{"id":"https://openalex.org/W2993666410","doi":"https://doi.org/10.1182/blood.v110.11.1806.1806","title":"Immunological and Clinical Responses in Patients with Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), Multiple Myeloma (MM) and Chronic Lymphocytic Leukemia (CLL) after RHAMM-R3 Peptide Vaccination.","display_name":"Immunological and Clinical Responses in Patients with Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), Multiple Myeloma (MM) and Chronic Lymphocytic Leukemia (CLL) after RHAMM-R3 Peptide Vaccination.","publication_year":2007,"publication_date":"2007-11-16","ids":{"openalex":"https://openalex.org/W2993666410","doi":"https://doi.org/10.1182/blood.v110.11.1806.1806","mag":"2993666410"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v110.11.1806.1806","doi":"https://doi.org/10.1182/blood.v110.11.1806.1806","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.1806.1806","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045920008","display_name":"Jochen Greiner","orcid":"https://orcid.org/0000-0003-1256-173X","observed_orcids":["https://orcid.org/0000-0003-1256-173X"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jochen Greiner","raw_affiliation_strings":["Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111818788","display_name":"Anita Schmitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anita Schmitt","raw_affiliation_strings":["Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090085247","display_name":"Krzysztof Giannopoulos","orcid":"https://orcid.org/0000-0003-0135-4030","observed_orcids":["https://orcid.org/0000-0003-0135-4030"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Krzysztof Giannopoulos","raw_affiliation_strings":["Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000286768","display_name":"Jinfei Chen","orcid":"https://orcid.org/0000-0001-5874-3462","observed_orcids":["https://orcid.org/0000-0001-5874-3462"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jinfei Chen","raw_affiliation_strings":["Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020662983","display_name":"Marlies Goetz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marlies Goetz","raw_affiliation_strings":["Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007372145","display_name":"Markus Rojewski","orcid":"https://orcid.org/0000-0003-4265-0442","observed_orcids":["https://orcid.org/0000-0003-4265-0442"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Rojewski","raw_affiliation_strings":["Institute of Clinical Transfusion Medicine, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Transfusion Medicine, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046912050","display_name":"Gerd Ritter","orcid":"https://orcid.org/0000-0002-3513-4661","observed_orcids":["https://orcid.org/0000-0002-3513-4661"]},"institutions":[{"id":"https://openalex.org/I4210150094","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05qdwtz81","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerd Ritter","raw_affiliation_strings":["New York Branch, Ludwig Institute of Cancer Research, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Branch, Ludwig Institute of Cancer Research, New York, USA","institution_ids":["https://openalex.org/I4210150094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058066873","display_name":"Sascha Gnjatic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150094","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05qdwtz81","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sascha Gnjatic","raw_affiliation_strings":["New York Branch, Ludwig Institute of Cancer Research, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York Branch, Ludwig Institute of Cancer Research, New York, USA","institution_ids":["https://openalex.org/I4210150094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001841343","display_name":"Philippe Guillaume","orcid":"https://orcid.org/0000-0002-6340-0963","observed_orcids":["https://orcid.org/0000-0002-6340-0963"]},"institutions":[{"id":"https://openalex.org/I4210117758","display_name":"Ludwig Cancer Research","ror":"https://ror.org/02cn3rm21","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4210117758","https://openalex.org/I4210150094"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Philippe Guillaume","raw_affiliation_strings":["Lausanne Branch, Ludwig Institute of Cancer Research, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lausanne Branch, Ludwig Institute of Cancer Research, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210117758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013435653","display_name":"Mark Ringhoffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mark Ringhoffer","raw_affiliation_strings":["Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040466390","display_name":"Martin Bommer","orcid":"https://orcid.org/0000-0003-3195-9129","observed_orcids":["https://orcid.org/0000-0003-3195-9129"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Bommer","raw_affiliation_strings":["Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053949970","display_name":"Richard F. Schlenk","orcid":"https://orcid.org/0000-0003-2215-2059","observed_orcids":["https://orcid.org/0000-0003-2215-2059","https://orcid.org/0000-0002-5298-3120"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Richard F. Schlenk","raw_affiliation_strings":["Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076032746","display_name":"Peter Liebisch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Liebisch","raw_affiliation_strings":["Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002578778","display_name":"Donald Werner Bunjes","orcid":"https://orcid.org/0000-0002-1952-5443","observed_orcids":["https://orcid.org/0000-0002-1952-5443"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Donald Bunjes","raw_affiliation_strings":["Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053119596","display_name":"Hiroshi Shiku","orcid":"https://orcid.org/0000-0002-0362-755X","observed_orcids":["https://orcid.org/0000-0002-0362-755X"]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Shiku","raw_affiliation_strings":["Medical School, Mie University, Tsu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School, Mie University, Tsu, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089395073","display_name":"Hartmut D\u00f6hner","orcid":"https://orcid.org/0000-0003-2116-5536","observed_orcids":["https://orcid.org/0000-0003-2116-5536"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hartmut Dohner","raw_affiliation_strings":["Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017514499","display_name":"Michael W. Schmitt","orcid":"https://orcid.org/0000-0002-1579-1509","observed_orcids":["https://orcid.org/0000-0002-1579-1509"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Schmitt","raw_affiliation_strings":["Internal Medicine III, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine III, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.1232,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.55580521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"110","issue":"11","first_page":"1806","last_page":"1806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhamm","display_name":"RHAMM","score":0.7139999866485596},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8629999756813049},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":1.0},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":1.0},{"id":"https://openalex.org/keywords/leukemia-associated-antigens","display_name":"leukemia-associated antigens","score":0.6700000166893005},{"id":"https://openalex.org/keywords/peptide-vaccine","display_name":"peptide vaccine","score":0.6309999823570251},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.6959999799728394},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.6290000081062317},{"id":"https://openalex.org/keywords/granzyme-b","display_name":"granzyme B","score":0.9449999928474426},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.7400000095367432},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.968999981880188},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.7850000262260437},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.5429999828338623},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.689415693283081},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6475046277046204},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5538361668586731},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5113930106163025},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.4354396164417267},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.43367063999176025},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.29758715629577637}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v110.11.1806.1806","doi":"https://doi.org/10.1182/blood.v110.11.1806.1806","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v110.11.1806.1806","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2069382319","https://openalex.org/W2991882170","https://openalex.org/W2546554812","https://openalex.org/W2993550330","https://openalex.org/W2096439958","https://openalex.org/W7098795513","https://openalex.org/W2094147411","https://openalex.org/W7100253120","https://openalex.org/W2569044221","https://openalex.org/W2586971939"],"abstract_inverted_index":{"Abstract":[0],"We":[1,174,286],"initiated":[2],"a":[3,38,75,80,120,217,244,280,298,321,343],"phase":[4],"I/II":[5],"R3":[6,105,192],"peptide":[7,106,332],"vaccination":[8,333],"for":[9,30,127,162,346],"patients":[10,61,87,93,101,258,278,293,317,351],"with":[11,62,70,74,96,102,108,202,294,318,352],"acute":[12],"myeloid":[13,295],"leukemia":[14,25,39],"(AML),":[15],"myelodysplastic":[16],"syndrome":[17],"(MDS),":[18],"multiple":[19],"myeloma":[20],"(MM)":[21],"and":[22,51,54,99,123,142,165,170,230,236,269,337],"chronic":[23],"lymphocytic":[24],"(CLL)":[26],"overexpressing":[27],"the":[28,109,145,148,303],"receptor":[29],"hyaluronic":[31],"acid":[32],"mediated":[33],"motility":[34],"(RHAMM).":[35],"RHAMM":[36,71,264,283,341],"is":[37,44],"associated":[40],"antigen":[41],"(LAA)":[42],"that":[43],"strongly":[45],"expressed":[46],"in":[47,179,197,200,210,233,254,266,291,302,350],"several":[48,292],"hematological":[49,354],"malignancies":[50],"induces":[52],"humoral":[53],"cellular":[55],"immune":[56,177],"responses.":[57,263,339],"In":[58,183,213],"this":[59],"study,":[60],"AML,":[63],"MDS,":[64],"MM":[65,319],"or":[66,79],"CLL":[67],"were":[68,88,94,137,154,272],"included":[69],"expression":[72],"but":[73],"limited":[76],"tumor":[77],"load":[78],"minimal":[81],"residual":[82],"disease.":[83],"To":[84],"date,":[85],"25":[86],"enrolled.":[89],"The":[90,113],"first":[91],"12":[92],"vaccinated":[95],"300":[97],"mcg":[98,104],"further":[100,347],"1000":[103],"emulsified":[107],"incomplete":[110],"Freund\u2019s":[111],"adjuvant.":[112],"vaccine":[114],"was":[115,125,224],"given":[116],"four":[117,255],"times":[118],"at":[119,147,243],"biweekly":[121],"interval":[122],"GM-CSF":[124],"added":[126],"five":[128],"days":[129],"each":[130],"vaccination.":[131,238,285],"Only":[132],"mild":[133],"drug-related":[134],"adverse":[135],"events":[136],"observed":[138],"such":[139],"as":[140],"erythema":[141],"induration":[143],"of":[144,150,181,190,205,220,252,256,282,300,323],"skin":[146],"site":[149],"injection.":[151],"Immunological":[152],"analysis":[153],"performed":[155],"using":[156],"enzyme":[157],"linked":[158],"immunospot":[159],"(ELISpot)":[160],"assays":[161],"Interferon":[163],"gamma":[164],"Granzyme":[166],"B,":[167],"tetramer":[168],"staining":[169],"chromium":[171,214],"release":[172,215],"assays.":[173,212],"detected":[175,249,287],"specific":[176,218],"responses":[178],"70%":[180],"patients.":[182],"most":[184],"patients,":[185],"we":[186,227,248],"found":[187],"an":[188,203,250],"increase":[189,204,251],"CD8+/HLA-A2/RHAMM":[191],"tetramer+/CD45RA+/CCR7\u2212/CD27\u2212/CD28\u2212":[193],"effector":[194],"T":[195,208],"cells":[196,209],"flow":[198],"cytometry":[199],"accordance":[201],"R3-specific":[206],"CD8+":[207],"ELISpot":[211],"assays,":[216],"lysis":[219],"RHAMM-positive":[221],"leukemic":[222],"blasts":[223,301],"shown.":[225],"Moreover,":[226],"measured":[228],"IL-2":[229,253],"IL-10":[231,240],"levels":[232,241],"sera":[234],"before":[235],"after":[237,284],"While":[239],"remained":[242],"rather":[245],"low":[246],"level,":[247],"ten":[257],"who":[259],"showed":[260,279,320],"also":[261],"clinical":[262,289,338],"transcripts":[265],"bone":[267,304],"marrow":[268],"peripheral":[270],"blood":[271],"quantified":[273],"by":[274],"real-time":[275],"RT-PCR.":[276],"Responding":[277],"decrease":[281],"positive":[288],"effects":[290],"disorders":[296],"showing":[297],"reduction":[299,322],"marrow.":[305],"One":[306],"MDS":[307],"patient":[308],"did":[309],"not":[310],"need":[311],"any":[312],"longer":[313],"erythrocyte":[314],"transfusions.":[315],"Two":[316],"free":[324],"light":[325],"chain":[326],"serum":[327],"levels.":[328],"Taken":[329],"together,":[330],"RHAMM-R3":[331],"induced":[334],"both":[335],"immunological":[336],"Therefore,":[340],"constitutes":[342],"promising":[344],"structure":[345],"targeted":[348],"immunotherapies":[349],"different":[353],"malignancies.":[355]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-12-13T00:00:00"}