{"id":"https://openalex.org/W2993963960","doi":"https://doi.org/10.5772/intechopen.90306","title":"Demethylation in Early Embryonic Development and Memory","display_name":"Demethylation in Early Embryonic Development and Memory","publication_year":2019,"publication_date":"2019-12-11","ids":{"openalex":"https://openalex.org/W2993963960","doi":"https://doi.org/10.5772/intechopen.90306","mag":"2993963960"},"language":"en","primary_location":{"id":"doi:10.5772/intechopen.90306","doi":"https://doi.org/10.5772/intechopen.90306","is_oa":true,"landing_page_url":"https://doi.org/10.5772/intechopen.90306","pdf_url":null,"source":{"id":"https://openalex.org/S4306463448","display_name":"IntechOpen eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310322558","host_organization_name":"IntechOpen","host_organization_lineage":["https://openalex.org/P4310322558"],"host_organization_lineage_names":["IntechOpen"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA Methylation Mechanism","raw_type":"book-chapter"},"parent_works":[{"id":"https://openalex.org/W3040314689","display_name":"DNA Methylation Mechanism","relationship":"volume"}],"lineage":["https://openalex.org/W2993963960","https://openalex.org/W3040314689"],"child_works_count":0,"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.5772/intechopen.90306","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020458397","display_name":"Carol Bernstein","orcid":"https://orcid.org/0000-0001-7761-6565","observed_orcids":["https://orcid.org/0000-0001-7761-6565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carol Bernstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Harris Bernstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harris Bernstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.542,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.62064549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-demethylation","display_name":"DNA demethylation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dna-base-excision-repair","display_name":"DNA base excision repair","score":0.8309999704360962},{"id":"https://openalex.org/keywords/tet-methylcytosine-dioxygenases","display_name":"TET methylcytosine dioxygenases","score":0.9369999766349792},{"id":"https://openalex.org/keywords/epigenetic-reprogramming","display_name":"epigenetic reprogramming","score":0.7360000014305115},{"id":"https://openalex.org/keywords/contextual-fear-conditioning","display_name":"contextual fear conditioning","score":0.6100000143051147},{"id":"https://openalex.org/keywords/hippocampal-gene-expression","display_name":"hippocampal gene expression","score":0.7070000171661377},{"id":"https://openalex.org/keywords/evolution-of-memory","display_name":"evolution of memory","score":0.6389999985694885},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.367837131023407},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.32010647654533386},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2981056869029999}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5772/intechopen.90306","doi":"https://doi.org/10.5772/intechopen.90306","is_oa":true,"landing_page_url":"https://doi.org/10.5772/intechopen.90306","pdf_url":null,"source":{"id":"https://openalex.org/S4306463448","display_name":"IntechOpen eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310322558","host_organization_name":"IntechOpen","host_organization_lineage":["https://openalex.org/P4310322558"],"host_organization_lineage_names":["IntechOpen"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA Methylation Mechanism","raw_type":"book-chapter"},{"id":"pmh:oai:biblioboard.com:b1356bc4-ddbb-45e3-9509-ba210e4a2c93","doi":null,"is_oa":true,"landing_page_url":"https://openresearchlibrary.org/viewer/b1356bc4-ddbb-45e3-9509-ba210e4a2c93","pdf_url":null,"source":{"id":"https://openalex.org/S4306401131","display_name":"BiblioBoard Library Catalog (Open Research Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"MODID-6d55e02e354:IntechOpen","raw_type":"CHAPTER"},{"id":"pmh:oai:intechopen.com:70316","doi":null,"is_oa":true,"landing_page_url":"http://www.intechopen.com/articles/show/title/demethylation-in-early-embryonic-development-and-memory","pdf_url":null,"source":{"id":"https://openalex.org/S4306401291","display_name":"Contact-less Assessment of In-vivo Body Signals Using Microwave Doppler Radar (InTech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210154139","host_organization_name":"Intech (Slovakia)","host_organization_lineage":["https://openalex.org/I4210154139"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.intechopen.com/chapter/pdf-download/70316","raw_type":"6"}],"best_oa_location":{"id":"doi:10.5772/intechopen.90306","doi":"https://doi.org/10.5772/intechopen.90306","is_oa":true,"landing_page_url":"https://doi.org/10.5772/intechopen.90306","pdf_url":null,"source":{"id":"https://openalex.org/S4306463448","display_name":"IntechOpen eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310322558","host_organization_name":"IntechOpen","host_organization_lineage":["https://openalex.org/P4310322558"],"host_organization_lineage_names":["IntechOpen"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"DNA Methylation Mechanism","raw_type":"book-chapter"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1570882820","https://openalex.org/W1821495885","https://openalex.org/W1828408764","https://openalex.org/W1971157495","https://openalex.org/W1971383450","https://openalex.org/W1979526394","https://openalex.org/W1982213571","https://openalex.org/W1986219537","https://openalex.org/W1991856249","https://openalex.org/W1996431759","https://openalex.org/W2001036497","https://openalex.org/W2018338317","https://openalex.org/W2029243559","https://openalex.org/W2031935406","https://openalex.org/W2032882684","https://openalex.org/W2033188250","https://openalex.org/W2033595893","https://openalex.org/W2036082680","https://openalex.org/W2036942985","https://openalex.org/W2038990611","https://openalex.org/W2039169438","https://openalex.org/W2043622843","https://openalex.org/W2060339471","https://openalex.org/W2068910046","https://openalex.org/W2073902410","https://openalex.org/W2078511755","https://openalex.org/W2088708165","https://openalex.org/W2089309776","https://openalex.org/W2089675753","https://openalex.org/W2092765329","https://openalex.org/W2106533942","https://openalex.org/W2107279676","https://openalex.org/W2108931268","https://openalex.org/W2112001893","https://openalex.org/W2113349101","https://openalex.org/W2130222411","https://openalex.org/W2134428957","https://openalex.org/W2141874138","https://openalex.org/W2145534945","https://openalex.org/W2155158396","https://openalex.org/W2157468016","https://openalex.org/W2159170019","https://openalex.org/W2165966433","https://openalex.org/W2171831910","https://openalex.org/W2199911847","https://openalex.org/W2225733508","https://openalex.org/W2279643582","https://openalex.org/W2302006885","https://openalex.org/W2313964077","https://openalex.org/W2410825513","https://openalex.org/W2416750831","https://openalex.org/W2433302803","https://openalex.org/W2484951111","https://openalex.org/W2508720811","https://openalex.org/W2552770540","https://openalex.org/W2559543273","https://openalex.org/W2617004827","https://openalex.org/W2618782736","https://openalex.org/W2626149659","https://openalex.org/W2783792475","https://openalex.org/W2786809699","https://openalex.org/W2790004746","https://openalex.org/W2804661515","https://openalex.org/W2808264497","https://openalex.org/W2895649839","https://openalex.org/W2910208922","https://openalex.org/W2926044868","https://openalex.org/W2970424016","https://openalex.org/W6929924300"],"related_works":["https://openalex.org/W4206630328","https://openalex.org/W2081746768","https://openalex.org/W2402025689","https://openalex.org/W2568127441","https://openalex.org/W1993981510","https://openalex.org/W2298442810","https://openalex.org/W2122218405","https://openalex.org/W2036082680","https://openalex.org/W2148360420","https://openalex.org/W2129598790"],"abstract_inverted_index":{"DNA":[0,9,73,102,175],"repair":[1,12,76,97],"processes":[2,52],"arose":[3],"early":[4],"in":[5,17,21,42,50,149,170],"evolution.":[6],"During":[7],"evolution,":[8],"base":[10,74],"excision":[11,75],"apparently":[13],"acquired":[14],"additional":[15],"roles":[16],"demethylation":[18,48],"of":[19,59,83,100,108,130,146,153,167,185,193],"cytosines":[20],"DNA.":[22],"Demethylation":[23],"is":[24,103],"central":[25],"to":[26,90,127,178],"two":[27],"mammalian":[28],"fundamental":[29],"processes.":[30],"Embryonic":[31],"reprogramming":[32],"and":[33,96],"neuronal":[34],"memory":[35,186],"require":[36],"rapid":[37],"gene":[38,180],"expression":[39],"alterations":[40],"depending":[41],"part":[43],"on":[44,56,72,113,173],"demethylations.":[45],"The":[46,165,182],"active":[47],"reactions":[49],"both":[51],"primarily":[53],"depend,":[54],"first,":[55],"the":[57,63,85,121,147,150,190],"family":[58],"5-methylcytosine":[60],"oxidases":[61],"sharing":[62],"acronym":[64],"ten-eleven":[65],"translocation":[66],"(TET":[67],"methylcytosine":[68],"dioxygenases)":[69],"and,":[70],"second,":[71],"enzymes.":[77],"In":[78],"mice,":[79],"within":[80],"6":[81],"h":[82,142],"fertilization,":[84],"paternal":[86],"chromosomes":[87],"are":[88,156],"close":[89],"100%":[91],"actively":[92],"demethylated":[93],"through":[94],"TET":[95],"activity.":[98],"(Methylation":[99],"maternal":[101,114],"blocked":[104],"during":[105],"subsequent":[106],"cycles":[107],"replication,":[109],"so":[110],"methyl":[111],"groups":[112],"DNA,":[115],"passively,":[116],"becomes":[117],"highly":[118],"diluted":[119],"over":[120,160],"next":[122],"4":[123],"days.)":[124],"Rats":[125],"subjected":[126],"one":[128],"instance":[129],"contextual":[131],"fear":[132],"conditioning":[133],"create":[134],"an":[135],"especially":[136],"strong":[137],"long-term":[138],"memory.":[139],"At":[140],"24":[141],"after":[143],"training,":[144],"9.2%":[145],"genes":[148,162],"rat":[151],"genomes":[152],"hippocampus":[154],"neurons":[155],"differentially":[157],"methylated,":[158],"including":[159],"500":[161],"with":[163,197],"demethylation.":[164],"emergence":[166,184],"embryonic":[168,198],"development":[169],"evolution":[171],"depended":[172],"preexisting":[174],"methylation/demethylation":[176,194],"pathways":[177],"modify":[179],"expression.":[181],"further":[183],"likely":[187],"evolved":[188],"from":[189],"earlier":[191],"set":[192],"capabilities":[195],"associated":[196],"development.":[199]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2019-12-13T00:00:00"}