{"id":"https://openalex.org/W2993872430","doi":null,"title":"The Protective Effect of Medicinal Herbs Extracts Including Cynara scolymus L., Cichorium intybus L. Taraxacum officinal L. and Berberis vulgaris L. in Single and in Combination Form in CCl4 Induced Rat Liver Toxicity","display_name":"The Protective Effect of Medicinal Herbs Extracts Including Cynara scolymus L., Cichorium intybus L. Taraxacum officinal L. and Berberis vulgaris L. in Single and in Combination Form in CCl4 Induced Rat Liver Toxicity","publication_year":2012,"publication_date":"2012-02-01","ids":{"openalex":"https://openalex.org/W2993872430","mag":"2993872430"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:78fa2ae96b704e829b832ba64226a266","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/78fa2ae96b704e829b832ba64226a266","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Medicinal Plants, Vol 11, Iss 41, Pp 78-85 (2012)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/78fa2ae96b704e829b832ba64226a266","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077643695","display_name":"Hasan Fallah Huseini","orcid":"https://orcid.org/0000-0002-3192-6012","observed_orcids":["https://orcid.org/0000-0002-3192-6012"]},"institutions":[{"id":"https://openalex.org/I2802694670","display_name":"Academic Center for Education, Culture and Research","ror":"https://ror.org/0126z4b94","country_code":"IR","type":"nonprofit","lineage":["https://openalex.org/I2802694670"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"H Fallah Huseini","raw_affiliation_strings":["\n             Department of Pharmacology and Applied Medicine, Institute of Medicinal Plants ACECR    \n\t"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\n             Department of Pharmacology and Applied Medicine, Institute of Medicinal Plants ACECR    \n\t","institution_ids":["https://openalex.org/I2802694670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101470398","display_name":"Ali Zaree Mahmoudabadi","orcid":"https://orcid.org/0000-0001-8475-1650","observed_orcids":["https://orcid.org/0000-0001-8475-1650"]},"institutions":[{"id":"https://openalex.org/I120514687","display_name":"Baqiyatallah University of Medical Sciences","ror":"https://ror.org/01ysgtb61","country_code":"IR","type":"education","lineage":["https://openalex.org/I120514687"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"A Zaree Mahmoudabady","raw_affiliation_strings":["\n             Department of Biochemistry, Baquiatallah University of Medical Sciences    \n\t"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\n             Department of Biochemistry, Baquiatallah University of Medical Sciences    \n\t","institution_ids":["https://openalex.org/I120514687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025523183","display_name":"H Naghdi Badi","orcid":"https://orcid.org/0000-0001-7070-8467","observed_orcids":["https://orcid.org/0000-0001-7070-8467"]},"institutions":[{"id":"https://openalex.org/I2802694670","display_name":"Academic Center for Education, Culture and Research","ror":"https://ror.org/0126z4b94","country_code":"IR","type":"nonprofit","lineage":["https://openalex.org/I2802694670"]},{"id":"https://openalex.org/I4210147708","display_name":"Institute of Medicinal Plant Development","ror":"https://ror.org/052nj8f19","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210141683","https://openalex.org/I4210147708"]}],"countries":["CN","IR"],"is_corresponding":false,"raw_author_name":"H Naghdi Badi","raw_affiliation_strings":["Department of Cultivation and Development, Institute of Medicinal Plants ACECR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cultivation and Development, Institute of Medicinal Plants ACECR","institution_ids":["https://openalex.org/I2802694670","https://openalex.org/I4210147708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032672163","display_name":"Seyed Moayed Alavian","orcid":"https://orcid.org/0000-0002-4443-6602","observed_orcids":["https://orcid.org/0000-0002-4443-6602"]},"institutions":[{"id":"https://openalex.org/I2802694670","display_name":"Academic Center for Education, Culture and Research","ror":"https://ror.org/0126z4b94","country_code":"IR","type":"nonprofit","lineage":["https://openalex.org/I2802694670"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"S.M. Alavian","raw_affiliation_strings":["\n             Department of Pharmacology and Applied Medicine, Institute of Medicinal Plants ACECR    \n\t"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\n             Department of Pharmacology and Applied Medicine, Institute of Medicinal Plants ACECR    \n\t","institution_ids":["https://openalex.org/I2802694670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067331540","display_name":"R Mohammadi Savadroodbari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802694670","display_name":"Academic Center for Education, Culture and Research","ror":"https://ror.org/0126z4b94","country_code":"IR","type":"nonprofit","lineage":["https://openalex.org/I2802694670"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"R Mohammadi Savadroodbari","raw_affiliation_strings":["\n             Department of Pharmacology and Applied Medicine, Institute of Medicinal Plants ACECR    \n\t"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\n             Department of Pharmacology and Applied Medicine, Institute of Medicinal Plants ACECR    \n\t","institution_ids":["https://openalex.org/I2802694670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067679659","display_name":"Mehdi Mehdizadeh","orcid":"https://orcid.org/0000-0002-9268-7318","observed_orcids":["https://orcid.org/0000-0002-9268-7318"]},"institutions":[{"id":"https://openalex.org/I161106909","display_name":"Iran University of Medical Sciences","ror":"https://ror.org/03w04rv71","country_code":"IR","type":"education","lineage":["https://openalex.org/I161106909"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"M Mehdizadeh","raw_affiliation_strings":["Department of Pathology Iran University of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Iran University of Medical Sciences","institution_ids":["https://openalex.org/I161106909"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.662,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.66317042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artichoke","display_name":"artichoke","score":0.828000009059906},{"id":"https://openalex.org/keywords/chicory","display_name":"chicory","score":0.9789999723434448},{"id":"https://openalex.org/keywords/taraxacum-officinale","display_name":"Taraxacum officinale","score":0.9990000128746033},{"id":"https://openalex.org/keywords/berberis-vulgaris","display_name":"Berberis vulgaris","score":1.0},{"id":"https://openalex.org/keywords/herbal-plant-extracts","display_name":"herbal plant extracts","score":0.7139999866485596},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.5339999794960022},{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.8769999742507935},{"id":"https://openalex.org/keywords/herbal-combination","display_name":"herbal combination","score":0.625},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.8339999914169312},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.7369999885559082},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9760000109672546},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.878000020980835},{"id":"https://openalex.org/keywords/taraxacum","display_name":"dandelion","score":0.9380000233650208},{"id":"https://openalex.org/keywords/berberis","display_name":"Berberis","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C2776500997","wikidata":"https://www.wikidata.org/wiki/Q131219","display_name":"Taraxacum officinale","level":5,"score":0.7875974178314209},{"id":"https://openalex.org/C2778011807","wikidata":"https://www.wikidata.org/wiki/Q158514","display_name":"Cichorium","level":2,"score":0.7551908493041992},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.7088847160339355},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.45350292325019836},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3363977074623108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3186342120170593},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16829660534858704},{"id":"https://openalex.org/C2778804639","wikidata":"https://www.wikidata.org/wiki/Q30024","display_name":"Dandelion","level":4,"score":0.04785829782485962},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:78fa2ae96b704e829b832ba64226a266","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/78fa2ae96b704e829b832ba64226a266","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Medicinal Plants, Vol 11, Iss 41, Pp 78-85 (2012)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:78fa2ae96b704e829b832ba64226a266","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/78fa2ae96b704e829b832ba64226a266","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Medicinal Plants, Vol 11, Iss 41, Pp 78-85 (2012)","raw_type":"article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W19083353","https://openalex.org/W201139420","https://openalex.org/W1246956350","https://openalex.org/W1570803478","https://openalex.org/W1574829340","https://openalex.org/W1775749144","https://openalex.org/W1967817279","https://openalex.org/W1976376115","https://openalex.org/W1978472590","https://openalex.org/W1986852176","https://openalex.org/W1999110537","https://openalex.org/W2008005752","https://openalex.org/W2009430120","https://openalex.org/W2010418588","https://openalex.org/W2021709462","https://openalex.org/W2027299002","https://openalex.org/W2027389066","https://openalex.org/W2032202007","https://openalex.org/W2037034011","https://openalex.org/W2051384892","https://openalex.org/W2054970111","https://openalex.org/W2055691199","https://openalex.org/W2063576996","https://openalex.org/W2071810521","https://openalex.org/W2085465078","https://openalex.org/W2086434450","https://openalex.org/W2300883430","https://openalex.org/W4234614872"],"related_works":["https://openalex.org/W2157847667","https://openalex.org/W7037776053","https://openalex.org/W2077862972","https://openalex.org/W4405825380","https://openalex.org/W2809502231","https://openalex.org/W7167331589","https://openalex.org/W2344234950","https://openalex.org/W2298834423","https://openalex.org/W2979207880","https://openalex.org/W4414511203"],"abstract_inverted_index":{"Background:":[0],"Several":[1],"herbal":[2,183,206],"remedies":[3],"are":[4],"used":[5],"in":[6,63,66,87,125,234],"traditional":[7],"medicine":[8],"for":[9,146],"treatment":[10],"of":[11,38,90,101,113,128,181,188,228],"liver":[12,35,74,158,238],"disorders,":[13],"but":[14],"their":[15],"efficacy,":[16],"safety,":[17],"and":[18,60,65,99,116,123,132,153,165,172,191,211,232],"dosage":[19,127],"have":[20],"not":[21,215],"been":[22],"investigated":[23],"so":[24],"far.":[25],"Objective:":[26],"The":[27,136],"present":[28,225],"study":[29,226],"was":[30],"aimed":[31],"to":[32,198,219],"evaluate":[33],"the":[34,126,156,185,203,208,224],"protective":[36],"effects":[37],"medicinal":[39],"herbs":[40],"extracts":[41,138,207],"such":[42,161],"as":[43,97,108,162,167,169,196,217],"Cynara":[44],"scolymus":[45],"leave":[46],"(artichok),":[47],"Cichorium":[48],"intybus":[49],"roots":[50],"(chichory),":[51],"Taraxacum":[52],"officinale":[53],"root":[54,59],"(dandelium),":[55],"Berberis":[56],"vulgaris":[57],"(barberry)":[58],"stems":[61],"extract":[62,115,154,184],"single":[64],"combination":[67,235],"form":[68,236],"against":[69],"carbon":[70],"tetrachloride":[71],"(CCl4)":[72],"induced":[73],"toxicity.":[75],"Methods:":[76],"Total":[77],"70":[78],"wistar":[79],"male":[80],"rat,":[81],"aged":[82],"5":[83],"months":[84],"were":[85,139,174,193],"divided":[86],"7":[88],"groups":[89,105,118,204],"10":[91],"rats":[92],"each.":[93],"One":[94],"group":[95,178],"kept":[96],"normal":[98],"out":[100],"six":[102],"CCl4":[103],"intoxicated":[104],"one":[106,110],"served":[107],"control,":[109],"received":[111,119],"mixture":[112,180],"four":[114,117],"artichok,":[120],"chichory,":[121,229],"dandelium,":[122],"barberry":[124,233],"150,":[129],"300,":[130],"300":[131],"250":[133],"mg/kg/day":[134],"respectively.":[135],"plant":[137],"injected":[140],"intra":[141],"peritoneal":[142],"simultaneously":[143],"with":[144],"intoxication":[145,152,239],"three":[147],"days.":[148],"Three":[149],"days":[150],"after":[151],"treatments":[155],"serum":[157,170,209,243],"enzymes":[159],"levels":[160,213],"ALT,":[163,189],"AST":[164,190],"ALP":[166,192],"well":[168],"gluthathion":[171],"catalase":[173,212],"determined.":[175],"Results:":[176],"In":[177,201,223],"receiving":[179,205],"4":[182],"blood":[186],"level":[187],"reduced":[194],"significantly":[195],"compared":[197,218],"control":[199,220],"group.":[200],"all":[202],"glutathione":[210],"did":[214],"differ":[216],"groups.":[221],"Conclusion:":[222],"administration":[227],"artichoke,":[230],"dandelium":[231],"prevent":[237],"withought":[240],"influence":[241],"on":[242],"antioxidant":[244],"properties.":[245]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-13T00:00:00"}
