{"id":"https://openalex.org/W2993678408","doi":"https://doi.org/10.1080/22221751.2019.1694394","title":"Limited evolution of the yellow fever virus 17d in a mouse infection model","display_name":"Limited evolution of the yellow fever virus 17d in a mouse infection model","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2993678408","doi":"https://doi.org/10.1080/22221751.2019.1694394","mag":"2993678408","pmid":"https://pubmed.ncbi.nlm.nih.gov/31797751","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6896426"},"language":"en","primary_location":{"id":"doi:10.1080/22221751.2019.1694394","doi":"https://doi.org/10.1080/22221751.2019.1694394","is_oa":true,"landing_page_url":"https://doi.org/10.1080/22221751.2019.1694394","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/22221751.2019.1694394?needAccess=true","source":{"id":"https://openalex.org/S2764760790","display_name":"Emerging Microbes & Infections","issn_l":"2222-1751","issn":["2222-1751"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Emerging Microbes & Infections","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/22221751.2019.1694394?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042391426","display_name":"Dieudonn\u00e9 Buh Kum","orcid":"https://orcid.org/0000-0001-8251-8230","observed_orcids":["https://orcid.org/0000-0001-8251-8230"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dieudonn\u00e9 Buh Kum","raw_affiliation_strings":["Aligos Belgium","KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy","Aligos Belgium, Leuven, Belgium","KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-8251-8230","affiliations":[{"raw_affiliation_string":"Aligos Belgium","institution_ids":[]},{"raw_affiliation_string":"KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Aligos Belgium, Leuven, Belgium","institution_ids":[]},{"raw_affiliation_string":"KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043590871","display_name":"Niraj Mishra","orcid":"https://orcid.org/0000-0002-8679-8847","observed_orcids":["https://orcid.org/0000-0002-8679-8847"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Niraj Mishra","raw_affiliation_strings":["KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy","KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-8679-8847","affiliations":[{"raw_affiliation_string":"KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]},{"raw_affiliation_string":"KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071909075","display_name":"Bram Vrancken","orcid":"https://orcid.org/0000-0001-6547-5283","observed_orcids":["https://orcid.org/0000-0001-6547-5283"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Bram Vrancken","raw_affiliation_strings":["KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory for Clinical and Epidemiological Virology","KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory for Clinical and Epidemiological Virology, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-6547-5283","affiliations":[{"raw_affiliation_string":"KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory for Clinical and Epidemiological Virology","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]},{"raw_affiliation_string":"KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory for Clinical and Epidemiological Virology, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065326116","display_name":"Hendrik Jan Thibaut","orcid":"https://orcid.org/0000-0001-5785-8276","observed_orcids":["https://orcid.org/0000-0001-5785-8276"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Hendrik Jan Thibaut","raw_affiliation_strings":["KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy","KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-5785-8276","affiliations":[{"raw_affiliation_string":"KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]},{"raw_affiliation_string":"KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073185475","display_name":"Annelies Wilder\u2010Smith","orcid":"https://orcid.org/0000-0003-0362-5375","observed_orcids":["https://orcid.org/0000-0003-0362-5375"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]},{"id":"https://openalex.org/I4405263306","display_name":"Heidelberg Institute of Global Health","ror":"https://ror.org/052rvyy58","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802164966","https://openalex.org/I4405263306"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"Annelies Wilder-Smith","raw_affiliation_strings":["Department of Disease Control, London School of Hygiene and Tropical Medicine","Heidelberg Institute of Global Health, University of Heidelberg","Department of Disease Control, London School of Hygiene and Tropical Medicine, London, United Kingdom","Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0362-5375","affiliations":[{"raw_affiliation_string":"Department of Disease Control, London School of Hygiene and Tropical Medicine","institution_ids":["https://openalex.org/I4210089966"]},{"raw_affiliation_string":"Heidelberg Institute of Global Health, University of Heidelberg","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4405263306"]},{"raw_affiliation_string":"Department of Disease Control, London School of Hygiene and Tropical Medicine, London, United Kingdom","institution_ids":["https://openalex.org/I4210089966"]},{"raw_affiliation_string":"Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4405263306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039280845","display_name":"Philippe Lemey","orcid":"https://orcid.org/0000-0003-2826-5353","observed_orcids":["https://orcid.org/0000-0003-2826-5353"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Philippe Lemey","raw_affiliation_strings":["KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory for Clinical and Epidemiological Virology","KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory for Clinical and Epidemiological Virology, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-2826-5353","affiliations":[{"raw_affiliation_string":"KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory for Clinical and Epidemiological Virology","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]},{"raw_affiliation_string":"KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory for Clinical and Epidemiological Virology, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089010495","display_name":"Johan H. Neyts","orcid":"https://orcid.org/0000-0002-0033-7514","observed_orcids":["https://orcid.org/0000-0002-0033-7514"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Johan Neyts","raw_affiliation_strings":["KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy","KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-0033-7514","affiliations":[{"raw_affiliation_string":"KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]},{"raw_affiliation_string":"KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084429609","display_name":"Kai Dallmeier","orcid":"https://orcid.org/0000-0002-8117-9166","observed_orcids":["https://orcid.org/0000-0002-8117-9166"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Kai Dallmeier","raw_affiliation_strings":["KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy","KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-8117-9166","affiliations":[{"raw_affiliation_string":"KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]},{"raw_affiliation_string":"KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5084429609","https://openalex.org/A5089010495"],"corresponding_institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"],"apc_list":{"value":2155,"currency":"GBP","value_usd":2643},"apc_paid":{"value":2155,"currency":"GBP","value_usd":2643},"fwci":3.4532,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.92406146,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"1734","last_page":"1746"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yellow-fever-virus-17d","display_name":"yellow fever virus 17D","score":0.968999981880188},{"id":"https://openalex.org/keywords/neurotropic-infection","display_name":"neurotropic infection","score":0.6740000247955322},{"id":"https://openalex.org/keywords/intra-host-viral-evolution","display_name":"intra-host viral evolution","score":0.8600000143051147},{"id":"https://openalex.org/keywords/quasispecies","display_name":"quasispecies","score":0.9259999990463257},{"id":"https://openalex.org/keywords/clonal-heterogeneity","display_name":"clonal heterogeneity","score":0.8169999718666077},{"id":"https://openalex.org/keywords/ag129-mice","display_name":"AG129 mice","score":0.7720000147819519},{"id":"https://openalex.org/keywords/dose-dependence","display_name":"dose dependence","score":0.6539999842643738},{"id":"https://openalex.org/keywords/antigenic-drift","display_name":"antigenic drift","score":0.843999981880188},{"id":"https://openalex.org/keywords/antiviral-resistance","display_name":"antiviral resistance","score":0.9440000057220459},{"id":"https://openalex.org/keywords/flavivirus-vaccines","display_name":"flavivirus vaccines","score":0.7009999752044678},{"id":"https://openalex.org/keywords/fractional-dosing","display_name":"fractional dosing","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C14500911","wikidata":"https://www.wikidata.org/wiki/Q3413375","display_name":"Viral quasispecies","level":4,"score":0.8304108381271362},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7508704662322998},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7262572646141052},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6837274432182312},{"id":"https://openalex.org/C2779131611","wikidata":"https://www.wikidata.org/wiki/Q154874","display_name":"Yellow fever","level":3,"score":0.6347111463546753},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.515598714351654},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.48770055174827576},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.43607622385025024},{"id":"https://openalex.org/C8769409","wikidata":"https://www.wikidata.org/wiki/Q2066554","display_name":"Viral evolution","level":4,"score":0.43489694595336914},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.412313848733902},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3311488926410675},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3272075355052948},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15996646881103516},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12184995412826538},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015004","descriptor_name":"Yellow Fever","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D015005","descriptor_name":"Yellow fever virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022341","descriptor_name":"Yellow Fever Vaccine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1080/22221751.2019.1694394","doi":"https://doi.org/10.1080/22221751.2019.1694394","is_oa":true,"landing_page_url":"https://doi.org/10.1080/22221751.2019.1694394","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/22221751.2019.1694394?needAccess=true","source":{"id":"https://openalex.org/S2764760790","display_name":"Emerging Microbes & Infections","issn_l":"2222-1751","issn":["2222-1751"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Emerging Microbes & Infections","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6896426","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6896426","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Emerg Microbes Infect","raw_type":"Text"},{"id":"pmid:31797751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31797751","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Emerging microbes & infections","raw_type":"Journal Article"},{"id":"pmh:oai:researchonline.lshtm.ac.uk:4655578","doi":null,"is_oa":false,"landing_page_url":"https://researchonline.lshtm.ac.uk/view/creators/idcvawil.html>;","pdf_url":null,"source":{"id":"https://openalex.org/S4306402527","display_name":"LSHTM Research Online (London School of Hygiene and Tropical Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210089966","host_organization_name":"London School of Hygiene & Tropical Medicine","host_organization_lineage":["https://openalex.org/I4210089966"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/645238","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/645238","pdf_url":"https://lirias.kuleuven.be/retrieve/1a3f2d5d-0b92-484d-85d8-df34447efe68","source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Emerg Microbes Infect, vol. 8 (1), (1734-1746)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:e287cfda8a9846fca27134d39da418bd","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e287cfda8a9846fca27134d39da418bd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Emerging Microbes and Infections, Vol 8, Iss 1, Pp 1734-1746 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/22221751.2019.1694394","doi":"https://doi.org/10.1080/22221751.2019.1694394","is_oa":true,"landing_page_url":"https://doi.org/10.1080/22221751.2019.1694394","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/22221751.2019.1694394?needAccess=true","source":{"id":"https://openalex.org/S2764760790","display_name":"Emerging Microbes & Infections","issn_l":"2222-1751","issn":["2222-1751"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Emerging Microbes & Infections","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7765445058","display_name":"Zika Preparedness Latin American Network","funder_award_id":"734584","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7778288888","display_name":"A global alliance for Zika virus control and prevention","funder_award_id":"734548","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8072534300","display_name":"Development of a Next-Generation, Dual-Target Rabies/Flavivirus Infectious DNA (iDNA) Vaccine","funder_award_id":"733176","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320929","display_name":"Universiteit Leiden","ror":"https://ror.org/027bh9e22"},{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"},{"id":"https://openalex.org/F4320323080","display_name":"Leids Universitair Medisch Centrum","ror":"https://ror.org/05xvt9f17"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2993678408.pdf","grobid_xml":"https://content.openalex.org/works/W2993678408.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W136988059","https://openalex.org/W179427592","https://openalex.org/W1186520945","https://openalex.org/W1926538315","https://openalex.org/W1930242224","https://openalex.org/W1965938470","https://openalex.org/W1974962296","https://openalex.org/W1977111143","https://openalex.org/W1978711639","https://openalex.org/W1980073965","https://openalex.org/W1983779252","https://openalex.org/W1994801641","https://openalex.org/W1997913859","https://openalex.org/W2003574450","https://openalex.org/W2003760082","https://openalex.org/W2016480047","https://openalex.org/W2027116769","https://openalex.org/W2030100825","https://openalex.org/W2043684997","https://openalex.org/W2050052145","https://openalex.org/W2059132547","https://openalex.org/W2060969557","https://openalex.org/W2061517634","https://openalex.org/W2061769992","https://openalex.org/W2062715434","https://openalex.org/W2065461553","https://openalex.org/W2074064766","https://openalex.org/W2083347487","https://openalex.org/W2096638210","https://openalex.org/W2097706568","https://openalex.org/W2097790240","https://openalex.org/W2098466244","https://openalex.org/W2098618245","https://openalex.org/W2106011172","https://openalex.org/W2107456552","https://openalex.org/W2114173013","https://openalex.org/W2117769971","https://openalex.org/W2123387190","https://openalex.org/W2125775699","https://openalex.org/W2130924724","https://openalex.org/W2135590074","https://openalex.org/W2138542194","https://openalex.org/W2142481964","https://openalex.org/W2144386534","https://openalex.org/W2146673939","https://openalex.org/W2148148996","https://openalex.org/W2151244977","https://openalex.org/W2159093669","https://openalex.org/W2332483916","https://openalex.org/W2342204193","https://openalex.org/W2408543002","https://openalex.org/W2468473435","https://openalex.org/W2566478608","https://openalex.org/W2594592790","https://openalex.org/W2633813775","https://openalex.org/W2748234621","https://openalex.org/W2791755096","https://openalex.org/W2791893523","https://openalex.org/W2799524357","https://openalex.org/W2804358107","https://openalex.org/W2849386281","https://openalex.org/W2892030056","https://openalex.org/W2896075412","https://openalex.org/W2896842144","https://openalex.org/W2899155229","https://openalex.org/W2902769207","https://openalex.org/W2903985069","https://openalex.org/W2950860230","https://openalex.org/W4299427611"],"related_works":["https://openalex.org/W7125400787","https://openalex.org/W2096638210","https://openalex.org/W3159864354","https://openalex.org/W2016338330","https://openalex.org/W7098483062","https://openalex.org/W2892250009","https://openalex.org/W2005008085","https://openalex.org/W2003277345","https://openalex.org/W2140602455","https://openalex.org/W2111107331"],"abstract_inverted_index":{"By":[0],"infecting":[1],"mice":[2,29,43,95],"with":[3,98,155],"the":[4,13,39,48,188],"yellow":[5,21],"fever":[6,22],"virus":[7,49,181],"vaccine":[8,138],"strain":[9],"17D":[10],"(YFV-17D;":[11],"Stamaril\u00ae),":[12],"dose":[14],"dependence":[15],"and":[16,57,119,139,193],"evolutionary":[17],"consequences":[18],"of":[19,38,86,91,102,176,190,195],"neurotropic":[20,46],"infection":[23,154],"was":[24,50,105],"assessed.":[25],"Highly":[26],"susceptible":[27,133],"AG129":[28],"were":[30,62,96],"used":[31],"to":[32,82,178,197],"allow":[33],"for":[34,137,149],"a":[35,84,99,110,116,131,147,156,173],"maximal/unlimited":[36],"expansion":[37,129],"viral":[40],"populations.":[41],"Infected":[42],"uniformly":[44],"developed":[45],"disease;":[47],"isolated":[51],"from":[52,109],"their":[53],"brains,":[54],"plaque":[55],"purified":[56],"sequenced.":[58],"Viral":[59],"RNA":[60],"populations":[61],"overall":[63],"rather":[64],"homogenous":[65],"[Shannon":[66],"entropies":[67],"0-0.15].":[68],"The":[69,123],"remaining,":[70],"yet":[71],"limited":[72,124,150,174],"intra-host":[73,125],"population":[74],"diversity":[75],"(0-11":[76],"nucleotide":[77],"exchanges":[78],"per":[79],"genome)":[80],"appeared":[81],"be":[83],"consequence":[85],"pre-existing":[87],"clonal":[88,121],"heterogeneities":[89],"(quasispecies)":[90],"Stamaril\u00ae.":[92],"In":[93],"parallel,":[94],"infected":[97],"molecular":[100],"clone":[101],"YFV-17D":[103,114],"which":[104],"in":[106,130,144,166],"vivo":[107],"launched":[108],"plasmid.":[111],"Such":[112],"plasmid-launched":[113],"had":[115],"further":[117],"reduced":[118],"almost":[120],"evolution.":[122],"evolution":[126,151],"during":[127],"unrestricted":[128],"highly":[132],"host":[134],"is":[135],"relevant":[136],"drug":[140],"development":[141,194],"against":[142],"flaviviruses":[143],"general.":[145],"Firstly,":[146],"propensity":[148],"even":[152],"upon":[153],"(very)":[157],"low":[158],"inoculum":[159],"suggests":[160],"that":[161],"fractional":[162],"dosing":[163],"as":[164],"implemented":[165],"current":[167],"YF-outbreak":[168],"control":[169],"may":[170],"pose":[171],"only":[172],"risk":[175],"reversion":[177],"pathogenic":[179],"vaccine-derived":[180],"variants.":[182],"Secondly,":[183],"it":[184],"also":[185],"largely":[186],"lowers":[187],"chance":[189],"antigenic":[191],"drift":[192],"resistance":[196],"antivirals.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-12-13T00:00:00"}