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.625,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.625,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.35420000553131104,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bazedoxifene","display_name":"bazedoxifene","score":1.0},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-modulators","display_name":"selective estrogen receptor modulators","score":0.9919999837875366},{"id":"https://openalex.org/keywords/postmenopausal-osteoporosis","display_name":"postmenopausal osteoporosis","score":0.972000002861023},{"id":"https://openalex.org/keywords/vertebral-fractures","display_name":"vertebral fractures","score":0.8960000276565552},{"id":"https://openalex.org/keywords/non-vertebral-fractures","display_name":"non-vertebral fractures","score":0.9980000257492065},{"id":"https://openalex.org/keywords/raloxifene","display_name":"raloxifene","score":0.906000018119812},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.6729999780654907},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.5329999923706055},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hot-flashes","display_name":"hot flashes","score":0.8700000047683716},{"id":"https://openalex.org/keywords/leg-cramps","display_name":"leg cramps","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cardiovascular-safety","display_name":"cardiovascular safety","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2779889926","wikidata":"https://www.wikidata.org/wiki/Q425223","display_name":"Raloxifene","level":5,"score":0.9465094804763794},{"id":"https://openalex.org/C2777944059","wikidata":"https://www.wikidata.org/wiki/Q903917","display_name":"Selective estrogen receptor modulator","level":5,"score":0.796277642250061},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7415197491645813},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6122027635574341},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.568967878818512},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5378721356391907},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48082125186920166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45253050327301025},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.36767593026161194},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07910451292991638},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.07328295707702637},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.06645587086677551},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017322","descriptor_name":"Clinical Trials, Phase II as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017326","descriptor_name":"Clinical Trials, Phase III as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020845","descriptor_name":"Selective Estrogen Receptor Modulators","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D050723","descriptor_name":"Fractures, Bone","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D050723","descriptor_name":"Fractures, Bone","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:21187592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21187592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W41516964","https://openalex.org/W58690323","https://openalex.org/W93053989","https://openalex.org/W1501473386","https://openalex.org/W1547733031","https://openalex.org/W1594144334","https://openalex.org/W2008492357","https://openalex.org/W2014707628","https://openalex.org/W2045562495","https://openalex.org/W2066613071","https://openalex.org/W2098511755","https://openalex.org/W2100604852","https://openalex.org/W2101503666","https://openalex.org/W2105894548","https://openalex.org/W2142099365","https://openalex.org/W2144930991","https://openalex.org/W2150891147","https://openalex.org/W2172421250","https://openalex.org/W2337485820","https://openalex.org/W2409360547","https://openalex.org/W2409679560","https://openalex.org/W2414044484","https://openalex.org/W2508997451","https://openalex.org/W2520211681","https://openalex.org/W2542822064","https://openalex.org/W2769671204","https://openalex.org/W2791309620","https://openalex.org/W2895903821","https://openalex.org/W2909894833","https://openalex.org/W2981617674","https://openalex.org/W2990840371","https://openalex.org/W3016852213","https://openalex.org/W3016940380","https://openalex.org/W3025259451","https://openalex.org/W3028330817","https://openalex.org/W3034225365","https://openalex.org/W3035467903","https://openalex.org/W3036451283","https://openalex.org/W3092541624","https://openalex.org/W3147479802","https://openalex.org/W6776928405"],"related_works":["https://openalex.org/W2005866113","https://openalex.org/W2132838985","https://openalex.org/W1506298504","https://openalex.org/W2104184770","https://openalex.org/W2137800159","https://openalex.org/W1998320251","https://openalex.org/W7073816263","https://openalex.org/W2108027777","https://openalex.org/W1976389084","https://openalex.org/W2036232268"],"abstract_inverted_index":{"Bazedoxifene":[0,113,176],"is":[1,177],"a":[2,6,92,116,156],"new-generation":[3],"SERM":[4],"with":[5,50,63,80,122,164,167,174],"novel":[7],"chemical":[8],"structure,":[9],"which":[10],"has":[11,47,114],"been":[12,48],"developed":[13],"to":[14,60,83,172,180],"provide":[15],"improved":[16,28],"efficacy":[17],"on":[18],"the":[19,22,41,64,72,88,106,128,160,187],"bone":[20],"and":[21,32,66,85,119,137,151],"lipid":[23],"profile,":[24],"as":[25,27,147,155],"well":[26],"safety":[29,118],"for":[30,108,186],"breast":[31],"endometrial":[33],"tissues.":[34],"A":[35,68],"statistically":[36],"significant":[37,69,124],"42%":[38],"reduction":[39,70],"in":[40,53,71,87,91,104,131,192],"incidence":[42,73,142],"of":[43,74,143,159,189],"new":[44,184],"vertebral":[45],"fractures":[46,76,110],"reported":[49,62,154],"bazedoxifene":[51,99,165],"treatment":[52,129,188],"an":[54,182],"overseas":[55],"phase":[56],"III":[57],"trial,":[58],"equal":[59],"that":[61,98,173],"bisphosphonates":[65],"raloxifene.":[67,112,175],"non-vertebral":[75,109],"was":[77,170],"also":[78],"shown":[79],"bazedoxifene,":[81],"compared":[82],"placebo":[84],"raloxifene":[86],"high-risk":[89],"population":[90],"post-hoc":[93],"analysis.":[94],"These":[95],"data":[96],"suggest":[97],"could":[100],"be":[101],"more":[102],"effective":[103],"reducing":[105],"risk":[107],"than":[111,166],"demonstrated":[115],"favorable":[117],"tolerability":[120],"profile":[121],"no":[123],"differences":[125],"observed":[126],"among":[127],"groups":[130],"coronary":[132],"artery":[133],"events,":[134,136,145],"cerebrovascular":[135],"overall":[138],"death":[139],"rates.":[140],"The":[141],"adverse":[144],"such":[146],"VTEs,":[148],"hot":[149],"flushes":[150],"leg":[152],"cramps,":[153],"class":[157],"effect":[158],"SERMs,":[161],"were":[162],"higher":[163],"placebo,":[168],"but":[169],"similar":[171],"thus":[178],"expected":[179],"become":[181],"important":[183],"option":[185],"postmenopausal":[190],"osteoporosis":[191],"Japan.":[193]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2019-12-13T00:00:00"}
