{"id":"https://openalex.org/W2993668211","doi":null,"title":"[Cardioprotective action of coenzyme Q in conditions of its endogenous synthesis activation in cardiac ischemia-reperfusion in old rats].","display_name":"[Cardioprotective action of coenzyme Q in conditions of its endogenous synthesis activation in cardiac ischemia-reperfusion in old rats].","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2993668211","mag":"2993668211","pmid":"https://pubmed.ncbi.nlm.nih.gov/19827631"},"language":"uk","primary_location":{"id":"pmid:19827631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19827631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061751437","display_name":"S V Timoshchuk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S V Timoshchuk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110386019","display_name":"Vavilova Hl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H L Vavilova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016086269","display_name":"N A Strutyns'ka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N A Strutyns'ka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109122494","display_name":"Sergey A. Talanov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S A Talanov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108597313","display_name":"Dmytro Petukhov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D M Petukhov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017522641","display_name":"Kuchmenko Ob","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O B Kuchmenko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078498913","display_name":"Donchenko Hv","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H V Donchenko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077669285","display_name":"V F Sahach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V F Sahach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1099,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.47541458,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"55","issue":"4","first_page":"58","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.8022000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.8022000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.1931000053882599,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coenzyme-q10","display_name":"coenzyme Q10","score":0.8830000162124634},{"id":"https://openalex.org/keywords/ubiquinone-biosynthesis","display_name":"ubiquinone biosynthesis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8870000243186951},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.9620000123977661},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5910000205039978},{"id":"https://openalex.org/keywords/langendorff-preparation","display_name":"isolated perfused heart","score":0.6470000147819519},{"id":"https://openalex.org/keywords/p-hydroxybenzoic-acid","display_name":"p-hydroxybenzoic acid","score":0.968999981880188},{"id":"https://openalex.org/keywords/methionine","display_name":"methionine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.9679999947547913},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.8479999899864197},{"id":"https://openalex.org/keywords/coronary-blood-flow","display_name":"coronary blood flow","score":0.9200000166893005},{"id":"https://openalex.org/keywords/oxygen-consumption","display_name":"oxygen consumption","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.7538922429084778},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6674832105636597},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.5037276148796082},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4807038903236389},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.4757349491119385},{"id":"https://openalex.org/C3017461755","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Myocardial ischemia","level":3,"score":0.4537239372730255},{"id":"https://openalex.org/C2779123261","wikidata":"https://www.wikidata.org/wiki/Q407635","display_name":"Coenzyme A","level":4,"score":0.4334403872489929},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43163707852363586},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4201200008392334},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.41553935408592224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35008692741394043},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33457884192466736},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32940900325775146},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.19038480520248413},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.190271258354187},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.13960278034210205},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002316","descriptor_name":"Cardiotonic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006334","descriptor_name":"Heart Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010226","descriptor_name":"Parabens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015425","descriptor_name":"Myocardial Reperfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024502","descriptor_name":"alpha-Tocopherol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:19827631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19827631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2047165080","https://openalex.org/W1984755783","https://openalex.org/W3631640","https://openalex.org/W2090032545","https://openalex.org/W2463711095","https://openalex.org/W2077312427","https://openalex.org/W2085228114","https://openalex.org/W4236709537","https://openalex.org/W2043876810","https://openalex.org/W2438751036"],"abstract_inverted_index":{"The":[0,36],"changes":[1],"of":[2,14,20,26,38,50,61,79,86,100,105,114],"functional":[3],"state":[4],"isolated":[5],"by":[6],"Lanhendorf":[7],"old":[8,55],"rat":[9,56],"hearts":[10],"with":[11,83],"low":[12],"content":[13],"ubiqinone--coenzyme":[15],"Q":[16],"(CoQ)":[17],"under":[18,103],"activation":[19,37,99],"it":[21,106],"endogenous":[22],"synthesis":[23],"through":[24],"administration":[25,104],"precursors--4-hydroxybenzoic":[27],"acid,":[28],"methionine":[29],"and":[30,65,76],"modulator":[31],"vitamin":[32],"E":[33],"were":[34],"studied.":[35],"ubiqinone":[39],"biosynthesis":[40,102],"contribute":[41],"to":[42,46,95],"cardioprotective":[43],"effect":[44,110],"due":[45],"reduce":[47],"the":[48,51,59,72,80,87,92,98,112,115],"degree":[49],"ischemia-reperfusion":[52],"injury":[53],"in":[54,111,119],"heart,":[57],"namely":[58],"restoration":[60],"myocardial":[62],"contractile":[63],"function":[64],"coronary":[66],"flow":[67],"as":[68,70],"well":[69],"decrease":[71],"end":[73],"diastolic":[74],"pressure":[75],"oxygen":[77],"cost":[78],"heart":[81,116],"compared":[82],"control":[84],"group":[85],"animals":[88],"during":[89],"ischemia-reperfusion.":[90],"Thus":[91],"results":[93],"allow":[94],"conclude":[96],"that":[97],"KoQ":[101],"precursors":[107],"has":[108],"protective":[109],"development":[113],"postreperfusion":[117],"damages":[118],"aging.":[120]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-12-13T00:00:00"}