{"id":"https://openalex.org/W2993765829","doi":null,"title":"Diagnosis of corticosteroid insufficiency in Thai patients with septic shock.","display_name":"Diagnosis of corticosteroid insufficiency in Thai patients with septic shock.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2993765829","mag":"2993765829","pmid":"https://pubmed.ncbi.nlm.nih.gov/20364574"},"language":"en","primary_location":{"id":"pmid:20364574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20364574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031858666","display_name":"Ranistha Ratanarat","orcid":"https://orcid.org/0000-0001-7137-5537","observed_orcids":["https://orcid.org/0000-0001-7137-5537"]},"institutions":[{"id":"https://openalex.org/I1332387789","display_name":"Siriraj Hospital","ror":"https://ror.org/0331zs648","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I1332387789"]},{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Ranistha Ratanarat","raw_affiliation_strings":["Division of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Siriraj hospital, Mahidol University, Bangkok, Thailand. ranittha@hotmail.com","Division of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Siriraj hospital, Mahidol University, Bangkok, Thailand. ranittha@hotmail.com","institution_ids":["https://openalex.org/I1332387789","https://openalex.org/I25399158"]},{"raw_affiliation_string":"Division of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I1332387789","https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049901433","display_name":"Panuwat Promsin","orcid":"https://orcid.org/0000-0001-8922-7145","observed_orcids":["https://orcid.org/0000-0001-8922-7145"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Panuwat Promsin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015937048","display_name":"Apiradee Sriwijitkamol","orcid":"https://orcid.org/0000-0003-2480-2449","observed_orcids":["https://orcid.org/0000-0003-2480-2449"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Apiradee Srivijitkamol","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075432754","display_name":"Chantanij Leemingsawat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chantanij Leemingsawat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082870933","display_name":"Chairat Permpikul","orcid":"https://orcid.org/0000-0001-5491-6987","observed_orcids":["https://orcid.org/0000-0001-5491-6987"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chairat Permpikul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"93 Suppl 1","issue":null,"first_page":"S187","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.6875,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.6875,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.30660000443458557,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11623","display_name":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/critical-illness-related-corticosteroid-insufficiency","display_name":"critical illness-related corticosteroid insufficiency","score":0.9459999799728394},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.8040000200271606},{"id":"https://openalex.org/keywords/acth-stimulation-test","display_name":"ACTH stimulation test","score":0.9649999737739563},{"id":"https://openalex.org/keywords/corticosteroid-responsiveness","display_name":"corticosteroid responsiveness","score":0.7680000066757202},{"id":"https://openalex.org/keywords/adrenal-insufficiency-diagnosis","display_name":"adrenal insufficiency diagnosis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/thai-patients","display_name":"Thai patients","score":0.6330000162124634},{"id":"https://openalex.org/keywords/diagnostic-cut-off-values","display_name":"diagnostic thresholds","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9414823055267334},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.841217577457428},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.7688114643096924},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.7412775158882141},{"id":"https://openalex.org/C2778129406","wikidata":"https://www.wikidata.org/wiki/Q2507454","display_name":"Adrenal insufficiency","level":2,"score":0.7394745945930481},{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.6930949687957764},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6548856496810913},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.6406373977661133},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5322219133377075},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4537428319454193},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4238685667514801},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4130541980266571},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3468175530433655},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000304","descriptor_name":"Adrenal Cortex Function Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000309","descriptor_name":"Adrenal Insufficiency","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000309","descriptor_name":"Adrenal Insufficiency","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000309","descriptor_name":"Adrenal Insufficiency","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005440","descriptor_name":"Fluid Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010913","descriptor_name":"Pituitary-Adrenal System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013785","descriptor_name":"Thailand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017052","descriptor_name":"Hospital Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20364574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20364574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","raw_type":"Journal Article"},{"id":"mag:2993765829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20364574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1992311120","https://openalex.org/W1999156610","https://openalex.org/W2007130516","https://openalex.org/W2049641826","https://openalex.org/W2053980980","https://openalex.org/W2166962064","https://openalex.org/W2768146862"],"related_works":["https://openalex.org/W4415153915","https://openalex.org/W4387381469","https://openalex.org/W8030577","https://openalex.org/W4411620777","https://openalex.org/W2166962064","https://openalex.org/W2580724340","https://openalex.org/W2899978927","https://openalex.org/W2168378551","https://openalex.org/W2777584026","https://openalex.org/W1971097161"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,221],"reported":[2],"incidence":[3],"of":[4,49,52,65,180,190,240,265,290,295,298,302,320],"critical":[5],"illness-related":[6],"corticosteroid":[7,29,80],"insufficiency":[8],"(CIRCI)":[9],"varies":[10],"widely,":[11],"depending":[12],"on":[13],"the":[14,19,72,177,191,205,215,224,246,275,279,284],"patient":[15],"population":[16],"studied":[17],"and":[18,46,93,109,123,137,283,300,329],"diagnostic":[20,53,74,249,316],"criteria":[21],"used.":[22,336],"Surviving":[23],"Sepsis":[24],"Campaign":[25],"guidelines":[26],"suggest":[27],"that":[28],"therapy":[30,81,108],"should":[31,333],"be":[32,59,171,335],"considered":[33,164],"for":[34,76,157,227,233,318],"adult":[35],"septic":[36,84,99,327],"shock":[37,85,100,328],"when":[38],"hypotension":[39],"responds":[40],"poorly":[41,88,104],"to":[42,70,79,90,106,130,251,255,271],"adequate":[43],"fluid":[44,91,107],"resuscitation":[45,92],"vasopressors,":[47],"regardless":[48],"any":[50],"results":[51],"tests.":[54],"However,":[55],"steroid":[56,165,194,229,321],"treatment":[57,257],"may":[58],"associated":[60],"with":[61,87,209,326],"an":[62],"increase":[63],"risk":[64],"infection.":[66],"This":[67],"study":[68],"aims":[69],"identify":[71],"best":[73],"tool":[75],"predicting":[77,228],"responsiveness":[78,230,322],"in":[82,120,154,187,204,214,323],"Thai":[83,324],"patients":[86,101,122,143,192,207,217,325],"responsive":[89,105,166],"vasopressors.":[94],"MATERIAL":[95],"AND":[96],"METHOD:":[97],"Twenty-nine":[98],"who":[102],"were":[103,111,144,163,193],"vasopressors":[110],"studied.":[112],"A":[113,288],"baseline":[114,234,262],"serum":[115,197],"total":[116],"cortisol":[117,198,235,238,263,306],"was":[118,128,134,185,199,231,245,277,281,286],"measured":[119],"all":[121],"then":[124,150],"250":[125],"mcg":[126],"corticotropin":[127],"injected":[129],"patients.":[131],"Cortisol":[132],"level":[133,239,264,307],"obtained":[135],"30":[136],"60":[138],"minutes":[139],"after":[140,176],"injection.":[141],"All":[142],"given":[145],"hydrocortisone":[146,256],"(100":[147],"mg":[148,152],"i.v.,":[149],"200":[151],"i.v.":[153],"24":[155],"hrs":[156,175],"at":[158],"least":[159],"5":[160],"days).":[161],"Patients":[162],"if":[167],"vasopressor":[168],"agent":[169],"could":[170],"discontinued":[172],"within":[173],"48":[174],"first":[178],"dose":[179],"hydrocortisone.":[181],"RESULTS:":[182],"Hospital":[183],"mortality":[184],"62%":[186,282],"which":[188],"45%":[189],"responsive.":[195],"Baseline":[196,305],"27.6":[200],"+/-":[201,211],"11.4":[202],"microg/dl":[203,213,242,270,312],"steroid-responsive":[206],"compared":[208],"40":[210],"16.9":[212],"steroid-nonresponsive":[216],"(p":[218,258],"=":[219,259,268,310],"0.03).":[220],"area":[222],"under":[223],"ROC":[225],"curves":[226],"0.72":[232],"level.":[236],"Serum":[237],"35":[241,269,311],"or":[243,267,309],"less":[244],"most":[247],"accurate":[248],"threshold":[250,317],"determine":[252],"hemodynamic":[253],"response":[254],"0.04).":[260],"Using":[261],"<":[266,308],"diagnose":[272],"adrenal":[273],"insufficiency,":[274],"sensitivity":[276,294],"85%,":[278],"specificity":[280,297],"accuracy":[285,301],"72%.":[287],"use":[289],"(delta":[291],"cortisol)":[292],"showed":[293],"50%,":[296],"30%":[299],"41%.":[303],"CONCLUSION:":[304],"is":[313],"a":[314],"useful":[315],"diagnosis":[319],"ACTH":[330],"stimulation":[331],"test":[332],"not":[334]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-12-13T00:00:00"}
