{"id":"https://openalex.org/W2993782230","doi":null,"title":"Articular cartilage: tissue design and chondrocyte-matrix interactions.","display_name":"Articular cartilage: tissue design and chondrocyte-matrix interactions.","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2993782230","mag":"2993782230","pmid":"https://pubmed.ncbi.nlm.nih.gov/9571449"},"language":"en","primary_location":{"id":"pmid:9571449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9571449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Instructional course lectures","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064323409","display_name":"Joseph A. Buckwalter","orcid":"https://orcid.org/0000-0003-4308-7583","observed_orcids":["https://orcid.org/0000-0003-4308-7583"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Buckwalter","raw_affiliation_strings":["Department of Orthopaedics, University of Iowa, Iowa City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, University of Iowa, Iowa City, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108135955","display_name":"Henry J. Mankin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H J Mankin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.8065,"has_fulltext":false,"cited_by_count":920,"citation_normalized_percentile":{"value":0.99517273,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"47","issue":null,"first_page":"477","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"articular cartilage","score":0.9940000176429749},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.6439999938011169},{"id":"https://openalex.org/keywords/type-ii-collagen","display_name":"type II collagen","score":0.8820000290870667},{"id":"https://openalex.org/keywords/type-ix-collagen","display_name":"type IX collagen","score":0.7319999933242798},{"id":"https://openalex.org/keywords/type-xi-collagen","display_name":"type XI collagen","score":0.9990000128746033},{"id":"https://openalex.org/keywords/collagen-vi","display_name":"collagen VI","score":0.9940000176429749},{"id":"https://openalex.org/keywords/aggrecan","display_name":"aggrecan","score":0.8889999985694885},{"id":"https://openalex.org/keywords/small-proteoglycans","display_name":"small proteoglycans","score":0.9169999957084656},{"id":"https://openalex.org/keywords/decorin","display_name":"decorin","score":0.8050000071525574},{"id":"https://openalex.org/keywords/biglycan","display_name":"biglycan","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fibromodulin","display_name":"fibromodulin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cartilage-oligomeric-matrix-protein","display_name":"cartilage oligomeric matrix protein","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tenascin","display_name":"tenascin","score":0.925000011920929},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":1.0},{"id":"https://openalex.org/keywords/non-collagenous-proteins","display_name":"non-collagenous proteins","score":0.8119999766349792},{"id":"https://openalex.org/keywords/matrix-turnover","display_name":"matrix turnover","score":0.7910000085830688},{"id":"https://openalex.org/keywords/joint-loading","display_name":"joint loading","score":0.6200000047683716},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C2779794767","wikidata":"https://www.wikidata.org/wiki/Q18248676","display_name":"Decorin","level":4,"score":0.7886291742324829},{"id":"https://openalex.org/C2778916964","wikidata":"https://www.wikidata.org/wiki/Q14905499","display_name":"Biglycan","level":5,"score":0.7666942477226257},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.6820974349975586},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.6744212508201599},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6643495559692383},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.64217609167099},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5658039450645447},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5639646053314209},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.5571213960647583},{"id":"https://openalex.org/C2778232976","wikidata":"https://www.wikidata.org/wiki/Q15320335","display_name":"Cartilage oligomeric matrix protein","level":4,"score":0.5548049807548523},{"id":"https://openalex.org/C2777738151","wikidata":"https://www.wikidata.org/wiki/Q1903925","display_name":"Tenascin","level":4,"score":0.5066948533058167},{"id":"https://openalex.org/C197534660","wikidata":"https://www.wikidata.org/wiki/Q21121862","display_name":"Aggrecan","level":5,"score":0.4482448995113373},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.41798773407936096},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.35978078842163086},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35959669947624207},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.29100096225738525},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.18978473544120789},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18820273876190186},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.1251143217086792},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10104840993881226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06583040952682495},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06332778930664062},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9571449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9571449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Instructional course lectures","raw_type":"Journal Article"},{"id":"mag:2993782230","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9571449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4245936818","https://openalex.org/W2411621054","https://openalex.org/W44863704","https://openalex.org/W2417986221","https://openalex.org/W2060147296","https://openalex.org/W2584587341","https://openalex.org/W4388228678","https://openalex.org/W185155162","https://openalex.org/W1569612555","https://openalex.org/W2038159923"],"abstract_inverted_index":{"The":[0,192,241],"unique":[1],"biologic":[2],"and":[3,16,22,45,51,64,67,81,106,109,119,126,142,171,175,181,189,209,217,262,273,280,310,319,343,350,364,380],"mechanical":[4,351],"properties":[5],"of":[6,13,34,41,74,92,139,169,173,203,211,253,264,270,282,298,304,322,331,340,347,355,362,377,383,389,397,409,411],"articular":[7],"cartilage":[8],"depend":[9],"on":[10,250],"the":[11,14,17,20,23,27,31,35,60,75,79,84,89,93,100,131,137,140,158,187,190,195,204,207,215,221,226,233,251,259,265,268,287,295,299,305,317,329,332,338,341,356,359,366,375,378,381,384,387,390,407,412],"design":[12],"tissue":[15,36,61,101,227,300,348,368],"interactions":[18,185],"between":[19,186],"chondrocytes":[21,80,85,141,156,188,254,363],"matrix":[24,37,76,124,193,236,247,288,342,379],"that":[25,58,213,245,313],"maintain":[26,220],"tissue.":[28],"Chondrocytes":[29],"form":[30,54,63],"macromolecular":[32,90,260],"framework":[33,91],"from":[38,197],"three":[39],"classes":[40],"molecules:":[42],"collagens,":[43],"proteoglycans,":[44,115],"noncollagenous":[46,149,177],"proteins.":[47],"Type":[48,69],"II,":[49],"IX,":[50],"XI":[52],"collagens":[53],"a":[55,148,167,291,395],"fibrillar":[56],"meshwork":[57],"gives":[59],"as":[62,166,232,290,400],"tensile":[65],"stiffness":[66,103],"strength.":[68],"VI":[70],"collagen":[71],"forms":[72],"part":[73],"immediately":[77],"surrounding":[78],"may":[82,134,163,405],"help":[83,128,153,314],"to":[86,88,104,111,122,129,152,154,157,200,219,255,274,302,315,335,345,372,392,394],"attach":[87],"matrix.":[94,132,159,191],"Large":[95],"aggregating":[96],"proteoglycans":[97],"(aggrecans)":[98],"give":[99],"its":[102,107,112],"compression":[105],"resilience":[108],"contribute":[110],"durability.":[113],"Small":[114],"including":[116,179,267,386],"decorin,":[117],"biglycan,":[118],"fibromodulin,":[120],"bind":[121,143],"other":[123,176],"macromolecules":[125,237],"thereby":[127],"stabilize":[130],"They":[133],"also":[135],"influence":[136,184],"function":[138],"growth":[144,401],"factors.":[145,402],"Anchorin":[146],"CII,":[147],"protein,":[150],"appears":[151],"anchor":[155],"Cartilage":[160],"oligomeric":[161],"protein":[162],"have":[164],"value":[165],"marker":[168],"turnover":[170,248],"degeneration":[172,410],"cartilage,":[174],"proteins,":[178],"tenascin":[180],"fibronectin,":[182],"can":[183],"protects":[194],"cells":[196,234,391],"injury":[198],"due":[199,301],"normal":[201,246],"use":[202,303,330,354],"joint,":[205],"determines":[206],"types":[208,279],"concentrations":[210],"molecules":[212],"reach":[214],"tells":[216],"helps":[218],"chondrocyte":[222],"phenotype.":[223],"Throughout":[224],"life,":[225],"undergoes":[228],"continual":[229],"internal":[230,367],"remodeling":[231,369],"replace":[235],"lost":[238],"through":[239],"degradation.":[240],"available":[242],"evidence":[243],"indicates":[244],"depends":[249],"ability":[252,388],"detect":[256],"alterations":[257,336,373,404],"in":[258,328,337,374],"composition":[261,339,376],"organization":[263],"matrix,":[266],"presence":[269],"degraded":[271],"molecules,":[272],"respond":[275,393],"by":[276],"synthesizing":[277],"appropriate":[278],"amounts":[281],"new":[283],"molecules.":[284],"In":[285],"addition,":[286],"acts":[289],"signal":[292],"transducer":[293],"for":[294],"cells.":[296],"Loading":[297],"joint":[306,333,357],"creates":[307],"mechanical,":[308],"electrical,":[309],"physicochemical":[311],"signals":[312],"direct":[316],"synthetic":[318,360],"degradative":[320],"activity":[321,361,382],"chondrocytes.":[323],"A":[324],"prolonged":[325],"severe":[326],"decrease":[327],"leads":[334,371],"eventually":[344],"loss":[346],"structure":[349],"properties,":[352],"whereas":[353],"stimulates":[358],"possibly":[365],"Aging":[370],"chondrocytes,":[385],"variety":[396],"stimuli":[398],"such":[399],"These":[403],"increase":[406],"probability":[408],"cartilage.":[413]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":32},{"year":2020,"cited_by_count":40},{"year":2019,"cited_by_count":34},{"year":2018,"cited_by_count":35},{"year":2017,"cited_by_count":44},{"year":2016,"cited_by_count":37},{"year":2015,"cited_by_count":46},{"year":2014,"cited_by_count":44},{"year":2013,"cited_by_count":55},{"year":2012,"cited_by_count":53}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-12-13T00:00:00"}