{"id":"https://openalex.org/W2993697693","doi":null,"title":"Alu RNA Induced Rpe Cell Apoptosis Triggered By DICER Dysregulation In Geographic Atrophy","display_name":"Alu RNA Induced Rpe Cell Apoptosis Triggered By DICER Dysregulation In Geographic Atrophy","publication_year":2011,"publication_date":"2011-04-22","ids":{"openalex":"https://openalex.org/W2993697693","mag":"2993697693"},"language":"en","primary_location":{"id":"mag:2993697693","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2353405","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063112023","display_name":"Valeria Tarallo","orcid":"https://orcid.org/0000-0002-6920-4402","observed_orcids":["https://orcid.org/0000-0002-6920-4402"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valeria Tarallo","raw_affiliation_strings":["Ophthalmology, University of Kentucky, Lexington, Kentucky"],"raw_orcid":"https://orcid.org/0000-0002-6920-4402","affiliations":[{"raw_affiliation_string":"Ophthalmology, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071474327","display_name":"Sami Dridi","orcid":"https://orcid.org/0000-0002-6441-2560","observed_orcids":["https://orcid.org/0000-0002-6441-2560"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sami Dridi","raw_affiliation_strings":["Ophthalmology, University of Kentucky, Lexington, Kentucky"],"raw_orcid":"https://orcid.org/0000-0002-6441-2560","affiliations":[{"raw_affiliation_string":"Ophthalmology, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058678129","display_name":"Hiroki Kaneko","orcid":"https://orcid.org/0000-0003-0731-6465","observed_orcids":["https://orcid.org/0000-0003-0731-6465"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroki Kaneko","raw_affiliation_strings":["Ophthalmology, University of Kentucky, Lexington, Kentucky"],"raw_orcid":"https://orcid.org/0000-0003-0731-6465","affiliations":[{"raw_affiliation_string":"Ophthalmology, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079068166","display_name":"Mark Ellsworth Kleinman","orcid":"https://orcid.org/0000-0001-8557-7949","observed_orcids":["https://orcid.org/0000-0001-8557-7949"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark E. Kleinman","raw_affiliation_strings":["Ophthalmology, University of Kentucky, Lexington, Kentucky"],"raw_orcid":"https://orcid.org/0000-0001-8557-7949","affiliations":[{"raw_affiliation_string":"Ophthalmology, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070085596","display_name":"Benjamin J. Fowler","orcid":"https://orcid.org/0000-0001-8995-4131","observed_orcids":["https://orcid.org/0000-0001-8995-4131"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin J. Fowler","raw_affiliation_strings":["Ophthalmology, University of Kentucky, Lexington, Kentucky"],"raw_orcid":"https://orcid.org/0000-0001-8995-4131","affiliations":[{"raw_affiliation_string":"Ophthalmology, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107119452","display_name":"Romulo Albuquerque","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Romulo Albuquerque","raw_affiliation_strings":["Ophthalmology, University of Kentucky, Lexington, Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068278401","display_name":"Judit Baffi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judit Baffi","raw_affiliation_strings":["Ophthalmology, University of Kentucky, Lexington, Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086654368","display_name":"Jayakrishna Ambati","orcid":"https://orcid.org/0000-0003-1622-6365","observed_orcids":["https://orcid.org/0000-0003-1622-6365"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jayakrishna Ambati","raw_affiliation_strings":["Ophthalmology, University of Kentucky, Lexington, Kentucky"],"raw_orcid":"https://orcid.org/0000-0003-1622-6365","affiliations":[{"raw_affiliation_string":"Ophthalmology, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.43893061,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"52","issue":"14","first_page":"2314","last_page":"2314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.03500000014901161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alu-rna","display_name":"Alu RNA","score":0.9449999928474426},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.8640000224113464},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/dicer","display_name":"Dicer","score":0.9449999928474426},{"id":"https://openalex.org/keywords/geographic-atrophy","display_name":"geographic atrophy","score":0.9779999852180481},{"id":"https://openalex.org/keywords/mirna-dysregulation","display_name":"microRNA dysregulation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C2779867133","wikidata":"https://www.wikidata.org/wiki/Q21111297","display_name":"Dicer","level":5,"score":0.8067666888237},{"id":"https://openalex.org/C2991880128","wikidata":"https://www.wikidata.org/wiki/Q47200750","display_name":"Geographic atrophy","level":3,"score":0.6836140155792236},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6507642269134521},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5506889820098877},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.5154872536659241},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4512062966823578},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.44353264570236206},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36731505393981934},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35147908329963684},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17221331596374512},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.17124152183532715},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1474696695804596},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2993697693","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2353405","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5099999904632568,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W965321202","https://openalex.org/W2085350682","https://openalex.org/W1163668938","https://openalex.org/W2048889430","https://openalex.org/W2915412546","https://openalex.org/W2040438916","https://openalex.org/W4247816260","https://openalex.org/W1041899203","https://openalex.org/W1991050184","https://openalex.org/W2111586778"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2019-12-13T00:00:00"}